LOCUS       NM_024541               4099 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens armadillo like helical domain containing 3 (ARMH3),
            mRNA.
ACCESSION   NM_024541
VERSION     NM_024541.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4099)
  AUTHORS   Mizuike,A. and Hanada,K.
  TITLE     DGARM/C10orf76/ARMH3 for Ceramide Transfer Zone at the Endoplasmic
            Reticulum-Distal Golgi Contacts
  JOURNAL   Contact (Thousand Oaks) 7, 25152564241239443 (2024)
   PUBMED   38515862
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4099)
  AUTHORS   Mizuike,A., Sakai,S., Katoh,K., Yamaji,T. and Hanada,K.
  TITLE     The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide
            trafficking to the distal Golgi
  JOURNAL   J Cell Biol 222 (7) (2023)
   PUBMED   37195633
  REMARK    GeneRIF: The C10orf76-PI4KB axis orchestrates CERT-mediated
            ceramide trafficking to the distal Golgi.
REFERENCE   3  (bases 1 to 4099)
  AUTHORS   McPhail,J.A., Lyoo,H., Pemberton,J.G., Hoffmann,R.M., van Elst,W.,
            Strating,J.R.P.M., Jenkins,M.L., Stariha,J.T.B., Powell,C.J.,
            Boulanger,M.J., Balla,T., van Kuppeveld,F.J.M. and Burke,J.E.
  TITLE     Characterization of the c10orf76-PI4KB complex and its necessity
            for Golgi PI4P levels and enterovirus replication
  JOURNAL   EMBO Rep 21 (2), e48441 (2020)
   PUBMED   31829496
REFERENCE   4  (bases 1 to 4099)
  AUTHORS   Chan,C.J., Le,R., Burns,K., Ahmed,K., Coyaud,E., Laurent,E.M.N.,
            Raught,B. and Melancon,P.
  TITLE     BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a
            GBF1 Binding Protein Essential for Golgi Maintenance and Secretion
  JOURNAL   Mol Cell Proteomics 18 (11), 2285-2297 (2019)
   PUBMED   31519766
REFERENCE   5  (bases 1 to 4099)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   6  (bases 1 to 4099)
  AUTHORS   Wojczynski,M.K., Li,M., Bielak,L.F., Kerr,K.F., Reiner,A.P.,
            Wong,N.D., Yanek,L.R., Qu,L., White,C.C., Lange,L.A.,
            Ferguson,J.F., He,J., Young,T., Mosley,T.H., Smith,J.A., Kral,B.G.,
            Guo,X., Wong,Q., Ganesh,S.K., Heckbert,S.R., Griswold,M.E.,
            O'Leary,D.H., Budoff,M., Carr,J.J., Taylor,H.A. Jr., Bluemke,D.A.,
            Demissie,S., Hwang,S.J., Paltoo,D.N., Polak,J.F., Psaty,B.M.,
            Becker,D.M., Province,M.A., Post,W.S., O'Donnell,C.J., Wilson,J.G.,
            Harris,T.B., Kavousi,M., Cupples,L.A., Rotter,J.I., Fornage,M.,
            Becker,L.C., Peyser,P.A., Borecki,I.B. and Reilly,M.P.
  TITLE     Genetics of coronary artery calcification among African Americans,
            a meta-analysis
  JOURNAL   BMC Med Genet 14, 75 (2013)
   PUBMED   23870195
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4099)
  AUTHORS   Greninger,A.L., Knudsen,G.M., Betegon,M., Burlingame,A.L. and
            DeRisi,J.L.
  TITLE     ACBD3 interaction with TBC1 domain 22 protein is differentially
            affected by enteroviral and kobuviral 3A protein binding
  JOURNAL   mBio 4 (2), e00098-e00013 (2013)
   PUBMED   23572552
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4099)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR002231.1, AW936405.1, DA311439.1, DT932690.1, DA020448.1,
            AK023176.1 and AK097972.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024541.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.266502.1,
                                           SRR1803615.209554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370033.9/ ENSP00000359050.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               DR002231.1         11-167
            158-312             DR002231.1         169-323
            313-562             AW936405.1         1-250
            563-687             DA311439.1         224-348
            688-900             DT932690.1         196-408             c
            901-1369            DA020448.1         1-469
            1370-2114           AK023176.1         1-745
            2115-3740           AK097972.1         480-2105
            3741-4099           AK023176.1         2372-2730
FEATURES             Location/Qualifiers
     source          1..4099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..4099
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /note="armadillo like helical domain containing 3"
                     /db_xref="GeneID:79591"
                     /db_xref="HGNC:HGNC:25788"
                     /db_xref="MIM:620867"
     exon            1..89
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            90..202
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2170
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /note="UPF0668 protein C10orf76; distal Golgi armadillo
                     repeat protein"
                     /codon_start=1
                     /product="armadillo-like helical domain-containing protein
                     3"
                     /protein_id="NP_078817.2"
                     /db_xref="CCDS:CCDS41563.1"
                     /db_xref="GeneID:79591"
                     /db_xref="HGNC:HGNC:25788"
                     /db_xref="MIM:620867"
                     /translation="MAQVEKRGGLLRKSSASKKPLKEKVVLMYDEIFMTEDPSKCSPR
                     FWEELFLMKVNLEYLEGKLESLDGEELMKIKDNINCLFQHCIQALGEEHPIRVVNALQ
                     TLCALIRGVHQKNKSTSGFDIINMLMGFDKAELCMKNLMESLDSLLCAEGSESLKSLC
                     LKLLLCLVTVTDNISQNTILEYVMINSIFEAILQILSHPPSRREHGYDAVVLLALLVN
                     YRKYESVNPYIVKLSIVDDEATLNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTN
                     MVGSMFIADAHEKISVQTNEAILLALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAP
                     TTPVTPLGTTPPSSDVISSVELPLDADVQTSNLLITFLKYSSIVMQDTKDEHRLHSGK
                     LCLIILTCIAEDQYANAFLHDDNMNFRVNLHRMPMRHRKKAADKNLPCRPLVCAVLDL
                     MVEFIVTHMMKEFPMDLYIRCIQVVHKLLCYQKKCRVRLHYTWRELWSALINLLKFLM
                     SNETVLLAKHNIFTLALMIVNLFNMFITYGDTFLPTPSSYDELYYEIIRMHQSFDNLY
                     SMVLRLSTNAGQWKEAASKVTHALVNIRAIINHFNPKIESYAAVNHISQLSEEQVLEV
                     VRANYDTLTLKLQDGLDQYERYSEQHKEAAFFKELVRSISTNVRRNLAFHTLSQEVLL
                     KEFSTIS"
     exon            203..259
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            260..406
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            407..514
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            515..607
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            608..682
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            683..769
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            770..826
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            827..870
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            871..931
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            932..978
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1054
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1148
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1250
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1309
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1375
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1445
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1506
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1595
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1678
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1805
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1881
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1960
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2077
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..4099
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /note="hexamer: AATAAA"
     polyA_site      3269
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /note="major polyA site"
     regulatory      4072..4077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /note="hexamer: ATTAAA"
     polyA_site      4099
                     /gene="ARMH3"
                     /gene_synonym="C10orf76; DGARM"
                     /note="major polyA site"
ORIGIN      
        1 gtgagcccgg agcagcggca gcgtcggtgg cgtcgagagc gagcgggccc gggaacggcg
       61 cgggtggtag aggaggagcc gcgggctcga ttctctaacc atggcacagg tagagaaacg
      121 tggaggtttg ctccggaaat cttcagcctc caaaaaacca ctgaaggaaa aagtggtgct
      181 gatgtatgat gagatcttca tgacagagga ccccagtaag tgcagtcctc ggttttggga
      241 ggagctcttt ctcatgaagg tgaatttaga gtacctagaa ggcaagctgg aatctcttga
      301 tggtgaggag ttaatgaaga tcaaggacaa tattaattgc ttattccaac actgcatcca
      361 ggctctggga gaggagcatc caattcgggt tgtcaatgca ttgcagaccc tgtgcgcact
      421 cattcgagga gtccatcaaa agaataagtc tacctctggg tttgacatta tcaacatgct
      481 gatgggcttt gacaaggcgg agctgtgcat gaagaacttg atggagagtt tggattcatt
      541 gctttgtgca gaaggttctg aaagtctgaa gagtttatgt ctgaaacttc tcctttgctt
      601 agtgaccgtg acagataaca tcagccagaa cactattctc gagtatgtaa tgatcaacag
      661 catatttgaa gcaattttac agatactttc ccatccccca agtcgtaggg agcatgggta
      721 tgatgctgtc gtcctcttgg ctttgctggt gaactataga aaatatgagt ctgtgaatcc
      781 ttatattgtg aagctgtcta tcgtggatga tgaggccaca ctcaatggaa tgggacttgt
      841 aattgctcag gctttatctg agtacaacag gcagtataaa gacaaggaag aagaacacca
      901 aagtggtttt ttctctgctt taacaaatat ggtgggcagc atgttcatag cagatgccca
      961 tgagaaaatc tcagtacaaa ccaatgaggc cattcttctg gcactttatg aagctgttca
     1021 tttaaatcgc aacttcatca cagtattagc tcagagccat ccagaaatgg gcttggtgac
     1081 gacccctgtc agtcctgctc ctacaacccc agtcacacca cttgggacca caccgccttc
     1141 ctctgatgtt ataagttctg tggaactccc actggatgca gatgtacaga ccagtaatct
     1201 actgataacc tttttaaagt atagctcaat tgtcatgcag gacaccaaag atgaacacag
     1261 gcttcacagt ggcaaactct gtctgattat ccttacatgt attgcagagg atcaatatgc
     1321 caatgcattt ttgcatgatg acaacatgaa ttttcgagta aacttacata gaatgcctat
     1381 gagacacagg aagaaggcag cagacaagaa tcttccctgc cgtcctttag tatgtgcagt
     1441 actggacctg atggtagagt ttattgtaac acacatgatg aaggagtttc ctatggatct
     1501 ctatatacgc tgcatccagg tagtacacaa actgctctgc taccagaaga agtgtcgggt
     1561 acgcctgcat tacacctggc gggagctctg gtcagccttg ataaatttgc tgaagttcct
     1621 tatgtcaaat gagactgtac ttttggccaa acacaacatt tttacattag cccttatgat
     1681 tgtgaaccta tttaatatgt ttatcacata tggcgacaca tttctgccaa cccccagcag
     1741 ctatgatgaa ctttactatg agattatccg catgcaccag agctttgaca acctctactc
     1801 catggtcctg aggctttcta ccaatgcagg ccagtggaag gaagcagcta gcaaggtgac
     1861 ccatgcattg gttaatatca gagccatcat caaccacttt aaccccaaaa ttgagtccta
     1921 cgctgctgtg aatcacatat cccaactgtc agaggagcag gtgctggagg tggtgagagc
     1981 caactatgac acgctcacgc tgaagctgca ggatggcctg gaccagtatg agcgctactc
     2041 agagcagcac aaggaagctg ccttcttcaa agagctggtt cgatccatta gcaccaacgt
     2101 ccggagaaac ctggccttcc acacactcag ccaagaagtc ctgctcaagg agttctccac
     2161 tatctcctga ggccacgcct acctgagcag cctctgactg cccttaccca tgaggatcat
     2221 gggctggagg gggagcgagg ggagaggggg ctgcccccga ggttggagag aaacacagat
     2281 accaagttct cttggtgaag accgcacttc aatggagctt gggcagcagg ggcaggaggg
     2341 tcaagccagg gataatctta tttggggagg aatgggtggg cacagtgggg agaggcctcc
     2401 aggaatgtgg ggacttccag agtgggctcc ctaaacagcc cctcacattt ccaatcttga
     2461 ggttacaagc tgtagctact gactaatttt cgggagctgg tgaggcaagc ctcagggtaa
     2521 tgccagcacc ctgaaagtca gtggctctgc tcggcttctg aaaacagatc aactctcaga
     2581 tatagctgga gctacatcct gcttcctttg ggcctggggc tgtgcttggc ttgaaatctg
     2641 tgtcccctgc ctgcactggc actttgtcca gtcatcggga cctttggctc agatttaggg
     2701 taagatagga atagggtacc tttttccttt tttttctgag acggagtctc actctgtcgc
     2761 ccaggctgga atgcagtggc gtgatctcgg ctttactgca gcctccgctt cctgggttca
     2821 agcgattctc ctgcctcagc ctcccgagta gctgggacta caggagcgtg tgccacgccc
     2881 ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttaccca ggatggtctc
     2941 aatatcctga gttcatgatc cacccacctt ggcctcccaa agtgctggga ttacaggcgt
     3001 gagccaccac acccagccag ttttcctatt ttctgaattc agaattgact tctctgggaa
     3061 aactggagat gagaatctgc ccagtgctct gctgtccagt caccgccttt tgaattttag
     3121 ttttggcacc aggagtaccg ttagctttcc ccttcttctg gcccatttga ctcatcagca
     3181 caatagggtc accaccttaa cttttaattt ctaatctgct ttactgtctt tagggtgtgt
     3241 atgaaataaa cattgacagg ctttctggag ccctcaaggt gcctactttg ctggttccct
     3301 ttccagcagc tcccccacct cccttagccc cccctcctct ggcagcctct cctgcctctg
     3361 ctgagctccc ctccacgtgt tccaccccct taccctgctg ttgtttacat ccaacctgcc
     3421 tgagaatttc ctctggggag gaatctattc ctgtcatggt ctagtgcctg ggagggagag
     3481 aactttctgg gggtagggtg ccctccatct gaaacaggcc aggtgagcat catgcataag
     3541 gcctccattc tgtccgctca gattctgggt ggggccacag gcaaatctcc tgacttatgg
     3601 ggagttggct tgtggttcct cccttggata gcctccatgg aaccactata ggctttccca
     3661 acagctgcct ctgaaatagc tgctgcttcg agatcctccc tttttaaagc actttctaaa
     3721 gccctcagga tggcgggagc aaacagcact ggtatattct aggagtaagt gcaggaattc
     3781 agcagtgaga gcatgtctgg gaccacctgg actgccatcc atttaacctc aaatctcttt
     3841 gggatactcg ccctccctgg gaaccagagt tctggctcta acattgagca gctatgcact
     3901 agttccagag aagccactaa caggctgcca tgtgtagatg taggttctta agagatcaca
     3961 ggctgggtca tctgatcact ggatggatag ctcagcctgg ggcatttagt gttttccctg
     4021 gtgataaatc cccaaggcag ctggatttgg agctggtggc aagttgaaat tattaaaaat
     4081 tgatttgtgt gggactgtc
//
