LOCUS       NM_001168478            2772 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens armadillo repeat containing X-linked 5 (ARMCX5),
            transcript variant 3, mRNA.
ACCESSION   NM_001168478
VERSION     NM_001168478.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Lao,L., Bourdeau,I., Gagliardi,L., He,X., Shi,W., Hao,B., Tan,M.,
            Hu,Y., Peng,J., Coulombe,B., Torpy,D.J., Scott,H.S., Lacroix,A.,
            Luo,H. and Wu,J.
  TITLE     ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in
            adrenal hyperplasia
  JOURNAL   Nucleic Acids Res 50 (11), 6343-6367 (2022)
   PUBMED   35687106
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Lopez-Domenech,G., Serrat,R., Mirra,S., D'Aniello,S., Somorjai,I.,
            Abad,A., Vitureira,N., Garcia-Arumi,E., Alonso,M.T.,
            Rodriguez-Prados,M., Burgaya,F., Andreu,A.L., Garcia-Sancho,J.,
            Trullas,R., Garcia-Fernandez,J. and Soriano,E.
  TITLE     The Eutherian Armcx genes regulate mitochondrial trafficking in
            neurons and interact with Miro and Trak2
  JOURNAL   Nat Commun 3, 814 (2012)
   PUBMED   22569362
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2772)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2772)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064983.1 and AL537480.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001168478.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-6 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.844580.1,
                                           SRR1660809.184096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000473968.7/ ENSP00000473737.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BC064983.1         286-348
            64-853              AL537480.3         1-790
            854-2772            BC064983.1         1026-2944
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..2772
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /note="armadillo repeat containing X-linked 5"
                     /db_xref="GeneID:64860"
                     /db_xref="HGNC:HGNC:25772"
                     /db_xref="MIM:301047"
     exon            1..333
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /inference="alignment:Splign:2.1.0"
     exon            334..446
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /inference="alignment:Splign:2.1.0"
     exon            447..492
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /inference="alignment:Splign:2.1.0"
     exon            493..2772
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             755..2431
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /codon_start=1
                     /product="armadillo repeat-containing X-linked protein 5"
                     /protein_id="NP_001161950.1"
                     /db_xref="CCDS:CCDS14500.1"
                     /db_xref="GeneID:64860"
                     /db_xref="HGNC:HGNC:25772"
                     /db_xref="MIM:301047"
                     /translation="MVDSGTEARARGKAEAGLQDGISGPATARVNGKTQAEAVAEAEL
                     KTESVTQAKAGDGAMTRTHTVTYREAMAVTREVIKVEDTTKTRVMVETKTKPLAERSI
                     VPQTKSKAMPMSRVSTVTKSEVKVVAVIEANIRSYAKSHDKANTGSRPDRREETSIGM
                     KSSDEDEENICSWFWTGEEPSVGSWFWPEEETSLQVYKPLPKIQEKPKPTHKPTLTIK
                     QKVIAWSRARYIVLVPVEGGEQSLPPEGNWTLVETLIETPLGIRPLTKIPPYHGPYYQ
                     TLAEIKKQIRQREKYGPNPKACHCKSRGFSLEPKEFDKLVALLKLTKDPFIHEIATMI
                     MGISPAYPFTQDIIHDVGITVMIENLVNNPNVKEHPGALSMVDDSSESSEEPKSGESY
                     IHQVCKGIISCPLNSPVQLAGLKLLGHLSIKFEDHYVITSYIPDFLTLLNKGSVKTKF
                     YVLKVFSCLSKNHANTRELISAKVLSSLVAPFNKNESKANILNIIEIFENINFQFKTK
                     AKLFTKEKFTKSELISIFQEAKQFGQKLQDLAEHSDPEVRDKVIRLILKL"
     regulatory      2743..2748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /note="hexamer: AATAAA"
     polyA_site      2772
                     /gene="ARMCX5"
                     /gene_synonym="GASP5"
                     /note="major polyA site"
ORIGIN      
        1 ctcccactgc cgttgtgggt aacgcggacg tggaagaacc tcgtctgcgg aggaaaaggt
       61 agatgttaaa tggtaactac gcgcgaggtt ctgaggagcc ctgggaacag gaaggagaaa
      121 agaataccaa aagtgacaac agtttgccaa tcgcagtctt taatctgata aagcggttat
      181 ctcgtcttga gtcccaggtg ccgagtcaat ccccatacac agccgccgcc attgcctcga
      241 gtccttgtgt ctgactgtct gttcctgctg ctgtatgaca cagcacctcg aggcaaggaa
      301 ataagaaaac tgcctctgat ccaagcagag aaggtagatc tgtccccagg tctgtggaac
      361 tgtcagttgt gaagttttgt aaaatggtca cccaacttaa aactaggaaa ttacgaagaa
      421 gagaaaattg ccctgtatct gttaaggtct gcctgtagat ctgctgtagg gcttgtcacc
      481 attggaagca aggtcctact tcagtggcag atctggtggc cttggagtgg ctgaagacca
      541 ccaccctcca cagggctggg cccatgcaca gccatccttc cctaccttga gtgagcttcc
      601 tctgcatgtt ttctatatca ctggcagagc ctgtagttgg aaaggggaca gagtgactac
      661 tggactttgt gtgaaaacac caaccgggac aaaacttcag tcaaggctga gacgggtggg
      721 ggtatataac ttgtccttac gttaaacttg gaacatggtt gactctggga cagaagcaag
      781 ggctagagga aaggctgagg ctggcctgca agatggaatc agtggtcctg ccactgctag
      841 agtgaatggt aaaacccagg ccgaggcagt ggctgaggca gaactgaaaa cagaatcagt
      901 gacccaggcc aaagctggtg atggagcaat gaccaggaca catacagtga cctacaggga
      961 ggctatggct gtgacaaggg aagtgatcaa ggtggaagat acaactaaga ctagagtcat
     1021 ggttgagact aagacaaaac ccctggcaga acgcagtata gtgccacaaa ccaagtcaaa
     1081 ggccatgcct atgtctaggg tcagtactgt aaccaagtct gaagtcaagg ttgttgctgt
     1141 cattgaggca aatattaggt cctatgccaa gtcacatgat aaggccaata ctgggtccag
     1201 acctgacaga agggaagaga ccagcattgg gatgaaatcc agtgatgagg atgaagaaaa
     1261 tatatgctcc tggttctgga ctggagaaga gcctagtgta gggtcctggt tctggcctga
     1321 agaagagacc tctcttcaag tttataagcc cctacctaag atccaggaaa agcccaagcc
     1381 cacacacaaa cccacactta ctataaaaca aaaggtaata gcatggtcaa gggccaggta
     1441 tattgtccta gttccagttg aaggagggga gcaatccttg cctccagaag gaaactggac
     1501 cctggttgag accttgattg aaactcctct ggggattcga cctttgacca agatcccacc
     1561 ttatcatggg ccttattacc agaccttagc tgagatcaaa aaacagatta ggcaaaggga
     1621 aaagtatggg cctaatccga aggcctgcca ctgcaaatca cgtggcttta gtttagagcc
     1681 taaagagttt gataaacttg ttgccctcct taagttaact aaggatcctt tcattcatga
     1741 aatagctaca atgataatgg gcatcagtcc tgcttatcca tttactcaag atataattca
     1801 tgatgtaggt attactgtta tgattgaaaa cttggtcaat aatcccaatg ttaaagaaca
     1861 ccctggagct ttaagtatgg tggatgacag ctctgagtct tccgaagaac caaaatcagg
     1921 ggagtcatat atacatcaag tttgtaaagg cataatctct tgccccttga actcccctgt
     1981 gcagctggct ggactgaaat tactagggca cttgagtata aaatttgaag atcactatgt
     2041 gattaccagt tatattccag atttcctcac cttgttaaac aagggaagtg tcaaaaccaa
     2101 gttttatgtt ttaaaagtgt tttcgtgttt gtctaaaaat cacgccaata caagagaatt
     2161 gatcagtgcc aaagtactgt catcattggt tgcacccttt aacaagaatg agtcaaaggc
     2221 caatattctt aatattattg aaatatttga gaatataaat tttcagttca aaacaaaggc
     2281 aaagctattt accaaggaaa agttcactaa atctgagctt atttcaatat tccaggaagc
     2341 aaaacagttt ggtcagaaac tccaagactt agcagagcac agtgatcccg aagtgagaga
     2401 taaagtcata cgattaatac taaaactctg aatacccctc tgttctcata aagcctcaaa
     2461 cagttttttg gagttgcaat atgaaaccaa tgcatattgt aattataaat tcaatactta
     2521 tgttttccat gttgattgag ggaggcaatt ttatggatac caattaatct tgagatcctg
     2581 aacatgtgct gatttttatt gtgctatata gtatataaat tgagatattt ttggtatttc
     2641 tgcaacgtga cctgataatg aatctattca tcctgagtaa gctatacttc tgtgctttat
     2701 attgatatgt gtattctttt gagattttat ttacatgttg ttaataaagt tgcatgctaa
     2761 aactggtgaa aa
//
