LOCUS       NM_001286036            4704 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT),
            transcript variant 6, mRNA.
ACCESSION   NM_001286036 XM_005245152
VERSION     NM_001286036.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4704)
  AUTHORS   Sun,X., Jing,L., Li,F., Zhang,M., Diao,X., Zhuang,J., Rastinejad,F.
            and Wu,D.
  TITLE     Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new
            dimerization modalities in the bHLH-PAS transcription factor family
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2208804119 (2022)
   PUBMED   36343253
  REMARK    GeneRIF: Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers
            reveal new dimerization modalities in the bHLH-PAS transcription
            factor family.
REFERENCE   2  (bases 1 to 4704)
  AUTHORS   Cooper,A.M., Nutter,C.A., Kuyumcu-Martinez,M.N. and Wright,C.W.
  TITLE     Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear
            Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies
  JOURNAL   Mol Cell Biol 42 (5), e0050321 (2022)
   PUBMED   35404107
  REMARK    GeneRIF: Alternative Splicing of the Aryl Hydrocarbon Receptor
            Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid
            Malignancies.
REFERENCE   3  (bases 1 to 4704)
  AUTHORS   Zhang,M., Hu,Y., Yang,F., Zhang,J., Zhang,J., Yu,W., Wang,M.,
            Lv,X., Li,J., Bai,T. and Chang,F.
  TITLE     Interaction between AhR and HIF-1 signaling pathways mediated by
            ARNT/HIF-1beta
  JOURNAL   BMC Pharmacol Toxicol 23 (1), 26 (2022)
   PUBMED   35473600
  REMARK    GeneRIF: Interaction between AhR and HIF-1 signaling pathways
            mediated by ARNT/HIF-1beta.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4704)
  AUTHORS   Scheel,J., Hussong,R., Schrenk,D. and Schmitz,H.J.
  TITLE     Variability of the human aryl hydrocarbon receptor nuclear
            translocator (ARNT) gene
  JOURNAL   J Hum Genet 47 (5), 217-224 (2002)
   PUBMED   12032587
REFERENCE   5  (bases 1 to 4704)
  AUTHORS   Scheel,J. and Schrenk,D.
  TITLE     Genomic structure of the human Ah receptor nuclear translocator
            gene (hARNT)
  JOURNAL   Hum Genet 107 (4), 397-399 (2000)
   PUBMED   11129342
REFERENCE   6  (bases 1 to 4704)
  AUTHORS   Salomon-Nguyen,F., Della-Valle,V., Mauchauffe,M., Busson-Le
            Coniat,M., Ghysdael,J., Berger,R. and Bernard,O.A.
  TITLE     The t(1;12)(q21;p13) translocation of human acute myeloblastic
            leukemia results in a TEL-ARNT fusion
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6757-6762 (2000)
   PUBMED   10829078
REFERENCE   7  (bases 1 to 4704)
  AUTHORS   Yamaguchi,Y. and Kuo,M.T.
  TITLE     Functional analysis of aryl hydrocarbon receptor nuclear
            translocator interactions with aryl hydrocarbon receptor in the
            yeast two-hybrid system
  JOURNAL   Biochem Pharmacol 50 (8), 1295-1302 (1995)
   PUBMED   7488247
REFERENCE   8  (bases 1 to 4704)
  AUTHORS   Wang,G.L., Jiang,B.H., Rue,E.A. and Semenza,G.L.
  TITLE     Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
            heterodimer regulated by cellular O2 tension
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5510-5514 (1995)
   PUBMED   7539918
REFERENCE   9  (bases 1 to 4704)
  AUTHORS   Reyes,H., Reisz-Porszasz,S. and Hankinson,O.
  TITLE     Identification of the Ah receptor nuclear translocator protein
            (Arnt) as a component of the DNA binding form of the Ah receptor
  JOURNAL   Science 256 (5060), 1193-1195 (1992)
   PUBMED   1317062
REFERENCE   10 (bases 1 to 4704)
  AUTHORS   Hoffman,E.C., Reyes,H., Chu,F.F., Sander,F., Conley,L.H.,
            Brooks,B.A. and Hankinson,O.
  TITLE     Cloning of a factor required for activity of the Ah (dioxin)
            receptor
  JOURNAL   Science 252 (5008), 954-958 (1991)
   PUBMED   1852076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK293027.1, AK223459.1,
            AB209877.1, AL355860.12 and BU730937.1.
            
            On May 31, 2019 this sequence version replaced NM_001286036.1.
            
            Summary: This gene encodes a protein containing a basic
            helix-loop-helix domain and two characteristic PAS domains along
            with a PAC domain. The encoded protein binds to ligand-bound aryl
            hydrocarbon receptor and aids in the movement of this complex to
            the nucleus, where it promotes the expression of genes involved in
            xenobiotic metabolism. This protein is also a co-factor for
            transcriptional regulation by hypoxia-inducible factor 1.
            Chromosomal translocation of this locus with the ETV6 (ets variant
            6) gene on chromosome 12 have been described in leukemias.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (6) uses an alternate in-frame
            splice site, compared to variant 1. The encoded isoform (6) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209877.1, SRR14038194.3809072.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK293027.1         171-173
            4-20                AK223459.1         37-53
            21-598              AB209877.1         1-578
            599-599             AL355860.12        37057-37057         c
            600-2907            AB209877.1         580-2887
            2908-4665           AL355860.12        10396-12153         c
            4666-4704           BU730937.1         25-63               c
FEATURES             Location/Qualifiers
     source          1..4704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..4704
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="aryl hydrocarbon receptor nuclear translocator"
                     /db_xref="GeneID:405"
                     /db_xref="HGNC:HGNC:700"
                     /db_xref="MIM:126110"
     exon            1..57
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2396
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="isoform 6 is encoded by transcript variant 6;
                     dioxin receptor, nuclear translocator; hypoxia-inducible
                     factor 1, beta subunit; class E basic helix-loop-helix
                     protein 2; hypoxia inducible factor 1 subunit beta"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor nuclear translocator
                     isoform 6"
                     /protein_id="NP_001272965.1"
                     /db_xref="CCDS:CCDS65642.1"
                     /db_xref="GeneID:405"
                     /db_xref="HGNC:HGNC:700"
                     /db_xref="MIM:126110"
                     /translation="MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRR
                     PGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRR
                     NKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLT
                     DQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV
                     DKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDP
                     VSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK
                     FCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELL
                     GKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPY
                     SDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQT
                     ELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINA
                     DQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFSGLAPPVTIVQPSASAGQMLAQIS
                     RHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSSFSSMSLPGA
                     PTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSE
                     QHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPPFSE"
     exon            58..169
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            170..214
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            215..259
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            260..304
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            305..518
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            519..732
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            733..835
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            836..901
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            902..987
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1064
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1199
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1274
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1426
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1537
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1610
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1731
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1834
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1976
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2139
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2306
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..4704
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4297..4302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="hexamer: AACAAA"
     polyA_site      4323
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="major polyA site"
     regulatory      4683..4688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="hexamer: ATTAAA"
     polyA_site      4704
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
ORIGIN      
        1 ggggtggcgc ggcggcggtg gcatctgcgg ccatggcggc gactactgcc aaccccgaaa
       61 tgacatcaga tgtaccatca ctgggtccag ccattgcctc tggaaactct ggacctggaa
      121 ttcaaggtgg aggagccatt gtccagaggg ctattaagcg gcgaccaggg ctggattttg
      181 atgatgatgg agaagggaac agtaaatttt tgaggtgtga tgatgatcag atgtctaacg
      241 ataaggagcg gtttgccagg tcggatgatg agcagagctc tgcggataaa gagagacttg
      301 ccagggaaaa tcacagtgaa attgaacggc ggcgacggaa caagatgaca gcctacatca
      361 cagaactgtc agatatggta cccacctgta gtgccctggc tcgaaaacca gacaagctaa
      421 ccatcttacg catggcagtt tctcacatga agtccttgcg gggaactggc aacacatcca
      481 ctgatggctc ctataagccg tctttcctca ctgatcagga actgaaacat ttgatcttgg
      541 aggcagcaga tggctttctg tttattgtct catgtgagac aggcagggtg gtgtatgtgt
      601 ctgactccgt gactcctgtt ttgaaccagc cacagtctga atggtttggc agcacactct
      661 atgatcaggt gcacccagat gatgtggata aacttcgtga gcagctttcc acttcagaaa
      721 atgccctgac agggcgtatc ctggatctaa agactggaac agtgaaaaag gaaggtcagc
      781 agtcttccat gagaatgtgt atgggctcaa ggagatcgtt tatttgccga atgaggtgtg
      841 gcagtagctc tgtggaccca gtttctgtga ataggctgag ctttgtgagg aacagatgca
      901 ggaatggact tggctctgta aaggatgggg aacctcactt cgtggtggtc cactgcacag
      961 gctacatcaa ggcctggccc ccagcaggtg tttccctccc agatgatgac ccagaggctg
     1021 gccagggaag caagttttgc ctagtggcca ttggcagatt gcaggtaact agttctccca
     1081 actgtacaga catgagtaat gtttgtcaac caacagagtt catctcccga cacaacattg
     1141 agggtatctt cacttttgtg gatcaccgct gtgtggctac tgttggctac cagccacagg
     1201 aactcttagg aaagaatatt gtagaattct gtcatcctga agaccagcag cttctaagag
     1261 acagcttcca acaggtagtg aaattaaaag gccaagtgct gtctgtcatg ttccggttcc
     1321 ggtctaagaa ccaagaatgg ctctggatga gaaccagctc ctttactttc cagaaccctt
     1381 actcagatga aattgagtac atcatctgta ccaacaccaa tgtgaagaac tctagccaag
     1441 aaccacggcc tacactctcc aacacaatcc agaggccaca actaggtccc acagctaatt
     1501 tacccctgga gatgggctca ggacagctgg cacccaggca gcagcaacag caaacagaat
     1561 tggacatggt accaggaaga gatggactgg ccagctacaa tcattcccag gtggttcagc
     1621 ctgtgacaac cacaggacca gaacacagca agccccttga gaagtcagat ggtttatttg
     1681 cccaggatag agatccaaga ttttcagaaa tctatcacaa catcaatgcg gatcagagta
     1741 aaggcatctc ctccagcact gtccctgcca cccaacagct attctcccag ggcaacacat
     1801 tccctcctac cccccggccg gcagagaatt tcagtggcct agcccctcct gtaaccattg
     1861 tccagccatc agcttctgca ggacagatgt tggcccagat ttcccgccac tccaacccca
     1921 cccaaggagc aaccccaact tggaccccta ctacccgctc aggcttttct gcccagcagg
     1981 tggctaccca ggctactgct aagactcgta cttcccagtt tggtgtgggc agctttcaga
     2041 ctccatcctc cttcagctcc atgtccctcc ctggtgcccc aactgcatcg cctggtgctg
     2101 ctgcctaccc tagtctcacc aatcgtggat ctaactttgc tcctgagact ggacagactg
     2161 caggacaatt ccagacacgg acagcagagg gtgtgggtgt ctggccacag tggcagggcc
     2221 agcagcctca tcatcgttca agttctagtg agcaacatgt tcaacaaccg ccagcacagc
     2281 aacctggcca gcctgaggtc ttccaggaga tgctgtccat gctgggagat cagagcaaca
     2341 gctacaacaa tgaagaattc cctgatctaa ctatgtttcc ccccttttca gaatagaact
     2401 attggggtga ggataagggg tgggggagaa aaaatcactg tttgttttta aaaagcaaat
     2461 ctttctgtaa acagaataaa agttcctctc ccttcccttc cctcacccct gacatgtacc
     2521 ccctttccct tctggctgtt cccctgctct gttgcctctc taaggtaaca tttatagaag
     2581 aaatggaatg aatctccaag gcttttagga ctgtctgaaa atttgaggct gggtgaagtt
     2641 aaaacacctt tccttatgtc tcctgacctg aaattgtata gtgttgattt gtgctgagat
     2701 caagaggcag gttagaagaa cctgacatcc actgtttgcc ttggatagta tggcttgttt
     2761 ttggaaagaa attctgaaga gagtggagga gaggagaaat gtcctcatat ttgaggacca
     2821 tgaaacattg taggtatata tggggcttta gcaagtttga gcataggctc tttttgctgc
     2881 ctgtgagcag tccctctgga aagaaacatg tgagtaagtg agagagagtg tgtgtgtatg
     2941 tgtgtgtgtg tgtgtgtgcg cacacatgct tctgtatttc actctttctc cctattaggg
     3001 agttatgcaa aatttgtccc cgattttacc tttgtctttc tgtgtacttt tcaaagagtc
     3061 ctaaggagtt aaatcttcca ggtattttcc acttagtatt gcagccaaag aatatttaaa
     3121 taaacgtctt tgctgcgctt gcatccatgc ccagccaata tacaactgta aagcaaatat
     3181 agaaagtcgg ctgttgatac gattgtctgt tatcgaacac attcagtgat aaagctgggt
     3241 tactgctgct tttggtgctc tcaccttatc tggaagatct gcaaacatta cctaaatagg
     3301 ctggcaagat aaacactttc tggaacccga gacttggcca taaagataat gctgcatttt
     3361 tctgtcagaa tcacatatga tgtgtgttct gtagaggtta tttctgcatg gaaactcaac
     3421 ttcttggatt agccgtccca gtgaaaatcc tcattgttgg agtgtaaacc aaatacgaag
     3481 ccctcttgca aagtagcctc tttcatccca tactcaaaat acccagttta gcaagcaact
     3541 gagatttaag tctctctggc cctaagaggt ttttcctctt tgctccctcc aatcttgaga
     3601 ttgggttttg ctttagagtg caagtatcat aattccgtat gatagatggg gcctggacac
     3661 ccatctcaac agggtcactt ggtaattaac aatagccata taaatgcgga tacaggttac
     3721 taccctcacc ctttaccttc ctcaggtaac agtcgtagat accagctttt tttttttttt
     3781 ttttaaattg gctttggcca gtagctaaag tgcaagactg aattaatgag aagatatatt
     3841 aaatgtagtc ataggggact gaggagcaag ggtggccttg aagaggccaa aggaatgtcc
     3901 atttgctgag tttcccttcc ttatgtctcc agtctggtgc caggtagtgg agtaaaaaag
     3961 gagacagttt atttttttat tctatgtgca cacttacagt atacatatat atttatatca
     4021 caatttacga aaccaaaaag ttgagtttcc aatggaaccc ttgtttttta ataatcgact
     4081 ttttaaatgt gatcaggact ataatattgt acagttatta tagggctttt ggggaagggg
     4141 aggatagcga gaagatgctc tgggggtttt gtttttgctt ttccttcagg gttttatttt
     4201 tgactgtttt gttttcttgt tggccatttc tgtattgctg gcatctgtgc taagctttac
     4261 agtggcaaaa ataatgacat gtagcaaaga ttttcaaaca aaatattttt tccttttgta
     4321 aaatttcttg tgttgtgtga tcttgattgc ggctttatca ttcctttcca gttcataaac
     4381 aacaggcacc cacaaccaga ggaatctata gtttaagctc cagacataca aacataaggc
     4441 acattgtgtc tttaatttca ggaatcagaa atcatagggt tctgatcaca ttgcacgcct
     4501 cccccctcac ttgtcctcct gatcctgaca cattctgagt aacatcagca ggaatgctct
     4561 gaccatgagg tgggggtttt ggggtgggcg ttgcctgggt tcttgggaga gaggggaaga
     4621 gtcgggactt gaaaaccact agggcacatc tggatgcctt cccccagtat gtccttttct
     4681 ggattaaaat gagtgaaatt taaa
//
