LOCUS       NM_031905               2371 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing 10 (ARMC10), transcript
            variant A, mRNA.
ACCESSION   NM_031905
VERSION     NM_031905.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Huang,Y., Zhang,Z., Xu,Y., Peng,Y., Xu,R., Luan,Y., Bie,X., Jia,J.,
            Zhang,C., Han,T., Zhou,B., Li,Z., Zheng,H., Yang,D. and He,Y.
  TITLE     ARMC10 regulates mitochondrial dynamics and affects mitochondrial
            function via the Wnt/beta-catenin signalling pathway involved in
            ischaemic stroke
  JOURNAL   J Cell Mol Med 28 (12), e18449 (2024)
   PUBMED   38924214
  REMARK    GeneRIF: ARMC10 regulates mitochondrial dynamics and affects
            mitochondrial function via the Wnt/beta-catenin signalling pathway
            involved in ischaemic stroke.
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Xie,L., Yin,Y., Jayakar,S., Kawaguchi,R., Wang,Q., Peterson,S.,
            Shi,C., Turnes,B.L., Zhang,Z., Oses-Prieto,J., Li,J.,
            Burlingame,A., Woolf,C.J., Geschwind,D., Rasband,M. and
            Benowitz,L.I.
  TITLE     The oncomodulin receptor ArmC10 enables axon regeneration in mice
            after nerve injury and neurite outgrowth in human iPSC-derived
            sensory neurons
  JOURNAL   Sci Transl Med 15 (708), eadg6241 (2023)
   PUBMED   37556559
  REMARK    GeneRIF: The oncomodulin receptor ArmC10 enables axon regeneration
            in mice after nerve injury and neurite outgrowth in human
            iPSC-derived sensory neurons.
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Chen,Z., Lei,C., Wang,C., Li,N., Srivastava,M., Tang,M., Zhang,H.,
            Choi,J.M., Jung,S.Y., Qin,J. and Chen,J.
  TITLE     Global phosphoproteomic analysis reveals ARMC10 as an AMPK
            substrate that regulates mitochondrial dynamics
  JOURNAL   Nat Commun 10 (1), 104 (2019)
   PUBMED   30631047
  REMARK    GeneRIF: Data show that the serine S45 site of armadillo repeat
            containing 10 (ARMC10) can be phosphorylated by AMP-activated
            protein kinase (AMPK) both in vitro and in vivo. .
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Zhou,X., Yang,G., Huang,R., Chen,X. and Hu,G.
  TITLE     SVH-B interacts directly with p53 and suppresses the
            transcriptional activity of p53
  JOURNAL   FEBS Lett 581 (25), 4943-4948 (2007)
   PUBMED   17904127
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Huang,R., Xing,Z., Luan,Z., Wu,T., Wu,X. and Hu,G.
  TITLE     A specific splicing variant of SVH, a novel human armadillo repeat
            protein, is up-regulated in hepatocellular carcinomas
  JOURNAL   Cancer Res 63 (13), 3775-3782 (2003)
   PUBMED   12839973
  REMARK    GeneRIF: a novel gene SVH, up-regulated in hepatocellular
            carcinoma, was identified; four variants SVH-A, -B, -C, and -D,
            resulting from alternative splicing in the coding region of the SVH
            transcript, were observed and localized in the endoplasmic
            reticulum
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY150854.1, AI761577.1,
            BQ440425.1, BU941174.1, BQ004061.1, AY150851.1 and BM989172.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_031905.4.
            
            Summary: This gene encodes a protein that contains an armadillo
            repeat and transmembrane domain. The encoded protein decreases the
            transcriptional activity of the tumor suppressor protein p53
            through direct interaction with the DNA-binding domain of p53, and
            may play a role in cell growth and survival. Upregulation of this
            gene may play a role in hepatocellular carcinoma. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene, and a pseudogene of this gene is located on
            the long arm of chromosome 3. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (A) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075500.1, AY150854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323716.8/ ENSP00000319412.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1207              AY150854.1         260-1466
            1208-1272           AI761577.1         268-332             c
            1273-1556           BQ440425.1         209-492
            1557-1926           BU941174.1         48-417
            1927-2098           BQ004061.1         292-463             c
            2099-2370           AY150851.1         2076-2347
            2371-2371           BM989172.1         22-22               c
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2371
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /note="armadillo repeat containing 10"
                     /db_xref="GeneID:83787"
                     /db_xref="HGNC:HGNC:21706"
                     /db_xref="MIM:611864"
     exon            1..272
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1165
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /note="isoform a is encoded by transcript variant A;
                     specific splicing variant involved in
                     hepatocarcinogenesis; splicing variant involved in
                     hepatocarcinogenesis protein"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 10 isoform
                     a"
                     /protein_id="NP_114111.2"
                     /db_xref="CCDS:CCDS5728.1"
                     /db_xref="GeneID:83787"
                     /db_xref="HGNC:HGNC:21706"
                     /db_xref="MIM:611864"
                     /translation="MGGPRGAGWVAAGLLLGAGACYCIYRLTRGRRRGDRELGIRSSK
                     SAGALEEGTSEGQLCGRSARPQTGGTWESQWSKTSQPEDLTDGSYDDVLNAEQLQKLL
                     YLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALN
                     ALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLTNMTVTNDHQHMLHS
                     YITDLFQVLLTGNGNTKVQVLKLLLNLSENPAMTEGLLRAQVDSSFLSLYDSHVAKEI
                     LLRVLTLFQNIKNCLKIEGHLAVQPTFTEGSLFFLLHGEECAQKIRALVDHHDAEVKE
                     KVVTIIPKI"
     exon            273..377
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /inference="alignment:Splign:2.1.0"
     exon            378..526
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /inference="alignment:Splign:2.1.0"
     exon            527..661
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /inference="alignment:Splign:2.1.0"
     exon            662..838
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /inference="alignment:Splign:2.1.0"
     exon            839..910
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /inference="alignment:Splign:2.1.0"
     exon            911..2371
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /note="hexamer: AGTAAA"
     polyA_site      1295
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /note="major polyA site"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /note="hexamer: AATATA"
     polyA_site      1364
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
     regulatory      1772..1777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /note="hexamer: AATAAA"
     polyA_site      1795
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
                     /note="hexamer: AATAAA"
     polyA_site      2371
                     /gene="ARMC10"
                     /gene_synonym="PNAS-112; PNAS112; PSEC0198; SVH"
ORIGIN      
        1 atttcctttc tccacatcca ggtcaggtgg cgtttgctgt ggcggctagg cccgcgtgcg
       61 ctggagacct ccgcgctggc ccccgcgagc ctcctgccct ggcccggcgc tgcggctctg
      121 ccgcggcggc agcatgggtg gcccccgggg cgcgggctgg gtggcggcgg gcctgctgct
      181 cggcgcgggc gcctgctact gcatttacag gctgacccgg ggtcggcggc ggggcgaccg
      241 cgagctcggg atacgctctt cgaagtccgc aggtgccctg gaagaaggga cgtcagaggg
      301 tcagttgtgc gggcgctcgg cccggcctca gacgggaggt acctgggagt cacagtggtc
      361 caagacctcg cagcctgaag acttaactga tggttcatat gatgatgttc taaatgctga
      421 acaacttcag aaactccttt acctgctgga gtcaacggag gatcctgtaa ttattgaaag
      481 agctttgatt actttgggta acaatgcagc cttttcagtt aaccaagcta ttattcgtga
      541 attgggtggt attccaattg ttgcaaacaa aatcaaccat tccaaccaga gtattaaaga
      601 gaaagcttta aatgcactaa ataacctgag tgtgaatgtt gaaaatcaaa tcaagataaa
      661 gatatacatc agtcaagtat gtgaggatgt cttctctggt cctctgaact ctgctgtgca
      721 gctggctgga ctgacattgt tgacaaacat gactgttacc aatgaccacc agcacatgct
      781 tcacagttac attacagacc tgttccaggt gttacttact ggaaatggaa acacgaaggt
      841 gcaagttttg aaactgcttt tgaatttgtc tgaaaatcca gccatgacag aaggacttct
      901 ccgtgcccaa gtggattcat cattcctttc cctttatgac agccacgtag caaaggagat
      961 tcttcttcga gtacttacgc tatttcagaa tataaagaac tgcctcaaaa tagaaggcca
     1021 tttagctgtg cagcctactt tcactgaagg ttcattgttt ttcctgttac atggagaaga
     1081 atgtgcccag aaaataagag ctttagttga tcaccatgat gcagaggtga aggaaaaggt
     1141 tgtaacaata atacccaaaa tctgattggt catatttttc caaagagtaa tgcagtctgg
     1201 atataaacgt attttctgtc ttccttataa ggggattctc ccagctgcta aatttaaaca
     1261 gtaaatatca cattttgtca ttaacacagc tataacttgc cgtggttctc agatttattt
     1321 tggactattt tgatgccaag tgaatataag agcttgtact gaaaccattt atttctttct
     1381 attttgctat ttgcaaatgc ttgttatctt ccctacatga agtggcagta acctttttca
     1441 catttaagct acccttctac cttttgaagt gatttgcagt tactcatctg agacagcatc
     1501 agtatttgac taaatcattg tttcacaact gaatagtctt gttcttttag tagcaacgaa
     1561 atcctaagct cttgaggcca ttcacctgcc aacctgacca tactgctttc aaaagtcttt
     1621 tctcatcagt agaatctatt ttggtcactt ctagtcaatg aaaaatgtaa acttttagga
     1681 gagaatgttt cttaggactc acccactcca ttcaatgtta tatataaaat agtgtgatca
     1741 atcacaatgt ccatctttag acagttggtt aaataaatta tctggtcttt gaaaagaccg
     1801 tgctgggcgc ggtggctctt gcctgtaatc ccagcacttt gggaggctga ggcgggcaga
     1861 tcacctgaga tcgggagttt gagaccaagc ctgaccaata tggagaaacc ctgtctctac
     1921 taagaacaca aaattagctg ggcatggtgg tgcatgcctg taatcccagc tacttgggag
     1981 gccgaggcag gagaattgct tgaacccggg aggcagaggt tgcagtgagc tgagatagcg
     2041 ccattgcact ccagcctggg caacaagagc aaaactctgt ctcaaaaaaa aaaaaaaatg
     2101 atggagctcc gaatgtgctt aagtggaaag atatctatga aatatggtgg ttttttaaaa
     2161 cacaaaaatt atagaatatg ggatcccgtg tgtgtgtgtg tgtgtttgaa tgaaaaatgc
     2221 ttatgtattg acagaacact tctagaatga tacccaaact cctggagtgg gagtggggaa
     2281 tgccttctac gtacacactg ttctactgtt tgaatttttt aatatgagcc caaattgtat
     2341 aatctttttt taataaaggg gagaaaaatc a
//
