LOCUS       NM_001661               1578 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 4D (ARL4D), mRNA.
ACCESSION   NM_001661
VERSION     NM_001661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Lin,M.C., Yu,C.J. and Lee,F.S.
  TITLE     Phosphorylation of Arl4A/D promotes their binding by the HYPK
            chaperone for their stable recruitment to the plasma membrane
  JOURNAL   Proc Natl Acad Sci U S A 119 (30), e2207414119 (2022)
   PUBMED   35857868
  REMARK    GeneRIF: Phosphorylation of Arl4A/D promotes their binding by the
            HYPK chaperone for their stable recruitment to the plasma membrane.
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Li,C.C., Wu,T.S., Huang,C.F., Jang,L.T., Liu,Y.T., You,S.T.,
            Liou,G.G. and Lee,F.J.
  TITLE     GTP-binding-defective ARL4D alters mitochondrial morphology and
            membrane potential
  JOURNAL   PLoS One 7 (8), e43552 (2012)
   PUBMED   22927989
  REMARK    GeneRIF: a portion of endogenous ARL4D and the
            GTP-binding-defective ARL4D mutant ARL4D(T35N) reside in the
            mitochondria
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   Hofmann,I., Thompson,A., Sanderson,C.M. and Munro,S.
  TITLE     The Arl4 family of small G proteins can recruit the cytohesin Arf6
            exchange factors to the plasma membrane
  JOURNAL   Curr Biol 17 (8), 711-716 (2007)
   PUBMED   17398095
  REMARK    GeneRIF: Study shows that three related Arf-like GTPases Arl4a,
            Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to
            the plasma membrane by binding to their PH domains irrespective of
            whether they are in the diglycine or triglycine form.
REFERENCE   4  (bases 1 to 1578)
  AUTHORS   Chiang,A.P., Nishimura,D., Searby,C., Elbedour,K., Carmi,R.,
            Ferguson,A.L., Secrist,J., Braun,T., Casavant,T., Stone,E.M. and
            Sheffield,V.C.
  TITLE     Comparative genomic analysis identifies an ADP-ribosylation
            factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)
  JOURNAL   Am J Hum Genet 75 (3), 475-484 (2004)
   PUBMED   15258860
REFERENCE   5  (bases 1 to 1578)
  AUTHORS   Nonaka,Y., Tsuda,N., Shichijo,S., Ito,M., Maeda,Y., Harada,M.,
            Kamura,T., Shigemori,M. and Itoh,K.
  TITLE     Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted
            and tumor-reactive cytotoxic T lymphocytes from patients with brain
            tumors
  JOURNAL   Tissue Antigens 60 (4), 319-327 (2002)
   PUBMED   12472661
  REMARK    GeneRIF: ARF4L 15-24 and ARF4L 69-77, possessed the ability to
            induce HLA-A2-restricted and tumor-reactive CTLs from peripheral
            blood mononuclear cells of patients with brain tumors
REFERENCE   6  (bases 1 to 1578)
  AUTHORS   Jacobs,S., Schilf,C., Fliegert,F., Koling,S., Weber,Y.,
            Schurmann,A. and Joost,H.G.
  TITLE     ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup
            of the ARF family characterization by rapid nucleotide exchange and
            a nuclear localization signal
  JOURNAL   FEBS Lett 456 (3), 384-388 (1999)
   PUBMED   10462049
REFERENCE   7  (bases 1 to 1578)
  AUTHORS   Harshman,K., Bell,R., Rosenthal,J., Katcher,H., Miki,Y.,
            Swenson,J., Gholami,Z., Frye,C., Ding,W., Dayananth,P. et al.
  TITLE     Comparison of the positional cloning methods used to isolate the
            BRCA1 gene
  JOURNAL   Hum Mol Genet 4 (8), 1259-1266 (1995)
   PUBMED   7581362
REFERENCE   8  (bases 1 to 1578)
  AUTHORS   Smith,S.A., Holik,P.R., Stevens,J., Melis,R., White,R. and
            Albertsen,H.
  TITLE     Isolation and mapping of a gene encoding a novel human
            ADP-ribosylation factor on chromosome 17q12-q21
  JOURNAL   Genomics 28 (1), 113-115 (1995)
   PUBMED   7590735
REFERENCE   9  (bases 1 to 1578)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI547763.1, BC000043.2,
            BM682844.1 and AC087650.12.
            
            On Nov 22, 2018 this sequence version replaced NM_001661.3.
            
            Summary: ADP-ribosylation factor 4D is a member of the
            ADP-ribosylation factor family of GTP-binding proteins. ARL4D is
            closely similar to ARL4A and ARL4C and each has a nuclear
            localization signal and an unusually high guanine nucleotide
            exchange rate. This protein may play a role in membrane-associated
            intracellular trafficking. [provided by RefSeq, Jul 2021].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.809045.1,
                                           SRR3476690.821045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320033.5/ ENSP00000322628.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BI547763.1         40-51
            13-1375             BC000043.2         1-1363
            1376-1577           BM682844.1         18-219              c
            1578-1578           AC087650.12        71584-71584
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1578
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
                     /note="ARF like GTPase 4D"
                     /db_xref="GeneID:379"
                     /db_xref="HGNC:HGNC:656"
                     /db_xref="MIM:600732"
     exon            1..101
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
                     /inference="alignment:Splign:2.1.0"
     exon            102..1578
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..779
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
                     /note="ADP-ribosylation factor-like protein 4L;
                     ADP-ribosylation factor-like 4D; ADP ribosylation factor
                     like GTPase 4D"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 4D"
                     /protein_id="NP_001652.2"
                     /db_xref="CCDS:CCDS11463.1"
                     /db_xref="GeneID:379"
                     /db_xref="HGNC:HGNC:656"
                     /db_xref="MIM:600732"
                     /translation="MGNHLTEMAPTASSFLPHFQALHVVVIGLDSAGKTSLLYRLKFK
                     EFVQSVPTKGFNTEKIRVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLVFVVD
                     AAEAERLEEAKVELHRISRASDNQGVPVLVLANKQDQPGALSAAEVEKRLAVRELAAA
                     TLTHVQGCSAVDGLGLQQGLERLYEMILKRKKAARGGKKRR"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
                     /note="hexamer: ATTAAA"
     polyA_site      1382
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
                     /note="major polyA site"
     regulatory      1545..1550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
                     /note="hexamer: ATTATA"
     polyA_site      1578
                     /gene="ARL4D"
                     /gene_synonym="ARF4L"
ORIGIN      
        1 agaggcagcg gttggaggcg cggtgggtgt ctgcgggggt ctcgcggggc ggctgcggtg
       61 tttcaccggg aaaggctcga ggagagcgcg gctcacgaga gataacccag ctgtgctccc
      121 tggaaccttc aatttcaagg cctccctgcc tctactaggc gccttagctc actatgggga
      181 accacttgac tgagatggcg cccactgcct cctccttctt gccccacttc caagccctgc
      241 atgtcgtggt cattgggctg gactctgctg gaaagacctc cctcctttac cgcctcaagt
      301 tcaaggagtt tgtccagagt gtccccacca aaggcttcaa caccgagaag atccgggtgc
      361 ccctcggggg atcgcgtggc atcaccttcc aagtgtggga cgtcgggggg caggagaagc
      421 tgcgaccact gtggcgctct tatacccgcc ggacagacgg tctagtgttt gtggtggacg
      481 ctgcggaggc tgagcggctg gaggaagcca aggtggagtt gcaccgaatc agccgggcct
      541 cggacaacca gggcgtgcca gtgctggtgc tggccaacaa gcaggaccag cccggggcac
      601 tgagcgctgc tgaggtggag aagaggctgg cagtccgaga gctagcagcc gccactctca
      661 ctcatgtgca aggctgcagc gctgtggacg gtctgggcct gcagcagggc cttgagcgcc
      721 tctatgagat gatcctcaag aggaagaagg cagctcgggg tggcaagaag agacggtgac
      781 ccaagccccc cctccctttc ctcccaccta gtaggggtct gcacacttgg acagcagggt
      841 gggaccagcc tgtgacctct cagtcagact ggggtgcagg acctgtccac ctcaatgaag
      901 gagagaggag catggggtgt cccgttttgg tgccacactg gggtggggat gggagatggg
      961 atgtctttgc atatctctct catcctctct ggagaagtgg gcgctgcagg actgtggaga
     1021 cgtaaatgta aactgtgact ctacctcgac cctgtttctt atttttcttc tctggctaaa
     1081 aatttttaat tggatgtgtt tgggggcggg gggatggaag tgacttggag aatgtgtttg
     1141 ggatgaaata actatctccc cttcctctgt cccccaactg gggagtctcc ccaggctgct
     1201 tttctaggaa taccagtcac atagttttta tttttgtgtc tgtgaaagtg ccaagaaccc
     1261 ctccccacat ttgtagatcc atgacccttt ttataagctg tgtgtgtcct ctgtattatt
     1321 gttattaact attttttagc atttgcctgt aagttattaa agactgataa ctgtagctct
     1381 taccttggtc tggggcattt tcctctcctt atcttgcccc agagacaatt caagatttct
     1441 atatggggtt gtggcgcagg gggagggaga tttatcttga agctgaattt gcaaagcaag
     1501 cacttataaa aattagattg tgtgttacgg gatggcttgt gaaaattata ggggggagtg
     1561 gaaaacccct caagctat
//
