LOCUS       NM_001001872            6495 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens armadillo like helical domain containing 4 (ARMH4),
            transcript variant 1, mRNA.
ACCESSION   NM_001001872
VERSION     NM_001001872.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6495)
  AUTHORS   De Luca,F., Kha,M., Sward,K. and Johansson,M.E.
  TITLE     Identification of ARMH4 and WIPF3 as human podocyte proteins with
            potential roles in immunomodulation and cytoskeletal dynamics
  JOURNAL   PLoS One 18 (1), e0280270 (2023)
   PUBMED   36649229
  REMARK    GeneRIF: Identification of ARMH4 and WIPF3 as human podocyte
            proteins with potential roles in immunomodulation and cytoskeletal
            dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6495)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6495)
  AUTHORS   Lee,D., Wang,Y.H., Kalaitzidis,D., Ramachandran,J., Eda,H.,
            Sykes,D.B., Raje,N. and Scadden,D.T.
  TITLE     Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses
            hematological malignancy
  JOURNAL   J Clin Invest 126 (4), 1300-1310 (2016)
   PUBMED   26927669
REFERENCE   4  (bases 1 to 6495)
  AUTHORS   Chung,S.A., Brown,E.E., Williams,A.H., Ramos,P.S., Berthier,C.C.,
            Bhangale,T., Alarcon-Riquelme,M.E., Behrens,T.W., Criswell,L.A.,
            Graham,D.C., Demirci,F.Y., Edberg,J.C., Gaffney,P.M., Harley,J.B.,
            Jacob,C.O., Kamboh,M.I., Kelly,J.A., Manzi,S., Moser-Sivils,K.L.,
            Russell,L.P., Petri,M., Tsao,B.P., Vyse,T.J., Zidovetzki,R.,
            Kretzler,M., Kimberly,R.P., Freedman,B.I., Graham,R.R. and
            Langefeld,C.D.
  CONSRTM   International Consortium for Systemic Lupus Erythematosus Genetics
  TITLE     Lupus nephritis susceptibility loci in women with systemic lupus
            erythematosus
  JOURNAL   J Am Soc Nephrol 25 (12), 2859-2870 (2014)
   PUBMED   24925725
REFERENCE   5  (bases 1 to 6495)
  AUTHORS   Lee,D., Sykes,S.M., Kalaitzidis,D., Lane,A.A., Kfoury,Y.,
            Raaijmakers,M.H., Wang,Y.H., Armstrong,S.A. and Scadden,D.T.
  TITLE     Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic
            Progenitors
  JOURNAL   Stem Cell Reports 3 (5), 832-840 (2014)
   PUBMED   25418727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292513.1, BC013707.1, BC146861.1, BX161411.1 and AL049838.3.
            
            On May 17, 2019 this sequence version replaced NM_001001872.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.218271.1,
                                           SRR1803611.97866.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267485.7/ ENSP00000267485.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1541              AK292513.1         1-1541
            1542-2031           BC013707.1         865-1354
            2032-2528           AK292513.1         2032-2528
            2529-2684           BC146861.1         2406-2561
            2685-3166           BX161411.1         2601-3082
            3167-3200           AK292513.1         3167-3200
            3201-6495           AL049838.3         147559-150853       c
FEATURES             Location/Qualifiers
     source          1..6495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..6495
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /note="armadillo like helical domain containing 4"
                     /db_xref="GeneID:145407"
                     /db_xref="HGNC:HGNC:19846"
     exon            1..139
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     exon            140..1564
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2520
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; uncharacterized protein C14orf37; upstream of
                     mTORC2; upstream of mTORC2 protein; armadillo-like helical
                     domain-containing protein 4"
                     /codon_start=1
                     /product="armadillo-like helical domain-containing protein
                     4 isoform 1 precursor"
                     /protein_id="NP_001001872.2"
                     /db_xref="CCDS:CCDS32089.1"
                     /db_xref="GeneID:145407"
                     /db_xref="HGNC:HGNC:19846"
                     /translation="MRGPIVLHICLAFCSLLLFSVATQCLAFPKIERRREIAHVHAEK
                     GQSDKMNTDDLENSSVTSKQTPQLVVSEDPMMMSAVPSATSLNKAFSINKETQPGQAG
                     LMQTERPGVSTPTESGVPSAEEVFGSSQPERISPESGLAKAMLTIAITATPSLTVDEK
                     EELLTSTNFQPIVEEITETTKGFLKYMDNQSFATESQEGVGLGHSPSSYVNTKEMLTT
                     NPKTEKFEADTDHRTTSFPGAESTAGSEPGSLTPDKEKPSQMTADNTQAAATKQPLET
                     SEYTLSVEPETDSLLGAPEVTVSVSTAVPAASALSDEWDDTKLESVSRIRTPKLGDNE
                     ETQVRTEMSQTAQVSHEGMEGGQPWTEAAQVALGLPEGETHTGTALLIAHGNERSPAF
                     TDQSSFTPTSLMEDMKVSIVNLLQSTGDFTESTKENDALFFLETTVSVSVYESEADQL
                     LGNTMKDIITQEMTTAVQEPDATLSMVTQEQVATLELIRDSGKTEEEKEDPSPVSDVP
                     GVTQLSRRWEPLATTISTTVVPLSFEVTPTVEEQMDTVTGPNEEFTPVLGSPVTPPGI
                     MVGEPSISPALPALEASSERRTVVPSITRVNTAASYGLDQLESEEGQEDEDEEDEEDE
                     DEEEEDEEEDEEDKDADSLDEGLDGDTELPGFTLPGITSQEPGLEEGNMDLLEGATYQ
                     VPDALEWEQQNQGLVRSWMEKLKDKAGYMSGMLVPVGVGIAGALFILGALYSIKVMNR
                     RRRNGFKRHKRKQREFNSMQDRVMLLADSSEDEF"
     exon            1565..1816
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2026
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2284
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2316
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2451
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..6495
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /note="hexamer: ATTAAA"
     polyA_site      3202
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /note="major polyA site"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /note="hexamer: AATAAA"
     polyA_site      3783
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
     regulatory      4261..4266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /note="hexamer: AATAAA"
     polyA_site      4292
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
     regulatory      6123..6128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
                     /note="hexamer: AATAAA"
     polyA_site      6147
                     /gene="ARMH4"
                     /gene_synonym="C14orf37; c14_5376; UT2"
ORIGIN      
        1 ctccccctag cgtcccagac agcggaggga gtcgccgccg ctaccgccgc cgccgccgca
       61 gggcccgccg ctgggatgcc gagcgcccgc gccgccgctg cctctgtcct ccgcgcgctg
      121 ctcagctgaa ggcgcacagg attcaattac tggacttgtc aactctgcca gtgtacgtgc
      181 catttctctt ccactatgag aggaccgatt gtattgcaca tttgtctggc tttctgtagc
      241 cttctgcttt tcagcgttgc cacacaatgt ctggccttcc ccaaaataga aaggaggagg
      301 gagatagcac atgttcatgc ggaaaaaggg cagtccgata agatgaacac cgatgaccta
      361 gaaaatagct ctgttacctc aaagcagact ccccaactgg tggtctctga agatccaatg
      421 atgatgtcag cagtaccatc ggcaacatca ttaaataaag cattctcgat taacaaagaa
      481 acccagcctg gacaagctgg gctcatgcaa acagaacgcc ctggtgtttc cacacctact
      541 gagtcaggtg tcccctcagc tgaagaagta tttggttcca gccagccaga gagaatatct
      601 cctgaaagtg gacttgccaa ggccatgtta accattgcta tcactgcgac tccttctctg
      661 actgttgatg aaaaggagga actccttaca agcactaact ttcagcccat tgtagaagag
      721 atcacagaaa ccacaaaagg ttttctgaag tatatggata atcaatcatt tgcaactgaa
      781 agtcaggaag gagttggttt gggacattca ccttcatcct atgtgaatac taaggaaatg
      841 ctaaccacca atccaaagac tgagaaattt gaagcagaca cagaccacag gacaacttct
      901 tttcctggtg ctgagtccac agcaggcagt gagcctggaa gcctcacccc tgataaggag
      961 aagccttcgc agatgacagc tgataacacc caggctgctg ccaccaagca accactcgaa
     1021 acttccgagt acaccctgag tgttgagcca gaaactgata gtctgctggg agccccagaa
     1081 gtcacagtga gtgtcagcac agctgttcca gctgcctctg ccttaagtga tgagtgggat
     1141 gacaccaaat tagagagtgt aagccggata aggaccccca agcttggaga caatgaagag
     1201 actcaggtga gaacggagat gtctcagaca gcacaagtaa gccatgaggg tatggaagga
     1261 ggccagcctt ggacagaggc tgcacaggtg gctctggggc tgcctgaagg ggaaacacac
     1321 acgggcacag ccctgctaat agcgcatggg aatgagagat cacctgcttt cactgatcaa
     1381 agttccttta cccccacaag tctgatggaa gacatgaaag tttccattgt gaacttgctc
     1441 caaagtacgg gagacttcac ggaatccacc aaggaaaacg atgccctgtt tttcttagaa
     1501 accactgttt ctgtctctgt atatgagtct gaggcagacc aactgttggg aaatacaatg
     1561 aaagacatca tcactcaaga gatgacaaca gctgttcaag agccagatgc cactttatcc
     1621 atggtgacac aagagcaggt tgctaccctc gagcttatca gagacagtgg caagactgag
     1681 gaagaaaagg aggacccctc tcctgtgtct gacgttcctg gtgttactca gctgtcaaga
     1741 agatgggagc ctctggccac tacaatttca actacagtcg tccctttgtc ttttgaagtt
     1801 actcccactg tggaagaaca aatggacaca gtcacagggc caaatgagga gttcacacca
     1861 gttctgggat ctccagtgac acctcctgga ataatggtgg gggaacccag catttcccct
     1921 gcacttcctg ctttggaggc atcctctgag agaagaactg ttgttccatc tattactcgt
     1981 gttaatacag ctgcctcata tggcctggac caacttgaat ctgaagaggg acaagaagat
     2041 gaggatgaag aggatgaaga agatgaagat gaagaagagg aagatgagga agaagatgag
     2101 gaagataaag atgcagactc gctggatgag ggcttggatg gtgacactga gctgccaggt
     2161 tttaccctcc ctggtatcac atcccaggaa ccaggcttag aggagggaaa catggacctg
     2221 ttggagggag ctacctacca ggtgccagat gccctcgagt gggaacagca gaatcaaggc
     2281 ctggtgagaa gctggatgga aaaattaaaa gacaaggctg gttacatgtc tgggatgctg
     2341 gtgcctgtag gggttgggat agctggagcc ttgttcatct tgggagccct ctacagcatt
     2401 aaggttatga atcgccgaag gagaaatggc ttcaaaaggc ataaaagaaa gcagagagaa
     2461 ttcaacagca tgcaagatcg agtaatgctc ttagccgaca gctctgaaga tgaattttga
     2521 attggactgg gttttaattg ggatattcaa cgatgctact attctaattt ttattttgga
     2581 gcagaaaaaa aaaaagaaca acctgccaca ttgctgctat caggccgtta gtcctagtgt
     2641 ctgctgggtg ctgggtagta gatttttctt gtactgagca gaaatggcat gttgtatact
     2701 aaacgtatca tgcagtattt ggttttattc tgtagtgaat tttccacaac cgtgggctac
     2761 aactcataaa tatgcaacat atatgttttt cagtaggagt tgctacatta ggcagagtaa
     2821 atattttgta gttttccaca gtgtcttttc cttggtttga attacctgca ttgagaataa
     2881 tgattgttgc caccaaggca tgcttgactc tgagatataa atcttaacaa agaataactt
     2941 ctcaagatat actctaccta cttgaaacca cagggttgtg ggccatggta catactgcat
     3001 ttgcatcaaa ctagcagtaa ctcagaatga aatcattttc attaagaagc tctctcagca
     3061 tattaggatt atatgtagat ttgtatgtat tttgcattat gtacttcagt ctcctagttt
     3121 tattattctc accttccgtt ttattcttgg cgaggaaaaa aatgcactag aaataataca
     3181 ttaaactgac tcttagtctt aatgtacgtt tgctgtctta aatagtgtga ttgagtccaa
     3241 cagactcaat catacatgtc atacatgttt atgattaaga gatattcttt ttgtgtgcta
     3301 gttgattttg ccgagaaaaa atgaagaaga attcaagaat gagatgaggg taggtaagct
     3361 ctcagagcat ttctgtctgc catttggttc tatgcttatg tggctgctaa tgtgactaat
     3421 tcagagtgtt gtatttccac atctgtggac tccaccatgg aaaaggtggg ctaccattgg
     3481 tccttatatg gctttattag aaaaatagac attctatcgt ttgtctgccc agtggccaga
     3541 gtcctggtga acaacagagc tcatgggaaa ccagcctctc tcagggcacc ccgctatgag
     3601 gatattgaaa tatgttcaat catttctcat ctcccttgga atgtaattcc ctgccctata
     3661 caaaatagga tattccaatg cgctatttga atctagggat tgaggatttg tagttgagtt
     3721 ttggggtaaa ggcttggctc attgccatgg aagaataaaa gttatttatt aatagtgctg
     3781 tcactgtgga gtacttgttg gtgtttatta gaagttgtct actatgttca agaaaagttg
     3841 cacagttatt cctcagagct actatgtgag gtaggacata tgtttttatt ctcccatttg
     3901 actgaagatg gaactgaagc agagaagtga aatgattttc caaagttgta cccagagaga
     3961 atcagcgtga gaacccactt ggacccagcc atgcaccctt atcttcagtt cagtaacctt
     4021 ttcatagact ttggtggaag cagtgacatt tcagggtcct tctttaaaac aaaggttcta
     4081 agggaatagc agggaatagc tgcctggtca aggaacgttt gatgtgaatt tccatctttg
     4141 ttaaatgaat gatgcctttc taatttctct cttactcaca cacaagttct ttccttcccc
     4201 atctcagtta tcagttattt cctttacagt catacatttg agtatcacct ctatggaact
     4261 aataaacctt cctagaatcc gtttttgaat aatgtctggc tcacaagaac attttcatca
     4321 aataatttta actctttttg ccaagagatg taagcaaata tgtgaaactg atcaagagaa
     4381 gtgaaaagct ctgtacagtc aaatagaagt tagcaactgg caaattagct caaggtcaga
     4441 ttttaaaaat agaattcaga atcatgacac tcagaagtga tttgtaattt cacgagtaga
     4501 gacatcctga tattgcataa gggatgtttt ccttttctaa gagcagccct ttgctgtaag
     4561 tgtttctaag gttgggagta agtgagcatg gtgtggcatt actgtctttg tattcttgac
     4621 aaactatttg ttgagaatac gtcgtaggcc acttaactga gtagcacatg ggtgatacta
     4681 gtggccatta ttgccttggg ctactcaatc tatagtctta actaaaccat ggctaatagg
     4741 ttgaatcttc aaactgtagt gtaataaatt cccaaataac agacccatat tttcatttct
     4801 cagaggtccg tgaggatgac atgtatgtga attttggctt aacacagtat ctctgtggtc
     4861 ctttttggga cacatgattt cttaaaggaa aagattatac ttagagtaca tttctgtaca
     4921 aacccattta aacatctgga ttgagtggaa ggtcggtgga tggtacaaat gacatgttta
     4981 ttttggccat tttccttgct gctggtggct gtggaataat gattttcagt ggttggctta
     5041 gattattaag aggatcagaa aaggttgtca tattttaaac aaaacctggg attagagatg
     5101 ctgctacgag atggaagtgc tggccagtgg ttatatagtg gtccagttga gaagtagtaa
     5161 atcaggcact tgtaggttta cccaaaataa gtgacaagta tgcttatatt tgcacaatta
     5221 aaatagaaag tcaacttttt attcaaacaa ctaggcttaa aacatttaac agtgaaacaa
     5281 ataaagctgt ctggaaagga gggctgattc ctgcagcttc agttgtgaac accatcccca
     5341 ctggactgag tttacccagc cagaactgcc agcatcccac cgcaggggca ggaactaggt
     5401 cttcttctcg gagggagagg cagtgtttcc agaatttgca ggctcataaa aatcacctgg
     5461 gacacttgtg aaacatacag atctcaaggc cttgccccag acctgatgag ttagaatctc
     5521 cagggaagga gcttggggta ttcatgcccc agcaagcttg ggaacacagc taggagggat
     5581 ctatctagag aaccacttcc ttatgataga gacaaggtca tttaaagtca caatgagata
     5641 ccacctcaca cctattggga tggctattat tcaataaaac aaaatataac aattgtttct
     5701 gaggatgtgg agaaattgga atccttgtat actgtgggtg ggaatgtaaa atggatagcc
     5761 actgtggaaa acagtatgaa gattcctcaa aaaattaaga tagaactact atataatcca
     5821 actatcccac ttctgggcat atatccaaaa gaatagaaat caggatcttg aagaagtatc
     5881 tgtacgcctg tgttcattgc ttatgcttat aagcatatta ttcacaataa gcttataagt
     5941 attattcaca atagccaaga tatggaaatt gcattgatag atatgcaaat atctatcaat
     6001 agatgaatgg ataaagaaaa tgtggtatat acatacagta gaatattatt cagccatagg
     6061 aaataaggaa attctgtcat tgtgacaata tggatataca tggagaacat tatgctaagt
     6121 gaaataaact agtgacagaa ggacaaatgc atgattgcac ttctttgagg tatccaaaat
     6181 aatcaaactc ataagggcag aggcaaaatg gtgcttgcca cgggctgggc aaagttaaag
     6241 gtggggagat gttgattaat tatgtttcag ttatgcaaga tgaataagtt ctagagctct
     6301 gctgtataac atagtgccta tagttaacaa tatcgtactg tgcagttaaa aatttgttaa
     6361 gagggccggg tgtggtggct cacgcctgta atcccagcac tttgggaggc caaggtgggc
     6421 agatcatgag gtcaggagat agaaaccatc ctggctaaca tggtgaaacc ccatctctac
     6481 taaaaataca aaaaa
//
