LOCUS       NM_001363941            4757 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing 8 (ARMC8), transcript
            variant 7, mRNA.
ACCESSION   NM_001363941 XM_006713564
VERSION     NM_001363941.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4757)
  AUTHORS   Zhan,T., Chen,M., Liu,W., Han,Z., Zhu,Q., Liu,M., Tan,J., Liu,J.,
            Chen,X., Tian,X. and Huang,X.
  TITLE     MiR-455-3p inhibits gastric cancer progression by repressing
            Wnt/beta-catenin signaling through binding to ARMC8
  JOURNAL   BMC Med Genomics 16 (1), 155 (2023)
   PUBMED   37400847
  REMARK    GeneRIF: MiR-455-3p inhibits gastric cancer progression by
            repressing Wnt/beta-catenin signaling through binding to ARMC8.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4757)
  AUTHORS   Li,X., Zhang,C., Yuan,Y., Wang,Y., Lu,S., Zhou,Z., Zhen,P. and
            Zhou,M.
  TITLE     Downregulation of ARMC8 promotes tumorigenesis through activating
            Wnt/beta-catenin pathway and EMT in cutaneous squamous cell
            carcinomas
  JOURNAL   J Dermatol Sci 102 (3), 184-192 (2021)
   PUBMED   34016486
  REMARK    GeneRIF: Downregulation of ARMC8 promotes tumorigenesis through
            activating Wnt/beta-catenin pathway and EMT in cutaneous squamous
            cell carcinomas.
REFERENCE   3  (bases 1 to 4757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4757)
  AUTHORS   Gul,I.S., Hulpiau,P., Sanders,E., van Roy,F. and van Hengel,J.
  TITLE     Armc8 is an evolutionarily conserved armadillo protein involved in
            cell-cell adhesion complexes through multiple molecular
            interactions
  JOURNAL   Biosci Rep 39 (8) (2019)
   PUBMED   30482882
  REMARK    GeneRIF: Armc8 is an evolutionarily conserved armadillo protein
            involved in cell-cell adhesion complexes through multiple molecular
            interactions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4757)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4757)
  AUTHORS   Jiang,G., Zhang,Y., Zhang,X., Fan,C., Wang,L., Xu,H., Yu,J. and
            Wang,E.
  TITLE     ARMc8 indicates aggressive colon cancers and promotes invasiveness
            and migration of colon cancer cells
  JOURNAL   Tumour Biol 36 (11), 9005-9013 (2015)
   PUBMED   26081621
  REMARK    GeneRIF: invasiveness and migration capacity of HT29 cells
            transfected with ARMc8 were significantly greater than those of
            control cells (p < 0.001), while ARMc8 siRNA treatment
            significantly reduced cell invasion and migration in LoVo cells
REFERENCE   7  (bases 1 to 4757)
  AUTHORS   Jiang,G., Yang,D., Wang,L., Zhang,X., Xu,H., Miao,Y., Wang,E. and
            Zhang,Y.
  TITLE     A novel biomarker ARMc8 promotes the malignant progression of
            ovarian cancer
  JOURNAL   Hum Pathol 46 (10), 1471-1479 (2015)
   PUBMED   26232863
  REMARK    GeneRIF: ARMc8 may enhance the invasion and metastasis of ovarian
            cancer cells
REFERENCE   8  (bases 1 to 4757)
  AUTHORS   Fan,C., Zhao,Y., Mao,X., Miao,Y., Lin,X., Jiang,G., Zhang,X.,
            Han,Q., Luan,L. and Wang,E.
  TITLE     Armc8 expression was elevated during atypia-to-carcinoma
            progression and associated with cancer development of breast
            carcinoma
  JOURNAL   Tumour Biol 35 (11), 11337-11343 (2014)
   PUBMED   25119601
  REMARK    GeneRIF: Armc8 expression was elevated during atypia-to-carcinoma
            progression and associated with cancer development of breast
            carcinoma.
REFERENCE   9  (bases 1 to 4757)
  AUTHORS   Xie,C., Jiang,G., Fan,C., Zhang,X., Zhang,Y., Miao,Y., Lin,X.,
            Wu,J., Wang,L., Liu,Y., Yu,J., Yang,L., Zhang,D., Xu,K. and Wang,E.
  TITLE     ARMC8alpha promotes proliferation and invasion of non-small cell
            lung cancer cells by activating the canonical Wnt signaling pathway
  JOURNAL   Tumour Biol 35 (9), 8903-8911 (2014)
   PUBMED   24894675
  REMARK    GeneRIF: Data suggest that armadillo repeat containing protein 8
            (ARMC8) might serve as a therapeutic target in non-small cell lung
            cancer (NSCLC).
REFERENCE   10 (bases 1 to 4757)
  AUTHORS   Kobayashi,N., Yang,J., Ueda,A., Suzuki,T., Tomaru,K., Takeno,M.,
            Okuda,K. and Ishigatsubo,Y.
  TITLE     RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat
            proteins ARMC8alpha and ARMC8beta are components of the CTLH
            complex
  JOURNAL   Gene 396 (2), 236-247 (2007)
   PUBMED   17467196
  REMARK    GeneRIF: RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and
            p44CTLH form complexes in cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068777.19 and AC022337.24.
            
            On May 17, 2019 this sequence version replaced NM_001363941.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.262609.1,
                                           SRR1803617.137907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000469044.6/ ENSP00000419413.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               AC068777.19        15509-15807
            300-376             AC068777.19        38025-38101
            377-448             AC068777.19        50134-50205
            449-591             AC068777.19        51597-51739
            592-689             AC068777.19        51844-51941
            690-782             AC068777.19        57126-57218
            783-863             AC068777.19        63242-63322
            864-939             AC068777.19        65517-65592
            940-1030            AC068777.19        65690-65780
            1031-1091           AC068777.19        67676-67736
            1092-1292           AC068777.19        69991-70191
            1293-1388           AC068777.19        73296-73391
            1389-1471           AC068777.19        91947-92029
            1472-1553           AC068777.19        92339-92420
            1554-1640           AC022337.24        3216-3302
            1641-1733           AC022337.24        6101-6193
            1734-1883           AC022337.24        9028-9177
            1884-1979           AC022337.24        10510-10605
            1980-2075           AC022337.24        20492-20587
            2076-2148           AC022337.24        25109-25181
            2149-2242           AC022337.24        26607-26700
            2243-4757           AC022337.24        31920-34434
FEATURES             Location/Qualifiers
     source          1..4757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..4757
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /note="armadillo repeat containing 8"
                     /db_xref="GeneID:25852"
                     /db_xref="HGNC:HGNC:24999"
                     /db_xref="MIM:618521"
     exon            1..299
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..2276
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /note="isoform 6 is encoded by transcript variant 7;
                     armadillo repeat-containing protein 8; GID complex subunit
                     5, VID28 homolog"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 8 isoform 6"
                     /protein_id="NP_001350870.1"
                     /db_xref="CCDS:CCDS87139.1"
                     /db_xref="GeneID:25852"
                     /db_xref="HGNC:HGNC:24999"
                     /db_xref="MIM:618521"
                     /translation="MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMK
                     NAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLL
                     DCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRS
                     RYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFE
                     NPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCI
                     VLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKY
                     PSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTG
                     LSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSML
                     CNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADIL
                     RSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEG
                     EHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISN
                     LIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYLA"
     exon            300..376
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            377..448
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            449..591
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            592..689
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            690..782
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            783..863
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..939
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1030
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1091
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1292
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1388
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1471
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1553
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1640
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1733
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1883
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1979
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2075
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2148
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2242
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..4757
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2880..2885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /note="hexamer: AATATA"
     polyA_site      2903
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /note="hexamer: AATAAA"
     polyA_site      4757
                     /gene="ARMC8"
                     /gene_synonym="GID5; HSPC056; S863-2; VID28"
                     /note="major polyA site"
ORIGIN      
        1 gcttccacct ctaacccagg ctcagagtag ctgctgtttc tgagagaacg attcgtagga
       61 cagcccctga cgccattccc ttttgccctt ctttctgcgg gcctttccgg tacttgagcg
      121 gtgtccagag cgtggccagt tctcgtctat ctggctgcct ttagggagcg gtgcctagcg
      181 ttggccaata gttggctgtc gaaagtgccg gcccccgcgc cggcgcctgc agcagccggg
      241 tgggaaggct caagatggcg tgcttgttgg agaccccaat ccgcatgagc gtcctttcgg
      301 aagtaacagc tagcagtcgc cactatgttg acaggctatt tgaccctgat ccccagaaag
      361 ttctacaagg tgtcatagac atgaaaaatg ctgtaattgg aaacaacaag cagaaagcca
      421 atctcattgt tttaggagct gttccaagat tgttgtactt gcttcagcaa gaaacctcaa
      481 gcacagagct gaaaactgaa tgtgcagtgg tgttgggaag tcttgctatg ggtactgaaa
      541 acaatgtcaa gtctctactg gactgccata ttatccctgc cttattgcaa ggactactgt
      601 ccccagacct gaagtttatt gaagcttgcc tccgatgcct gcgtaccatc ttcaccagtc
      661 ctgtcactcc agaggagcta ctgtatacag atgccacagt gataccacac ctcatggcac
      721 tgcttagcag gtcccgctat acccaggagt acatctgtca gatcttctca cactgctgta
      781 aagggccaga tcatcaaaca attttattta accacggtgc agttcagaat attgctcacc
      841 tactaacctc actgtcctac aaagttcgaa tgcaagcact gaaatgtttc tcagttttag
      901 cttttgaaaa cccccaggta tcgatgaccc tggtaaatgt tttggttgat ggagaattgt
      961 taccacagat ttttgtgaag atgttacaga gggataagcc tattgagatg cagctcacat
     1021 cagcaaaatg tttaacttac atgtgtagag ctggagcaat tcggacagat gataactgta
     1081 ttgtattaaa gacattacct tgtttggttc gaatgtgcag taaggagaga ttactagagg
     1141 agagagttga aggagctgag acacttgcct atctgattga accagatgtt gagctacaga
     1201 gaatcgctag cataactgat cacctcattg ccatgcttgc tgattatttc aagtatccca
     1261 gctcagtgag tgccatcact gatattaaaa ggcttgatca tgatttaaaa catgctcacg
     1321 aactccgcca ggctgcattc aagctctatg cctctcttgg agcaaatgat gaagacatcc
     1381 ggaagaagat cattgagact gaaaatatga tggaccgaat tgtgactggc ttgtctgagt
     1441 ctagtgtcaa ggtgcggtta gctgccgtca gatgtttgca cagtttatcc agatctgtgc
     1501 agcagcttcg aaccagtttc caggatcatg ctgtttggaa acctttaatg aaggttttac
     1561 aaaatgcacc agatgaaatc ctagtggtag catcttccat gctgtgtaat cttcttcttg
     1621 aattttctcc aagcaaagag ccaattttgg aatcaggagc cgtagagcta ctttgtggat
     1681 taactcagag tgaaaatcct gctttacgag tgaatggaat ttgggcttta atgaatatgg
     1741 catttcaggc tgaacaaaaa ataaaagcag atattttacg aagcttgagt actgaacagc
     1801 tattccggtt attatcagat tcagatttga atgtgctgat gaagacattg ggacttctta
     1861 gaaatctcct ctccactcgt cctcatatag ataaaataat gagtactcat ggaaagcaaa
     1921 ttatgcaagc cgtcactctt attctagaag gggaacataa cattgaggtc aaagagcaga
     1981 cactgtgcat cttagccaac atagcggatg ggacaacagc aaaagatctt attatgacca
     2041 atgatgatat cctacagaaa atcaagtatt acatgggcca ttcacatgtt aaactgcagc
     2101 ttgcagccat gttttgtata tcaaacctca tatggaatga agaggaaggt tcacaagaac
     2161 gccaggataa attacgagac atgggcatcg tagatattct acacaaactg agtcagtcac
     2221 cagattcaaa cctttgtgac aaggcaaaga tggcactgca gcagtacctg gcatgatggg
     2281 agtgcccctg ggcacctgcg agcatcccac ctccttgttt aaggaagtac aggaaccagc
     2341 ctcatttgat tccttctatt tgcacaagtc accttggact gcagggagct gttttgcaaa
     2401 agcagtttag taggcttaga tctcaaattc atcttgagaa catttttttg aggtagtaat
     2461 ttcctcagaa gactcttgtg ttttgttttg gttttttttt ctgagctact cggactcttt
     2521 attagaacaa tcaatcattt tcctttggac ctacaatttt tgcctatgct gcagccactt
     2581 tgtgagtgag aatgaatatg tctgtgtgaa cacacaggca tgcgtgtgta tgtgcacgta
     2641 catgggccag aatgaatgga tgtgtgtgtg tgagggatac ctcagatttt tcttttctta
     2701 ttttgtgtga aaatctcttt tctacagatt ttccagggtt taagcattgc ttgctgtata
     2761 aaaaacttta ctgaattata tacagtttga atgaaatgtt attttaaaaa caaaacaatt
     2821 gttaagtgtt ccataaaggt tatgttgaat tttggtcaga tgaatatttg taagtaaaaa
     2881 atatatgcat ttctgaacct caacttacat agattttctt tatataaaaa aaaagaaaaa
     2941 aaaagaaaaa gttggctata gttggcctga ttaacaggca ctatacatgg tgctgtgcaa
     3001 aatagtaagc tagcatctta ctgccgtcaa tattagcagg tacagagcct tttttcatcc
     3061 taattcagta agttctcagg cttccaagtc aaatggagaa gtaaagtgag gcaacagatt
     3121 caccataggc tttttgaagc atcaaaggga aatataacta ctgatagtga aagcccagcc
     3181 atgacccaga tgggcttacc cttgacagga actggggacc aagagcctcc caattgccct
     3241 aactcctgtc attggtatta gcaatatctg gccagattta gaaccagtca tggaaacttg
     3301 tgctcaaact aaaagtaggt catcacttcc cagaaacaga ataccttgtg cttcctgaaa
     3361 cagcatatat cactgtgaaa ctaaagaata ttctacagac acccctgtag aaagaaacaa
     3421 agaacaggat agtttagaaa gctttctgtt agctgtattc agcaaatttc atactagttg
     3481 ctcaggactg ctagttggta tgcttttgta aaacgagatt gaaatttaat aaaagatgca
     3541 actaaaatct ttcctgcatg aagctaaaag cactcaagtt gagagagggg caagggaatc
     3601 tccccaggat gactgaagat gacttctttt tacagcaagt actgttagcc tttctgcacc
     3661 ccttagcttg gcccctgctc caacttctgg gtcagcagca aggtgaactc aacagaagtt
     3721 gctcttgact gtttgaaggt agaagcagcc taccttttct ctttgctaaa agaaggtcaa
     3781 aggcttcgca accaggatgc aaggtctgcg gtccagaagc ttgcggtgag tgtgtgccac
     3841 tgatggagct ccaagcccac ccaccagcca ctcctgatgg ggttgctcac actgcagctg
     3901 ccctatcacc accctgcacg ttccttggaa gatttaaatg tttggttgca aatgaatgtt
     3961 ttaaaaatgt atttaatgca atttttcctg ctctcaacat gaccacccaa gattcaaaca
     4021 cagagacttc caagttacta ttttttcaga acatcaccga ttttaaaatc tgtcacaaca
     4081 ggacttggtt ttgtgcagat atcagagtgc taatgtgaga aacccagtta aaagaaaact
     4141 tagtttattg ggaagaaagc ctcaggccca ctcgtttcta gaactgtgaa aatatccttg
     4201 gttggcattt ttaacacaaa acactatagt gttggtatta aatagtacta ggtaaatata
     4261 aagaaaccaa taatgaattg ctgagacaat cttgaaccca aatagcatta gaaagctgaa
     4321 ggcccaatga aataacactt tcacacttaa actctgtgga taaattttgc ctgtgggtat
     4381 aaacagatgg tcaaattaaa aatgctttac tataattaac ttttctgatt tgaatgaagg
     4441 gaaatgtatt tattgaaaca aagctgtttg ctgctttatg caggtgcagt gttcagtcag
     4501 caaggaagtg ggaagagtgg acatggtatt gtgtctacac ccaagttctt aactaagctt
     4561 ctcgctctaa tactgcattc tgtttctcct tttgtgccct gattgtaatc caaaatttat
     4621 gaactagaaa agaatgtcca atttaataag ttgcattttt ttttctttaa gcactttatt
     4681 cagaacaata catgttcttc tggtagtgtt tggataatat gattttaaca catgctaata
     4741 aaagccaaga aaaatca
//
