LOCUS       NM_001286702            2810 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens armadillo repeat containing 1 (ARMC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001286702 XM_005251265
VERSION     NM_001286702.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Wagner,F., Kunz,T.C., Chowdhury,S.R., Thiede,B., Fraunholz,M.,
            Eger,D. and Kozjak-Pavlovic,V.
  TITLE     Armadillo repeat-containing protein 1 is a dual localization
            protein associated with mitochondrial intermembrane space bridging
            complex
  JOURNAL   PLoS One 14 (10), e0218303 (2019)
   PUBMED   31644573
  REMARK    GeneRIF: ArmC1 represents therefore a peripheral MICOS/MIB
            component that appears to play a role in mitochondrial distribution
            in the cell.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC349250.1, AC055822.10, AK304463.1, AC100814.2 and AA808041.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001286702.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an exon in the central coding region compared to variant 1.
            These differences cause translation initiation at an alternate AUG
            and result in an isoform (2) with a shorter and distinct
            N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.843859.1,
                                           SRR14038194.4344534.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DC349250.1         41-95
            56-56               AC055822.10        168293-168293
            57-893              AK304463.1         51-887
            894-2448            AC100814.2         8964-10518
            2449-2810           AA808041.1         12-373              c
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..2810
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="armadillo repeat containing 1"
                     /db_xref="GeneID:55156"
                     /db_xref="HGNC:HGNC:17684"
                     /db_xref="MIM:620385"
     exon            1..180
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            181..398
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..874
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 1 isoform 2"
                     /protein_id="NP_001273631.1"
                     /db_xref="CCDS:CCDS69490.1"
                     /db_xref="GeneID:55156"
                     /db_xref="HGNC:HGNC:17684"
                     /db_xref="MIM:620385"
                     /translation="MSAWPYFIYGPSQPSSRPLRFACSSILGRMPCKQRKDERRTGYD
                     VELTKCYTESRRNLCEEALLKIKGVISFTFQMAVQRCVVRIRSDLKAEALASAIASTK
                     VMKAQQVVKSESGEEMLVPFQDTPVEVEQNTELPDYLPEDESPTKEQDKAVSRVGSHP
                     EGGASWLSTAANFLSRSFYW"
     exon            399..490
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            491..607
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            608..682
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     exon            683..2810
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2774..2779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="hexamer: AATAAA"
     polyA_site      2810
                     /gene="ARMC1"
                     /gene_synonym="Arcp"
                     /note="major polyA site"
ORIGIN      
        1 agagcctttg cccgccagcg ccttcgctct ttggctccct gagttagtcc ggttgcttgc
       61 gatcgccgcg gccggggctg cgaaccgaag ggctcgctcc gcgccgcctg ggtctctacc
      121 tcatccgtag gtgtggccct gatggtgtgg caggctctgg actcctaaag ctctggagcg
      181 aatttaagat tttattcatg tgcatggcat agaagatgaa ttcttccact tccaccatga
      241 gtgaagagcc tgacgctcta tcggtagtta accagttacg ggatctagca gcagatccgt
      301 taaacagaag agccatcgtc caggatcagg gatgtctgcc tggccttatt ttatttatgg
      361 accatcccaa ccctccagtc gtccactccg ctttgcttgc tcttcgatac ttggcagaat
      421 gccgtgcaaa cagagaaaag atgaaaggag aactgggtat gatgttgagc ttacaaaatg
      481 ttatacagaa tctcggagaa atctatgtga agaggctttg ttaaaaatta aaggtgttat
      541 tagctttact tttcaaatgg ctgttcaaag gtgtgtggtg cgaatccgtt cagatttgaa
      601 agctgaggct ttggcatcag caatagcatc aaccaaggtt atgaaagctc agcaagttgt
      661 gaaaagtgaa agtggagaag agatgttggt cccattccaa gatactcctg tggaagttga
      721 acagaacaca gagctacctg actacctgcc tgaggatgag agtcccacaa aggaacagga
      781 caaagcggtg tcccgggtcg gctcacaccc agaaggtgga gctagctggc ttagcacagc
      841 tgcaaacttt ttatccagat cattttattg gtgacttcac ttttgggctc aaggactgtg
      901 tgaaccaaca aggggccagt tttccattgt tgtggtgaac tgtcaagtgc aatttgcaat
      961 aagttatcat gaaaagtttt tagattacac gatcgcatat gctgcatttc acgttttatt
     1021 ggacatttta ccccactgag tggtaaaaag gacagaggct acagatggag ttgctttgtt
     1081 tatgaaagta ttttggtttg ttttctttca tttaattgcc tcatatttaa aaaccatggg
     1141 tccactgtta aaaccacatg tgtatgtgca gctttacatt ttattttacg tgaagcatgt
     1201 gattaggaaa actcattttc ttttcaagcc tcaggaccta cctgaagaga agttttcttg
     1261 tagctcaagt tgtgcatgaa ttactgaata ttttactgtg cttttcttca tgaagggtac
     1321 atgctttgta ctcttcactg aaagctgaaa acatttcttg ttaccctctt ttgtgccttt
     1381 ttattttgcc aaccgtgttt atagaaagga cattactaat gacattttgc agattaaaaa
     1441 cattcatttg aacacagtag tcccctagaa aaacaactct acaaaaattt tgcagcctta
     1501 ttcattataa ttttgataaa attaacacaa aatcagtcaa gaaggaaaca tgtatattag
     1561 tgaagtgttt ttggagactg tttgaatgtg accaaatgtg gttctagttg acttcttttc
     1621 actttggctt atatcaattc ttgagagtta atgtgatcat gatattgcaa acaactataa
     1681 atggtctcta ggccttactt tgtgattata cgttatctcc ggctagaaaa aaataatggt
     1741 agtaaagaaa ctgacaaact gaaaataaga aaacaaaaat caaatgccta taataccata
     1801 atgccagttt ggtatagagt ccaactttaa aacatgaatt gctcgacaga gttctattca
     1861 gtaggtgttt ctttgtattg tcttttgtga atttattatg aaaatgctgc gttgtgttga
     1921 atgaaaaaga cccaaattac tgcttatgaa gaaataaagc cagcattgat cacttaatcc
     1981 tgtttctcat gtccagccag aaaaaagaac ttcagtgaag gtaagataaa taaatacata
     2041 cacatatgtt tttttggtag ataagtgcta attacatata tgtaatgctt tattaaattt
     2101 ctgaaatatt tggtaactaa aattttcttt ttggaaatta ataaatccag atacatatta
     2161 atgttgatat gagtaaaaac aaataggaag aaattgaaat ttcttttcat caacatgtag
     2221 agctgctatt ttactatttg gagaatatga tgtgaaaatt ggacctcaaa gggtttcctt
     2281 gtgttttcat tgtaaaatac catcatcagt gagagtcttg agttcactaa cattgtcacc
     2341 ttctggagag agagttaatg gggggcattg aggatgatat ttttttacat gtgtttggtt
     2401 tctgattcaa gtgacacgca caaactgaaa aaaaaaaaac aaaaaaagca acaataactt
     2461 tcagggcacc tattgctcta aatgcataat ataacttgct gccagaacca gatgtgttta
     2521 aaaaagaaaa taaaaccacc ttctttctat agccattaaa gcaaacttta ctgttctaac
     2581 aaatttgtat tttattttgc attgccacac atctgcttat ttaaaaacta catccctttg
     2641 gtagtaatgt ttcaggacaa gtaggtatta cagcttgatg tttgtgtgtt ctaattctaa
     2701 gagttcttta ttccagatca tatagagtag ttaagacaac tgtaacagca ttttttgaaa
     2761 tacattgtaa aataataaaa ggtaacataa ttaaaatcga gtggatatta
//
