LOCUS       NM_032131               3734 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing 2 (ARMC2), transcript
            variant 1, mRNA.
ACCESSION   NM_032131
VERSION     NM_032131.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Zhao,S., Liu,Q., Su,L., Meng,L., Tan,C., Wei,C., Zhang,H., Luo,T.,
            Zhang,Q., Tan,Y.Q., Tu,C., Chen,H. and Gao,X.
  TITLE     Identification of novel homozygous asthenoteratospermia-causing
            ARMC2 mutations associated with multiple morphological
            abnormalities of the sperm flagella
  JOURNAL   J Assist Reprod Genet 41 (5), 1297-1306 (2024)
   PUBMED   38492154
  REMARK    GeneRIF: Identification of novel homozygous
            asthenoteratospermia-causing ARMC2 mutations associated with
            multiple morphological abnormalities of the sperm flagella.
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Lechtreck,K.F., Liu,Y., Dai,J., Alkhofash,R.A., Butler,J.,
            Alford,L. and Yang,P.
  TITLE     Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for
            intraflagellar transport of radial spokes
  JOURNAL   Elife 11, e74993 (2022)
   PUBMED   34982025
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Khan,I., Dil,S., Zhang,H., Zhang,B., Khan,T., Zeb,A., Zhou,J.,
            Nawaz,S., Zubair,M., Khan,K., Ma,H. and Shi,Q.
  TITLE     A novel stop-gain mutation in ARMC2 is associated with multiple
            morphological abnormalities of the sperm flagella
  JOURNAL   Reprod Biomed Online 43 (5), 913-919 (2021)
   PUBMED   34493464
  REMARK    GeneRIF: A novel stop-gain mutation in ARMC2 is associated with
            multiple morphological abnormalities of the sperm flagella.
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Coutton,C., Martinez,G., Kherraf,Z.E., Amiri-Yekta,A., Boguenet,M.,
            Saut,A., He,X., Zhang,F., Cristou-Kent,M., Escoffier,J., Bidart,M.,
            Satre,V., Conne,B., Fourati Ben Mustapha,S., Halouani,L.,
            Marrakchi,O., Makni,M., Latrous,H., Kharouf,M., Pernet-Gallay,K.,
            Bonhivers,M., Hennebicq,S., Rives,N., Dulioust,E., Toure,A.,
            Gourabi,H., Cao,Y., Zouari,R., Hosseini,S.H., Nef,S.,
            Thierry-Mieg,N., Arnoult,C. and Ray,P.F.
  TITLE     Bi-allelic Mutations in ARMC2 Lead to Severe
            Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in
            Humans and Mice
  JOURNAL   Am J Hum Genet 104 (2), 331-340 (2019)
   PUBMED   30686508
  REMARK    GeneRIF: bi-allelic mutations in ARMC2 cause male infertility in
            humans and mice by inducing a typical 'multiple morphological
            abnormalities of the flagella' phenotype, indicating that this gene
            is necessary for sperm flagellum structure and assembly
REFERENCE   5  (bases 1 to 3734)
  AUTHORS   Dowling,J.K., Becker,C.E., Bourke,N.M., Corr,S.C., Connolly,D.J.,
            Quinn,S.R., Pandolfi,P.P., Mansell,A. and O'Neill,L.A.J.
  TITLE     Promyelocytic leukemia protein interacts with the
            apoptosis-associated speck-like protein to limit inflammasome
            activation
  JOURNAL   J Biol Chem 289 (10), 6429-6437 (2014)
   PUBMED   24407287
REFERENCE   6  (bases 1 to 3734)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   7  (bases 1 to 3734)
  AUTHORS   Hancock,D.B., Soler Artigas,M., Gharib,S.A., Henry,A.,
            Manichaikul,A., Ramasamy,A., Loth,D.W., Imboden,M., Koch,B.,
            McArdle,W.L., Smith,A.V., Smolonska,J., Sood,A., Tang,W.,
            Wilk,J.B., Zhai,G., Zhao,J.H., Aschard,H., Burkart,K.M.,
            Curjuric,I., Eijgelsheim,M., Elliott,P., Gu,X., Harris,T.B.,
            Janson,C., Homuth,G., Hysi,P.G., Liu,J.Z., Loehr,L.R., Lohman,K.,
            Loos,R.J., Manning,A.K., Marciante,K.D., Obeidat,M., Postma,D.S.,
            Aldrich,M.C., Brusselle,G.G., Chen,T.H., Eiriksdottir,G.,
            Franceschini,N., Heinrich,J., Rotter,J.I., Wijmenga,C.,
            Williams,O.D., Bentley,A.R., Hofman,A., Laurie,C.C., Lumley,T.,
            Morrison,A.C., Joubert,B.R., Rivadeneira,F., Couper,D.J.,
            Kritchevsky,S.B., Liu,Y., Wjst,M., Wain,L.V., Vonk,J.M.,
            Uitterlinden,A.G., Rochat,T., Rich,S.S., Psaty,B.M., O'Connor,G.T.,
            North,K.E., Mirel,D.B., Meibohm,B., Launer,L.J., Khaw,K.T.,
            Hartikainen,A.L., Hammond,C.J., Glaser,S., Marchini,J., Kraft,P.,
            Wareham,N.J., Volzke,H., Stricker,B.H., Spector,T.D.,
            Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R., Heckbert,S.R.,
            Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A., Strachan,D.P.,
            Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and London,S.J.
  TITLE     Genome-wide joint meta-analysis of SNP and SNP-by-smoking
            interaction identifies novel loci for pulmonary function
  JOURNAL   PLoS Genet 8 (12), e1003098 (2012)
   PUBMED   23284291
REFERENCE   8  (bases 1 to 3734)
  AUTHORS   Soler Artigas,M., Loth,D.W., Wain,L.V., Gharib,S.A., Obeidat,M.,
            Tang,W., Zhai,G., Zhao,J.H., Smith,A.V., Huffman,J.E., Albrecht,E.,
            Jackson,C.M., Evans,D.M., Cadby,G., Fornage,M., Manichaikul,A.,
            Lopez,L.M., Johnson,T., Aldrich,M.C., Aspelund,T., Barroso,I.,
            Campbell,H., Cassano,P.A., Couper,D.J., Eiriksdottir,G.,
            Franceschini,N., Garcia,M., Gieger,C., Gislason,G.K., Grkovic,I.,
            Hammond,C.J., Hancock,D.B., Harris,T.B., Ramasamy,A.,
            Heckbert,S.R., Heliovaara,M., Homuth,G., Hysi,P.G., James,A.L.,
            Jankovic,S., Joubert,B.R., Karrasch,S., Klopp,N., Koch,B.,
            Kritchevsky,S.B., Launer,L.J., Liu,Y., Loehr,L.R., Lohman,K.,
            Loos,R.J., Lumley,T., Al Balushi,K.A., Ang,W.Q., Barr,R.G.,
            Beilby,J., Blakey,J.D., Boban,M., Boraska,V., Brisman,J.,
            Britton,J.R., Brusselle,G.G., Cooper,C., Curjuric,I., Dahgam,S.,
            Deary,I.J., Ebrahim,S., Eijgelsheim,M., Francks,C., Gaysina,D.,
            Granell,R., Gu,X., Hankinson,J.L., Hardy,R., Harris,S.E.,
            Henderson,J., Henry,A., Hingorani,A.D., Hofman,A., Holt,P.G.,
            Hui,J., Hunter,M.L., Imboden,M., Jameson,K.A., Kerr,S.M.,
            Kolcic,I., Kronenberg,F., Liu,J.Z., Marchini,J., McKeever,T.,
            Morris,A.D., Olin,A.C., Porteous,D.J., Postma,D.S., Rich,S.S.,
            Ring,S.M., Rivadeneira,F., Rochat,T., Sayer,A.A., Sayers,I.,
            Sly,P.D., Smith,G.D., Sood,A., Starr,J.M., Uitterlinden,A.G.,
            Vonk,J.M., Wannamethee,S.G., Whincup,P.H., Wijmenga,C.,
            Williams,O.D., Wong,A., Mangino,M., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., North,K.E., Omenaas,E., Palmer,L.J.,
            Pietilainen,K.H., Pin,I., Pola Sbreve Ek,O., Pouta,A., Psaty,B.M.,
            Hartikainen,A.L., Rantanen,T., Ripatti,S., Rotter,J.I., Rudan,I.,
            Rudnicka,A.R., Schulz,H., Shin,S.Y., Spector,T.D., Surakka,I.,
            Vitart,V., Volzke,H., Wareham,N.J., Warrington,N.M., Wichmann,H.E.,
            Wild,S.H., Wilk,J.B., Wjst,M., Wright,A.F., Zgaga,L., Zemunik,T.,
            Pennell,C.E., Nyberg,F., Kuh,D., Holloway,J.W., Boezen,H.M.,
            Lawlor,D.A., Morris,R.W., Probst-Hensch,N., Kaprio,J., Wilson,J.F.,
            Hayward,C., Kahonen,M., Heinrich,J., Musk,A.W., Jarvis,D.L.,
            Glaser,S., Jarvelin,M.R., Ch Stricker,B.H., Elliott,P.,
            O'Connor,G.T., Strachan,D.P., London,S.J., Hall,I.P., Gudnason,V.
            and Tobin,M.D.
  CONSRTM   International Lung Cancer Consortium; GIANT consortium
  TITLE     Genome-wide association and large-scale follow up identifies 16 new
            loci influencing lung function
  JOURNAL   Nat Genet 43 (11), 1082-1090 (2011)
   PUBMED   21946350
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3734)
  AUTHORS   Xu,J., Zheng,S.L., Isaacs,S.D., Wiley,K.E., Wiklund,F., Sun,J.,
            Kader,A.K., Li,G., Purcell,L.D., Kim,S.T., Hsu,F.C., Stattin,P.,
            Hugosson,J., Adolfsson,J., Walsh,P.C., Trent,J.M., Duggan,D.,
            Carpten,J., Gronberg,H. and Isaacs,W.B.
  TITLE     Inherited genetic variant predisposes to aggressive but not
            indolent prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 2136-2140 (2010)
   PUBMED   20080650
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3734)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA196834.1, AK292499.1, BC030603.2, AW195322.1 and AL390208.17.
            
            On Nov 23, 2018 this sequence version replaced NM_032131.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030603.2, SRR1803611.252307.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392644.9/ ENSP00000376417.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA196834.1         7-24
            19-2806             AK292499.1         19-2806
            2807-3239           BC030603.2         2807-3239
            3240-3624           AW195322.1         108-492             c
            3625-3730           AW195322.1         1-106               c
            3731-3734           AL390208.17        48076-48079
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3734
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="armadillo repeat containing 2"
                     /db_xref="GeneID:84071"
                     /db_xref="HGNC:HGNC:23045"
                     /db_xref="MIM:618424"
     exon            1..125
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            126..386
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2772
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="isoform a is encoded by transcript variant 1;
                     armadillo repeat-containing protein 2"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 2 isoform a"
                     /protein_id="NP_115507.4"
                     /db_xref="CCDS:CCDS5069.2"
                     /db_xref="GeneID:84071"
                     /db_xref="HGNC:HGNC:23045"
                     /db_xref="MIM:618424"
                     /translation="MLSPNDKMLGKLDPFYQPSVSKQKTSAEIISEARNALRTVRTQR
                     PFTPQEAQRKLFGPASSRTSENRPPSSFSLHASSFESSDSRPISGTRLSPLELKPKVP
                     ASPTREEDSCFSFPKPPVDPAKIRRVSNARARLFRAASQRALLPDRSLPPSDSKKTVE
                     SKETVMMGDSMVKINGIYLTKSNAICHLKSHPLQLTDDGGFSEIKEQEMFKGTTSLPS
                     HLKNGGDQGKRHARASSCPSSSDLSRLQTKAVPKADLQEEDAEIEVDEVFWNTRIVPI
                     LRELEKEENIETVCAACTQLHHALEEGNMLGNKFKGRSILLKTLCKLVDVGSDSLSLK
                     LAKIILALKVSRKNLLNVCKLIFKISRNEKNDSLIQNDSILESLLEVLRSEDLQTNME
                     AFLYCMGSIKFISGNLGFLNEMISKGAVEILINLIKQINENIKKCGTFLPNSGHLLVQ
                     VTATLRNLVDSSLVRSKFLNISALPQLCTAMEQYKGDKDVCTNIARIFSKLTSYRDCC
                     TALASYSRCYALFLNLINKYQKKQDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTL
                     LSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVL
                     AANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLL
                     KLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGV
                     LLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSC
                     FGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKPVAQQLLNRIQRHH
                     TFLEPLPIPSF"
     exon            387..459
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            460..631
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            632..839
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            840..916
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1015
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1191
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1294
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1518
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1664
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1764
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2083
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2206
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2320
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2453
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2614
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..3734
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3045..3050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="hexamer: ATTAAA"
     polyA_site      3072
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="major polyA site"
     regulatory      3221..3226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="hexamer: AATAAA"
     polyA_site      3247
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="major polyA site"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="ARMC2"
                     /gene_synonym="bA787I22.1; SPGF38"
                     /note="major polyA site"
ORIGIN      
        1 agtggccgag cggcgtcgtg gggttacccc gcccgcgcca gcgctgcatc cctggccgct
       61 acccggggag agccggagga tgaattgaac ctcgcagccg ctgctatctc cagtgctcat
      121 cacagggtgt ggtgtctatc tgaagaatat tttactttca aaggaaagat gctgtctcca
      181 aatgataaaa tgttaggaaa actggatcca ttttatcaac cttcagtgtc caagcagaag
      241 accagtgcag aaatcataag tgaagcaaga aatgcattaa gaacagttag aacccaaaga
      301 ccatttacac cacaggaggc tcaaagaaaa ctattcggac ctgcatcctc aagaacatca
      361 gaaaatagac ctccttcctc cttcagcctc catgcatcca gttttgagtc atctgattcc
      421 aggcctatct ctggcacacg tcttagtcca ctagagctga aaccgaaagt tccagcatct
      481 cccaccagag aggaggattc ctgcttttcc tttcctaagc ccccagtgga ccctgcgaag
      541 attagaagag taagcaacgc cagggctcgc ttattcaggg ctgcctccca gcgggccctt
      601 ctgccggaca gatcccttcc tccctccgac tcaaagaaga cagtggaatc caaagaaaca
      661 gttatgatgg gggactctat ggtgaaaata aatgggattt atttaacaaa atcaaatgct
      721 atttgccact taaagagtca cccacttcag ctaactgatg atggaggctt cagtgaaata
      781 aaggagcaag aaatgttcaa aggaacaaca tctttaccat ctcatctcaa gaatggaggg
      841 gaccagggga agagacatgc gagggcctca tcatgcccca gtagctcaga cctgagcagg
      901 ctgcaaacca aagcagtccc aaaagctgac ctgcaagaag aggacgcaga aatagaagta
      961 gacgaagtct tttggaatac aaggattgta ccgattttgc gtgaattaga aaaggaagaa
     1021 aacattgaaa cggtttgtgc tgcttgcaca caacttcatc atgctttaga ggaaggaaac
     1081 atgcttggaa ataaatttaa gggaagaagt attctcctga agaccctgtg taaactagtt
     1141 gatgttggtt cagactcgct cagccttaaa cttgcaaaaa taattctagc acttaaagtg
     1201 agtagaaaga atcttcttaa tgtctgcaaa cttatattta aaattagcag gaatgagaag
     1261 aatgattctt tgattcaaaa tgacagcatt ctggaatcat tattggaggt actaagaagt
     1321 gaagacctgc aaactaacat ggaagctttt ttatactgta tggggtctat aaagttcatt
     1381 tctggaaatc tgggatttct taatgaaatg atcagcaaag gtgctgtgga aatactgata
     1441 aatttgataa aacaaataaa tgagaacatc aagaaatgtg gtacattttt gcctaattcg
     1501 ggccacttgc tagtccaggt gactgctaca ttgagaaact tggttgattc atcattagta
     1561 agaagtaagt tcctaaacat cagtgccctt ccccagctct gcacggcaat ggaacagtac
     1621 aagggtgaca aggacgtctg taccaatatt gccagaatat tcagcaaact tacttcttac
     1681 cgtgactgct gcacagcctt ggccagctat tccagatgtt atgccttatt tctgaatcta
     1741 attaacaaat accagaagaa gcaggattta gtcgtccgtg ttgtttttat tcttggcaac
     1801 ctgacggcaa aaaataacca ggctcgtgaa caattttcca aagagaaagg gagcatccaa
     1861 actctgctgt cattattcca gacgttccat cagctggatc tgcattccca gaagccggtg
     1921 ggccaacgag gcgagcagca cagggcgcag aggccgccgt cagaggcaga ggacgtgctc
     1981 atcaagctga ctcgtgtgct ggccaacatt gccatccacc cgggcgtggg cccggtgctg
     2041 gccgccaacc cggggatagt gggcctgctc ctgaccacgc tggaatacaa gtcacttgat
     2101 gattgtgagg agctggtgat caatgctaca gcgacaatca acaatttatc ttactaccaa
     2161 gtgaagaatt ccataattca agacaaaaag ctatatattg ctgaattgct cttaaagctt
     2221 cttgtcagta acaacatgga tggaatcctg gaggctgtgc gtgttttcgg aaatctctcc
     2281 caggaccatg atgtctgcga tttcattgtg cagaacaatg tccacaggtt catgatggcg
     2341 ctgctggatg ctcagcatca ggatatctgc ttttctgcct gtggtgttct cctcaatctc
     2401 actgtggata aagacaagcg tgtcatcttg aaagaaggag gtggcattaa aaagttagtg
     2461 gactgtttaa gagatttggg tcctactgat tggcagctgg cctgcttggt ttgtaaaact
     2521 ttatggaact tcagtgaaaa catcactaat gcttcgtcat gttttggaaa tgaagacacc
     2581 aacacactct tactcttgct ctcatcattt ttagatgaag aactagcact ggatggcagt
     2641 tttgatccag acctaaaaaa ctatcacaaa ctccattggg aaacagaatt caaacctgtg
     2701 gcacagcagc ttctaaaccg aattcagaga catcacacct tcctggaacc cctgcccatt
     2761 ccctctttct aacatgatgc agattaacag tagaaacgag aactcacgtc tccctcattc
     2821 ttaagaactg gtaacaaacg tgaacatttt tttcagcatt aacaaatgtg gaaagttttt
     2881 caagaactgg ttttagtgag tagctgaagt attttttaaa attaagcatt tcttcttgtt
     2941 aggtattatg gaaaaatgaa tatacacatt atatttcctg ttgagagaaa tgtaagatga
     3001 aaatatgtgc attttcaagt aaatgacttt ttcttctatt ctctattaaa caatttagtt
     3061 ctagtcttaa aatcttgatt taacaatttt ggaattgaag tgttcataag ttaaatgaac
     3121 tgtgcaatga aggctgttag attatataga aagaagggta ggcaacatga gtggaacacg
     3181 ttacaacata ggatctgtac taattcttac tatgtcaaat aataaatgct ctcattaggt
     3241 accagtattt ttttggtctt tatattaaga gaaggagtaa gcagaaaaac ttaaagaaaa
     3301 ctgctttggg ccatctgttc tttattaaat aagtaaaata gataaaatga gagtatattt
     3361 tcatttgaaa taaaatgact ggactaagac agtccttcta attgtaactc tctgtgtttg
     3421 acaggtgagg taatgtatta gaaagaatgc aggcttaggt gaatggtata cctgaatctg
     3481 aatccatgct ctcccctgct agctttgtgg gcctggagca agtaacttaa tttcttgagc
     3541 tgcaactgca aaatgggaat catatcaatt ttactgtagt gtagtttgga acaaaccatt
     3601 aaatgggcaa atggcccagt ccagtgtatc atgtggagtg ggtgttcaag aacattatga
     3661 tggcaagcac tttcttagct tgccatcctt tgtaggatga gtttggcctt tgaataaatg
     3721 attaaagagc aaaa
//
