LOCUS       NM_018120               3000 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing 1 (ARMC1), transcript
            variant 1, mRNA.
ACCESSION   NM_018120
VERSION     NM_018120.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Wagner,F., Kunz,T.C., Chowdhury,S.R., Thiede,B., Fraunholz,M.,
            Eger,D. and Kozjak-Pavlovic,V.
  TITLE     Armadillo repeat-containing protein 1 is a dual localization
            protein associated with mitochondrial intermembrane space bridging
            complex
  JOURNAL   PLoS One 14 (10), e0218303 (2019)
   PUBMED   31644573
  REMARK    GeneRIF: ArmC1 represents therefore a peripheral MICOS/MIB
            component that appears to play a role in mitochondrial distribution
            in the cell.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC349250.1, AC055822.10, BC018846.2, AC100814.2 and AA808041.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018120.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.161470.1,
                                           SRR1803613.81647.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276569.8/ ENSP00000276569.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DC349250.1         41-95
            56-56               AC055822.10        168293-168293
            57-1202             BC018846.2         77-1222
            1203-2638           AC100814.2         9083-10518
            2639-3000           AA808041.1         12-373              c
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..3000
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="armadillo repeat containing 1"
                     /db_xref="GeneID:55156"
                     /db_xref="HGNC:HGNC:17684"
                     /db_xref="MIM:620385"
     exon            1..180
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            181..398
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1064
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 1 isoform 1"
                     /protein_id="NP_060590.1"
                     /db_xref="CCDS:CCDS6181.1"
                     /db_xref="GeneID:55156"
                     /db_xref="HGNC:HGNC:17684"
                     /db_xref="MIM:620385"
                     /translation="MNSSTSTMSEEPDALSVVNQLRDLAADPLNRRAIVQDQGCLPGL
                     ILFMDHPNPPVVHSALLALRYLAECRANREKMKGELGMMLSLQNVIQKTTTPGETKLL
                     ASEIYDILQSSNMADGDSFNEMNSRRRKAQFFLGTTNKRAKTVVLHIDGLDDTSRRNL
                     CEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTKVMKAQQVVKSESGE
                     EMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHPEGGASWLSTAANFL
                     SRSFYW"
     exon            399..490
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            491..680
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            681..797
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            798..872
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            873..3000
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2964..2969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="hexamer: AATAAA"
     polyA_site      3000
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="major polyA site"
ORIGIN      
        1 agagcctttg cccgccagcg ccttcgctct ttggctccct gagttagtcc ggttgcttgc
       61 gatcgccgcg gccggggctg cgaaccgaag ggctcgctcc gcgccgcctg ggtctctacc
      121 tcatccgtag gtgtggccct gatggtgtgg caggctctgg actcctaaag ctctggagcg
      181 aatttaagat tttattcatg tgcatggcat agaagatgaa ttcttccact tccaccatga
      241 gtgaagagcc tgacgctcta tcggtagtta accagttacg ggatctagca gcagatccgt
      301 taaacagaag agccatcgtc caggatcagg gatgtctgcc tggccttatt ttatttatgg
      361 accatcccaa ccctccagtc gtccactccg ctttgcttgc tcttcgatac ttggcagaat
      421 gccgtgcaaa cagagaaaag atgaaaggag aactgggtat gatgttgagc ttacaaaatg
      481 ttatacagaa aactacaact ccaggagaaa caaaacttct ggcctctgaa atctatgaca
      541 ttcttcagtc ctccaatatg gcagatggtg atagttttaa tgagatgaat tcacgtcgaa
      601 ggaaagctca attttttctg ggaactacaa acaaacgtgc caaaacagtg gttttgcata
      661 tagatggcct tgatgatacg tctcggagaa atctatgtga agaggctttg ttaaaaatta
      721 aaggtgttat tagctttact tttcaaatgg ctgttcaaag gtgtgtggtg cgaatccgtt
      781 cagatttgaa agctgaggct ttggcatcag caatagcatc aaccaaggtt atgaaagctc
      841 agcaagttgt gaaaagtgaa agtggagaag agatgttggt cccattccaa gatactcctg
      901 tggaagttga acagaacaca gagctacctg actacctgcc tgaggatgag agtcccacaa
      961 aggaacagga caaagcggtg tcccgggtcg gctcacaccc agaaggtgga gctagctggc
     1021 ttagcacagc tgcaaacttt ttatccagat cattttattg gtgacttcac ttttgggctc
     1081 aaggactgtg tgaaccaaca aggggccagt tttccattgt tgtggtgaac tgtcaagtgc
     1141 aatttgcaat aagttatcat gaaaagtttt tagattacac gatcgcatat gctgcatttc
     1201 acgttttatt ggacatttta ccccactgag tggtaaaaag gacagaggct acagatggag
     1261 ttgctttgtt tatgaaagta ttttggtttg ttttctttca tttaattgcc tcatatttaa
     1321 aaaccatggg tccactgtta aaaccacatg tgtatgtgca gctttacatt ttattttacg
     1381 tgaagcatgt gattaggaaa actcattttc ttttcaagcc tcaggaccta cctgaagaga
     1441 agttttcttg tagctcaagt tgtgcatgaa ttactgaata ttttactgtg cttttcttca
     1501 tgaagggtac atgctttgta ctcttcactg aaagctgaaa acatttcttg ttaccctctt
     1561 ttgtgccttt ttattttgcc aaccgtgttt atagaaagga cattactaat gacattttgc
     1621 agattaaaaa cattcatttg aacacagtag tcccctagaa aaacaactct acaaaaattt
     1681 tgcagcctta ttcattataa ttttgataaa attaacacaa aatcagtcaa gaaggaaaca
     1741 tgtatattag tgaagtgttt ttggagactg tttgaatgtg accaaatgtg gttctagttg
     1801 acttcttttc actttggctt atatcaattc ttgagagtta atgtgatcat gatattgcaa
     1861 acaactataa atggtctcta ggccttactt tgtgattata cgttatctcc ggctagaaaa
     1921 aaataatggt agtaaagaaa ctgacaaact gaaaataaga aaacaaaaat caaatgccta
     1981 taataccata atgccagttt ggtatagagt ccaactttaa aacatgaatt gctcgacaga
     2041 gttctattca gtaggtgttt ctttgtattg tcttttgtga atttattatg aaaatgctgc
     2101 gttgtgttga atgaaaaaga cccaaattac tgcttatgaa gaaataaagc cagcattgat
     2161 cacttaatcc tgtttctcat gtccagccag aaaaaagaac ttcagtgaag gtaagataaa
     2221 taaatacata cacatatgtt tttttggtag ataagtgcta attacatata tgtaatgctt
     2281 tattaaattt ctgaaatatt tggtaactaa aattttcttt ttggaaatta ataaatccag
     2341 atacatatta atgttgatat gagtaaaaac aaataggaag aaattgaaat ttcttttcat
     2401 caacatgtag agctgctatt ttactatttg gagaatatga tgtgaaaatt ggacctcaaa
     2461 gggtttcctt gtgttttcat tgtaaaatac catcatcagt gagagtcttg agttcactaa
     2521 cattgtcacc ttctggagag agagttaatg gggggcattg aggatgatat ttttttacat
     2581 gtgtttggtt tctgattcaa gtgacacgca caaactgaaa aaaaaaaaac aaaaaaagca
     2641 acaataactt tcagggcacc tattgctcta aatgcataat ataacttgct gccagaacca
     2701 gatgtgttta aaaaagaaaa taaaaccacc ttctttctat agccattaaa gcaaacttta
     2761 ctgttctaac aaatttgtat tttattttgc attgccacac atctgcttat ttaaaaacta
     2821 catccctttg gtagtaatgt ttcaggacaa gtaggtatta cagcttgatg tttgtgtgtt
     2881 ctaattctaa gagttcttta ttccagatca tatagagtag ttaagacaac tgtaacagca
     2941 ttttttgaaa tacattgtaa aataataaaa ggtaacataa ttaaaatcga gtggatatta
//
