LOCUS       NM_178815               7170 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 5B (ARL5B), mRNA.
ACCESSION   NM_178815
VERSION     NM_178815.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7170)
  AUTHORS   Houghton,F.J., Makhoul,C., Cho,E.H., Williamson,N.A. and
            Gleeson,P.A.
  TITLE     Interacting partners of Golgi-localized small G protein Arl5b
            identified by a combination of in vivo proximity labelling and
            GFP-Trap pull down
  JOURNAL   FEBS Lett 596 (18), 2382-2399 (2022)
   PUBMED   35789482
  REMARK    GeneRIF: Interacting partners of Golgi-localized small G protein
            Arl5b identified by a combination of in vivo proximity labelling
            and GFP-Trap pull down.
REFERENCE   2  (bases 1 to 7170)
  AUTHORS   Zhang,L., Hu,X., Wu,H., Tian,H., Zeng,J., Song,D., Yang,K.,
            Chen,J., Xu,J. and Dong,F.
  TITLE     Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and
            Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5
            Signaling
  JOURNAL   Curr Cancer Drug Targets 22 (10), 843-853 (2022)
   PUBMED   35546774
  REMARK    GeneRIF: Knockdown of ARL5B Induces Mitochondrial-mediated
            Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by
            Activating MDA5 Signaling.
REFERENCE   3  (bases 1 to 7170)
  AUTHORS   Jaimon,E., Tripathi,A., Khurana,A., Ghosh,D., Sugatha,J. and
            Datta,S.
  TITLE     Binding with heat shock cognate protein HSC70 fine-tunes the Golgi
            association of the small GTPase ARL5B
  JOURNAL   J Biol Chem 297 (6), 101422 (2021)
   PUBMED   34798070
  REMARK    GeneRIF: Binding with heat shock cognate protein HSC70 fine-tunes
            the Golgi association of the small GTPase ARL5B.
REFERENCE   4  (bases 1 to 7170)
  AUTHORS   Zhao,S., Zhang,Y., Pei,M., Wu,L. and Li,J.
  TITLE     miR-145 inhibits mitochondrial function of ovarian cancer by
            targeting ARL5B
  JOURNAL   J Ovarian Res 14 (1), 8 (2021)
   PUBMED   33419459
  REMARK    GeneRIF: miR-145 inhibits mitochondrial function of ovarian cancer
            by targeting ARL5B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7170)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7170)
  AUTHORS   Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
            Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
  TITLE     GWAS for discovery and replication of genetic loci associated with
            sudden cardiac arrest in patients with coronary artery disease
  JOURNAL   BMC Cardiovasc Disord 11, 29 (2011)
   PUBMED   21658281
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7170)
  AUTHORS   Han,M.R., Schellenberg,G.D. and Wang,L.S.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association reveals genetic effects on human Abeta42
            and tau protein levels in cerebrospinal fluids: a case control
            study
  JOURNAL   BMC Neurol 10, 90 (2010)
   PUBMED   20932310
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7170)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 7170)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   10 (bases 1 to 7170)
  AUTHORS   Sebald,E., Krueger,R., King,L.M., Cohn,D.H. and Krakow,D.
  TITLE     Isolation of a new member of the ADP-ribosylation like factor gene
            family, ARL8, from a cartilage cDNA library
  JOURNAL   Gene 311, 147-151 (2003)
   PUBMED   12853149
  REMARK    GeneRIF: ARL8 contains six exons and five introns, and encodes a
            179 amino acid protein that shares homology to the other ARL
            proteins.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512641.9 and AL133611.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178815.4.
            
            Summary: ARL5B (ARL8) belongs to a family of proteins that are
            structurally similar to ADP-ribosylation factors (ARFs; see MIM
            103180). ARLs and ARFs are part of the RAS superfamily of
            regulatory GTPases.[supplied by OMIM, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027275.1, SRR1660803.160272.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377275.4/ ENSP00000366487.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AL512641.9         23488-23740
            254-314             AL512641.9         30632-30692
            315-462             AL512641.9         32587-32734
            463-546             AL512641.9         36679-36762
            547-698             AL512641.9         38041-38192
            699-4668            AL512641.9         39225-43194
            4669-7170           AL133611.1         1019-3520
FEATURES             Location/Qualifiers
     source          1..7170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.31"
     gene            1..7170
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /note="ARF like GTPase 5B"
                     /db_xref="GeneID:221079"
                     /db_xref="HGNC:HGNC:23052"
                     /db_xref="MIM:608909"
     exon            1..253
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..747
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /note="ADP-ribosylation factor-like 8;
                     ADP-ribosylation-like factor 8; ADP-ribosylation
                     factor-like 5B; ADP-ribosylation factor-like protein 8;
                     ADP ribosylation factor like GTPase 5B"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 5B"
                     /protein_id="NP_848930.1"
                     /db_xref="CCDS:CCDS7131.1"
                     /db_xref="GeneID:221079"
                     /db_xref="HGNC:HGNC:23052"
                     /db_xref="MIM:608909"
                     /translation="MGLIFAKLWSLFCNQEHKVIIVGLDNAGKTTILYQFLMNEVVHT
                     SPTIGSNVEEIVVKNTHFLMWDIGGQESLRSSWNTYYSNTEFIILVVDSIDRERLAIT
                     KEELYRMLAHEDLRKAAVLIFANKQDMKGCMTAAEISKYLTLSSIKDHPWHIQSCCAL
                     TGEGLCQGLEWMTSRIGVR"
     exon            254..314
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /inference="alignment:Splign:2.1.0"
     exon            315..462
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /inference="alignment:Splign:2.1.0"
     exon            463..546
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /inference="alignment:Splign:2.1.0"
     exon            547..698
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /inference="alignment:Splign:2.1.0"
     exon            699..7170
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7152..7157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /note="hexamer: AATAAT"
     polyA_site      7170
                     /gene="ARL5B"
                     /gene_synonym="ARL8"
                     /note="major polyA site"
ORIGIN      
        1 agtgggctcg aaacaaaggg ctgtccggtg gggattcgtc gcggcgcctt ctgagtggtc
       61 gggtcgaggc ttctcggcct agcagtgccc tcgctgcgcg atctcaggcg ggttctcctc
      121 ggctccgcgc agcccgcgcc gcggtggggg acccggcgca gcggcacctg ctgccgaggg
      181 accccgcggc ccgccccggt gctcgtgatg gggctgatct tcgccaaact gtggagcctc
      241 ttctgtaacc aagaacacaa agtaattata gtgggactgg ataatgcagg gaaaaccacc
      301 attctttacc aattcttaat gaatgaagtg gttcatactt ctccaaccat aggaagcaat
      361 gttgaagaaa tagttgtgaa gaacactcat tttcttatgt gggatattgg tggtcaggag
      421 tctctgcgat catcctggaa cacatattac tcaaatacag agttcatcat tcttgttgtt
      481 gatagcattg acagggaacg actagctatt acaaaagaag aattatacag aatgttggct
      541 catgaggatt tacggaaggc tgcagtcctt atctttgcaa ataaacagga tatgaaaggg
      601 tgtatgacag cagctgaaat ctcgaaatac ctcaccctta gttcaattaa ggatcatcca
      661 tggcacattc aatcctgctg tgctctcaca ggagaagggt tatgccaagg tctagagtgg
      721 atgacctccc ggattggtgt gagataactt ttttgcttga aagagactgc tctatttatt
      781 ctgtgacatg aacatttttt cctagtacct ttggctgcta aggcagcagc atgtttaatt
      841 tataacaaca caaacctctg agagcaacac ttgaatcaag tgcagctgaa ctggaacata
      901 aaagattttt tcttaacttt ttttttttaa cacactaatc ttcagttgga tgaatgtaat
      961 gtataactat gttttcagca acaattcttc tgtttattct aattaatcag tgactgcctt
     1021 gtaagaaatg tttgtcatat gcgtgatgtc ttctgaaata ttcttataac cttaatgacc
     1081 aattgctttc aattcttgac cagcactccc tcccaaccag agaattactg gtttgataga
     1141 gtagtcttgg aaaccatcag gtactgcctg cagacttctc cagcactaaa tatatttgtt
     1201 ccctctataa accattcatc tttcggacag aacttactgt aaagaaagaa atctgcctag
     1261 aggatatatg taaggaagat tccacatcat gagtacttgc cttttaactt tcccccacat
     1321 tactgttgag tcatggaata atgtttaagt tgttatttgc atggaaatta agtaggctgt
     1381 ttatttatct aaaggaatca agtccactct tctgcctgca acatttgttc aaaaactaac
     1441 caaggtaaaa tatttatttg aaagcccaac tttgatgtta aatattcttg aataaatctg
     1501 ttattttaag aatatcacat tattcaatgc atataaaact atcagaagtt agtaaatcat
     1561 accagcacta aaaataagac aattggaata tattttagca tcagtttaca aacaacttta
     1621 ttatcaacag aaattttagc tcttttcttt gcaagatata tcacagctgc tttgggcagt
     1681 agctgaagcc gaagtatgaa cagtccattt tgtttcttaa aatttgaagt cgtgtctgtc
     1741 atagcatttt tactaccagc agtatgttac ttaaaaaact acatggcttt ccttgaattt
     1801 atttgacggt attatgtaat agacttgaaa caattgccat ctttgtagtt atgccttggg
     1861 ttctaaaatg ttataggaaa ctgctgaatt gaatcctagc ttttagaata ttaataggag
     1921 actcaaagtt aatattctta acaacttaaa attaaaaaaa gtcataatct atcaaaagtt
     1981 tatttattgg atggcattaa aacatttttg aggcagttgt ctaatatgaa caataatcta
     2041 aacaatatat tccttaaatt aagaggaaag acaagtgtcg tatttcgatc ctgtttattc
     2101 aaatgtgtga ttttgctgaa atgaaaggga taaaatgaat acttagagaa taatacttca
     2161 tttttgcagt actttttaat tttgataaaa aagatacaaa gttcataata tcaaaatatg
     2221 tgttcaaaat tggtatttta attttaatat ttttgtaagt tgatttaaat tttgctcttt
     2281 tttcaggtgt gcttggttta ttatatttag tcaagttaat ttagtcgaat gtggtaacat
     2341 ttttctgatt tatctttagt tggagcacac ccttgaactg aacagtggcc aaaggaaagc
     2401 tttctgggct ttggaaagta gttgtttaac tttgttttaa gccgttttct tagtgattct
     2461 gtatcaagta gaggataagt gtagtttaac ttagttttta atataaccca taatcaagaa
     2521 catgagcgaa aagcagacat aaatcgatat ggatggtttg tggtgtgtgt gggatgtggg
     2581 ggaattaaga aaatgccatt tacctaagca cagtttgcct gaatttctgc ttggttgtgt
     2641 tgtttaccgt aagtactgag ggtagtttcc ctaagtctgt cctgagaaaa agcatactta
     2701 gtactcctgt atttgttctt atgaaatgac tatctgcctt cttgtatcta gtaagattgg
     2761 ctggctcaat tttcttctgt caaattatat ggttattttt tatattacca catcagcatt
     2821 atattaaaag tgtttttaat agttgattgt attttgccaa ctactagtat agactcaaat
     2881 ttgctattta atttttaaaa tacaatttat tttgtaaatc ctttaaaaaa tatttggtta
     2941 gttttggatt agaaatgatt tatgttagcc atgtgttgaa gatgaaattg gcatcagtgt
     3001 agacggtgct gattgggaaa agttcatgat taggaaattc atgtaagact ttttaagagt
     3061 attttttagg ttttcactca atctttcctg tcacagtaac gtgaaaactg attattcttt
     3121 actccaagag aatgttttaa cccaagcaag tatctaatac tagagcattg gttctgacat
     3181 tcattgtaaa tcagtgaact gtaagatact gtctaaaaaa tgtacatttg taattagtgc
     3241 ctttattcat attttgaaat aagttcttag ttttatatta tacctgttct ttagaagtca
     3301 tgttagcagc taattatttc agtgatgaaa taatttgtgt tttatatccc ccttcacctc
     3361 catgtattgg ttagcacagt ttatagtaag tgaaaagcaa gggacccacc tacattacct
     3421 tcaggagact gttctacctt ttaatttgaa aacaaggaaa ttaaatttta acagaaatct
     3481 tttaagtatg ttataaccaa agtgttcaat tatccttgca agttcaaata cagcattttt
     3541 cttaattttg agcgtgtcat gtccttcatc tttaaaccca tcattcttat tgaagcccat
     3601 ttgagaactc ttagaattaa tagaaccttt tataagggaa tatatggaat attttttatt
     3661 gttaatgtaa cttaattcct taaaacctgg aatattaata tatataatct attaaaagct
     3721 gaagattaaa tatgtaattt ttgcttttag tttcttgtgt tagtatgctt aaaggtatca
     3781 atacttttat tctatattca ttagaagaaa ggtaataaat ttaagtttca ttgctgaaaa
     3841 attttaaatg agtgccaccc catagccata gtcattttga ttaagcataa tttaactttc
     3901 attatagcat aaagagaaaa taattatttt agtatggaaa cagtgatagg cagtgctgta
     3961 aacaatattc tctgaaaagt tgtgggggtc acaaagaaaa ttttaaagaa tatagaagct
     4021 tttttaaaaa atctttttag tgtagtttct tagaacaaat tataaacata atcattctga
     4081 ataatcaatt tttatttagt ccttaactat gtaaaaccgt atcagtagaa aaatgtgctg
     4141 gtgtcgtgtc taaagatgga taaatttctt tggaatttat ctttggagac caactttatg
     4201 aggcagactt tttgtctaca gctttggaac caaaaaaact tcactctaat tcagtcctaa
     4261 aggctatttt acattttgcc ggggtaaagt gacttcaaga tacagcatgg tgtcttgtat
     4321 ctagtagaat attgtgctag ccatctaaaa aagtggattt gagccttaat ttggccgttt
     4381 ctcaattgtc tagttgacct tagacaatta gtgtccatgg ctttcctttt gtttttccca
     4441 tactgaggaa cttaaactac agctctaaaa tgtcttttgg ttttaaaatt ctgaatgctt
     4501 atatactact attaaaaatt aaaaatccct caaatagtag ggcaatacag gtaatatgaa
     4561 attaaatgta tttttatcca ttatttgatt cccacctgtt attttattta gaatacgaat
     4621 acaaccaagt agggaaaaac gtatcagtaa ctgctattca acttaaattc agcgaattaa
     4681 tagctgaata gaaatagcta atgacaatgc aaaagagaaa acaagccata ttgctaagaa
     4741 aaggatagta agctgcttag aaagaaccag cctgtgttgg aaataattct cttctagata
     4801 atttacctta ttttcttggc ttgtactaat tgaatggaag tggttaattt gttcagagtt
     4861 tattgccgtt tgatgccacc ccagtctata gttctgtgtg actttccata ttgaaagagt
     4921 agggttagta gccaggttgt cagtctttta caaatgtcta cataaatgtc tacataaatc
     4981 tgaaagtggt ttatattcaa ggttagtttt tcagtagcgt ctcctcctta ttcattcact
     5041 tttactgtga agactgaaat ccaaaagcca ggttccccaa aaaagtattt ttaaaaaatt
     5101 ttaggggacc aaaataaata gaggaagacc aatataaaaa aatatgttca actattccat
     5161 tttaaattta aagcagaaaa aaaaattgtg cccctcagac ctaaaggcag ctttaaatgt
     5221 atatagtttg gtgaaacatt tgggaaatat taatttggag gtttagaagc atacgaaaaa
     5281 caaattcaaa gcacttgaaa gtaaagacaa tatcatgagg tcgaaaaaac ttcaaaagga
     5341 tattaggtaa gagaaaatgt gaatgaaagc agtgaatttc tgcctctcct cgtatttagg
     5401 gtacttaaaa ttactaaaaa atactgtctt tttaccatac agctagatgg cctgtattat
     5461 tcttaatgtg gccaaaggag tgaagactga ttagggtttt agaatttgga actgtagtca
     5521 cataaaggca tcttttgcat ttcttaaacc agtaatctac attttctcct ggaaatggag
     5581 aaatatgaaa tgtgctgtgc atagcttttg gaatagaaaa caaagtttta aaagaatgga
     5641 tatgttttct tgcacaactt gtaaaatttt aattaaaaaa ttacctcatt tttcaatcca
     5701 taaggtgctt tgctcaagtt tgtgggatgt ttgtaccatc ccataaaaac ccccttcacc
     5761 caaactgtat ttgaaatatg caaaattcat aactaaggga tagcattcct tggagacttt
     5821 gttttgtttt actcttgttt accagctggg ccaacatggt agatatatga gattcacata
     5881 tggtttcatt aaagcacata ggaaagtgct cagtcaatat ttaattagtt taattagata
     5941 agggaaagga gaaatcctaa atttgatgga ttcttttata ctgtgaatat atttccatca
     6001 gtgttggtaa gatatcaaat gactatcagt tgatcccagt catcagtgac ttatttgcat
     6061 atttaagccc tattcacaag agaccataat cattttaatc ttatattttc cctcaggaaa
     6121 tttagggact ctgaagcccc tattttattc tcttggagta aactgttgag tgtagttaca
     6181 aaaactttta tttatgactt aaaaaaagtt tagctgctat ttcagtgaaa gtgtaaaata
     6241 aaacggtcat gatttttttc aattacagaa tagttacaaa ttttaccatg ttcatctatt
     6301 ccacagagca tgttaaaaac aacaacaaca aaaacctaac agcaattaca accttggtgt
     6361 tgcgtttatt ctaatcagag tgaatgatta taatcacact ttgctatttt aacataaatt
     6421 ggtgctttag agcattaaag aggaagcagc aggccctgta ctcagtattt attatttctt
     6481 gcctcagaat gcaaaacaac tttaaagtgt ctatattcat atatatgtgc atttcttaag
     6541 atttaaatac aaactgttgt tactccttaa gcttcaggct ttctgcgaaa gctctaagaa
     6601 tatcttcatt actatgcttg gtcaactgga agatggtatt aataaggtca gaattaggaa
     6661 ttggattgct ctgtgggtcc tccggtattg tgcagaggaa agaaaaatgt ctttcacacc
     6721 acaaactgtg tgtctgaacc ccagccaaac aaatgtgttc cattggtcca atatataagc
     6781 attaacaaca acaacaaaaa atttaaaaca agtaaattaa tgcattcaca tgatcacttc
     6841 ttgaaaatgg ttcaaagcat gttttcctga tggtgggatt gtttaaatga catgttttaa
     6901 agtttttaat actttattag ttatgaagtg cttcttttat atgttaagtt taggttgcca
     6961 gtactcataa tttttatttc tgcaattatg ttataatgag ttgtttgcat gcctacttaa
     7021 cccaagtaaa acgatgctgt ttgctctgga atgttcatct tttagacagg ttttggctca
     7081 tttccaatca tggtgcaata tagtgtaaca ttcatttgtt ttcattcaac agttttattt
     7141 ttgtcataat aaataattac ttttccaata
//
