LOCUS       NM_024573               2397 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens acidic residue methyltransferase 1 (ARMT1), transcript
            variant 1, mRNA.
ACCESSION   NM_024573
VERSION     NM_024573.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2397)
  AUTHORS   Dennis,T.N., Kenjic,N., Kang,A.S., Lowenson,J.D., Kirkwood,J.S.,
            Clarke,S.G. and Perry,J.J.P.
  TITLE     Human ARMT1 structure and substrate specificity indicates that it
            is a DUF89 family damage-control phosphatase
  JOURNAL   J Struct Biol 212 (1), 107576 (2020)
   PUBMED   32682077
  REMARK    GeneRIF: Human ARMT1 structure and substrate specificity indicates
            that it is a DUF89 family damage-control phosphatase.
REFERENCE   2  (bases 1 to 2397)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2397)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   4  (bases 1 to 2397)
  AUTHORS   Hoelz,D.
  TITLE     Armt1: a phoenix rises from the ashes
  JOURNAL   Oncotarget 6 (32), 32291-32292 (2015)
   PUBMED   26450907
  REMARK    GeneRIF: Studies show that acidic residue methyltransferase 1
            (Armt1) has a vital role in regulation of the DNA damage response
            likely through its ability to O-methylate glutamyl residues of the
            DNA repair factor proliferating cell nuclear antigen (PCNA).
REFERENCE   5  (bases 1 to 2397)
  AUTHORS   Perry,J.J., Ballard,G.D., Albert,A.E., Dobrolecki,L.E., Malkas,L.H.
            and Hoelz,D.J.
  TITLE     Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase
            that targets PCNA and is linked to the DNA damage response
  JOURNAL   Cell Rep 10 (8), 1288-1296 (2015)
   PUBMED   25732820
  REMARK    GeneRIF: Armt1 protein specifically targets proliferating cell
            nuclear antigen (PCNA) in breast cancer cells, predominately
            methylating glutamate side chains.
REFERENCE   6  (bases 1 to 2397)
  AUTHORS   Kim,D.H., Lee,S.T., Won,H.H., Kim,S., Kim,M.J., Kim,H.J., Kim,S.H.,
            Kim,J.W., Kim,H.J., Kim,Y.K., Sohn,S.K., Moon,J.H., Jung,C.W. and
            Lipton,J.H.
  TITLE     A genome-wide association study identifies novel loci associated
            with susceptibility to chronic myeloid leukemia
  JOURNAL   Blood 117 (25), 6906-6911 (2011)
   PUBMED   21540461
REFERENCE   7  (bases 1 to 2397)
  AUTHORS   Dunbier,A.K., Anderson,H., Ghazoui,Z., Lopez-Knowles,E.,
            Pancholi,S., Ribas,R., Drury,S., Sidhu,K., Leary,A., Martin,L.A.
            and Dowsett,M.
  TITLE     ESR1 is co-expressed with closely adjacent uncharacterised genes
            spanning a breast cancer susceptibility locus at 6q25.1
  JOURNAL   PLoS Genet 7 (4), e1001382 (2011)
   PUBMED   21552322
  REMARK    GeneRIF: C6ORF211 correlates with proliferation and clinical
            outcome in tumors.
REFERENCE   8  (bases 1 to 2397)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK022972.1 and BC011348.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024573.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.315398.1, AK022972.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367294.4/ ENSP00000356263.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2393              AK022972.1         180-2572
            2394-2397           BC011348.1         2322-2325
FEATURES             Location/Qualifiers
     source          1..2397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..2397
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /note="acidic residue methyltransferase 1"
                     /db_xref="GeneID:79624"
                     /db_xref="HGNC:HGNC:17872"
                     /db_xref="MIM:616332"
     exon            1..121
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1406
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /note="isoform a is encoded by transcript variant 1;
                     UPF0364 protein C6orf211; protein-glutamate
                     O-methyltransferase; sugar phosphate phosphatase ARMT1;
                     damage-control phosphatase ARMT1"
                     /codon_start=1
                     /product="damage-control phosphatase ARMT1 isoform a"
                     /protein_id="NP_078849.1"
                     /db_xref="CCDS:CCDS5233.1"
                     /db_xref="GeneID:79624"
                     /db_xref="HGNC:HGNC:17872"
                     /db_xref="MIM:616332"
                     /translation="MAVVPASLSGQDVGSFAYLTIKDRIPQILTKVIDTLHRHKSEFF
                     EKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNES
                     DGKSRWFYSPWLLVECYMYRRIHEAIIQSPPIDYFDVFKESKEQNFYGSQESIIALCT
                     HLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLK
                     PFILLNDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELAT
                     EVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMSKCGADWEEYIKMGKWVYHNHI
                     FWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGF
                     HPAPLCTIRTLKAEIQVGLQPGQGEQLLASEPSWWTTGKYGIFQYDGPL"
     exon            122..227
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /inference="alignment:Splign:2.1.0"
     exon            228..472
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /inference="alignment:Splign:2.1.0"
     exon            473..638
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /inference="alignment:Splign:2.1.0"
     exon            639..2397
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2380..2385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /note="hexamer: AATGAA"
     polyA_site      2397
                     /gene="ARMT1"
                     /gene_synonym="C6orf211"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcctt cgcggcggta ccgcctctgt ttctgcggcg attgaacagc cgagctttgc
       61 ggccgggatc gcggaaagtg atggctgtcg tcccggcgtc tctctcagga caggacgtgg
      121 gatcatttgc atatcttaca attaaagaca gaataccaca gatcttaact aaggttattg
      181 atacattgca tcgacataaa agtgaatttt ttgagaaaca cggagaggaa ggcgtggaag
      241 ctgaaaagaa agctatctct ctcctttcta aattacggaa tgaattgcaa acagataaac
      301 catttatccc cttggttgag aaatttgttg atactgatat atggaatcag tacctagaat
      361 atcaacagag tcttttaaat gaaagtgatg gaaaatcaag atggttctac tcaccgtggt
      421 tgttggtaga atgttacatg tatcgaagaa ttcatgaagc aattatccag agtccaccaa
      481 tcgattactt tgatgtattt aaagaatcaa aagagcaaaa tttctatggg tcacaggaat
      541 ccatcattgc tttatgtact cacctgcaac aattgataag aactattgaa gacctagatg
      601 aaaatcagct gaaagatgag ttttttaaac ttctgcagat ttcactgtgg ggaaataagt
      661 gtgatctgtc tctctcaggt ggagaaagta gttctcagaa taccaatgta ctaaattcat
      721 tggaagacct aaaacctttc attttattga atgatatgga acatctttgg tcattgctta
      781 gcaattgcaa gaaaacaaga gaaaaagctt ctgctactag agtgtatatt gttctcgata
      841 attctggatt tgagcttgtt acagatttaa tattagccga cttcttgttg tcctctgaac
      901 tggctactga ggttcatttt tatggaaaaa caattccatg gtttgtttct gatactacta
      961 tacatgattt taattggtta attgaacagg taaaacacag taatcataag tggatgtcca
     1021 agtgtggggc tgactgggaa gagtatatta aaatgggtaa atgggtttac cacaatcata
     1081 tattttggac tctgcctcat gagtactgtg caatgcctca ggttgcacct gacttatatg
     1141 ctgaactaca gaaggcacat ttaattttat tcaagggtga tttgaattac aggaagttga
     1201 caggtgacag aaaatgggag ttttctgttc catttcatca ggctctgaat ggcttccatc
     1261 ctgcaccact ctgtaccata agaacattaa aagctgaaat tcaggttggt ctgcagcctg
     1321 ggcaagggga acagctcctg gcctctgagc ccagctggtg gaccactgga aaatatggaa
     1381 tatttcagta cgatggtccc ctttgacttg atttaggagc tctcagttgc atagaaagat
     1441 ctggtgagca ccttttcatc cccagaaaag gagcacgtga attgagtcgc ctggcggctc
     1501 tgtacgcgct cagggaagct tagcttcttg gtgcccatct acgtgcactg gatgattttt
     1561 cttttgaaca ttttgcccca ctacactgtt ttggggatag ctgggttaag caagttaaag
     1621 atatttacat ttatattgga attttagcaa ctttttttca ggttaaatat ataatttcaa
     1681 gtgcttttaa tgaacttatt tttaattggc tagggagcaa aaaataagtg agttctgctt
     1741 ttagttagtt aaccttgttc ttttcttaaa tagtacactg catggtattt aatattccag
     1801 gaagcatggg attttatttt gcttgatttt gggcacatga aataatagct ctaggaaaat
     1861 gcgcatctta atgactcttt gtaaagagag gcatttctta caactgtgat gtttgcttac
     1921 ataaaagtta cctcataagt taattctaac ttttattctt gaattttatt tcatttcaat
     1981 agcttgtttc atttgcacgc ctttgtattt tgattgacct gtagaatgga tgttaggaaa
     2041 ctcaaaattg aacacagtga aacaaatggt atttgaagaa atgtaatatc ttttatattc
     2101 tatttatgat atccataatc aaatgagatt attttaccac ataaatgttt taaatatcag
     2161 atttttagtt tgcagtttta ggaaaatgct ttagatagaa aaggttctta tgcattgaat
     2221 ttggagtact accaacaatg aatgaattta ttttttatat tcttacacat tttattggtc
     2281 attgtcacag atagtaaata ctaaaaattt caggtcagtt tgttttgaaa ctgaaattgg
     2341 aaataaatct ggaaatgttt tgttgcacta aaataataaa atgaattgta ctgaaaa
//
