LOCUS       NM_012097               5264 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ARF like GTPase 5A (ARL5A), transcript variant 1,
            mRNA.
ACCESSION   NM_012097
VERSION     NM_012097.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5264)
  AUTHORS   Ishida,M. and Bonifacino,J.S.
  TITLE     ARFRP1 functions upstream of ARL1 and ARL5 to coordinate
            recruitment of distinct tethering factors to the trans-Golgi
            network
  JOURNAL   J Cell Biol 218 (11), 3681-3696 (2019)
   PUBMED   31575603
  REMARK    GeneRIF: The ARFRP1 functions upstream of two other ARL GTPases,
            ARL1 and ARL5, which in turn recruit golgins and GARP,
            respectively, to the trans-Golgi network (TGN).
            Erratum:[J Cell Biol. 2019 Nov 4;218(11):3880-3881. doi:
            10.1083/jcb.20190509710072019c.. PMID: 31604800]
REFERENCE   2  (bases 1 to 5264)
  AUTHORS   Shi,M., Chen,B., Mahajan,D., Boh,B.K., Zhou,Y., Dutta,B., Tie,H.C.,
            Sze,S.K., Wu,G. and Lu,L.
  TITLE     Amino acids stimulate the endosome-to-Golgi trafficking through
            Ragulator and small GTPase Arl5
  JOURNAL   Nat Commun 9 (1), 4987 (2018)
   PUBMED   30478271
  REMARK    GeneRIF: Arl5, an ARF-like family small GTPase, interacts with
            Ragulator in an amino acid-regulated manner and both Arl5 and its
            effector, the Golgi-associated retrograde protein complex (GARP),
            are required for the AA-stimulated trafficking.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5264)
  AUTHORS   Rosa-Ferreira,C., Christis,C., Torres,I.L. and Munro,S.
  TITLE     The small G protein Arl5 contributes to endosome-to-Golgi traffic
            by aiding the recruitment of the GARP complex to the Golgi
  JOURNAL   Biol Open 4 (4), 474-481 (2015)
   PUBMED   25795912
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5264)
  AUTHORS   Wang,Q., Huang,Z., Guo,W., Ni,S., Xiao,X., Wang,L., Huang,D.,
            Tan,C., Xu,Q., Zha,R., Zhang,J., Sheng,W., He,X. and Du,X.
  TITLE     microRNA-202-3p inhibits cell proliferation by targeting
            ADP-ribosylation factor-like 5A in human colorectal carcinoma
  JOURNAL   Clin Cancer Res 20 (5), 1146-1157 (2014)
   PUBMED   24327274
  REMARK    GeneRIF: microRNA-202-3p inhibits cell proliferation by targeting
            ADP-ribosylation factor-like 5A in human colorectal carcinoma.
REFERENCE   5  (bases 1 to 5264)
  AUTHORS   Wang,Z.X., Shi,L., Liu,J.F., An,X.M., Chang,W.R. and Liang,D.C.
  TITLE     2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the
            small GTP-binding proteins
  JOURNAL   Biochem Biophys Res Commun 332 (3), 640-645 (2005)
   PUBMED   15896705
  REMARK    GeneRIF: crystal structure
REFERENCE   6  (bases 1 to 5264)
  AUTHORS   Lin,C.Y., Li,C.C., Huang,P.H. and Lee,F.J.
  TITLE     A developmentally regulated ARF-like 5 protein (ARL5), localized to
            nuclei and nucleoli, interacts with heterochromatin protein 1
  JOURNAL   J Cell Sci 115 (Pt 23), 4433-4445 (2002)
   PUBMED   12414990
  REMARK    GeneRIF: developmentally regulated ARL5, with its distinctive
            nuclear/nucleolar localization and interaction with HP1alpha, may
            play a role(s) in nuclear dynamics and/or signaling cascades during
            embryonic development
REFERENCE   7  (bases 1 to 5264)
  AUTHORS   He,H., Dai,F., Yu,L., She,X., Zhao,Y., Jiang,J., Chen,X. and
            Zhao,S.
  TITLE     Identification and characterization of nine novel human small
            GTPases showing variable expressions in liver cancer tissues
  JOURNAL   Gene Expr 10 (5-6), 231-242 (2002)
   PUBMED   12450215
REFERENCE   8  (bases 1 to 5264)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097448.2.
            
            On Nov 23, 2018 this sequence version replaced NM_012097.3.
            
            Summary: The protein encoded by this gene belongs to the ARF family
            of GTP-binding proteins. With its distinctive nuclear/nucleolar
            localization and interaction with HP1alpha, the protein is
            developmentally regulated and may play a role(s) in nuclear
            dynamics and/or signaling cascades during embryonic development.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. This gene has multiple pseudogenes.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.153524.1,
                                           SRR1660807.82911.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295087.13/ ENSP00000295087.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC097448.2         45643-45933         c
            292-352             AC097448.2         32651-32711         c
            353-500             AC097448.2         31681-31828         c
            501-584             AC097448.2         29869-29952         c
            585-736             AC097448.2         24333-24484         c
            737-5264            AC097448.2         16309-20836         c
FEATURES             Location/Qualifiers
     source          1..5264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..5264
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /note="ARF like GTPase 5A"
                     /db_xref="GeneID:26225"
                     /db_xref="HGNC:HGNC:696"
                     /db_xref="MIM:608960"
     exon            1..291
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..785
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like 5; ADP-ribosylation
                     factor-like protein 5; ADP-ribosylation factor-like
                     protein 5A; ADP-ribosylation factor-like 5A; ADP
                     ribosylation factor like GTPase 5A"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 5A isoform
                     1"
                     /protein_id="NP_036229.1"
                     /db_xref="CCDS:CCDS2195.1"
                     /db_xref="GeneID:26225"
                     /db_xref="HGNC:HGNC:696"
                     /db_xref="MIM:608960"
                     /translation="MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHT
                     SPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVT
                     REELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCAL
                     TGEGLCQGLEWMMSRLKIR"
     exon            292..352
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /inference="alignment:Splign:2.1.0"
     exon            353..500
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /inference="alignment:Splign:2.1.0"
     exon            501..584
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /inference="alignment:Splign:2.1.0"
     exon            585..736
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /inference="alignment:Splign:2.1.0"
     exon            737..5264
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /note="hexamer: AATAAA"
     polyA_site      3082
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /note="major polyA site"
     regulatory      5238..5243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
                     /note="hexamer: AATAAA"
     polyA_site      5264
                     /gene="ARL5A"
                     /gene_synonym="ARFLP5; ARL5"
ORIGIN      
        1 gcagacaacg cggcggcgat gtccgcgagc caggcgagtg ccgcggcggc agcggcgggg
       61 ccttgcgcgc ggcagggcgg cctgggcttc ggcctccctc cggttccctg gaagcgggcc
      121 cgcgaccagc gcgggagcag cagcagaggc ggaggctcca gcgcgtctct ctcctccccc
      181 tcagcctgag ccgggggaag ccaggcggcc cgggtgtctg gagggggggg gtccgctgcc
      241 cgagaatggg aattctcttc actagaatat ggagactgtt caatcaccag gagcacaaag
      301 ttatcattgt tgggctggat aatgcaggga aaactaccat tctttaccaa ttttctatga
      361 atgaagttgt acatacatct cctacaatag gaagtaatgt agaagagata gtgattaata
      421 atacacgttt cctaatgtgg gatattggtg gccaagaatc tcttcgttct tcctggaaca
      481 cttactatac taacacagag tttgtaatag ttgttgtgga cagtacagac agagagagga
      541 tttctgtaac tagagaagaa ctctataaaa tgttagcgca tgaggaccta agaaaagctg
      601 gattgctgat ttttgctaat aaacaagatg ttaaagaatg catgactgta gcagaaatct
      661 cccagttttt gaagctaact tctattaaag atcaccagtg gcatatccag gcatgctgtg
      721 ctctaactgg cgagggattg tgccaaggac ttgaatggat gatgtcacga cttaagatta
      781 gatgatctct actgacctct tctcatagat tttgtataaa tgaagtgctg gactttacct
      841 gaaagctgca aaaattaatg gtttagatat atttataata aactgattta aactttttct
      901 ataagaagaa aaattaagac cacttatttg aaaacaaaga tgaagtctca ccttccagtt
      961 tgctttctca ttagtttttt ccaaagtaag ttattgaagc tgtgattgac atttttctca
     1021 taatgaatcc tctcaggaca ttgtgtagcc tatggtaagt acaaagggag aggaagacat
     1081 tttgaatttt aagagcttta ttatcagttt aaccctccct agttgaatgt tattttcttc
     1141 ttgttccatt aagtcagaat acaaatcagc acagatattc gaatgtttcc aatattttaa
     1201 aatgtaatgt tacttatgaa aagtattttg cttaaggttg tgtgtgtatt gtgtatatac
     1261 ctcaagttca agttaatggc attgatttat gttccagaca aaaataacac aaataataat
     1321 atccttcgtt ataaccacaa tgagataagt attggcatta gtgttcagtg ccattttata
     1381 ctttctctct gtgttctctg tattgtacta accaacctcc caaatcgctg agctgcttgt
     1441 ttaaaaaaaa aaaaaaggaa aaggaaaaag catgacattg tgtatcgatt ttttgttgtt
     1501 gaccaaaatc acacacatgg aaacatgtaa ttcaacagag tgggaaagct agcagattct
     1561 tggcttagta ttactaatag gcaggattgt acaatgagca actatcagat tattcctttc
     1621 agtggttctt atggcatcta aattactgaa taaattatta atccattaat cagtgaatca
     1681 aattatgatt acaattatca aatgaatgct cagcattaat tgaaaactgt tttgtgaaac
     1741 atgtctaccc agaaaagtag cattctataa atactattaa acaacttagc tatattattt
     1801 ttaagtatta aattatatgt caagcagtta aagtgaattt cagagtaaaa gtaaggcatg
     1861 tttctgagca acattgataa tttcttaatt tgcaaatttc ttcttatttt ggtacttgga
     1921 atatagtgtg agatttttta tttctaaatt ttgttgtatc ttctattaca taaatgcatt
     1981 gacaattata aaatgcaagt gttttttgaa tgattttaag aatttggctt aaaaattgat
     2041 tgatacaacg tattatttgt actaagaagt aacttgaccc aaaacacctt ttatgtttgc
     2101 ttagggtata ttttttcagt gtctgaaagt caaaggtatt cctgtcacaa ctgtaaacaa
     2161 acttatccta aatgtgttaa aacatattct tgggtactct atttatgtat ctttcatgcc
     2221 ttgaaaatct gaaggttaat ccaaactcac atgttttagc atatttgaga aaaaaaaact
     2281 accttcaata tcagcctttt aaatttcatg aagattttgg tgaggaataa tagtatatag
     2341 tttaagtatt gacaaaactt tgaaagtttc tttctttaaa atgggaaata ctcaatatct
     2401 aaatccaggt caggcatggg atatcagtat ttaacattgg atgttttatg ttttatattt
     2461 ataatgttca aaatgcaagc ataacattta atatttgtcc acatggtttt acaaaagtaa
     2521 atcttaaatt actaagcttt tcccatatgt tctcgtactt tctcaaatcc ctataaagaa
     2581 ttacttgtta tctattaaaa atctccttta cccaaatctg tattatggtt tcgccagaca
     2641 aatattatgt gatgtagccc agaaaatcca caccttttgt cctttttatg ttttaatttg
     2701 aataatcatg tgcttagtcc cttggattac tgccacatca gtttaacacg atatcagcac
     2761 attcccttgt catcatcaag gtgttggctc agatttattc ttaattggat gtttaaagca
     2821 tgtactacct tgttacagtt ggtttagtgt agtggattat tgacatgaca tcatgagaag
     2881 atgtgtaatt ttataccaca tttataaaac atgattttgt tttctaccct tcaaggtaaa
     2941 cattaaaaat aaggtggtac ttgtgtactt gtacataaaa ccaaaattat agttgggaaa
     3001 aaaataaatt tatatatgaa aatgtcaaaa tcattttaaa agtattattt tcaaataaaa
     3061 tggagaagct ggtgaaaagt catattggca atttttatgt agtttaagtg gaattaagca
     3121 gagggagatg cttttgggtt tttaatatgc cacttctgag tgaaaacatc tcgtggagtc
     3181 attgtgttca gctctgagaa gaacaaagat tcatagttct gtacatgtgg ctggatttaa
     3241 atatcctgtt tttgatacta attttgaaag tcatgtaact tcttttgata tctgggcaaa
     3301 agtaaccata tgctataagc atttgaatat gtttaatttt atcataatag catctgtaaa
     3361 agtacatctt acacattata tagagggttc ttgtttgaaa ttttcagttc tctttatctt
     3421 cccagtacct cttggtcctc ataatgggca aaggatacaa cgaaggcagg ttgtataggg
     3481 gttatagtgg ggaagtggat aggggattca ttttcttatg tgacattttg ccttaagaat
     3541 ataaaagtgc tttagcactg atggctggca tttttaatat aggcagtgaa agtgacttta
     3601 gaagcatggg atgaaataga gggaagaaga gtttttattt tctggccttt aaaaagtgcc
     3661 tagtaggtca tttgagaccc agagaaatgc acagagcttg agcaaaggca tgaagtccct
     3721 gacattgttt tcctttttgt ctcagcatat agtattaaga tgcctagaaa taggactcta
     3781 ttgttccctc ttgtataggc actttacatt tcttgtcact acagcaacca catacagtac
     3841 agacaacctc caaacctgtt tatattagtg taaatagaaa atctatagac aactttctag
     3901 ttttctctgg aggcattttt gggaatgtac gtgtaatagg ctctgctttg tatacaggag
     3961 ataataccac atcatcggtt atctccaaac tccagtcttc tctcaactgc ccagttgtat
     4021 gttgtcatca atcacttttt caaggctggg tagagacaag tttctcctcg taactttgac
     4081 ctctcccact ctccaaatgt aatctggacc tcattgcttt caaggtcagc ttccccatag
     4141 ctcaggtatc ctttgctctc ctgtatcttc atttactatt agtgaagaga tctctgtcct
     4201 ggaggttatt ctaaactttc tttgtaacta ttgttataga caatggtttc caaaccagtg
     4261 gtttctatgt agcttttcta gttccttgct atcttctcac cactggcttg aggtagtgat
     4321 ttggactttg ctcattagag agcattatca gagatgtgga gtccatcaga agaccagctt
     4381 gcagtgtgta tagcatatag atgccaatat tagaattctt taaattatat ttaacatttt
     4441 catgcttctt aatttaactt cacatgttgg gaagtagatt cagaaagata ggagaaatac
     4501 ccagactcta ccacttccgt gagctactag ttaggcatgg gcaggattaa gttttatgtg
     4561 tattatcttc ccactaccaa gaatggttat gtttcacaga ataccagttc agtttgattt
     4621 ggaaaaagat gccaaaccaa atttatatgt agtctataat ctaagggcat tcttgaaact
     4681 attgcccaca tcccattttt tttttcatgt ttacttacaa aacagagata aacattagat
     4741 gtctaaagga gttagtaatg aaaagcctat ccttaaaaaa taaacctgtt gaaatgggct
     4801 ttaaagacat cgaaataatc acttgtcatg cattgactgt aaatgcagat agagaaatat
     4861 gtctttgaag ctccacttac acaaaaataa aacttgtata tcatgctccc tcaaagaatg
     4921 tgcgatagat tattttaaga ccatgataat agagtaaaaa ggaaagaaag ccagaaatta
     4981 caattttgga tgctaaaaag taactttcta gttaacccta aagtcctgtc agattgtgaa
     5041 gaaatgttcc aggatacact tggattagtt atgcagtatt tcttatcaat gtctagccct
     5101 tgtgtattgt tctgaaaact aaagtttaaa tctttatgct gttgcttgct agatatcctg
     5161 ttctttggta gaaaattccc atagtctgta ctcaagaagt gcctaaaaat ggatttgtgt
     5221 tgattttaag cccatctaat aaattatatg tattttctat ggta
//
