LOCUS       NM_177949               2819 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens armadillo repeat containing X-linked 2 (ARMCX2),
            transcript variant 1, mRNA.
ACCESSION   NM_177949
VERSION     NM_177949.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2819)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2819)
  AUTHORS   Wang,T., Zhong,H., Qin,Y., Wei,W., Li,Z., Huang,M. and Luo,X.
  TITLE     ARMCX Family Gene Expression Analysis and Potential Prognostic
            Biomarkers for Prediction of Clinical Outcome in Patients with
            Gastric Carcinoma
  JOURNAL   Biomed Res Int 2020, 3575038 (2020)
   PUBMED   32685472
  REMARK    GeneRIF: ARMCX Family Gene Expression Analysis and Potential
            Prognostic Biomarkers for Prediction of Clinical Outcome in
            Patients with Gastric Carcinoma.
            Erratum:[Biomed Res Int. 2021 Feb 9;2021:3179693. doi:
            10.1155/2021/3179693.. PMID: 33644226]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2819)
  AUTHORS   Zeller,C., Dai,W., Steele,N.L., Siddiq,A., Walley,A.J.,
            Wilhelm-Benartzi,C.S., Rizzo,S., van der Zee,A., Plumb,J.A. and
            Brown,R.
  TITLE     Candidate DNA methylation drivers of acquired cisplatin resistance
            in ovarian cancer identified by methylome and expression profiling
  JOURNAL   Oncogene 31 (42), 4567-4576 (2012)
   PUBMED   22249249
  REMARK    GeneRIF: Data indicate that ARMCX2, COL1A1, MDK, MEST and MLH1
            genes acquired methylation in drug-resistant ovarian
            cancer-sustaining (side population) cells.
REFERENCE   4  (bases 1 to 2819)
  AUTHORS   Lopez-Domenech,G., Serrat,R., Mirra,S., D'Aniello,S., Somorjai,I.,
            Abad,A., Vitureira,N., Garcia-Arumi,E., Alonso,M.T.,
            Rodriguez-Prados,M., Burgaya,F., Andreu,A.L., Garcia-Sancho,J.,
            Trullas,R., Garcia-Fernandez,J. and Soriano,E.
  TITLE     The Eutherian Armcx genes regulate mitochondrial trafficking in
            neurons and interact with Miro and Trak2
  JOURNAL   Nat Commun 3, 814 (2012)
   PUBMED   22569362
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2819)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2819)
  AUTHORS   Kurochkin,I.V., Yonemitsu,N., Funahashi,S.I. and Nomura,H.
  TITLE     ALEX1, a novel human armadillo repeat protein that is expressed
            differentially in normal tissues and carcinomas
  JOURNAL   Biochem Biophys Res Commun 280 (1), 340-347 (2001)
   PUBMED   11162520
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291342.1, AC234775.5 and
            BC015926.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_177949.3.
            
            Summary: This gene encodes a protein containing a potential
            N-terminal transmembrane domain and multiple armadillo (arm)
            repeats. Proteins containing arm repeats are involved in
            development, maintenance of tissue integrity, and tumorigenesis.
            This gene is located in a cluster of related genes on chromosome X.
            There is a pseudogene for this gene on chromosome 7. Alternative
            splicing in the 5' UTR results in multiple transcript variants
            encoding the same protein. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291342.1, SRR1803611.235778.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356824.9/ ENSP00000349281.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1179              AK291342.1         1-1179
            1180-1180           AC234775.5         42222-42222
            1181-2819           BC015926.1         1025-2663
FEATURES             Location/Qualifiers
     source          1..2819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..2819
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /note="armadillo repeat containing X-linked 2"
                     /db_xref="GeneID:9823"
                     /db_xref="HGNC:HGNC:16869"
                     /db_xref="MIM:300363"
     exon            1..93
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /inference="alignment:Splign:2.1.0"
     exon            94..176
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /inference="alignment:Splign:2.1.0"
     exon            177..249
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /inference="alignment:Splign:2.1.0"
     exon            250..314
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /inference="alignment:Splign:2.1.0"
     exon            315..384
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /inference="alignment:Splign:2.1.0"
     exon            385..2819
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..2410
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /note="armadillo repeat protein ALEX2; ARM protein lost in
                     epithelial cancers on chromosome X 2"
                     /codon_start=1
                     /product="armadillo repeat-containing X-linked protein 2"
                     /protein_id="NP_808818.1"
                     /db_xref="CCDS:CCDS14490.1"
                     /db_xref="GeneID:9823"
                     /db_xref="HGNC:HGNC:16869"
                     /db_xref="MIM:300363"
                     /translation="MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNR
                     AVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAA
                     SSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGA
                     PKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAA
                     EAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATG
                     AVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE
                     VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVL
                     ALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALM
                     AMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVN
                     SIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEI
                     LINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVK
                     VIKLVNKF"
     regulatory      2790..2795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /note="hexamer: AATAAA"
     polyA_site      2819
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2; GASP9"
                     /note="major polyA site"
ORIGIN      
        1 ctcctctggg taccaactct attgcgcagc tcgctgccgt gcgtttaacc caggcgagga
       61 ggaggaggag aaaattcccc cagattcggg caggcccgca ccccacattc cgtcctgttt
      121 tgagaggagg agggaagaga aataaacgtg gcagcgcata gaaggccagc agggagactg
      181 ctttccagac acctccggcc cacacagccg ttcacccccc gtcttttcag tcctggaaaa
      241 ggaattcggt ctgtccttag gatgaagctc taactgaact gaagtaagga gaaacagcct
      301 tgaatctttg gagggtctgt cttccttttg ggctctgtgc aactgcagct acagtggaaa
      361 aaagcaaact gctcttgatc ccaggccctg cctaagcctc agcagaactt gtaagcctaa
      421 actgaagagc ctcacccgga cgagcaggca tcccttaacc ttaagcaatc cagttccacg
      481 ccctggatca gtgaataacc ccagctgcac catgagccgc gttcgggatg ctggctgtgt
      541 agcggcgggg atagtgatag gggctggtgc ctggtactgt gtctacaaat acaccagggg
      601 gagagaccag accaagaaga gaatggccaa gcccaaaaac cgggctgtgg ctgggactgg
      661 agccagggct agagctgggc taagagccgg attcacaatc gaccttgggt caggattcag
      721 tcccccaacc ccagtccgtg ctgaagcaga ggacagggcc caggatgaag cctctgctct
      781 ggacacagtt ggagctgagg cagtggcccc agctgcatcc agcgctgagg ctcagagtgg
      841 ggcaggcagt caggcccaag aggcagatgg agccggggtt gggcctaagg ccgaatcagt
      901 agttggggct gcaatggctt ctgcaatagc accacctccc ggggtgacag aggcccttgg
      961 ggctgcagaa gcccctgcaa tggcaggggc tcccaaagtg gcagaagctc ccagagaagc
     1021 ggagacttcc agggcagcgg tgcctcctgg gacagtggtg cctaccgaag cggcagcacc
     1081 cactgaggtg accgagggtc ctggggtagc agcacctacc aaggtagctg aagctcccgg
     1141 ggtggcatcg cctaccgagg cagctgaggc tcctgtgccg gcaacgccta ctggggctgc
     1201 agcacctact ggggctgcag agtctcctgg aacttctggt tcccctagaa cagcggtggt
     1261 tcctggaaca tcagctgcca agaaagcaac ccctggggct cacactgggg ctataccgaa
     1321 agccacatca gcgactggag cggtacccaa aggtggaggc aagggtgtaa ccaggtcccg
     1381 gaatgggggc aagggcaagg gcaagaaaag caaagttgaa gtagacgaac tggggatggg
     1441 cttccgtcct ggagatgggg ctgcagcagc tgctgcagcc tctgctaatg gcggacaggc
     1501 tttcctggca gaggtccctg attctgagga aggggagtcc gggtggactg acacagagtc
     1561 agattcagac tctgagcccg agacccagcg cagagggagg ggaagaagac ccgttgccat
     1621 gcagaagcgc ccctttcctt atgaaattga tgagattctg ggtgtccgcg atctcaggaa
     1681 ggtccttgcc ttgcttcaga aatctgatga tcctttcatc caacaggtag ctttgctcac
     1741 tctgagcaac aatgccaatt attcatgcaa tcaagagaca atccgcaaat tgggaggcct
     1801 cccaattatt gcaaacatga tcaacaaaac tgatccacac attaaggaaa aagccttaat
     1861 ggccatgaat aacctgagtg agaattatga aaatcagggc cggcttcagg tgtacatgaa
     1921 taaagtgatg gatgatatca tggcctctaa cctgaactca gcagttcaag tagttggact
     1981 aaaatttcta acaaacatga ctattactaa tgactaccaa cacctgcttg tcaattccat
     2041 tgcaaacttt ttccgtttgc tatctcaggg aggtggaaaa atcaaggttg agattttgaa
     2101 aatcctttcg aattttgctg aaaatccaga tatgttgaag aaacttctca gtacccaagt
     2161 gccagcatca tttagttccc tctataattc ttacgtggaa tcagaaatcc ttattaatgc
     2221 ccttactcta tttgagatta tctatgacaa tctcagagca gaagtgttta actatagaga
     2281 attcaataaa ggttcccttt tttacttatg cactacatct ggagtgtgtg ttaagaaaat
     2341 tagagcctta gcaaatcacc atgacctctt agtgaaagtg aaagttataa aactagtgaa
     2401 caaattctga ttggttatgt accgtcaaaa gacttgaaga aatttcatga ttttgcagtg
     2461 tggaagcgtt gaaaattgaa agttactgct tttccacttg ctcatatagt aaagggatcc
     2521 tttcagctgc cagtgttgaa taatgtatca tccagagtga tgttatctgt gacagtcacc
     2581 agctttaagc tgaaccattt tatgaatacc aaataaatag acctcttgta ctgaaaacat
     2641 atttgtgact ttaatcgtgc tgcttggata gaaatatttt tactggttct tctgaattga
     2701 cagtaaacct gtccattatg aatggcctac tgttctatta tttgttttga cttgaattta
     2761 tccaccaaag acttcatttg tgtatcatca ataaagttgt atgtttcaac tgacaaaaa
//
