LOCUS       NM_173081               3718 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing 3 (ARMC3), transcript
            variant 1, mRNA.
ACCESSION   NM_173081
VERSION     NM_173081.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3718)
  AUTHORS   Rahim,F., Tao,L., Khan,K., Ali,I., Zeb,A., Khan,I., Dil,S.,
            Abbas,T., Hussain,A., Zubair,M., Zhang,H., Hui,M., Khan,M.A.,
            Shah,W. and Shi,Q.
  TITLE     A homozygous ARMC3 splicing variant causes asthenozoospermia and
            flagellar disorganization in a consanguineous family
  JOURNAL   Clin Genet 106 (4), 437-447 (2024)
   PUBMED   39221575
  REMARK    GeneRIF: A homozygous ARMC3 splicing variant causes
            asthenozoospermia and flagellar disorganization in a consanguineous
            family.
REFERENCE   2  (bases 1 to 3718)
  AUTHORS   Rehman,A.U., Hamid,M., Khan,S.A., Eisa,M., Ullah,W., Rehman,Z.U.,
            Khan,M.A., Basit,S., Muhammad,N., Khan,S. and Wasif,N.
  TITLE     The Expansion of the Spectrum in Stuttering Disorders to a Novel
            ARMC Gene Family (ARMC3)
  JOURNAL   Genes (Basel) 13 (12), 2299 (2022)
   PUBMED   36553564
  REMARK    GeneRIF: The Expansion of the Spectrum in Stuttering Disorders to a
            Novel ARMC Gene Family (ARMC3).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3718)
  AUTHORS   Lei,Y., Zhang,X., Xu,Q., Liu,S., Li,C., Jiang,H., Lin,H., Kong,E.,
            Liu,J., Qi,S., Li,H., Xu,W. and Lu,K.
  TITLE     A conserved Vac8/ARMC3-PtdIns3K-CI cascade regulates autophagy
            initiation and functions in spermiogenesis by promoting ribophagy
  JOURNAL   Autophagy 17 (12), 4512-4514 (2021)
   PUBMED   34705610
REFERENCE   4  (bases 1 to 3718)
  AUTHORS   Patir,A., Fraser,A.M., Barnett,M.W., McTeir,L., Rainger,J.,
            Davey,M.G. and Freeman,T.C.
  TITLE     The transcriptional signature associated with human motile cilia
  JOURNAL   Sci Rep 10 (1), 10814 (2020)
   PUBMED   32616903
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3718)
  AUTHORS   Pausch,H., Venhoranta,H., Wurmser,C., Hakala,K., Iso-Touru,T.,
            Sironen,A., Vingborg,R.K., Lohi,H., Soderquist,L., Fries,R. and
            Andersson,M.
  TITLE     A frameshift mutation in ARMC3 is associated with a tail stump
            sperm defect in Swedish Red (Bos taurus) cattle
  JOURNAL   BMC Genet 17, 49 (2016)
   PUBMED   26923438
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3718)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   7  (bases 1 to 3718)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 3718)
  AUTHORS   Li,X., Liu,B., Ji,C.N., Kang,Y. and Mao,Y.
  TITLE     Cloning and expression of ARMC3_v2, a novel splicing variant of the
            human ARMC3 gene
  JOURNAL   Genetika 42 (7), 999-1003 (2006)
   PUBMED   16915934
  REMARK    GeneRIF: ARMC3_v2 was detected in human skeletal muscle, liver,
            spleen and thymus; in contrast, ARMC3_v1 in skeletal muscle, lung,
            prostate and testis
REFERENCE   9  (bases 1 to 3718)
  AUTHORS   Okada,T., Akada,M., Fujita,T., Iwata,T., Goto,Y., Kido,K.,
            Okada,T., Matsuzaki,Y., Kobayashi,K., Matsuno,S., Sunamura,M. and
            Kawakami,Y.
  TITLE     A novel cancer testis antigen that is frequently expressed in
            pancreatic, lung, and endometrial cancers
  JOURNAL   Clin Cancer Res 12 (1), 191-197 (2006)
   PUBMED   16397042
  REMARK    GeneRIF: KU-CT-1 is a new cancer testis antigen that is expressed
            in pancreatic, lung, and endometrial cancers
REFERENCE   10 (bases 1 to 3718)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC039312.1, AK302985.1, AL139815.12 and CB240778.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173081.4.
            
            Summary: Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM)
            domains are imperfect 45-amino acid repeats involved in
            protein-protein interactions. ARM domain-containing proteins, such
            as ARMC3, function in signal transduction, development, cell
            adhesion and mobility, and tumor initiation and metastasis (Li et
            al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298032.10/ ENSP00000298032.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1931              BC039312.1         23-1953
            1932-1932           AK302985.1         1948-1948
            1933-2780           BC039312.1         1955-2802
            2781-2940           AL139815.12        48748-48907
            2941-3718           CB240778.1         19-796              c
FEATURES             Location/Qualifiers
     source          1..3718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..3718
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /note="armadillo repeat containing 3"
                     /db_xref="GeneID:219681"
                     /db_xref="HGNC:HGNC:30964"
                     /db_xref="MIM:611226"
     exon            1..54
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            55..103
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2674
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 81; armadillo repeat-containing
                     protein 3; beta-catenin-like protein"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 3 isoform 1"
                     /protein_id="NP_775104.2"
                     /db_xref="CCDS:CCDS7142.1"
                     /db_xref="GeneID:219681"
                     /db_xref="HGNC:HGNC:30964"
                     /db_xref="MIM:611226"
                     /translation="MGKKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAK
                     ACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKK
                     LLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLS
                     SPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVI
                     ANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGL
                     KKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKI
                     AASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANAN
                     AAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRS
                     ANTVVQSKAALAVTATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCA
                     GDELTANELCRLGALDILEEVNVSGTRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSN
                     IINDGFYDYGRINPGTKLLPLKELCLQEPSDLRAVLLINSKSYVSPPSSMEDKSDVGY
                     GRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDKSEPASGRNTVLSKSATKEKGWR
                     KSKGKKEEEKVKEEEEVMVVPKFVGEGSSDKEWCPPSDPDFSMYVYEVTKSILPITNI
                     KEQIEDLAKYVAEKMGGKIPKEKLPDFSWELHISELKFQLKSNVIPIGHVKKGIFYHR
                     ALLFKALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGGLPAPEMYVIDLMFHPG
                     GLMKLRSREADLYRFI"
     exon            104..221
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            222..347
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            348..416
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            417..592
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            593..787
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            788..971
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1124
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1230
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1480
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1617
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1786
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1884
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1983
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2100
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2301
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2464
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..3718
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2763..2768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /note="hexamer: AATAAA"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /note="hexamer: AATAAA"
     polyA_site      2782
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /note="major polyA site"
     polyA_site      2796
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
     regulatory      3699..3704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
                     /note="hexamer: AATAAA"
     polyA_site      3718
                     /gene="ARMC3"
                     /gene_synonym="CT81; KU-CT-1; VAC8"
ORIGIN      
        1 gttcgtctgc tgggtttgcg gagcagctag ctactcggcg ggatctcccg gcaggatggg
       61 taaaaagata aagaaggaag tagagcctcc tcctaaggat gtgtttgacc cattaatgat
      121 tgaaagcaaa aaagcagcaa ctgtggtgtt aatgcttaat tctccagaag aggaaatttt
      181 ggctaaagca tgtgaagcca tttataaatt tgctttaaaa ggtgaggaaa ataaaacaac
      241 cctccttgaa cttggagctg tggaaccttt aactaagcta ctcacccatg aagacaaaat
      301 tgtaagaaga aatgctacta tgatatttgg aatcctggct tctaataatg atgttaaaaa
      361 attgttaagg gagttagatg tcatgaattc tgtcattgcc cagctcgctc cagaagaaga
      421 agtagttatc catgagtttg ctagtctttg tctagcaaac atgtctgcag agtacaccag
      481 taaagtgcaa atatttgaac atgggggatt agagccactc atcagactac tgagtagccc
      541 tgacccggat gtaaagaaga actctatgga atgcatttac aacttggtgc aggattttca
      601 gtgtcgagct aaacttcaag aactaaatgc aatacctcct atcttagatc tcttgaagtc
      661 agaatatcca gtgattcagt tgttggctct caaaacctta ggtgttattg caaatgataa
      721 ggagtctcga acaatgctaa gagacaatca aggattggac catcttatta agatcctaga
      781 aactaaggaa ttgaatgacc ttcatataga agcacttgca gtgatagcca attgccttga
      841 agacatggat actatggtgc agattcagca gacagggggt cttaaaaagc tcctgtcatt
      901 tgcagaaaac tctacaattc ctgatattca gaagaatgca gcaaaagcca ttactaaagc
      961 agcttatgat cctgaaaata gaaaactttt tcatgaacaa gaggttgaaa agtgccttgt
     1021 agcccttttg ggttctgaaa atgatggaac taaaattgct gcttcccaag ctatttcagc
     1081 aatgtgtgag aattcaggca gcaaagattt tttcaataat caggggattc cacagttaat
     1141 tcagttgcta aaaagtgaca atgaagaggt acgggaagca gcagctctag ccctggcaaa
     1201 cctaaccact tgcaaccctg ctaatgcaaa cgctgctgct gaagctgatg gtattgatcc
     1261 attaataaac ctcctgtcta gtaaacgaga tggagccatt gccaacgctg ctacagtatt
     1321 aacaaacatg gccatgcagg agcccctgcg cctgaacata cagaatcacg acatcatgca
     1381 tgccatcatc agcccactgc gttctgcaaa cacagtcgtg cagagcaaag ctgctctcgc
     1441 tgtcaccgca actgcgtgtg acgttgaagc ccggactgag ttaagaaatt ctggtggatt
     1501 ggagcccctg gtagagctgc tacgctccaa gaatgatgaa gtgaggaagc acgccagttg
     1561 ggcagtgatg gtctgtgctg gtgacgagct gacggccaat gaattatgca ggctcggggc
     1621 tttagatatc cttgaagaag ttaacgtatc aggaactcgg aaaaataaat tcagtgaggc
     1681 agcttataat aagttgctca ataacaatct ttccctgaaa tacagccaga ctggctattt
     1741 gtcatcaagt aacataatta acgatggatt ctatgattat ggtcggataa atcccggcac
     1801 caaactgttg cctttgaagg agctctgctt acaagaacca agtgacctac gggctgtact
     1861 cttaatcaac agtaaatctt acgtttctcc accttcatct atggaagata aatcagatgt
     1921 tggttatgga cgaagtattt cttcttcatc ttccttaaga agatcaagta aagaaaagaa
     1981 caaaaaaaat agttatcatt ttagtgctgg atttggatct cccatagaag acaaatcaga
     2041 gccagcttct ggacgaaata ctgttctcag caaaagcgcc accaaagaaa aaggatggag
     2101 gaaaagcaaa ggaaaaaaag aagaggaaaa agtgaaagag gaggaagagg ttatggtggt
     2161 accaaaattt gttggtgaag gaagctctga caaagaatgg tgtcctccct ctgaccctga
     2221 tttctctatg tatgtgtatg aggtgaccaa atcaatactg ccaataacca atattaagga
     2281 acagattgag gatctggcaa agtatgtagc agaaaaaatg ggtggtaaga ttccaaaaga
     2341 gaaactacct gatttcagct gggaacttca cataagtgaa ctgaaatttc aacttaaatc
     2401 caatgttata ccgattggac atgtcaaaaa aggaatcttc taccatcgag ctttgctttt
     2461 caaggctctg gctgatagaa ttggcattgg ttgctcccta gttcgcggag agtacggtag
     2521 agcgtggaat gaagtcatgc tgcagaatga ctctcggaag ggagtgattg ggggcctccc
     2581 cgctcctgag atgtacgtga ttgacctcat gttccatcca ggtggactga tgaagttgag
     2641 aagtcgagag gctgatcttt acagattcat ttaagccatc agacgaacac aagagaggct
     2701 caaacaagaa attcactgtg tacactctct aagacattct ccaaattgat tttatctctt
     2761 taaataaaaa ctttaaataa aagtattaga aatgttttct ctgcgtagaa attaggaagc
     2821 ttggagtgaa ctttgctgtg cttctgattt caggcttttg gcaagagttc tgtcttatta
     2881 ggtcattttc cgctcactga ccctcacata aagctgattg ttgtcgaaat tcatccagcc
     2941 cactgtgtcc tgaggagcgt ctctgtcatt taggaatcac atgtagcact cagctgctgc
     3001 acccaggaca acactgtggc ctcatgactg tcatctttca tgcccagaat gcttcaggca
     3061 tgctcagtta agcaaactaa gtgaattttt agtatttgca atcaccttgt ctcagtttca
     3121 tttaagattt tgatagttta gatagaataa acacagatct gagtgttaca aattcctttc
     3181 taaaaatttt tgtttctatt tttaaaaatt catcattaaa aacactttaa tatagtgaat
     3241 taaaaatatt tctaaagtat atttccataa aatggttttg gtttcatctt gtctgtgtta
     3301 gcttggaaac ataccttcag ctaaaaacaa ttctgatttg ctcttccaca ttttaatgct
     3361 gggccattaa tatattattt tcaatttata gaactaaaaa atttttattt tttggaaaac
     3421 tttgaagcat aaaggtagag caaatctttg ctgaggaatt gtgttttagt attgagcaca
     3481 aaatggggag taaattcaca tttcaaatga taagacaaaa actactaatg tggttaatct
     3541 cgtgaagtac atattgccta gtcacgctta aagtccagtg ttgacctgta tagtcatttt
     3601 cctagaagac gttttaaagt gaatttgatt ttagaaatta aagctaagat tattttgtat
     3661 taatttgtaa tttcaaataa tataattctt tatttcagaa taaatttatt tcaaatgg
//
