LOCUS       NM_018694               1023 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ARF like GTPase 6 interacting protein 4 (ARL6IP4),
            transcript variant 1, mRNA.
ACCESSION   NM_018694
VERSION     NM_018694.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1023)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1023)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1023)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 1023)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1023)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 1023)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1023)
  AUTHORS   Fenner,B.J., Scannell,M. and Prehn,J.H.
  TITLE     Expanding the substantial interactome of NEMO using protein
            microarrays
  JOURNAL   PLoS One 5 (1), e8799 (2010)
   PUBMED   20098747
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1023)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1023)
  AUTHORS   Li,Q., Zhao,H., Jiang,L., Che,Y., Dong,C., Wang,L., Wang,J. and
            Liu,L.
  TITLE     An SR-protein induced by HSVI binding to cells functioning as a
            splicing inhibitor of viral pre-mRNA
  JOURNAL   J Mol Biol 316 (4), 887-894 (2002)
   PUBMED   11884129
REFERENCE   10 (bases 1 to 1023)
  AUTHORS   Sasahara,K., Yamaoka,T., Moritani,M., Tanaka,M., Iwahana,H.,
            Yoshimoto,K., Miyagawa,J., Kuroda,Y. and Itakura,M.
  TITLE     Molecular cloning and expression analysis of a putative nuclear
            protein, SR-25
  JOURNAL   Biochem Biophys Res Commun 269 (2), 444-450 (2000)
   PUBMED   10708573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026362.38.
            
            On Aug 11, 2020 this sequence version replaced NM_018694.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015909.1, BX436896.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315580.10/ ENSP00000313422.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC026362.38        53057-53121
            66-236              AC026362.38        53505-53675
            237-545             AC026362.38        53947-54255
            546-663             AC026362.38        54333-54450
            664-733             AC026362.38        54845-54914
            734-1023            AC026362.38        54996-55285
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1023
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /note="ARF like GTPase 6 interacting protein 4"
                     /db_xref="GeneID:51329"
                     /db_xref="HGNC:HGNC:18076"
                     /db_xref="MIM:607668"
     exon            1..65
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /inference="alignment:Splign:2.1.0"
     exon            66..236
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..790
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /note="isoform 1 is encoded by transcript variant 1; SRp25
                     nuclear protein; splicing factor, arginine/serine-rich 20;
                     HSVI binding protein; ADP ribosylation factor like GTPase
                     6 interacting protein 4; ADP-ribosylation factor-like
                     protein 6-interacting protein 4; splicing regulator
                     SRrp38; SR-15; aip-4; HSP-975; ARL-6-interacting protein
                     4; ADP-ribosylation-like factor 6 interacting protein 4;
                     splicing factor SRrp37; ADP-ribosylation factor-like 6
                     interacting protein 4; ADP-ribosylation factor GTPase 6
                     interacting protein 4"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein
                     6-interacting protein 4 isoform 1"
                     /protein_id="NP_061164.4"
                     /db_xref="CCDS:CCDS31923.3"
                     /db_xref="GeneID:51329"
                     /db_xref="HGNC:HGNC:18076"
                     /db_xref="MIM:607668"
                     /translation="MAHVGSRKRSRSRSRSRGRGSEKRKKKSRKDTSRNCSASTSQGR
                     KASTAPGAEASPSPCITERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRK
                     KRGKYKDKRRKKKKKRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEEDGPVLTD
                     EQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRTRLIKGDGEVLEEIVTKERHREIN
                     KQATRGDCLAFQMRAGLLP"
     exon            237..545
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /inference="alignment:Splign:2.1.0"
     exon            546..663
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /inference="alignment:Splign:2.1.0"
     exon            664..733
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /inference="alignment:Splign:2.1.0"
     exon            734..1023
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1002..1007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /note="hexamer: ATTAAA"
     polyA_site      1023
                     /gene="ARL6IP4"
                     /gene_synonym="SFRS20; SR-25; SRp25; SRrp37"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcgccg ccgcttcctc tcgagaaggc gcggggcggg ctgtccggcc cgcagggcgg
       61 tcgagcccgc ggcgccatgg ctcacgtcgg ctcccgcaag cgctcgagga gtcgcagccg
      121 gtcccgggga cgggggtcgg aaaagagaaa gaagaagagc aggaaagaca cctcgaggaa
      181 ctgctcggcc tccacatccc aaggtcgcaa ggccagcacg gcccctgggg cggaggcctc
      241 accttctccc tgcatcacag agagaagcaa gcagaaggcc cggaggagaa caagatccag
      301 ctcctcctcc tcttcttcca gttcttctag ctcctcttct tcctcctcgt cctcctcctc
      361 ttcctccagt gatggccgga agaagcgggg gaagtacaag gacaagagga ggaagaagaa
      421 gaagaagagg aagaagctga agaagaaggg caaggagaag gcggaagcac agcaggtgga
      481 ggctctgccg ggcccctcgc tggaccagtg gcaccgatca gctggggagg aagaggatgg
      541 cccagtcctg acggatgagc agaagtcccg aatccaggcc atgaagccca tgaccaagga
      601 ggagtgggat gcccggcaga gcatcatccg caaggtggtg gaccctgaga cggggcgcac
      661 caggcttatt aagggagatg gcgaggtcct agaggaaatc gtaaccaaag aacgacacag
      721 agagatcaac aagcaagcca cccgagggga ctgcctggcc ttccagatgc gagctgggtt
      781 gcttccctga gggcccccgc tggccaaggc ctgtggacga cgctggcggc ccagcctggg
      841 caggtttcag ggtgccagtg ggaagcctga tgggtgctgg tggcctttcc cccgtggatt
      901 ggtctctggc ccagcccagt ctcttctcag gggcaggggg tggaggttgg ggtcaccggc
      961 ctgcttggca cccccatctg aaagagcagc acttctcagc tattaaaggc cccctggata
     1021 gac
//
