LOCUS       NM_024585               2151 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing 7 (ARMC7), transcript
            variant 1, mRNA.
ACCESSION   NM_024585
VERSION     NM_024585.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Bai,R., Wan,R., Wang,L., Xu,K., Zhang,Q., Lei,J. and Shi,Y.
  TITLE     Structure of the activated human minor spliceosome
  JOURNAL   Science 371 (6535) (2021)
   PUBMED   33509932
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK300997.1, BC011728.1 and AC022211.5.
            
            On Nov 22, 2018 this sequence version replaced NM_024585.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.965129.1, BC011728.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245543.6/ ENSP00000245543.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK300997.1         18-35
            19-956              BC011728.1         1-938
            957-957             AC022211.5         18739-18739
            958-2144            BC011728.1         940-2126
            2145-2151           AC022211.5         19927-19933
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2151
                     /gene="ARMC7"
                     /note="armadillo repeat containing 7"
                     /db_xref="GeneID:79637"
                     /db_xref="HGNC:HGNC:26168"
     exon            1..411
                     /gene="ARMC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..917
                     /gene="ARMC7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     armadillo repeat-containing protein 7"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 7 isoform 1"
                     /protein_id="NP_078861.1"
                     /db_xref="CCDS:CCDS11714.1"
                     /db_xref="GeneID:79637"
                     /db_xref="HGNC:HGNC:26168"
                     /translation="MAQKPKVDPHVGRLGYLQALVTEFQETQSQDAKEQVLANLANFA
                     YDPSNYEYLRQLQVLDLFLDSLSEENETLVEFAIGGLCNLCPDRANKEHILHAGGVPL
                     IINCLSSPNEETVLSAITTLMHLSPPGRSFLPELTATPVVQCMLRFSLSASARLRNLA
                     QIFLEDFCSPRQVAEARSRQAHSALGIPLPRSVAPRQR"
     exon            412..555
                     /gene="ARMC7"
                     /inference="alignment:Splign:2.1.0"
     exon            556..2151
                     /gene="ARMC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2087..2092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC7"
                     /note="hexamer: AATAAA"
     polyA_site      2112
                     /gene="ARMC7"
                     /note="major polyA site"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC7"
                     /note="hexamer: ATTAAA"
     polyA_site      2151
                     /gene="ARMC7"
ORIGIN      
        1 ggaaccgagc ccaggagccg gggacggtgc gccagtgccc cctccgcgag ccccaaccag
       61 tagacggttc cctgtctccc gcgccccaat ttcgattttc aaacgcaact cctacaggat
      121 tctgagaccc cgtcccatct cccatatccc atttccagct gcaaattact gcagaatctg
      181 aacccaggaa agaaacccat ttgccgaccc cctcttccct ctccagacag gtggagagcg
      241 ggtgagggtc tcgctcggct ttccccctgc acctttccca ccctcccgcc cgtccctggg
      301 ggtcctccgt caccgcggcc atggcccaga agccgaaggt ggacccccac gtcgggcggc
      361 tgggatacct gcaggcgctg gtcacggaat tccaggagac ccaaagccaa gacgccaagg
      421 agcaagtcct cgccaacctc gccaacttcg cttatgaccc cagcaactac gagtatctgc
      481 ggcagctgca ggtcctggat ttatttctcg attcgctgtc ggaggagaat gagaccctgg
      541 tggagtttgc tattggaggc ctgtgcaacc tgtgcccaga cagggccaac aaggagcaca
      601 tcctgcacgc aggaggtgtc ccactcatca tcaactgcct atccagcccc aatgaggaga
      661 cggtgctgtc tgccatcacc acgctcatgc acctgagccc gccgggccgc agctttctcc
      721 cagagctgac cgccacgccc gtggtgcagt gcatgcttcg cttctccctc tcggccagcg
      781 ccaggctccg gaacctggca cagatcttcc tggaggactt ctgctccccc cgccaggtgg
      841 ccgaggcccg cagccggcag gcgcactctg ccctgggtat cccactgccg aggagcgtgg
      901 ccccacggca gcgctgatcc atggagactg cgagaccgtg gcacccctac tgctggagac
      961 cacagtcctg atgtggacgc agggaacggg gagcacatac tgccccattg gtgccttttc
     1021 agccatctga aaggcgggtt ctttcagcag gacaggcatt tacactgatg aaacgccact
     1081 gggagtgagg aagccagact ccagagacac ggagaagatc aaactggagc tgcgttcata
     1141 ggctggcact ctcaatccta catcaggtgc caccaccacc agactcaggc cctggtgtaa
     1201 gaagcggcca agtgcctgga cccagaggct ttgcaggaca gtgttctcag gagctgggcc
     1261 tgaggcttag gagagctgcc ttcgctgcag gaaatcaggg attatccctt aacagaagtg
     1321 tctggagtag ttttcaggta taggaatgag atgcctcgtg gtgaaaggat ctcaccctgg
     1381 gaagatgtgg tgccccctcc agggctctgg aggatggatg cctcccccag gggctctcca
     1441 agctgggcat ttgggcctgg tggatgccaa cctggataac ctgtggccca gcattgactg
     1501 tccacccagc cttgctgtta ggcaccatga ctccaagatg aagatgtggt ccctgccctt
     1561 gagtgacagc ccagggactt aatgtggcca tcgggcatca agcacaaggc catgcaggtg
     1621 atgatacgtc ggaatagagg caccagccct ggtaactgca tcttctcccc ttgccacccc
     1681 atggccccgg ctgaaagctt cggccctcct ctgctgtcac tcaatgatgg ggagccctac
     1741 cccagaagtg tatcccacga gggcatcagg gacgcagtga gtgttgctca agggagtcag
     1801 gaagagacgg caacgtaaag gatgtggctc catgtccatg gtgccccctg gtcaacataa
     1861 ggagcgtggg atccgatgga aaggtggagc tcagggaaaa tgggggtcct tgcctctcgt
     1921 gtaccccctc aaggctgacc ccttagatgg cccaggaatg gcaggtgcta caaaaatggt
     1981 acccacgtgg gcatggaaat ggggcagatt aggggaccac tggactcaga ggggagggaa
     2041 gggctcatca gcacccgctc agggagcctg tccctttatg ttcccaaata aagggtccta
     2101 gaagactaga aagccaaggt cttttattaa aggtcccgac tggttttccc a
//
