LOCUS       NM_018184               2933 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens ARF like GTPase 8B (ARL8B), mRNA.
ACCESSION   NM_018184
VERSION     NM_018184.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2933)
  AUTHORS   Cao,M.M., Li,Y.M., Ding,X., Fang,F. and Yang,L.Y.
  TITLE     ARL8B promotes hepatocellular carcinoma progression and inhibits
            antitumor activity of lenvatinib via MAPK/ERK signaling by
            interacting with RAB2A
  JOURNAL   Cell Signal 124, 111470 (2024)
   PUBMED   39413890
  REMARK    GeneRIF: ARL8B promotes hepatocellular carcinoma progression and
            inhibits antitumor activity of lenvatinib via MAPK/ERK signaling by
            interacting with RAB2A.
REFERENCE   2  (bases 1 to 2933)
  AUTHORS   Rawat,S., Chatterjee,D., Marwaha,R., Charak,G., Kumar,G., Shaw,S.,
            Khatter,D., Sharma,S., de Heus,C., Liv,N., Klumperman,J., Tuli,A.
            and Sharma,M.
  TITLE     RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval
            for cargo sorting to lysosomes
  JOURNAL   J Cell Biol 222 (1) (2023)
   PUBMED   36282215
  REMARK    GeneRIF: RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR
            retrieval for cargo sorting to lysosomes.
REFERENCE   3  (bases 1 to 2933)
  AUTHORS   Ghosh,S., Dellibovi-Ragheb,T.A., Kerviel,A., Pak,E., Qiu,Q.,
            Fisher,M., Takvorian,P.M., Bleck,C., Hsu,V.W., Fehr,A.R.,
            Perlman,S., Achar,S.R., Straus,M.R., Whittaker,G.R., de
            Haan,C.A.M., Kehrl,J., Altan-Bonnet,G. and Altan-Bonnet,N.
  TITLE     beta-Coronaviruses Use Lysosomes for Egress Instead of the
            Biosynthetic Secretory Pathway
  JOURNAL   Cell 183 (6), 1520-1535 (2020)
   PUBMED   33157038
REFERENCE   4  (bases 1 to 2933)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2933)
  AUTHORS   Moest,T., Zhao,W., Zhao,Y., Schussler,J.M., Yan,W., Gorvel,J.P. and
            Meresse,S.
  TITLE     Contribution of bacterial effectors and host proteins to the
            composition and function of Salmonella-induced tubules
  JOURNAL   Cell Microbiol 20 (12), e12951 (2018)
   PUBMED   30212607
  REMARK    GeneRIF: Arl8b contributes to the recruitment of LAMP1 to
            Salmonella-induced tubules. Salmonella SifA protein interacts with
            Arl8b.
REFERENCE   6  (bases 1 to 2933)
  AUTHORS   Bagshaw,R.D., Callahan,J.W. and Mahuran,D.J.
  TITLE     The Arf-family protein, Arl8b, is involved in the spatial
            distribution of lysosomes
  JOURNAL   Biochem Biophys Res Commun 344 (4), 1186-1191 (2006)
   PUBMED   16650381
  REMARK    GeneRIF: Arl8b is involved in trafficking processes for lysosomes.
REFERENCE   7  (bases 1 to 2933)
  AUTHORS   Hofmann,I. and Munro,S.
  TITLE     An N-terminally acetylated Arf-like GTPase is localised to
            lysosomes and affects their motility
  JOURNAL   J Cell Sci 119 (Pt 8), 1494-1503 (2006)
   PUBMED   16537643
REFERENCE   8  (bases 1 to 2933)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 2933)
  AUTHORS   Okai,T., Araki,Y., Tada,M., Tateno,T., Kontani,K. and Katada,T.
  TITLE     Novel small GTPase subfamily capable of associating with tubulin is
            required for chromosome segregation
  JOURNAL   J Cell Sci 117 (Pt 20), 4705-4715 (2004)
   PUBMED   15331635
  REMARK    GeneRIF: Results suggest that the novel GTPases Gie1 and Gie2
            associate with microtubules, and might be involved in chromosome
            segregation.
REFERENCE   10 (bases 1 to 2933)
  AUTHORS   Secombe,J. and Parkhurst,S.M.
  TITLE     Drosophila Topors is a RING finger-containing protein that
            functions as a ubiquitin-protein isopeptide ligase for the hairy
            basic helix-loop-helix repressor protein
  JOURNAL   J Biol Chem 279 (17), 17126-17133 (2004)
   PUBMED   14871887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC063125.1 and AK001564.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018184.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.66611.1,
                                           SRR1660803.16300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256496.8/ ENSP00000256496.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2749              BC063125.1         50-2798
            2750-2933           AK001564.1         2758-2941
FEATURES             Location/Qualifiers
     source          1..2933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.1"
     gene            1..2933
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /note="ARF like GTPase 8B"
                     /db_xref="GeneID:55207"
                     /db_xref="HGNC:HGNC:25564"
                     /db_xref="MIM:616596"
     exon            1..297
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..735
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /EC_number="3.6.5.2"
                     /note="ADP-ribosylation factor-like 10C; ADP-ribosylation
                     factor-like protein 10C; novel small G protein
                     indispensable for equal chromosome segregation 1;
                     ADP-ribosylation factor-like 8B; GTPase indispensable for
                     equal segregation of chromosomes 1; ADP ribosylation
                     factor like GTPase 8B"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 8B"
                     /protein_id="NP_060654.1"
                     /db_xref="CCDS:CCDS2566.1"
                     /db_xref="GeneID:55207"
                     /db_xref="HGNC:HGNC:25564"
                     /db_xref="MIM:616596"
                     /translation="MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQ
                     FSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADRE
                     KIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCY
                     SISCKEKDNIDITLQWLIQHSKSRRS"
     exon            298..378
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..452
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..546
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..614
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..685
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2933
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1579..1584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /note="hexamer: AATAAA"
     polyA_site      1601
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /note="hexamer: AATAAA"
     polyA_site      2768
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /note="major polyA site"
     regulatory      2913..2918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
                     /note="hexamer: AATAAA"
     polyA_site      2933
                     /gene="ARL8B"
                     /gene_synonym="ARL10C; Gie1"
ORIGIN      
        1 atatgatccg ctcggcttcc tgggtctggc tgctgccgcc cgccggtgtc cgcccgtgtc
       61 gcgccggggc accaaggagc cgttggaggg tccgggcgga ggcccgctcg tgtggaagtc
      121 gtcgacgccg ccgctcgtcc gtcctcccgt ccgttctcgc tcccggccgc catcatgctg
      181 gcgctcatct cccgcctgct ggactggttc cgttcgctct tctggaagga agagatggag
      241 ctgacgctcg tggggctgca gtactcgggc aagaccacct tcgtcaatgt catcgcgtca
      301 ggtcaattca gtgaagatat gatacccaca gtgggcttca acatgaggaa ggtaactaaa
      361 ggtaacgtca caataaagat ctgggacata ggaggacaac cccgatttcg aagcatgtgg
      421 gagcggtatt gcagaggagt caatgctatt gtttacatga tagatgctgc agatcgtgaa
      481 aagatagaag cttcccgaaa tgagctacat aatcttctag ataaaccaca gttacaagga
      541 attccagtgc tagtgcttgg aaacaagaga gatcttccta atgccttgga tgagaaacag
      601 ctaattgaaa aaatgaatct gtctgctatt caggatagag aaatttgctg ctattcaatt
      661 tcttgcaaag aaaaggataa tatagatatc acacttcagt ggcttattca gcattcaaaa
      721 tctagaagaa gctgaagcat ctcctgaagt cttccagtcc ttcttggcta taatcctaga
      781 attattgtcc gttcctctga agtaattccc agaatacggt ccttcctaaa ccccagaaat
      841 tgcctttttc agagtttatt tctcatgtgc actgctgaag atgaatatcc ctaatccttc
      901 ataaagaatc agctagagtt gtcatgataa agtcagcaca cacaaaaagg cttcttacac
      961 atacctgtct taaaccatgt gtagagcttt aaaaacagaa aaaaaacccc atatacttat
     1021 gaccatctta aatcaagaaa attgcatatt tccattctgg tctttctggg ccagattttt
     1081 atattggttt tcagtaaatg tctatctata atatttcatt atagagtcca gtagcttaat
     1141 actgacactg acttgataca gcatgaagtt tctagtgcca cacacagtat ttagaaaacc
     1201 tttaggcgtg aatgactcat gtgggatata tgtaaacata atgtttattt tatctcacaa
     1261 atgcatgtga aatgtataat tacatcttag gaatccaaaa tggtctgcag agagtgagcg
     1321 gaggcaccag atcaatgttg gttctttgca ctggtgagat tctgcctgat gaatattaaa
     1381 gatatcctgc tttctgagaa ctctatcacc agatggcagt tgggatatgg gaggaactaa
     1441 agcatcctgt tttgtatctg tccagatcat tatttctgtc tcttgttttt tcttcctggt
     1501 tcaggatact tttttaaggg gttgagaatt gaagattttc caaaagcgtt catgaattta
     1561 gagcattcca cccaatataa taaaacctgt taagaatgtc agtctttgtt caaacatctg
     1621 tttgttctat ctccagtcat taaatcagtg ctgctgcatg acactcttaa ctcctgactt
     1681 tttatatcca gtcataaagt tgactttcag cacaaaagat acttataaac aaataaaaaa
     1741 tttttatttt tctctcttac tgatgtaagc tttggcactc ttttgactgg tgccattaga
     1801 catcttgatt attgtgacaa ctctagacct gcctgcttta tctaatgtaa tcatgctcaa
     1861 tgtctacagg ttgtttaata atcagtcaca cagagaactg aggaactgat gctgtttgtt
     1921 tgcttctatg atacagagat gtctaaaaac ttcaaatgga catgttttgt agtttagcga
     1981 cttccgtata cataaaggga catattaata ctggttcatt tgtaaattat tattcatata
     2041 gaccactgta gtagataaaa ctctatggta cacctgctta tgtgttgcct cacactgtgt
     2101 gtgattttgt ttcttttgtt aagcagcact tatgtagact gcatttccaa atgtgttgag
     2161 cactcagagt gtagtcaaca gtaagttctt ttaatgaata tcagttttaa tttatagact
     2221 gccatggcct taaaaatatt ctgtacaata tactgcactg tgttgcacag acactacttg
     2281 cttttctcca ttcatatttt tatgagtaga atctgggctt ttaaatttct cttcttattc
     2341 tttgaagcat gttgcatact accctggtgg gatggatggt tctgtaaatg aagggatatt
     2401 taaacttgct actgttgttc aacaccatta atggtcagtg tgaaccatta caaagaatgt
     2461 ggcaacttgc ttgtgcctaa aaggaggaat tggaactaga atgtgtgact ctgtggggac
     2521 tgcataggtt tgttaattga cctatagcta aaccttaatg tgtttgtgtg tctatacatt
     2581 gctttccgca tttcaagaca tccagacgct attaccaaca ttttcctgtg cattaacctc
     2641 tgcatgtgaa aacttttaac agttactgaa ctatgtaaat atgtgaattt ttttatttag
     2701 gtggatgcat tttttgtctg tttactgctc ttctcagctt tattcaataa acttgcattt
     2761 taagggttgt attggcaatt ttaacttaaa atgtgcatca tgatggaagg tgcagacttt
     2821 tttggaagtt tccgagagga gggtctatag accatttgtc agaaatcaga tcagccctca
     2881 aagaatgggg tctgtgggct agttaaaata gaaataaact tttaaaatat cca
//
