LOCUS       NM_177947               3348 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing X-linked 3 (ARMCX3),
            transcript variant 2, mRNA.
ACCESSION   NM_177947
VERSION     NM_177947.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Du,J., Zhang,X., Zhou,H., Miao,Y., Han,Y., Han,Q. and Wang,E.
  TITLE     Alex3 suppresses non-small cell lung cancer invasion via
            AKT/Slug/E-cadherin pathway
  JOURNAL   Tumour Biol 39 (7), 1010428317701441 (2017)
   PUBMED   28705116
  REMARK    GeneRIF: reduction of Alex3 correlates with the development of
            non-small cell lung cancer and predicts adverse clinical outcome of
            non-small cell lung cancer patients. The effect of Alex3 on
            inhibiting invasion and migration may attribute to upregulation of
            E-cadherin expression through AKT-Slug pathway inactivation.
REFERENCE   5  (bases 1 to 3348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3348)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3348)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 3348)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3348)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3348)
  AUTHORS   Kurochkin,I.V., Yonemitsu,N., Funahashi,S.I. and Nomura,H.
  TITLE     ALEX1, a novel human armadillo repeat protein that is expressed
            differentially in normal tissues and carcinomas
  JOURNAL   Biochem Biophys Res Commun 280 (1), 340-347 (2001)
   PUBMED   11162520
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG035798.1, BC005194.1,
            BX647802.1 and AC234775.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_177947.2.
            
            Summary: This gene encodes a member of the ALEX family of proteins
            which may play a role in tumor suppression. The encoded protein
            contains a potential N-terminal transmembrane domain and a single
            Armadillo (arm) repeat. Other proteins containing the arm repeat
            are involved in development, maintenance of tissue integrity, and
            tumorigenesis. This gene is closely localized with other family
            members on the X chromosome. Three transcript variants encoding the
            same protein have been identified for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005194.1, SRR1803613.187618.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471229.7/ ENSP00000454483.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BG035798.1         35-69
            36-1981             BC005194.1         1-1946
            1982-3346           BX647802.1         1972-3336
            3347-3348           AC234775.5         71299-71300         c
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3348
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /note="armadillo repeat containing X-linked 3"
                     /db_xref="GeneID:51566"
                     /db_xref="HGNC:HGNC:24065"
                     /db_xref="MIM:300364"
     exon            1..126
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /inference="alignment:Splign:2.1.0"
     exon            127..206
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /inference="alignment:Splign:2.1.0"
     exon            207..267
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /inference="alignment:Splign:2.1.0"
     exon            268..338
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /inference="alignment:Splign:2.1.0"
     exon            339..3348
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..1624
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /note="arm protein lost in epithelial cancers, X
                     chromosome, 3; ARM protein lost in epithelial cancers on
                     chromosome X 3"
                     /codon_start=1
                     /product="armadillo repeat-containing X-linked protein 3"
                     /protein_id="NP_808816.1"
                     /db_xref="CCDS:CCDS14489.1"
                     /db_xref="GeneID:51566"
                     /db_xref="HGNC:HGNC:24065"
                     /db_xref="MIM:300364"
                     /translation="MGYARKVGWVTAGLVIGAGACYCIYRLTRGRKQNKEKMAEGGSG
                     DVDDAGDCSGARYNDWSDDDDDSNESKSIVWYPPWARIGTEAGTRARARARARATRAR
                     RAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIR
                     DLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNS
                     SVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAM
                     TRELLRAQVPSSLGSLFNKKENKEVILKLLVIFENINDNFKWEENEPTQNQFGEGSLF
                     FFLKEFQVCADKVLGIESHHDFLVKVKVGKFMAKLAEHMFPKSQE"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /note="hexamer: AATGAA"
     polyA_site      1821
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /note="hexamer: AATAAA"
     polyA_site      1989
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /note="hexamer: AATAAA"
     polyA_site      3348
                     /gene="ARMCX3"
                     /gene_synonym="ALEX3; dJ545K15.2; GASP6"
                     /note="major polyA site"
ORIGIN      
        1 agaagtcctt cttgtcctgg tcgttgttcc cgtctgagta ccagctcccc actgccctga
       61 gggcgggccg gcctgcggcg gagggaaaaa ggaagaggag aaggaaattg tcccgaatcc
      121 ctgcagtctt tctgtaggtt gcggcacaac gccaggcaaa agaagaggaa ggaatttaat
      181 cctaatcggt ggaggtcgat ttgagggtct gctgtagcag gtggctccgc ttgaagcgag
      241 ggaggaagtt tcctccgatc agtagagatt ggaaagattg ttgggagtgg cacaccacta
      301 gggaaaagaa gaaggggcga actgcttgtc ttgaggaggt caacccccag aatcagctct
      361 tgtggccttg aagtggctga agacgatcac cctccacagg cttgagccca gtcccacagc
      421 cttcctcccc cagcctgagt gactactcta ttccttggtc cctgctattg tcggggacga
      481 ttgcatgggc tacgccagga aagtaggctg ggtgaccgca ggcctggtga ttggggctgg
      541 cgcctgctat tgcatttata gactgactag gggaagaaaa cagaacaagg aaaaaatggc
      601 tgagggtgga tctggggatg tggatgatgc tggggactgt tctggggcca ggtataatga
      661 ctggtctgat gatgatgatg acagcaatga gagcaagagt atagtatggt acccaccttg
      721 ggctcggatt gggactgaag ctggaaccag agctagggcc agggcaaggg ccagggctac
      781 ccgggcacgt cgggctgtcc agaaacgggc ttcccccaat tcagatgata ccgttttgtc
      841 ccctcaagag ctacaaaagg ttctttgctt ggttgagatg tctgaaaagc cttatattct
      901 tgaagcagct ttaattgctc tgggtaacaa tgctgcttat gcatttaaca gagatattat
      961 tcgtgatctg ggtggtctcc caattgtcgc aaagattctc aatactcggg atcccatagt
     1021 taaggaaaag gctttaattg tcctgaataa cttgagtgtg aatgctgaaa atcagcgcag
     1081 gcttaaagta tacatgaatc aagtgtgtga tgacacaatc acttctcgct tgaactcatc
     1141 tgtgcagctt gctggactga gattgcttac aaatatgact gttactaatg agtatcagca
     1201 catgcttgct aattccattt ctgacttttt tcgtttattt tcagcgggaa atgaagaaac
     1261 caaacttcag gttctgaaac tccttttgaa tttggctgaa aatccagcca tgactaggga
     1321 actgctcagg gcccaagtac catcttcact gggctccctc tttaataaga aggagaacaa
     1381 agaagttatt cttaaacttc tggtcatatt tgagaacata aatgataatt tcaaatggga
     1441 agaaaatgaa cctactcaga atcaattcgg tgaaggttca ctttttttct ttttaaaaga
     1501 atttcaagtg tgtgctgata aggttctggg aatagaaagt caccatgatt ttttggtgaa
     1561 agtaaaagtt ggaaaattca tggccaaact tgctgaacat atgttcccaa agagccagga
     1621 ataacacctt gattttgtaa tttagaagca acacacattg taaactattc attttctcca
     1681 ccttgtttat atggtaaagg aatcctttca gctgccagtt ttgaataatg aatatcatat
     1741 tgtatcatca atgctgatat ttaactgagt tggtctttag gtttaagatg gataaatgaa
     1801 tatcactact tgttctgaaa acatgtttgt tgctttttat ctcgctgcct agattgaaat
     1861 attttgctat ttcttctgca taagtgacag tgaaccaatt catcatgagt aagctccctt
     1921 ctgtcatttt cattgattta atttgtgtat catcaataaa attgtatgtt aatgctggaa
     1981 agaaaaaaag aagaaagaaa gaaaccatcc ctgtccttca gtttataatc tagttggaga
     2041 gataagaaac gtacaaacca aaagataaca gaatatctga agcatgtact cattgtcaga
     2101 tgttccctct gagagcacag aggaggcaaa agcttctgtg ggatgtgcta gtcggctaaa
     2161 gcttcacaga ggaggtggca attgaaaatg agtcctgaat ggggtagggt ggttagggaa
     2221 ttccatgaga caagacaagg ggggcatggt gtgagaaagg catggaagta ggaaccctct
     2281 tcctatgaca ggagatcatt ctgcttagag tggagagtgt ggagagtggg agtagataat
     2341 tttggaaagc tgggtgaagc cagttgtgga gaattgtttg aatattatcc cattgaatac
     2401 ccagagccac taaatctttt tttactagaa aataattggg gtccatatga aagtctctat
     2461 tactgagtag tgtcaatgag ggtgtggcaa aatggagcct ttcacatcct agtggtggcc
     2521 atttggtaat acagatataa gccttaaact atgtaaaccc ttgtcctaag gaagtaattg
     2581 aataattgcc caaagattgt atgtatgagg ctgttcatcc cagcactgtc taagctagta
     2641 aaaattggaa acaatttaag tatctagcac attggattgg ttataaagca aggaatgttc
     2701 acacagtagg atattataag tatgctgatg gaaatctata ttgccaggaa aagctattca
     2761 ttatgcgttg tgaagtcaga aagtaaaaaa gggtagatag aagtattcga agtatagttc
     2821 cattttttga gactaataaa acatatgttt aaaaggacac taaaaactgg agttatagat
     2881 atccagatag aaacagtagt tatctttggg tagaagaata atgagtgatc tttacttttt
     2941 tactttttat tcatctttgt gtttttattt atctaaaatg ggtattgatt tttaggacgg
     3001 ttttgaaaaa gaaaagtgtt gggaatgaag caagtgattg attggaaaac atactgaatg
     3061 gaagaaatat ttagattaaa aatgaggtag gttgaagttt cttctctgaa atgatagata
     3121 aatggtgaag ataaggctta ttgtgaggat tcagtgaggt aatatatgca aagtacttac
     3181 aatgttctgg cacatagtaa ttaattaaga aaatcgagca cccttaatta cctagaatgc
     3241 agggttgtta gttttttggt tgacttttgt tttgctgggg cattctgcca tgttttagtg
     3301 tcatttaata aataatagta acaataaagg ttaacattta ttaagtga
//
