LOCUS       NM_001363794            1447 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 9 (ARL9), transcript variant 1, mRNA.
ACCESSION   NM_001363794 XM_005265719
VERSION     NM_001363794.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1447)
  AUTHORS   Yang,H.D., Jin,X.X., Gu,B.B., Yu-Zhang, Li,D. and Yan,L.L.
  TITLE     ARL9 is upregulated and serves as a biomarker for a poor prognosis
            in colon adenocarcinoma
  JOURNAL   BMC Gastroenterol 23 (1), 48 (2023)
   PUBMED   36823542
  REMARK    GeneRIF: ARL9 is upregulated and serves as a biomarker for a poor
            prognosis in colon adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1447)
  AUTHORS   Tan,Y., Zhang,S., Xiao,Q., Wang,J., Zhao,K., Liu,W., Huang,K.,
            Tian,W., Niu,H., Lei,T. and Shu,K.
  TITLE     Prognostic significance of ARL9 and its methylation in low-grade
            glioma
  JOURNAL   Genomics 112 (6), 4808-4816 (2020)
   PUBMED   32882327
  REMARK    GeneRIF: Prognostic significance of ARL9 and its methylation in
            low-grade glioma.
REFERENCE   3  (bases 1 to 1447)
  AUTHORS   Louro,R., Nakaya,H.I., Paquola,A.C., Martins,E.A., da Silva,A.M.,
            Verjovski-Almeida,S. and Reis,E.M.
  TITLE     RASL11A, member of a novel small monomeric GTPase gene family, is
            down-regulated in prostate tumors
  JOURNAL   Biochem Biophys Res Commun 316 (3), 618-627 (2004)
   PUBMED   15033445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114766.5 and AC108215.4.
            
            On Aug 29, 2019 this sequence version replaced NM_001363794.1.
            
            Summary: ARL9 is a member of the small GTPase protein family with a
            high degree of similarity to ARF (MIM 103180) proteins of the RAS
            superfamily.[supplied by OMIM, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.154888.1,
                                           SRR18074967.2680248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000640821.3/ ENSP00000492671.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AC114766.5         63763-64113
            352-514             AC114766.5         69157-69319
            515-690             AC108215.4         770-945
            691-1447            AC108215.4         5789-6545
FEATURES             Location/Qualifiers
     source          1..1447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..1447
                     /gene="ARL9"
                     /note="ARF like GTPase 9"
                     /db_xref="GeneID:132946"
                     /db_xref="HGNC:HGNC:23592"
                     /db_xref="MIM:612405"
     exon            1..351
                     /gene="ARL9"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..870
                     /gene="ARL9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like protein 9; ADP-ribosylation
                     factor-like 9; ADP ribosylation factor like GTPase 9"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 9 isoform
                     1"
                     /protein_id="NP_001350723.1"
                     /db_xref="CCDS:CCDS87224.1"
                     /db_xref="GeneID:132946"
                     /db_xref="HGNC:HGNC:23592"
                     /db_xref="MIM:612405"
                     /translation="MERGKVKKKEKEKETQEEKIGEKGREEKVKRKEVEQKIKQKQEK
                     QERRKGKEKEEKRTKQGKETNKEKEQFKGQEEKGENKDSTLTRTPLEPLEKNKQILVL
                     GLDGAGKTSVLHSLASNRVQHSVAPTQGFHAVCINTEDSQMEFLEIGGSKPFRSYWEM
                     YLSKGLLLIFVVDSADHSRLPEAKKYLHQLIAANPVLPLVVFANKQDLEAAYHITDIH
                     EALALSEVGNDRKMFLFGTYLTKNGSEIPSTMQDAKDLIAQLAADVQ"
     exon            352..514
                     /gene="ARL9"
                     /inference="alignment:Splign:2.1.0"
     exon            515..690
                     /gene="ARL9"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1447
                     /gene="ARL9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      955..960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL9"
                     /note="hexamer: AATAAA"
     polyA_site      977
                     /gene="ARL9"
                     /note="major polyA site"
     regulatory      1111..1116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL9"
                     /note="hexamer: AATACA"
     polyA_site      1131
                     /gene="ARL9"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL9"
                     /note="hexamer: AACAAA"
     polyA_site      1447
                     /gene="ARL9"
ORIGIN      
        1 acacctgggg cccagagcca ccgctcagca cgcgggcacg cggcgggagg gaaggaaacc
       61 gcggcgctgg ggatggagag ggggaaagtg aagaagaaag agaaggaaaa ggagacgcag
      121 gaggagaaaa tcggagaaaa gggtagggaa gagaaagtga aaagaaagga ggtggagcag
      181 aaaattaaac aaaagcaaga gaagcaggag aggagaaagg gaaaagagaa agaggaaaag
      241 aggacaaagc aagggaagga gacaaacaaa gagaaggaac aatttaaggg acaagaagag
      301 aaaggggaga acaaggacag caccttgaca aggaccccgc tcgagccgct ggagaaaaac
      361 aagcaaatcc tagtgctggg cctggatgga gcaggaaaaa ccagtgtcct gcactctcta
      421 gcttcaaaca gagtccagca cagtgtggca cccacccaag gtttccatgc agtttgcatc
      481 aacactgaag acagccagat ggagttcctg gagattggtg gcagtaaacc ttttcggtcc
      541 tactgggaaa tgtacctatc caagggattg ctgctgatct ttgtggtgga ttcagcagat
      601 cacagccgat tacctgaagc caagaaatac cttcatcagc taattgcagc aaacccagta
      661 cttcctctgg ttgtgtttgc aaacaaacag gatcttgaag cagcctatca cattacagat
      721 atccatgaag ctttggcatt atctgaagtg ggaaatgaca ggaagatgtt cttgtttgga
      781 acctacctga ctaagaatgg ctcagagata ccctccacca tgcaagatgc caaagacttg
      841 attgcacagc tggctgcaga tgtgcagtga ccaggactca gcccactgtg cggctcacga
      901 ctgagatgtc atcagtgttg aatggcaggc ttgaagccaa aggtttccac ctcaaataaa
      961 aattaagcca tttcctattt tctcagtgca tgggatgtat atagttagcc ctccatatcc
     1021 atgggttcca catctgggga ttcaagaact gtggatccaa aacattcaaa aagtaaaccc
     1081 actgaagaat aataacacaa caataaaaat aatacacatt ttaaaataca atataacaac
     1141 tatttacata gcattttcat tgtattaggt attataagta atctaaagat gatttaaaat
     1201 acacgagtag aagtgtgtag gttatatgta aatatgccat tttccatcag gagcttgagc
     1261 atccacattt gcctgtgagg atcttggaat cagtctccct gagaatacca acggacaact
     1321 gtacaaagat aatgctaaca taataacagc atctctattt ggattttgaa tgttaaaaat
     1381 atttgtaaaa cagtgtattg ggggtattgg gatttttaat caacaaaggt aaaatgaaca
     1441 ttagcaa
//
