LOCUS       NM_016608               2125 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens armadillo repeat containing X-linked 1 (ARMCX1), mRNA.
ACCESSION   NM_016608
VERSION     NM_016608.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2125)
  AUTHORS   Lv,C., Yang,D., Zhang,D., Shen,J., Wang,Z., He,S., Meng,L., Song,J.
            and Zhao,J.
  TITLE     The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis
            and Influences Chemotherapy
  JOURNAL   J Immunol Res 2023, 2623317 (2023)
   PUBMED   36726491
  REMARK    GeneRIF: The Expression of ARMCX1 in Gastric Cancer Contributes to
            Prognosis and Influences Chemotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2125)
  AUTHORS   Wang,T., Zhong,H., Qin,Y., Wei,W., Li,Z., Huang,M. and Luo,X.
  TITLE     ARMCX Family Gene Expression Analysis and Potential Prognostic
            Biomarkers for Prediction of Clinical Outcome in Patients with
            Gastric Carcinoma
  JOURNAL   Biomed Res Int 2020, 3575038 (2020)
   PUBMED   32685472
  REMARK    GeneRIF: ARMCX Family Gene Expression Analysis and Potential
            Prognostic Biomarkers for Prediction of Clinical Outcome in
            Patients with Gastric Carcinoma.
            Erratum:[Biomed Res Int. 2021 Feb 9;2021:3179693. doi:
            10.1155/2021/3179693.. PMID: 33644226]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2125)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2125)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2125)
  AUTHORS   Zhu,Z., Yang,Q., Zhang,B., Wu,W., Yuan,F. and Zhu,Z.
  TITLE     miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting
            ALEX1 in Vitro and in Vivo
  JOURNAL   Cell Physiol Biochem 52 (3), 606-616 (2019)
   PUBMED   30907988
  REMARK    GeneRIF: Up-regulation of ALEX1 effectively rescued the cell
            apoptosis induced by miR-106b inhibitor and promoted the expression
            levels of phosphorylation of JAK1 and STAT3.
REFERENCE   6  (bases 1 to 2125)
  AUTHORS   Iseki,H., Takeda,A., Andoh,T., Kuwabara,K., Takahashi,N.,
            Kurochkin,I.V., Ishida,H., Okazaki,Y. and Koyama,I.
  TITLE     ALEX1 suppresses colony formation ability of human colorectal
            carcinoma cell lines
  JOURNAL   Cancer Sci 103 (7), 1267-1271 (2012)
   PUBMED   22494058
  REMARK    GeneRIF: Findings suggest that overexpression of ALEX1 (armadillo
            repeat containing, X-linked [ARMCX]) plays a negative role in
            colorectal tumorigenesis.
REFERENCE   7  (bases 1 to 2125)
  AUTHORS   Iseki,H., Takeda,A., Andoh,T., Takahashi,N., Kurochkin,I.V.,
            Yarmishyn,A., Shimada,H., Okazaki,Y. and Koyama,I.
  TITLE     Human Arm protein lost in epithelial cancers, on chromosome X 1
            (ALEX1) gene is transcriptionally regulated by CREB and
            Wnt/beta-catenin signaling
  JOURNAL   Cancer Sci 101 (6), 1361-1366 (2010)
   PUBMED   20398052
  REMARK    GeneRIF: Human Arm protein lost in epithelial cancers, on
            chromosome X 1 (ALEX1) gene is transcriptionally regulated by CREB
            and Wnt/beta-catenin signaling.
REFERENCE   8  (bases 1 to 2125)
  AUTHORS   Winter,E.E. and Ponting,C.P.
  TITLE     Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism
            sustained by gene conversion events
  JOURNAL   BMC Evol Biol 5, 54 (2005)
   PUBMED   16221301
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2125)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   10 (bases 1 to 2125)
  AUTHORS   Kurochkin,I.V., Yonemitsu,N., Funahashi,S.I. and Nomura,H.
  TITLE     ALEX1, a novel human armadillo repeat protein that is expressed
            differentially in normal tissues and carcinomas
  JOURNAL   Biochem Biophys Res Commun 280 (1), 340-347 (2001)
   PUBMED   11162520
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB039670.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016608.1.
            
            Summary: This gene encodes a member of the ALEX family of proteins
            and may play a role in tumor suppression. The encoded protein
            contains a potential N-terminal transmembrane domain and two
            Armadillo (arm) repeats. Other proteins containing the arm repeat
            are involved in development, maintenance of tissue integrity, and
            tumorigenesis. This gene is closely localized with other family
            members, including ALEX2 and ALEX3, on the X chromosome. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039670.1, BC002691.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372829.8/ ENSP00000361917.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2125              AB039670.1         17-2141
FEATURES             Location/Qualifiers
     source          1..2125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..2125
                     /gene="ARMCX1"
                     /gene_synonym="ALEX1; GASP7"
                     /note="armadillo repeat containing X-linked 1"
                     /db_xref="GeneID:51309"
                     /db_xref="HGNC:HGNC:18073"
                     /db_xref="MIM:300362"
     exon            1..114
                     /gene="ARMCX1"
                     /gene_synonym="ALEX1; GASP7"
                     /inference="alignment:Splign:2.1.0"
     exon            115..168
                     /gene="ARMCX1"
                     /gene_synonym="ALEX1; GASP7"
                     /inference="alignment:Splign:2.1.0"
     exon            169..233
                     /gene="ARMCX1"
                     /gene_synonym="ALEX1; GASP7"
                     /inference="alignment:Splign:2.1.0"
     exon            234..2125
                     /gene="ARMCX1"
                     /gene_synonym="ALEX1; GASP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1717
                     /gene="ARMCX1"
                     /gene_synonym="ALEX1; GASP7"
                     /note="arm protein lost in epithelial cancers, X
                     chromosome, 1; ARM protein lost in epithelial cancers on
                     chromosome X 1"
                     /codon_start=1
                     /product="armadillo repeat-containing X-linked protein 1"
                     /protein_id="NP_057692.1"
                     /db_xref="CCDS:CCDS14487.1"
                     /db_xref="GeneID:51309"
                     /db_xref="HGNC:HGNC:18073"
                     /db_xref="MIM:300362"
                     /translation="MGRTREAGCVAAGVVIGAGACYCVYRLAWGRDENEKIWDEDEES
                     TDTSEIGVETVKGAKTNAGAGSGAKLQGDSEVKPEVSLGLEDCPGVKEKAHSGSHSGG
                     GLEAKAKALFNTLKEQASAKAGKGARVGTISGNRTLAPSLPCPGGRGGGCHPTRSGSR
                     AGGRASGKSKGKARSKSTRAPATTWPVRRGKFNFPYKIDDILSAPDLQKVLNILERTN
                     DPFIQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTKDPIIREKTYNALNNLSV
                     NAENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDFFA
                     LLFLGNHFTKIQIMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNILTL
                     FENINDNIKNEGLASSRKEFSRSSLFFLFKESGVCVKKIKALANHNDLVVKVKVLKVL
                     TKL"
ORIGIN      
        1 gtccttctaa tcctagtctt cgtttggtcc ggttgcactc ttcctatagc ccagagggcg
       61 agagggcctg tggcctgggg gaaggaggac gaggttctgc ctggatccca gcagtaggac
      121 gctgtgccat ttgggaacaa aggaatagtc tgcctggaat ccctgcagat cttggggccg
      181 gaggccagtc caacccttgg agcaggaaga aacgcaaagt tgtcaagaac caagtcgagc
      241 tgcctcagag ccggcccgca gtagctgcag actccgcccg cgacgtgtgc gcgcttctct
      301 gggccagagc gagcctgttt tgtgctcggg ttaagagatt tgtcccagct ataccatggg
      361 ccgcactcgg gaagctggct gcgtggccgc tggtgtggtt atcggggctg gtgcctgcta
      421 ctgtgtatac agactggctt ggggaagaga cgagaacgag aaaatctggg acgaagacga
      481 ggagtctacg gacacctcag agattggggt tgagactgtg aaaggagcta aaactaacgc
      541 tggggcaggg tctggggcca aacttcaggg tgattcagag gtcaagcctg aggtgagttt
      601 gggactcgag gattgtccgg gtgtaaaaga gaaggcccat tcaggatccc acagcggagg
      661 tggcctagag gccaaggcca aggccctttt caacacgctg aaggaacagg caagtgcaaa
      721 ggcaggcaaa ggggctaggg tgggtaccat ctctgggaac aggacccttg caccgagttt
      781 accctgccca ggaggcaggg gtggaggctg ccaccccacc aggagtggat ctagggccgg
      841 gggcagggca agtggaaaat ccaagggaaa ggcccgaagt aagagcacca gggctccagc
      901 tacaacatgg cctgtccgga gaggcaagtt caactttcct tataaaattg atgatattct
      961 gagtgctccc gacctccaaa aggtcctcaa catcctggag cgaacaaatg atccttttat
     1021 tcaagaagta gccttggtca ctctgggtaa caatgcagca tattcattta accagaatgc
     1081 catacgtgaa ttgggtggtg tcccaattat tgcaaaactg ataaaaacaa aagaccccat
     1141 aattagggaa aagacttaca atgcccttaa taacttgagt gtgaacgcag aaaatcaggg
     1201 caagattaag acgtacatca gtcaagtgtg tgatgacacc atggtctgtc gcttggactc
     1261 agctgtgcag atggctgggc taagactgtt aaccaacatg actgtgacta atcattacca
     1321 acatttgctt tcctattctt ttccagactt ttttgctttg ttattcctgg gaaatcactt
     1381 caccaagata cagattatga aactaattat aaactttact gaaaatccag ccatgacaag
     1441 agagctggtc agttgtaaag taccatcaga attgatttcc ctctttaata aagaatggga
     1501 tagagagatt cttcttaata tccttaccct atttgagaat ataaatgaca acataaaaaa
     1561 tgaagggctc gcatcatcca ggaaagaatt cagcagaagt tcactttttt tcttattcaa
     1621 agagtctgga gtttgtgtta agaaaatcaa agcactagca aatcacaatg atctggtggt
     1681 gaaagtaaaa gtcctgaaag tattaaccaa actctaattt ggagtctgtc ccaaacaata
     1741 ttgagatatt tgcagttggt acgatgtgat ttgtaaattc tttgtttttc attgtgcgta
     1801 tatggtaaag agatcttttc agctgctatt ttggaataat gactatcata tatcataaca
     1861 gtgactgatg ttggttgtaa tggttgggtt taggatgaac cattttaagg atgccaaatg
     1921 aaatattagt atttgtacac agaaagaatt tattgatttg atcttattac ctagattgag
     1981 attttttaat ctttcctcta cctaaactga caatgaattg gttatacatc atgcataagc
     2041 tacactttta tattagttta tatttgttat tctaagactt gtgtttcatc aataaagttg
     2101 tgttttaagc agcagaaaaa aaaaa
//
