LOCUS       NM_015161               2278 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens ARL6 interacting reticulophagy regulator 1 (ARL6IP1),
            transcript variant 1, mRNA.
ACCESSION   NM_015161
VERSION     NM_015161.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2278)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 2278)
  AUTHORS   Byrne,D.J., Garcia-Pardo,M.E., Cole,N.B., Batnasan,B., Heneghan,S.,
            Sohail,A., Blackstone,C. and O'Sullivan,N.C.
  TITLE     Liver X receptor-agonist treatment rescues degeneration in a
            Drosophila model of hereditary spastic paraplegia
  JOURNAL   Acta Neuropathol Commun 10 (1), 40 (2022)
   PUBMED   35346366
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2278)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2278)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2278)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2278)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2278)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   8  (bases 1 to 2278)
  AUTHORS   Lui,H.M., Chen,J., Wang,L. and Naumovski,L.
  TITLE     ARMER, apoptotic regulator in the membrane of the endoplasmic
            reticulum, a novel inhibitor of apoptosis
  JOURNAL   Mol Cancer Res 1 (7), 508-518 (2003)
   PUBMED   12754298
  REMARK    GeneRIF: novel endoplasmic reticulum integral membrane protein
            which protects cells by inhibiting caspase-9 activity and reveal a
            possible role for ARMER in cell survival
REFERENCE   9  (bases 1 to 2278)
  AUTHORS   Pettersson,M., Bessonova,M., Gu,H.F., Groop,L.C. and Jonsson,J.I.
  TITLE     Characterization, chromosomal localization, and expression during
            hematopoietic differentiation of the gene encoding Arl6ip,
            ADP-ribosylation-like factor-6 interacting protein (ARL6)
  JOURNAL   Genomics 68 (3), 351-354 (2000)
   PUBMED   10995579
REFERENCE   10 (bases 1 to 2278)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC406882.1 and BC010281.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015161.2.
            
            Summary: This gene belongs to the ARL6ip family and encodes a
            transmembrane protein that is predominantly localized to
            intracytoplasmic membranes. It is highly expressed in early myeloid
            progenitor cells and thought to be involved in protein transport,
            membrane trafficking, or cell signaling during hematopoietic
            maturation. Mutations in this gene are associated with spastic
            paraplegia 61 (SPG61). Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1135795.1,
                                           SRR3476690.254845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267779 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304414.12/ ENSP00000306788.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DC406882.1         131-144
            15-2278             BC010281.1         1-2264
FEATURES             Location/Qualifiers
     source          1..2278
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..2278
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /note="ARL6 interacting reticulophagy regulator 1"
                     /db_xref="GeneID:23204"
                     /db_xref="HGNC:HGNC:697"
                     /db_xref="MIM:607669"
     exon            1..119
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..695
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like 6 interacting protein 1;
                     ADP-ribosylation factor GTPase 6 interacting protein 1;
                     ADP ribosylation factor like GTPase 6 interacting protein
                     1; ARF like GTPase 6 interacting protein 1; apoptotic
                     regulator in the membrane of the endoplasmic reticulum;
                     ADP-ribosylation factor-like protein 6-interacting protein
                     1; aip-1; ARL-6-interacting protein 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein
                     6-interacting protein 1 isoform 1"
                     /protein_id="NP_055976.1"
                     /db_xref="CCDS:CCDS10572.1"
                     /db_xref="GeneID:23204"
                     /db_xref="HGNC:HGNC:697"
                     /db_xref="MIM:607669"
                     /translation="MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWF
                     PPAIMGVVSLVFLIIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQ
                     QRFHEICSNLVKTRRRAVGWWKRLFTLKEEKPKMYFMTMIVSLAAVAWVGQQVHNLLL
                     TYLIVTSLLLLPGLNQHGIILKYIGMAKREINKLLKQKEKKNE"
     exon            120..253
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /inference="alignment:Splign:2.1.0"
     exon            254..373
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /inference="alignment:Splign:2.1.0"
     exon            374..491
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /inference="alignment:Splign:2.1.0"
     exon            492..576
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /inference="alignment:Splign:2.1.0"
     exon            577..2278
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /note="hexamer: AATGAA"
     polyA_site      1913
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /note="hexamer: AATAAA"
     polyA_site      2278
                     /gene="ARL6IP1"
                     /gene_synonym="AIP1; ARL6IP; ARMER; SPG61"
                     /note="major polyA site"
ORIGIN      
        1 gggttgtggt tggtgtgcgg gtttcggttg gaggactcgt tggggaggtg gcctgcgctt
       61 gtagagactg catccccgag acgatggcgg agggagataa tcgcagcacc aacctgctgg
      121 ctgcagagac tgcaagtctg gaagaacagc tgcaaggatg gggagaagtg atgctgatgg
      181 ctgataaagt cctccgatgg gaaagagcct ggtttccacc tgccatcatg ggtgtggttt
      241 ctttggtgtt tctgattatc tactatctag atccatctgt tctgtccggc gtttcctgtt
      301 ttgttatgtt tttgtgcttg gctgactacc ttgttcccat tctagcgcct agaatttttg
      361 gctccaataa atggaccact gaacaacagc aaagattcca tgaaatttgc agcaatctag
      421 taaaaactcg acgcagagct gtgggttggt ggaaacgcct cttcacacta aaggaagaaa
      481 aacctaagat gtacttcatg accatgatcg tttcccttgc tgcggttgct tgggtgggac
      541 aacaagtcca caacctgctt ctcacctacc tgatagtgac ttccttacta ttgcttcctg
      601 gactaaacca acatggaatc attttgaagt acattggaat ggccaagagg gagataaaca
      661 aacttctcaa acaaaaagaa aagaaaaacg aatgattcat ctgctttaat cagtgtgatt
      721 aatgcagcac ccattgcccc gggaaccgtt tctgctgtac tatctggata ctaaaatgtt
      781 acggaagtag ctctttgttc tccctcactc tgcccttagt taatagaaat tcagactcgc
      841 caagtaaggc ttcgtgcata gtgtcttcat gtcgcgtata gttgagcgcg ttcttagcag
      901 ttggcttcat ggacaactca ttagtgtttt gacttttctt acccagcgtt aattgaattc
      961 ttgcttttag acaacttcct ttttgtagtg gtgaaccttg ccctttagta cagttcaagt
     1021 gaatctggat aattgttcat ctttgcttta gcttagatac catgtagtgg tctgtggcta
     1081 caggaagctg gttctgtctg cttccacagt ctgcttaaaa aactgtctga cttcgtgaat
     1141 atagagacca agtttaccac ttctgatgaa gagaccaatt aagattcatt cctcattctg
     1201 tttctttcca gtgggagaag agtccccatg aaataagatg aaactgattc catgcactag
     1261 tacatgtagg cttctccctt gtgcaaagct tagcaatttg taggaaactt tgatcttttt
     1321 gtccaagaaa aggaatgtct gacaggctta agctttcgtc cccttgcact tagactcgaa
     1381 gttagtaaat ccttaaaggc tttttaatag cagacttcca aaagattgca tttaggattt
     1441 ctagcatgct tttaatttca gattttcagc tgacattagc tatagtatac agtaggttaa
     1501 gactcatgtc tatgactttc actctaagac tggcaaaagg acagcagtct tctatgttta
     1561 gtcaatattc atttcagtag aagataatct tatctaattt ttgagaccag aataagcctt
     1621 ttaaggtaaa cctcaaaatt atcattttat ggtaatactg accattttag tcccctaggt
     1681 ttgacatggg agatagtgac tacactggtg tctgactttt ttcctagaga tttctccctg
     1741 aaaaatacaa gggctgttgg tgagagcaga cttgaggtga tgatagttgg cctctggtct
     1801 acaaagattt cataactcct tggaaagctt cttataatca ttcttaactt cttggtagct
     1861 agaaatttag agtagttgaa atctttagga atgaacttct gagggccaaa aaatgtgact
     1921 gacgggaaca attcttaaac tgattaacta gctgtaatat agttttgtga atttattgca
     1981 ctgatgttgt accttgtggt atatctgtcc ctattaaata agtgttgttt tctcctcttt
     2041 aatattgctg tgaacagtgg tgcccattgt agcatatgtt tgattttttt ttattatttc
     2101 ataagaaaac tacgttaatt ttaccttact ttcattgtaa ataagcctgt cttcctatct
     2161 ggattttttg tgtgcataca tattctactg attaactact tttgcagttt taatcctgta
     2221 ttatttcttc tactttgttt tgtgtaaaag gggaaaaaat aaaaaaagct ggaatctt
//
