LOCUS       NM_001352754            7879 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens armadillo repeat containing 9 (ARMC9), transcript
            variant 4, mRNA.
ACCESSION   NM_001352754
VERSION     NM_001352754.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7879)
  AUTHORS   Lo,C.H., Liu,Z., Chen,S., Lin,F., Berneshawi,A.R., Yu,C.Q.,
            Koo,E.B., Kowal,T.J., Ning,K., Hu,Y., Wang,W.J., Liao,Y.J. and
            Sun,Y.
  TITLE     Primary cilia formation requires the Leigh syndrome-associated
            mitochondrial protein NDUFAF2
  JOURNAL   J Clin Invest 134 (13), e175560 (2024)
   PUBMED   38949024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7879)
  AUTHORS   Latour,B.L., Van De Weghe,J.C., Rusterholz,T.D., Letteboer,S.J.,
            Gomez,A., Shaheen,R., Gesemann,M., Karamzade,A., Asadollahi,M.,
            Barroso-Gil,M., Chitre,M., Grout,M.E., van Reeuwijk,J., van
            Beersum,S.E., Miller,C.V., Dempsey,J.C., Morsy,H., Bamshad,M.J.,
            Nickerson,D.A., Neuhauss,S.C., Boldt,K., Ueffing,M.,
            Keramatipour,M., Sayer,J.A., Alkuraya,F.S., Bachmann-Gagescu,R.,
            Roepman,R. and Doherty,D.
  CONSRTM   University of Washington Center for Mendelian Genomics; Genomics
            England Research Consortium
  TITLE     Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes
            Joubert syndrome
  JOURNAL   J Clin Invest 130 (8), 4423-4439 (2020)
   PUBMED   32453716
REFERENCE   3  (bases 1 to 7879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7879)
  AUTHORS   Ohno,T., Meguro,A., Takeuchi,M., Yamane,T., Teshigawara,T.,
            Kitaichi,N., Horie,Y., Namba,K., Ohno,S., Nakao,K., Sakamoto,T.,
            Sakai,T., Nakano,T., Keino,H., Okada,A.A., Takeda,A., Fukuhara,T.,
            Mashimo,H., Ohguro,N., Oono,S., Enaida,H., Okinami,S. and Mizuki,N.
  TITLE     Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada
            Disease in Japanese Patients
  JOURNAL   Ocul Immunol Inflamm 27 (5), 699-705 (2019)
   PUBMED   30395750
  REMARK    GeneRIF: Our study suggests that ARMC9 variants do not play a
            critical role in the development of Vogt-Koyanagi disease.
REFERENCE   5  (bases 1 to 7879)
  AUTHORS   Kar,A., Phadke,S.R., Das Bhowmik,A. and Dalal,A.
  TITLE     Whole exome sequencing reveals a mutation in ARMC9 as a cause of
            mental retardation, ptosis, and polydactyly
  JOURNAL   Am J Med Genet A 176 (1), 34-40 (2018)
   PUBMED   29159890
  REMARK    GeneRIF: Our report of variant in ARMC9 Leading to Joubert syndrome
            phenotype (JS30), elucidates the genetic heterogeneity of Joubert
            syndrome, and expands the gene list for ciliopathies.
REFERENCE   6  (bases 1 to 7879)
  AUTHORS   Van De Weghe,J.C., Rusterholz,T.D.S., Latour,B., Grout,M.E.,
            Aldinger,K.A., Shaheen,R., Dempsey,J.C., Maddirevula,S.,
            Cheng,Y.H., Phelps,I.G., Gesemann,M., Goel,H., Birk,O.S.,
            Alanzi,T., Rawashdeh,R., Khan,A.O., Bamshad,M.J., Nickerson,D.A.,
            Neuhauss,S.C.F., Dobyns,W.B., Alkuraya,F.S., Roepman,R.,
            Bachmann-Gagescu,R. and Doherty,D.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Mutations in ARMC9, which Encodes a Basal Body Protein, Cause
            Joubert Syndrome in Humans and Ciliopathy Phenotypes in Zebrafish
  JOURNAL   Am J Hum Genet 101 (1), 23-36 (2017)
   PUBMED   28625504
  REMARK    GeneRIF: ARMC9 localizes to the basal body of the cilium and is
            upregulated during ciliogenesis.
REFERENCE   7  (bases 1 to 7879)
  AUTHORS   Rubicz,R., Yolken,R., Alaedini,A., Drigalenko,E.,
            Charlesworth,J.C., Carless,M.A., Severance,E.G., Krivogorsky,B.,
            Dyer,T.D., Kent,J.W. Jr., Curran,J.E., Johnson,M.P., Cole,S.A.,
            Almasy,L., Moses,E.K., Blangero,J. and Goring,H.H.
  TITLE     Genome-wide genetic and transcriptomic investigation of variation
            in antibody response to dietary antigens
  JOURNAL   Genet Epidemiol 38 (5), 439-446 (2014)
   PUBMED   24962563
REFERENCE   8  (bases 1 to 7879)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
REFERENCE   9  (bases 1 to 7879)
  AUTHORS   Chubb,D., Weinhold,N., Broderick,P., Chen,B., Johnson,D.C.,
            Forsti,A., Vijayakrishnan,J., Migliorini,G., Dobbins,S.E.,
            Holroyd,A., Hose,D., Walker,B.A., Davies,F.E., Gregory,W.A.,
            Jackson,G.H., Irving,J.A., Pratt,G., Fegan,C., Fenton,J.A.,
            Neben,K., Hoffmann,P., Nothen,M.M., Muhleisen,T.W., Eisele,L.,
            Ross,F.M., Straka,C., Einsele,H., Langer,C., Dorner,E., Allan,J.M.,
            Jauch,A., Morgan,G.J., Hemminki,K., Houlston,R.S. and
            Goldschmidt,H.
  TITLE     Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences
            multiple myeloma risk
  JOURNAL   Nat Genet 45 (10), 1221-1225 (2013)
   PUBMED   23955597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009407.8, AC018738.4 and KF510794.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001352754.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.243255.1,
                                           SRR1803613.31649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611582.5/ ENSP00000484804.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC009407.8         184259-184326
            69-160              AC009407.8         191825-191916
            161-286             AC009407.8         193754-193879
            287-397             AC009407.8         200458-200568
            398-457             AC018738.4         1-60
            458-613             AC018738.4         1697-1852
            614-706             AC018738.4         7787-7879
            707-731             AC018738.4         11833-11857
            732-889             AC018738.4         20283-20440
            890-988             AC018738.4         25002-25100
            989-1023            AC018738.4         41645-41679
            1024-1135           AC018738.4         44050-44161
            1136-1228           AC018738.4         47365-47457
            1229-1319           AC018738.4         56041-56131
            1320-1443           AC018738.4         58014-58137
            1444-1583           AC018738.4         61695-61834
            1584-1660           AC018738.4         63441-63517
            1661-1735           AC018738.4         67118-67192
            1736-1826           AC018738.4         76412-76502
            1827-1882           AC018738.4         81257-81312
            1883-1987           AC018738.4         116851-116955
            1988-2103           AC018738.4         130033-130148
            2104-2240           AC018738.4         140856-140992
            2241-2370           KF510794.1         125-254
            2371-2543           AC018738.4         155010-155182
            2544-7879           AC018738.4         156570-161905
FEATURES             Location/Qualifiers
     source          1..7879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..7879
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /note="armadillo repeat containing 9"
                     /db_xref="GeneID:80210"
                     /db_xref="HGNC:HGNC:20730"
                     /db_xref="MIM:617612"
     exon            1..68
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            69..160
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2566
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /note="isoform 1 is encoded by transcript variant 4; lisH
                     domain-containing protein ARMC9;
                     armadillo/beta-catenin-like repeats; melanoma/melanocyte
                     specific protein KU-MEL-1; melanoma/melanocyte-specific
                     tumor antigen KU-MEL-1; armadillo repeat-containing
                     protein 9"
                     /codon_start=1
                     /product="lisH domain-containing protein ARMC9 isoform 1"
                     /protein_id="NP_001339683.2"
                     /db_xref="CCDS:CCDS74666.1"
                     /db_xref="GeneID:80210"
                     /db_xref="HGNC:HGNC:20730"
                     /db_xref="MIM:617612"
                     /translation="MGDILAHESELLGLVKEYLDFAEFEDTLKTFSKECKIKGKPLCK
                     TVGGSFRDSKSLTIQKDLVAAFDNGDQKVFFDLWEEHISSSIRDGDSFAQKLEFYLHI
                     HFAIYLLKYSVGRPDKEELDEKISYFKTYLETKGAALSQTTEFLPFYALPFVPNPMVH
                     PSFKELFQDSWTPELKLKLIKFLALISKASNTPKLLTIYKENGQSNKEILQQLHQQLV
                     EAERRSVTYLKRYNKIQADYHNLIGVTAELVDSLEATVSGKMITPEYLQSVCVRLFSN
                     QMRQSLAHSVDFTRPGTASTMLRASLAPVKLKDVPLLPSLDYEKLKKDLILGSDRLKA
                     FLLQALRWRLTTSHPGEQRETVLQAYISNDLLDCYSHNQRSVLQLLHSTSDVVRQYMA
                     RLINAFASLAEGRLYLAQNTKVLQMLEGRLKEEDKDIITRENVLGALQKFSLRRPLQT
                     AMIQDGLIFWLVDVLKDPDCLSDYTLEYSVALLMNLCLRSTGKNMCAKVAGLVLKVLS
                     DLLGHENHEIQPYVNGALYSILSVPSIREEARAMGMEDILRCFIKEGNAEMIRQIEFI
                     IKQLNSEELPDGVLESDDDEDEDDEEDHDIMEADLDKDELIQPQLGELSGEKLLTTEY
                     LGIMTNTGKTRRKGLANVQWSGDEPLQRPVTPGGHRNGYPVVEDQHTPPQTAQHARNG
                     HPQALPAAHEAVYREGKPSTPESCVSSSSAIIAKPGEWLPRGRQEEPRPAPTGTPRQP
                     REAPQDPGNGVTTRECASAFTCKPRAPCTPEMLDWNPPKAKASVLAPLFSSCGPQQAS
                     RPGSTASSTRGLPSSQSHRK"
     exon            161..286
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            287..457
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            458..613
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            614..706
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            707..731
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            732..889
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            890..988
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1023
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1135
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1228
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1319
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1443
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1660
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1735
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1826
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1882
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1987
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2103
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2240
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2370
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2543
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..7879
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3707..3712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /note="hexamer: AATAAA"
     polyA_site      3727
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
     polyA_site      7879
                     /gene="ARMC9"
                     /gene_synonym="ARM; JBTS30; KU-MEL-1; NS21"
                     /note="major polyA site"
ORIGIN      
        1 gcccgggtga cggctgcgga ggtggcggcc gggctgggat agcgcgagtg tccgcggccg
       61 agcagcagag atttttgctg tgagaattaa ttaccagtaa cagttcaata tgggggacat
      121 tctggctcat gaatctgaat tacttggact agtgaaagag tatttagatt ttgctgaatt
      181 tgaagacacc ttgaaaacat tttcaaaaga atgcaaaata aaaggaaaac cattgtgtaa
      241 aacagtaggc ggatctttca gagactccaa atcattgaca attcagaagg atcttgtcgc
      301 tgcatttgac aacggagacc agaaggtgtt cttcgatctg tgggaggagc acatttcaag
      361 ttccatccga gatggggact cctttgccca gaagctggaa ttctatctcc acatccattt
      421 tgccatctat cttttgaagt actctgtggg gagaccggac aaagaggagc tggatgaaaa
      481 gatttcctac ttcaaaacct acctggagac caaaggggca gccttgagcc agaccacaga
      541 gtttcttcct ttctatgccc ttccttttgt tcccaaccct atggtgcacc cctcatttaa
      601 agaactcttc caggattcct ggactccaga gttaaagttg aagttgataa agtttctagc
      661 tttaatatct aaagccagca acacgccaaa gcttttaaca atatataagg agaatggaca
      721 aagtaacaaa gaaatcttgc agcagctcca ccagcagctg gttgaagctg aacgtaggtc
      781 agtgacatac ctcaaacggt acaataagat ccaggccgac taccacaatc tcattggagt
      841 cacagcagag ctggtggatt ctctagaggc cacagtcagc ggcaagatga tcacccctga
      901 gtacctccag agcgtctgtg tccgcctgtt cagtaaccag atgcggcaga gcctggcgca
      961 tagtgtggac ttcacgaggc ctgggacggc atccaccatg ttacgagcct ccttggcacc
     1021 cgtgaaattg aaggatgtcc cattactgcc ctccttggat tatgagaaac tgaagaagga
     1081 tttgattttg gggagtgacc gcttgaaagc cttcttgttg caggctctgc gctggcgctt
     1141 gaccacatcc catcctggag agcagaggga gaccgttctg caagcctaca tcagcaatga
     1201 cctcttggac tgttatagcc acaaccagag gagtgtgctt cagttgctgc actccacgag
     1261 cgacgtggtg cggcagtaca tggccaggct catcaatgct tttgcgtcac tggcagaagg
     1321 tcgcctctac cttgcccaga acacaaaggt gctgcagatg ctggagggaa ggctgaagga
     1381 ggaggacaag gatatcatca ccagggagaa tgttcttggg gccctgcaga agttcagtct
     1441 caggcgcccg ctgcagacag cgatgattca agacggcctc atcttctggc tggttgatgt
     1501 tctgaaggac cctgactgcc tgtctgacta cacgctggag tactcggtgg ctttgctcat
     1561 gaacctctgc ctccgcagca cagggaagaa catgtgtgcc aaggtggcag gcctcgtgct
     1621 caaagtcctt tcggatcttc ttggccatga aaaccatgag atacagccgt atgtgaatgg
     1681 agctctgtac agcatccttt ctgttccatc cattcgtgag gaagcaagag caatgggaat
     1741 ggaagacatc ctacgctgct tcatcaaaga aggcaatgct gaaatgatcc gccagataga
     1801 attcatcatc aagcagctaa attccgaaga gctaccagat ggtgttcttg aatctgatga
     1861 tgatgaagat gaagatgatg aagaggacca tgacatcatg gaagccgatc tggacaaaga
     1921 cgaactgatc cagccccagc tcggagaact ctcaggagag aagcttctga ccacggagta
     1981 cctggggatc atgaccaaca cggggaagac aaggcggaag gggctggcta atgtgcagtg
     2041 gagcggggat gagcccctgc aaaggcccgt cacccccggc ggccacagaa acgggtaccc
     2101 agtggtggaa gaccaacaca cacctcccca gacagcccag cacgccagaa acggccaccc
     2161 gcaggccctg ccagccgctc acgaggctgt ctacagggag ggcaagccca gcaccccgga
     2221 gtcctgcgtc tcctcttcat cagccatcat cgccaagcca ggagagtggc tcccaagagg
     2281 acgccaggaa gagcctcgcc cagcccccac ggggaccccc cgccagccaa gggaggcgcc
     2341 ccaggaccca ggcaatggag tgaccaccag ggaatgtgca tcagccttca cctgcaagcc
     2401 ccgggccccc tgcactccag agatgctgga ctggaaccca cccaaggcaa aggcgtcagt
     2461 tctggcccct ctgttctctt cgtgtggccc ccagcaggcc agccgccccg gctccacagc
     2521 gtcctccaca aggggcctgc cgagcagcca gtctcacagg aagtaaggat gtccccgggt
     2581 gtccccatca cgttgccgga ggaccagcca gcttcccgct ctcagctggc agcagctgcc
     2641 ggtgatggat gtgaagggac agttgtccac aagactctgg gagctgaggg gaggccggct
     2701 ctccaggcag caccagagca aggccatcgc agccccgcca gccgggtcac tttctcccag
     2761 ggcagagcca ccaaggaggg ctggggagag cctggcattg ccctcctgga gaggggaatt
     2821 tcctgctcac ccttcacaca cagaggagag gggtggcttt tgcccgcagg agatcttctg
     2881 gccccagaaa cagcaggtgc tggatttgca gccctggccc tccaggcccc aacagggcga
     2941 cagtgtaggg ccagcctgga gcagggcttt tccaaggctg ctgaagccag ccctcctcac
     3001 ttgggctgac taccaggacc cagaaggaac tcagggtgaa gctcatttta ttctcaagcc
     3061 tgcgtctcag cagcaaagtt ggtgttttct tcctgtgtta aaatctgaga aagaaggcca
     3121 ggtgcggtgg ctcacgcctg taattccagg actttggaag gctgaggcgg gcagatcacg
     3181 aggtcaggag atcgagacca tcctggctaa cgtggtgaaa ccccgtctct actaaaaaaa
     3241 tacaaaaaaa ttagccgggc gtggtggcgg gcgcttgtag tcccagctac tctggaggct
     3301 gaggcaggag aatggcgtga acccgggagg cggagcttgc agtgagccga gatcgtgcca
     3361 ctgcactcta gcctgggtga cagagcgaga ctccgtcccc aaaaaaaaaa ttctgagaat
     3421 atggtgtgtt ccagcctctt caaagctctg ctcttctgca cacgtttttt gaaggcctta
     3481 aaaaggccac cagtgtgacc agggagcacc ctctgcctcc ctccctgcac tgggaccata
     3541 aacataaaca gctctaccag caaagtgacc catcccgcgg gggaggcctg cgcacgcccc
     3601 tcaccagggc tgtcatcaga atccagtctt aggacagagg aaggatgttt gccttcagga
     3661 ccagcaagtc acaggtgtcc tggatgttac ccaagctcta aaatcaaata aaacccatca
     3721 gtatttagtg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3781 gtgtgtatga gtgtatgaag ggaaatggaa agcagagaaa agtcgcgtgc cctcccccag
     3841 gcacctgatc tgcccacaga cccttcaatg gggacatctc tggtcccaat ggtcgtaaat
     3901 aaaggctaag cgctggattt ttccatggcc ccctgactcc tcaggagcgc aggcagagga
     3961 ggtaaacagg aggccaggtt acccatgaga tgaccagaag ctcatccagg gccgggaccc
     4021 tggttcatct cgtgaattct tggcagcggc tccaggctgg gcacattaga tgctgtcatg
     4081 tgactggcct ggtggccacc tcttggttct ctggaaatgt gtccactctg tgctcaggga
     4141 agaaggctgc cgtcctgacc tgtcagccac caggccctct ctgaactcct cacttgaccc
     4201 ggaggcattg ggagcaaaca caaagctcgc ccctggtgtc agtggtgcag acagaggaaa
     4261 agcagagggt ccgcaaaatg caactcctcc gtggtgagac tttgaaaagg tgtagagtgg
     4321 ttgcagacaa acagcaaagg agtggaatgg aaaaatctct cttgctcccc acaagaagtc
     4381 cactccccta cggattcctc agatgccact ggctggcaca gcctttcccg cccttggtgt
     4441 gggagcagca gaagtccagc gggggtggga gaatcatcgg ggtcaggtca gtgtctccct
     4501 cgtctgaagt caaccactac ttttccctca agcctaccaa agagctaaag tctgatctgt
     4561 agatgtctga tggtttgagg agaagaaaag atagtctttt agagaagtgg ggagtatcca
     4621 acttagggtc aaaatacact gagattaggc cgggcacagt ggctcacacc tgtaatccca
     4681 gtgctttggg aggccgaggc ggatggatca cttgaggcct ccaggagttc gagaccagcc
     4741 tggccaacat ggcgaaaccc cgtctctact aaaatacaaa aaattagctg gatgtggtgg
     4801 tgggtgcctg taatctcagc tactcaagga ggctgaggca caagaatagc ttgaaccggg
     4861 agatggaaga tgcagtgagc caagatcacg cccctgcact ccagcctggg cgacagagac
     4921 tccgtcaaaa aaaaaaaaaa aatacattga gattaccagg tggggtatgt gtggttcttc
     4981 caggaaagtg ctgaaaatat cacccaggcc tctgcgccac gccctgggag agtacactcc
     5041 tgggctcacg cctctgcatt ccaaggctga cagctagaaa tatactttgt aaaataccaa
     5101 caacttattc acaaatattc caactatcta ccagctccaa tgagcttgct gaggatgggt
     5161 atgaccccag tctaagggga aagaatctaa aacacaagta aacctgttta aaggccagat
     5221 ctccagatgg agatccaagc agatggcgcc taaggtttgc ccttgaaaac taccaaggaa
     5281 gccacagaga gggatctttg gaccttctgg aaaatggtaa ggccccaggt agattatggc
     5341 tcctctgccc tggaggctga gccgcccctc tggttacctc acatcttctg gtttcttctg
     5401 agtgggactt gatctcattt ctgcattcac agcaaggtgg aactgtctgg caagagctta
     5461 aattaggacc tgtggtgggg actttaatag gcaggtggag gtttgagatc cagtgagatg
     5521 ccagagatta gtcaataggt gaggaaagat ttggcccaaa tcaaaagagc taaaaaaaaa
     5581 ataataaaat aaaaataaaa ataaaatagt tgaacaaata aggttcatga aaaaaaaaga
     5641 aaagaaagaa aaggtaaaga aaagaaatcc atgataaaat atcaaacttt ttaataaaaa
     5701 caagtctggc cctgtacttg gatgacccca cctggcttgt ctaaccctaa tcccagcccc
     5761 agttttaata aaactgtatt tacaaaatag gcagctggga cgtggaccag agataccaat
     5821 ttgatttttt ttaaatatta cattaaaata ttacatcatg tgtcttcatt actgagtttt
     5881 ggggtagccc tttaaatttt gtatgcaagg tgaatacctc acccctctct cctggcctag
     5941 aatctggggg atcctcctgt ccctcccaca gtgcctgata gcacagcctg gggctggtgg
     6001 tgtgcctgtt tgcctagctt tatctctcca gatactattt ggggtgtgct gttctaagaa
     6061 gtgattaggt tagcttttgc atattaacaa actacctctg aaacttagtg gcttaaacca
     6121 acaaatgtat tagctttata atgatttgga tcagtgatgg gggctgggca cggacaggcg
     6181 attcttctgc tgggcttggc tgaactcaac tatgtcttat ggtcagaggg cagtcagggg
     6241 cttcgctcat gtctggtagt tggctgttgg ctgagccctt ggttctcctc tggcttaggc
     6301 ttgttcacat ggtggcctcg gggctcccat ggcagttaga gaaatcaagc ccaagtctca
     6361 tatcacgttc actattctcc cattgtccaa agcagaccac atggccaagg cccaagtctg
     6421 tgtgaaagga tgtggataca gggaccccga atgaaccaga ggcaatactg ctgcaagcta
     6481 ccacatagat gctgttcaga gctttgcagg accaaatctt ttagggctgt ttttccattg
     6541 tggtataccc tctccattta gattcaattg aacaaatata ttctttgggg ctgcagtgtg
     6601 tcagatgtgg agacatggtc ccactggctt tcaagttgcc atccatcttc tagggagaat
     6661 ttctggcctt ttcggatggc atggtccagg ccggagcacc agccccaggt tgaaacatca
     6721 ggcaggtttc taggaaatgg ttgcaaaatt agcaaaaagt cagggctaca gagccctatc
     6781 cagagtcgtc atcttaaggt gtctactaaa gcctgggggt ggatgggatc tcagaagggg
     6841 gactagagaa ataggaaact ggggacagaa cccgggggtg agaaagaaga cagcaggtgt
     6901 tgtgggaagt cagggacccc aaacggaggg actggctgaa gccatgacag aagaacgtgg
     6961 attgtgatga tttcatggac atttattagt tcccccaaat taatactttt gtaatttctt
     7021 atgcctgtct ttactacagt ctctaaacat aagttgtgaa tatttcatgg acacttatca
     7081 cttccccagt caataccctt gtgatttcct atgcctgtct ttactttaat ctcttaatcc
     7141 tgtcagctga gggggatgta tgttgcctca ggaccctgta ataattgcat taactgcaca
     7201 aattgtacag catgtgtgtt tgcgcaatat gaaatctgag caccttgaaa aaagaacagg
     7261 gtaacagcaa ttgttcaggg aataagagag ataaccttaa actctgacca ctggtgagtc
     7321 gggcggaaca gagccatatt tctcttcttt caaaagcaaa tgggagaaat atcgctgaat
     7381 tctttttctc agcatggaac atcccctgag aaagagaatg cacacctggg ggtgggtctc
     7441 tgaactggcc cccctccccc gggggcgtgg tcgtctctta tggtcgaggc tgcagagatg
     7501 aaataaactc cagtctccca tagcgctccc aggcttatta ggaggaggaa attcccgcct
     7561 aataaatttt ggtcagaccg gttgctctca aaccctgtct cctgataaga tgttatcaat
     7621 gacaatggtg cccaaaactt cattagcaat tttaattttg ccttggtcct gtggtcctgt
     7681 gatctcgccc tgcctccact tgccttgtga tattctatta ccctgttaag tacttgatgt
     7741 ctgtcaccca cacctattcg cacactccct ccccttttga aaatccctaa taaaaacttg
     7801 ctggtttttg tggcttgtgg ggcatcacgg atcctaccaa cgtgtgatgt ctcccccgga
     7861 cacccagctt tacaatttc
//
