LOCUS       NM_006407               2134 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 6 interacting protein 5 (ARL6IP5),
            mRNA.
ACCESSION   NM_006407
VERSION     NM_006407.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Kim,J.Y., Bahar,E., Lee,J.Y., Chang,S., Kim,S.H., Park,E.Y.,
            Do,S.I., Yoon,H. and Kim,H.S.
  TITLE     ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and
            promoting apoptosis pathways in ovarian carcinoma
  JOURNAL   Cell Death Dis 13 (3), 239 (2022)
   PUBMED   35293383
  REMARK    GeneRIF: ARL6IP5 reduces cisplatin-resistance by suppressing DNA
            repair and promoting apoptosis pathways in ovarian carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Dai,Y., Wu,M. and Zhuang,H.
  TITLE     Correlation between JWA gene polymorphism and acute lymphoblastic
            leukemia
  JOURNAL   Minerva Med 112 (4), 534-536 (2021)
   PUBMED   31726816
  REMARK    GeneRIF: Correlation between JWA gene polymorphism and acute
            lymphoblastic leukemia.
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Xu,L., Cheng,L., Yang,F., Pei,B., Liu,X., Zhou,J., Zhu,Y. and
            Wang,S.
  TITLE     JWA suppresses the invasion of human breast carcinoma cells by
            downregulating the expression of CXCR4
  JOURNAL   Mol Med Rep 17 (6), 8137-8144 (2018)
   PUBMED   29658570
  REMARK    GeneRIF: These data demonstrated that JWA suppressed the
            migration/invasion of breast carcinoma cells by downregulating the
            expression of CXCR4, and suggested that JWA may harbor prognostic
            and therapeutic potential in patients with breast cancer.
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Qiu,D., Wang,Q., Wang,Z., Chen,J., Yan,D., Zhou,Y., Li,A.,
            Zhang,R., Wang,S. and Zhou,J.
  TITLE     RNF185 modulates JWA ubiquitination and promotes gastric cancer
            metastasis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (5 Pt A), 1552-1561 (2018)
   PUBMED   29481911
  REMARK    GeneRIF: increased RNF185 expression facilitated GC cell migration
            in vitro and promoted GC metastasis in vivo by downregulating JWA
            expression.
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Butchbach,M.E., Guo,H. and Lin,C.L.
  TITLE     Methyl-beta-cyclodextrin but not retinoic acid reduces
            EAAT3-mediated glutamate uptake and increases GTRAP3-18 expression
  JOURNAL   J Neurochem 84 (4), 891-894 (2003)
   PUBMED   12562531
  REMARK    GeneRIF: protein expression is upregulated by
            methyl-beta-cyclodextrin and not by retinoic acid
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Ikemoto,M.J., Inoue,K., Akiduki,S., Osugi,T., Imamura,T., Ishida,N.
            and Ohtomi,M.
  TITLE     Identification of addicsin/GTRAP3-18 as a chronic
            morphine-augmented gene in amygdala
  JOURNAL   Neuroreport 13 (16), 2079-2084 (2002)
   PUBMED   12438930
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Butchbach,M.E., Lai,L. and Lin,C.L.
  TITLE     Molecular cloning, gene structure, expression profile and
            functional characterization of the mouse glutamate transporter
            (EAAT3) interacting protein GTRAP3-18
  JOURNAL   Gene 292 (1-2), 81-90 (2002)
   PUBMED   12119102
  REMARK    GeneRIF: highly conserved protein and genomic organization amongst
            vertebrates
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   Lin,C.I., Orlov,I., Ruggiero,A.M., Dykes-Hoberg,M., Lee,A.,
            Jackson,M. and Rothstein,J.D.
  TITLE     Modulation of the neuronal glutamate transporter EAAC1 by the
            interacting protein GTRAP3-18
  JOURNAL   Nature 410 (6824), 84-88 (2001)
   PUBMED   11242046
REFERENCE   10 (bases 1 to 2134)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092060.2, BG483337.1,
            AF125530.1, AF070523.1 and BU149630.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006407.3.
            
            Summary: Expression of this gene is affected by vitamin A. The
            encoded protein of this gene may be associated with the
            cytoskeleton. A similar protein in rats may play a role in the
            regulation of cell differentiation. The rat protein binds and
            inhibits the cell membrane glutamate transporter EAAC1. The
            expression of the rat gene is upregulated by retinoic acid, which
            results in a specific reduction in EAAC1-mediated glutamate
            transport. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA554914.1, AF070523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273258.4/ ENSP00000273258.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC092060.2         127840-127841
            3-10                BG483337.1         2-9
            11-1233             AF125530.1         1-1223
            1234-2108           AF070523.1         1239-2113
            2109-2130           BU149630.1         340-361
            2131-2134           AC092060.2         148992-148995
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..2134
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /note="ARF like GTPase 6 interacting protein 5"
                     /db_xref="GeneID:10550"
                     /db_xref="HGNC:HGNC:16937"
                     /db_xref="MIM:605709"
     exon            1..287
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..678
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /note="PRA1 domain family 3; glutamate transporter
                     EEAC1-associated protein; dermal papilla derived protein
                     11; ADP ribosylation factor like GTPase 6 interacting
                     protein 5; putative MAPK activating protein PM27; JM5;
                     aip-5; protein JWa; ARL-6-interacting protein 5;
                     prenylated Rab acceptor protein 2; glutamate transporter
                     EAAC1-interacting protein; cytoskeleton-related vitamin
                     A-responsive protein; ADP-ribosylation factor-like protein
                     6-interacting protein 5; ADP-ribosylation-like factor 6
                     interacting protein 5; ADP-ribosylation factor-like 6
                     interacting protein 5; ADP-ribosylation factor GTPase 6
                     interacting protein 5"
                     /codon_start=1
                     /product="PRA1 family protein 3"
                     /protein_id="NP_006398.1"
                     /db_xref="CCDS:CCDS2912.1"
                     /db_xref="GeneID:10550"
                     /db_xref="HGNC:HGNC:16937"
                     /db_xref="MIM:605709"
                     /translation="MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQ
                     TNYLVVAAMMISIVGFLSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFV
                     MVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRT
                     PMGIVLDALEQQEEGINRLTDYISKVKE"
     exon            288..505
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /inference="alignment:Splign:2.1.0"
     exon            506..2134
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1419..1424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /note="hexamer: AATAAA"
     polyA_site      1441
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /note="hexamer: AATAAA"
     regulatory      2099..2104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /note="hexamer: ATTAAA"
     polyA_site      2108
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
                     /note="major polyA site"
     polyA_site      2134
                     /gene="ARL6IP5"
                     /gene_synonym="addicsin; DERP11; GTRAP3-18; hp22; HSPC127;
                     jmx; JWA; PRAF3; Yip6b"
ORIGIN      
        1 gcaaagccga ccgagacgga gccgctgtca actctccaac tcagctcagc tgatcggttg
       61 ccgccgccgc cgccgccaga ttctggaggc gaagaacgca aagctgagaa catggacgtt
      121 aatatcgccc cactccgcgc ctgggacgat ttcttcccgg gttccgatcg ctttgcccgg
      181 ccggacttca gggacatttc caaatggaac aaccgcgtag tgagcaacct gctctattac
      241 cagaccaact acctggtggt ggctgccatg atgatttcca ttgtggggtt tctgagtccc
      301 ttcaacatga tcctgggagg aatcgtggtg gtgctggtgt tcacagggtt tgtgtgggca
      361 gcccacaata aagacgtcct tcgccggatg aagaagcgct accccacgac gttcgttatg
      421 gtggtcatgt tggcgagcta tttccttatc tccatgtttg gaggagtcat ggtctttgtg
      481 tttggcatta cttttccttt gctgttgatg tttatccatg catcgttgag acttcggaac
      541 ctcaagaaca aactggagaa taaaatggaa ggaataggtt tgaagaggac accgatgggc
      601 attgtcctgg atgccctaga acagcaggaa gaaggcatca acagactcac tgactatatc
      661 agcaaagtga aggaataaac ataacttacc tgagctaggg ttgcagcaga aattgagttg
      721 cagcttgccc ttgtccagac ctatgttctg cttgcgtttt tgaaacagga ggtgcacgta
      781 ccacccaatt atctatggca gcatgcatgt ataggccgaa ctattatcag ctctgatgtt
      841 tcagagagaa gacctcagaa accgaaagaa aaccaccacc ctcctattgt gtctgaagtt
      901 tcacgtgtgt ttatgaaatc taatgggaaa tggatcacac gatttcttta agggaattaa
      961 aaaaaataaa agaattacgg cttttacagc aacaatacga ttatcttata ggaaaaaaaa
     1021 aatcattgta aagtatcaag acaatacgag taaatgaaaa ggctgttaaa gtagatgaca
     1081 tcatgtgtta gcctgttcct aatcccctag aattgtaatg tgtgggatat aaattagttt
     1141 ttattattct cttaaaaatc aaagatgatc tctatcactt tgccacctgt ttgatgtgca
     1201 gtggaaactg gttaagccag ttgttcatac ttcctttaca aatataaaga tagctgttta
     1261 ggatattttg ttacattttt gtaaattttt gaaatgctag taatgtgttt tcaccagcaa
     1321 gtatttgttg caaacttaat gtcattttcc ttaagatggt tacagctatg taacctgtat
     1381 tattctggac ggacttatta aaatacaaac agacaaaaaa taaaacaaaa cttgagttct
     1441 atttaccttg cacatttttt gttgttacag tgaaaaaaat ggtccaagaa aatgtttgcc
     1501 atttttgcat tgtttcgttt ttaactggaa catttagaaa gaaggaaatg aatgtgcatt
     1561 ttattaattc cttaggggca caaggaggac aataatagct gatcttttga aatttgaaaa
     1621 acgtctttag atgaccaagc aaaaagactt taaaaaatgg taatgaaaat ggaatgcagc
     1681 tactgcagct aataaaaaat tttagatagc aattgttaca accatatgcc tttatagcta
     1741 gacattagaa ttatgatagc atgagtttat acattctatt atttttcctc cctttctcat
     1801 gtttttataa ataggtaata aaaaatgttt tgcctgccaa ttgaatgatt tcgtagctga
     1861 agtagaaaca tttaggtttc tgtagcatta aattgtgaag acaactggag tggtacttac
     1921 tgaagaaact ctctgtatgt cctagaataa gaagcaatga tgtgctgctt ctgatttttc
     1981 ttgcatttta aattctcagc caacctacag ccatgatctt tagcacagtg atatcaccat
     2041 gacttcacag acatggtcta gaatctgtac ccttacccac atatgaagaa taaaattgat
     2101 taaaggtttt tttggtgaga ctttatttaa tgca
//
