LOCUS       NM_019007               1840 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens armadillo repeat containing X-linked 6 (ARMCX6),
            transcript variant 1, mRNA.
ACCESSION   NM_019007
VERSION     NM_019007.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Zhang,X., Gomez,L., Below,J.E., Naj,A.C., Martin,E.R., Kunkle,B.W.
            and Bush,W.S.
  TITLE     An X Chromosome Transcriptome Wide Association Study Implicates
            ARMCX6 in Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 98 (3), 1053-1067 (2024)
   PUBMED   38489177
  REMARK    GeneRIF: An X Chromosome Transcriptome Wide Association Study
            Implicates ARMCX6 in Alzheimer's Disease.
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Lopez-Domenech,G., Serrat,R., Mirra,S., D'Aniello,S., Somorjai,I.,
            Abad,A., Vitureira,N., Garcia-Arumi,E., Alonso,M.T.,
            Rodriguez-Prados,M., Burgaya,F., Andreu,A.L., Garcia-Sancho,J.,
            Trullas,R., Garcia-Fernandez,J. and Soriano,E.
  TITLE     The Eutherian Armcx genes regulate mitochondrial trafficking in
            neurons and interact with Miro and Trak2
  JOURNAL   Nat Commun 3, 814 (2012)
   PUBMED   22569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC007677.2 and AI076820.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_019007.3.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1, 2, and 3 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007677.2, SRR3476690.215381.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361910.9/ ENSP00000354708.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1839              BC007677.2         2-1840
            1840-1840           AI076820.1         25-25               c
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..1840
                     /gene="ARMCX6"
                     /gene_synonym="GASP10"
                     /note="armadillo repeat containing X-linked 6"
                     /db_xref="GeneID:54470"
                     /db_xref="HGNC:HGNC:26094"
                     /db_xref="MIM:301048"
     exon            1..116
                     /gene="ARMCX6"
                     /gene_synonym="GASP10"
                     /inference="alignment:Splign:2.1.0"
     exon            117..198
                     /gene="ARMCX6"
                     /gene_synonym="GASP10"
                     /inference="alignment:Splign:2.1.0"
     exon            199..1840
                     /gene="ARMCX6"
                     /gene_synonym="GASP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1247
                     /gene="ARMCX6"
                     /gene_synonym="GASP10"
                     /codon_start=1
                     /product="protein ARMCX6"
                     /protein_id="NP_061880.2"
                     /db_xref="CCDS:CCDS14488.1"
                     /db_xref="GeneID:54470"
                     /db_xref="HGNC:HGNC:26094"
                     /db_xref="MIM:301048"
                     /translation="MGRAREVGWMAAGLMIGAGACYCVYKLTIGRDDSEKLEEEGEEE
                     WDDDQELDEEEPDIWFDFETMARPWTEDGDWTEPGAPGGTEDRPSGGGKANRAHPIKQ
                     RPFPYEHKNTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQDINSHLASL
                     SMARNTSPTPDPTVREALCAPDNLNASIESQGQIKMYINEVCRETVSRCCNSFLQQAG
                     LNLLISMTVINNMLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQ
                     MLFSFMSLFIRNGNREILLETPAP"
     regulatory      1815..1820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMCX6"
                     /gene_synonym="GASP10"
                     /note="hexamer: AATAAA"
     polyA_site      1840
                     /gene="ARMCX6"
                     /gene_synonym="GASP10"
                     /note="major polyA site"
ORIGIN      
        1 acgtgaccaa gagccgccta gagcacaagt cctgctagtc gcctccgtct gggtaccagc
       61 cccctattac tctgcaggcg tgtgaagaaa gaaggaaact agctcggacc gtgcaggttt
      121 gtaggtctgt tggcctgtag gtttcggcac aagtttcagc gagagaagga gaaaactgcc
      181 ttggttggaa ccttgcagat tcatcacaag agagctacaa gagcctggaa gaagctgaag
      241 actgctaccc tccatcctta ctcaccctgg acctgagaga cctcttcaat caggtggagc
      301 aaggccctct cctgtcctgc cccaaggctg gcacagactt gagcatgggc cgggctcggg
      361 aagtgggttg gatggcggca ggactgatga ttggggctgg tgcctgctac tgcgtttaca
      421 aactgaccat aggaagagat gacagtgaga agctggagga ggagggggaa gaggagtggg
      481 acgatgacca ggagctggat gaggaggagc ctgatatttg gtttgatttt gaaactatgg
      541 ctcggccctg gactgaggat ggggattgga ctgaacctgg ggccccaggt ggcactgagg
      601 acaggccctc agggggaggc aaggccaacc gagcacaccc aataaaacag cggccattcc
      661 cctatgaaca taaaaatact tggagtgctc aaaattgtaa aaatggcagt tgtgttctgg
      721 acctctccaa gtgtcttttc attcagggaa aactgttgtt tgccgagccc aaggatgcgg
      781 gctttccatt tagccaggat atcaatagcc atttggccag cctctcaatg gctagaaaca
      841 cgagccccac tccagacccc actgttagag aggctttgtg tgccccggat aacttaaatg
      901 cgagtattga aagtcagggc cagattaaga tgtacatcaa tgaagtgtgt cgggagactg
      961 tgtcacgttg ctgcaactca tttctgcagc aggccggatt aaatttgtta ataagcatga
     1021 cagttattaa taacatgctt gccaagtccg cttcagactt gaagtttcct ttgatatcag
     1081 agggaagtgg atgtgctaag gttcaggttt tgaaaccgct gatgggtttg tctgaaaagc
     1141 cagtcttggc gggggagtta gtcggtgccc agatgctctt ctcattcatg tccctcttta
     1201 tcagaaatgg aaacagagag attctcctgg aaacccctgc cccataaacg gccctctcga
     1261 acacaatggg acggaatcca cccacaacgc gcttggtttg cagatgtcaa agaatctgca
     1321 gagggtgcta ctgaagatcc agccttagcc aatcaccacc tcattgggtg aaagttccag
     1381 ggctcaatcc aggaccacac tcttattggc caggcagggg ctcccacaga gctttgagta
     1441 acttcttggt tgtgcagtct gcaggcaatg ttggcattgt aaattcctcc cttgcagcct
     1501 ccttcatgtg gtgaggggat cacttcagct gcctgctgtg gacaaagaac atcaaattac
     1561 agcatcacga gtgctattgt tgcctgtggt ggtctccctg tccaagcggg accgctttgc
     1621 agagaccaga ggcatatcgc ggcttgagct gaaaatgcat ttgttgcagc ttaggttgaa
     1681 ttatttttcg tttgctcttt cttctacacg cgcctgatgg atagtgaacc tattcatcaa
     1741 aaaagtgcac tgctcttctg tctattgtac cgacttaacc tcttccaccc aagtccgcat
     1801 ctgtgtgtat catcaataaa gttgtgtgct ttgattggca
//
