LOCUS       NM_001199196            2461 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens armadillo repeat containing 6 (ARMC6), transcript
            variant 1, mRNA.
ACCESSION   NM_001199196
VERSION     NM_001199196.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2461)
  AUTHORS   Adamik,M., Soldanova,Z., Drotarova,M., Breckova,K., Petr,M.,
            Helma,R., Jenner,L.P., Vorlickova,M., Sykorova,E. and Brazdova,M.
  TITLE     Human ARMC6 binds in vitro to both cancer genes and telomeric RNA,
            favoring G-quadruplex structure recognition
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1867 (3), 195050 (2024)
   PUBMED   39029558
  REMARK    GeneRIF: Human ARMC6 binds in vitro to both cancer genes and
            telomeric RNA, favoring G-quadruplex structure recognition.
REFERENCE   2  (bases 1 to 2461)
  AUTHORS   Dokladal,L., Benkova,E., Honys,D., Duplakova,N., Lee,L.Y.,
            Gelvin,S.B. and Sykorova,E.
  TITLE     An armadillo-domain protein participates in a telomerase
            interaction network
  JOURNAL   Plant Mol Biol 97 (4-5), 407-420 (2018)
   PUBMED   29948659
REFERENCE   3  (bases 1 to 2461)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   4  (bases 1 to 2461)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX869901.1, BC067125.1 and
            BQ012036.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001199196.1.
            
            Summary: The function of this gene's protein product has not been
            determined. A related protein in mouse suggests that this protein
            has a conserved function. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.100075.1,
                                           SRR1803613.286489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535612.6/ ENSP00000444156.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               CX869901.1         26-231
            207-2456            BC067125.1         1-2250
            2457-2461           BQ012036.1         20-24               c
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2461
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /note="armadillo repeat containing 6"
                     /db_xref="GeneID:93436"
                     /db_xref="HGNC:HGNC:25049"
     exon            1..328
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..436
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..1913
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     armadillo repeat-containing protein 6"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 6 isoform 1"
                     /protein_id="NP_001186125.1"
                     /db_xref="CCDS:CCDS56089.1"
                     /db_xref="GeneID:93436"
                     /db_xref="HGNC:HGNC:25049"
                     /translation="MSERCCSRYSSGASIGCTPTSTQAKMVSKRIAQETFDAAVRENI
                     EEFAMGPEEAVKEAVEQFESQGVDLSNIVKTAPKVSADGSQEPTHDILQMLSDLQESV
                     ASSRPQEVSAYLTRFCDQCKQDKACRFLAAQKGAYPIIFTAWKLATAGDQGLLLQSLN
                     ALSVLTDGQPDLLDAQGLQLLVATLTQNADEADLTCSGIRCVRHACLKHEQNRQDLVK
                     AGVLPLLTGAITHHGHHTDVVREACWALRVMTFDDDIRVPFGHAHNHAKMIVQENKGL
                     KVLIEATKAFLDNPGILSELCGTLSRLAIRNEFCQEVVDLGGLSILVSLLADCNDHQM
                     RDQSGVQELVKQVLSTLRAIAGNDDVKDAIVRAGGTESIVAAMTQHLTSPQVCEQSCA
                     ALCFLALRKPDNSRIIVEGGGAVAALQAMKAHPQKAGVQKQACMLIRNLVAHGQAFSK
                     PILDLGAEALIMQARSAHRDCEDVAKAALRDLGCHVELRELWTGQRGNLAP"
     exon            437..603
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..686
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1260
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1430
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1562
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1700
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..2461
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2436..2441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /note="hexamer: AATAAA"
     polyA_site      2461
                     /gene="ARMC6"
                     /gene_synonym="R30923_1"
                     /note="major polyA site"
ORIGIN      
        1 gcggcccggc tctcttgcgc aagcgcgctg tccgcttctt ctgggcggac gctctggagg
       61 caaaacattt ccctgctggg ggcggcgacc accgtgagcg tcccggaagg ggcggcaaag
      121 acgcctccgt cgcgcacgag gtggcctcgt tggctttacc ttggttcgcg gtcgtccttg
      181 gttatcgtga gcgtccgcga gtctctggga ggccaagcct aggggcgcca cagcgcctgc
      241 gcgcgtacgg cggccggaag gggctagagg cggctccctg ggtgacaacc gcgcgcccca
      301 cctttcccca cgtggccgcg aagaccggca cctgtgcact gagtgcctgc tgcgtgtcgg
      361 gccccgtcct aggcagtggg gacaaggagg ctacagggta caaataaatg agtgaacgat
      421 gttgctctag atacagctca ggagcatcta tcggctgcac gccaacatca acacaggcga
      481 agatggtctc caagcgcatt gcccaggaga cctttgatgc agctgtgcgc gagaacatcg
      541 aggagtttgc gatggggcca gaggaggcag tgaaagaggc cgtggagcag tttgaatcgc
      601 aaggggttga tctgagcaac attgtaaaga cggcacctaa agtctctgca gacggatccc
      661 aggagcccac acatgacatc ctgcagatgc tcagtgacct ccaggagtct gtggccagct
      721 ctcgccccca ggaggtgtca gcatacctca cccgcttctg cgaccagtgc aaacaggaca
      781 aggcctgccg cttcctcgcg gcccagaagg gggcctaccc catcatcttc actgcctgga
      841 agctggccac tgcaggtgac cagggccttc tgctccagtc cctcaatgcc ctgtcggtgc
      901 tgactgatgg acagccagac ctcctggatg cccagggcct gcagctccta gtggccacgc
      961 tgacccagaa tgctgatgag gctgacctga cctgctctgg gatccgctgt gtgcgtcacg
     1021 cttgcctgaa acatgaacag aatcggcaag acctggtgaa agctggcgtg ctgcctctgc
     1081 tgactggtgc catcacccat catggccacc acactgacgt ggtcagggaa gcctgctggg
     1141 ccctgcgtgt catgaccttc gatgacgaca tccgtgtgcc ctttggccat gcccacaacc
     1201 atgccaagat gattgtgcag gagaacaaag gcttgaaggt gctcatcgaa gccaccaaag
     1261 cgttcctgga taaccctggc atcctgagcg agctctgtgg aaccctgtcc cgcctggcca
     1321 ttcgcaacga gttctgccag gaggtcgtcg acctcggggg cctgagcatt ctggtgtccc
     1381 tgctagccga ctgcaatgac caccagatga gggaccagag cggcgttcag gagctcgtga
     1441 agcaagtgct gagcaccctg cgagccatcg caggcaacga cgacgtgaaa gatgctattg
     1501 tccgtgctgg tgggacggag tccatcgtgg ctgctatgac ccagcatctg accagccccc
     1561 aggtgtgtga gcagagctgc gcggccctgt gcttcctggc cctgcgtaag cccgacaaca
     1621 gccgcatcat cgtggagggt ggcggggctg tggcagcact gcaggccatg aaggcacacc
     1681 cgcagaaggc cggcgtgcag aaacaggctt gcatgctgat ccgaaacctg gtggcccacg
     1741 gccaggcctt ctcgaagccc atcctggacc tgggggctga ggcactcatc atgcaggccc
     1801 gatctgccca ccgtgactgt gaggacgtgg ccaaggccgc cctgcgggac ctgggttgtc
     1861 atgtcgagct ccgagagctg tggacaggcc agaggggcaa cctggcgcca tgaccccagg
     1921 cccagtctgg gccgtgactc tgggtgagtc gtgtgactca ggaatggggg tagatccatg
     1981 tcctccactg tcccccatta gttctgtccc cttcacaatg agaagtgttt tctggcaggc
     2041 cctaggtaaa gggtcggggg aggggggagc cttgtaggga ggcctctaca cagaagaaag
     2101 cagcccccat gtcccagcca cttctgggtc ccagccagca gcacggatgt tactgtcctg
     2161 ctccttcccc cagccccacg ccctaccaga gggggcaaag ggcacgtccc atcactcact
     2221 gccctgtctg aaatgtggca gccactgtgg gccaggctca gggcagggca ggcgattcca
     2281 gtggggttgg gccccctggc gcctgctgct tactgcagtt tcatgcaggc ctctgctcct
     2341 tgtctttctt acctgtaaaa tgggtctcag atgctccgcc ctgcttggcc ccagcttgtc
     2401 tgtctctggg tcctgggcca gccaggatac ctgataataa aagatcattg ggtgaacagc
     2461 g
//
