LOCUS       NM_001199818            3940 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ARMCX5-GPRASP2 readthrough (ARMCX5-GPRASP2),
            transcript variant 1, mRNA.
ACCESSION   NM_001199818
VERSION     NM_001199818.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3940)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3940)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3940)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3940)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3940)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3940)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3940)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
REFERENCE   8  (bases 1 to 3940)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 3940)
  AUTHORS   Simonin,F., Karcher,P., Boeuf,J.J., Matifas,A. and Kieffer,B.L.
  TITLE     Identification of a novel family of G protein-coupled receptor
            associated sorting proteins
  JOURNAL   J Neurochem 89 (3), 766-775 (2004)
   PUBMED   15086532
REFERENCE   10 (bases 1 to 3940)
  AUTHORS   Heese,K., Yamada,T., Akatsu,H., Yamamoto,T., Kosaka,K., Nagai,Y.
            and Sawada,T.
  TITLE     Characterizing the new transcription regulator protein p60TRP
  JOURNAL   J Cell Biochem 91 (5), 1030-1042 (2004)
   PUBMED   15034937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035551.6, BG392679.1 and AL035427.17.
            
            Summary: This locus represents naturally occurring readthrough
            transcription among the adjacent armadillo repeat containing,
            X-linked 5 (ARMCX5), G protein-coupled receptor associated sorting
            proteins 1 and 2 (GPRASP1 and GPRASP2), basic helix-loop-helix
            family member b9 (BHLHB9), and long intergenic non-protein coding
            RNA 630 (LINC00630) genes on chromosome X. Transcripts may make use
            of multiple alternative promoters and polyadenylation signals in
            this region. Readthrough transcripts may produce proteins identical
            to the proteins encoded by GPRASP2 or BHLHB9. [provided by RefSeq,
            Apr 2017].
            
            Transcript Variant: This variant (1) incorporates exons from ARMCX5
            and GPRASP2 and encodes the same protein as GPRASP2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803611.145433.1, ERR3218372.286566.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA2144120 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 9737, 64860,
                                      80823, 114928, 100287765
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AL035551.6         80810-81031
            223-791             BG392679.1         34-602
            792-3940            AL035427.17        92803-95951
FEATURES             Location/Qualifiers
     source          1..3940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3940
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /note="ARMCX5-GPRASP2 readthrough"
                     /db_xref="GeneID:100528062"
                     /db_xref="HGNC:HGNC:42000"
     exon            1..225
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            226..379
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            380..425
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            426..597
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            598..665
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            666..743
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            744..3940
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1077..3593
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /note="isoform Gprasp2 is encoded by transcript variant 1;
                     G-protein coupled receptor-associated sorting protein 2;
                     protein BHLHb9; ARMCX5-GPRASP2-BHLHB9-LINC00630
                     readthrough; transcription regulator of 60 kDa"
                     /codon_start=1
                     /product="G-protein coupled receptor-associated sorting
                     protein 2 isoform Gprasp2"
                     /protein_id="NP_001186747.1"
                     /db_xref="GeneID:100528062"
                     /db_xref="HGNC:HGNC:42000"
                     /translation="MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQA
                     TTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDA
                     RAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAES
                     GSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEA
                     SNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEA
                     YVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEF
                     YKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFW
                     AEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFG
                     SWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGF
                     RSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVRE
                     IREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMR
                     SASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQV
                     CEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLK
                     MLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSL
                     IDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS"
     regulatory      3915..3920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /note="hexamer: AATAAA"
     polyA_site      3940
                     /gene="ARMCX5-GPRASP2"
                     /gene_synonym="ARMCX5-GPRASP2-BHLHB9-LINC00630; bHLHb9;
                     GPRASP3; p60TRP"
                     /note="major polyA site"
ORIGIN      
        1 cgccgttttc cctatatccg gaattcgtcc ctgcgcattc caatacctga agcggccaca
       61 gggtacagga cagggagccc tccgacagaa aagagtcgcg gcgctaaaca aagcctgata
      121 tcactccgct tccataagcc ggatccccat aaactacgct ctagctcctc ccactgccgt
      181 tgtgggtaac gcggacgtgg aagaacctcg tctgcggagg aaaagtccca ggtgccgagt
      241 caatccccat acacagccgc cgccattgcc tcgagtcctt gtgtctgact gtctgttcct
      301 gctgctgtat gacacagcac ctcgaggcaa ggaaataaga aaactgcctc tgatccaagc
      361 agagaaggtc agtgagaagg tctgcctgta gatctgctgt agggcttgtc accattggaa
      421 gcaagaactc ctgtagcctg taataccagc tgtgggtact actctcagtg ttggagatca
      481 tcaaaataca attggaccag accctttgga aataattctg tgtctcaaat gccctgtgga
      541 gcacacactt aatcagttga tggctatgga attttccaac atcagctaaa gagaagggcc
      601 tactttaagg ctggccaatt ctgcaagaaa ggcaaggagg aggagactgg ctcacagctc
      661 tggaggaccc ccttctgtca gctgtggggc ttgacaccac ttgaacaaga aaaggagggg
      721 gaaactgcac cacatcagtg aagatccacc tccagtggct gctctgctgg tggtggagtt
      781 gctgctgaca accaccctca acgggtctgc acccatccag gaaatatctg tcttccttta
      841 gcttggttgt acctgttctc actctatctg tattattgaa ttattgactg agactgtgtt
      901 tgggaaggag gctgagtgac tactggactg gatattgact ctaactctta ttcccaagct
      961 tatatcctta atcacctaaa gatcagagtg tgaagaaaca aacctgtgac agatctgtgg
     1021 ttgaggttta gactacggga ggagtatatt acctgacttt ctttgtaact tgtaccatga
     1081 ctggggcaga gattgagcct agtgcccagg ccaagcctga aaagaaggct ggggaagagg
     1141 ttatcgctgg gcctgagaga gagaatgatg tccctctggt ggtcagaccc aaggttagga
     1201 cccaggcaac tactggggca aggcccaaaa ctgagaccaa gtctgtgcct gcggcaaggc
     1261 ccaaaactga ggcccaagca atgtctgggg caaggcccaa aactgaggtc caagtaatgg
     1321 gtggtgcaag acccaaaacg gaggctcaag gaatcacagg ggccaggccc aaaaccgatg
     1381 ccagggcagt aggtggcgct cgttctaaaa ctgatgccaa ggcaatccct ggagcaaggc
     1441 ccaaggatga ggcccaggca tgggcccaga gtgaatttgg gactgaagca gtgtcacagg
     1501 cagaaggagt gtcccagact aatgccgttg cttggccact ggccactgct gagtctggat
     1561 cagttactaa atctaagggc ctgtctatgg atagagaact agtcaatgtg gatgctgaaa
     1621 cctttcctgg cacccagggt cagaaaggaa tccagccctg gtttggacca ggggaggaga
     1681 ctaatatggg gtcttggtgc tattccaggc ccagggccag agaggaggcc tctaatgagt
     1741 ctgggttctg gtcagcagat gagacctcta cagcgtcttc tttctggact ggagaagaga
     1801 caagtgtcag atcatggccc agggaagagt ccaataccag gtccaggcac agggctaaac
     1861 atcagactaa tcccaggtcc aggcccagat ccaagcaaga agcctatgtt gattcctggt
     1921 ctggatctga ggatgaggcc agcaacccat tctccttctg ggttggagaa aataccaata
     1981 acttgttcag gcccagagtc agggaggagg caaatatcag gtccaagctc aggacaaata
     2041 gagaagattg ttttgaatct gagtctgaag atgagttcta taagcagtcc tgggttttgc
     2101 ctggagaaga ggccaatagt agattcaggc acagagacaa agaagatcct aatactgcct
     2161 tgaaactcag ggcccagaaa gatgttgaca gtgatagggt caaacaagaa cccaggtttg
     2221 aggaggaagt cattattggg tcctggttct gggcagaaaa agaggccagt ttggagggtg
     2281 gagcttcagc aatctgtgaa tctgagccag gaactgagga gggggccatt ggcggatccg
     2341 cgtactgggc tgaggaaaag tccagtttgg gggctgtggc cagagaagag gccaagccgg
     2401 agtctgaaga agaggccata tttgggtcct ggttctggga cagagatgag gcctgctttg
     2461 acctaaatcc ctgtcctgtg tacaaggtca gtgataggtt cagagatgca gctgaggagc
     2521 ttaatgcatc ctccaggccc caaacctggg acgaggtcac tgttgaattc aaacctggtc
     2581 tttttcatgg ggttggcttc cgatccacaa gcccctttgg aattcccgaa gaggcttctg
     2641 aaatgcttga ggcaaagccc aagaacctgg aacttagccc agaaggagaa gagcaggaat
     2701 ctttgcttca gcctgatcag cctagtcctg agttcacatt tcagtatgat ccttcctacc
     2761 ggtcagtccg ggaaattcga gagcatctta gggccaggga gagtgcagag tctgagagtt
     2821 ggtcctgcag ctgcatacaa tgtgagctga aaattggttc tgaagagttt gaagaattcc
     2881 ttttattaat ggacaaaatt cgggatcctt ttattcatga aatatctaaa attgcaatgg
     2941 gtatgagaag tgcttctcaa tttacccgag atttcattcg agattcaggt gttgtctcac
     3001 ttattgaaac cttgcttaat tatccatcct ctagagttag gacaagtttt ttggaaaata
     3061 tgattcacat ggctccacct tatccaaatc taaacatgat tgagacattc atatgtcaag
     3121 tgtgtgagga aacccttgca catagtgtgg attcccttga gcagctgact ggaataagga
     3181 tgcttagaca cctcactatg actattgact atcacacact gattgccaac tatatgtccg
     3241 ggtttctctc cttattaacc acagccaatg cgagaacgaa gtttcacgtt ctgaaaatgc
     3301 tattgaattt gtctgaaaat cctgctgtgg caaaaaaact attcagtgcc aaagctcttt
     3361 caatatttgt gggtctcttt aacatagaag agacaaatga taatattcaa attgttatta
     3421 aaatgtttca gaatatcagt aacattataa aaagtggaaa gatgtcctta attgatgatg
     3481 atttcagtct tgagccgctt atttctgcat ttcgtgaatt tgaggagtta gctaagcaac
     3541 tacaagccca aatagacaac caaaatgatc ctgaggtggg acaacaaagt taatatgatt
     3601 aaccacctgc cgctgatcag ccttatgttc ccaaagagcc ctgagtagtg ctttggtgtt
     3661 cacagtctgt ttttttgttg taacttatat tttttaatgc tgatgttaac tttgtcaaac
     3721 tcttgttttg agctggatca ttttgtggat gccaaatgaa tatcaaaact gaaaacacat
     3781 ttgttgatat ttgtcttgct gtccagattg cggtattttt cagtattaag ttttcaatga
     3841 actgtgtcac ctaagtaagc taccctgcta ttcgttgttt aaatatatgg ttctctattt
     3901 gagtctgtgt tttcaataaa gttctatgtt aaaattggca
//
