LOCUS       NM_001282431            3866 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 4C (ARL4C), transcript variant 1,
            mRNA.
ACCESSION   NM_001282431 XM_005246055
VERSION     NM_001282431.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3866)
  AUTHORS   Alkhatib,D.Z.R., Thi Kim Truong,T., Fujii,S., Hasegawa,K.,
            Nagano,R., Tajiri,Y. and Kiyoshima,T.
  TITLE     Stepwise activation of p63 and the MEK/ERK pathway induces the
            expression of ARL4C to promote oral squamous cell carcinoma cell
            proliferation
  JOURNAL   Pathol Res Pract 246, 154493 (2023)
   PUBMED   37141698
  REMARK    GeneRIF: Stepwise activation of p63 and the MEK/ERK pathway induces
            the expression of ARL4C to promote oral squamous cell carcinoma
            cell proliferation.
REFERENCE   2  (bases 1 to 3866)
  AUTHORS   Kanai,R., Uehara,T., Yoshizawa,T., Kamakura,M., Nakajima,T.,
            Kinugawa,Y., Iwaya,M., Asaka,S., Kitazawa,M., Nagaya,T. and Ota,H.
  TITLE     ARL4C is associated with epithelial-to-mesenchymal transition in
            colorectal cancer
  JOURNAL   BMC Cancer 23 (1), 478 (2023)
   PUBMED   37237373
  REMARK    GeneRIF: ARL4C is associated with epithelial-to-mesenchymal
            transition in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3866)
  AUTHORS   Yang,J., Peng,S. and Zhang,K.
  TITLE     ARL4C depletion suppresses the resistance of ovarian cancer to
            carboplatin by disrupting cholesterol transport and autophagy via
            notch-RBP-Jkappa-H3K4Me3-OSBPL5
  JOURNAL   Hum Exp Toxicol 41, 9603271221135064 (2022)
   PUBMED   36366750
  REMARK    GeneRIF: ARL4C depletion suppresses the resistance of ovarian
            cancer to carboplatin by disrupting cholesterol transport and
            autophagy via notch-RBP-Jkappa-H3K4Me3-OSBPL5.
REFERENCE   4  (bases 1 to 3866)
  AUTHORS   Yang,Y., Xu,X., Xie,Y., Liu,Y., Ning,C., Ai,Y., Lv,C., Wei,H.,
            Ge,X., Yi,T., Piao,Y., Wang,X. and Jin,X.
  TITLE     Identification of Neural Progenitor Cell-associated
            Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for
            Prognosis of Glioma
  JOURNAL   Curr Pharm Des 28 (26), 2189-2202 (2022)
   PUBMED   35718975
  REMARK    GeneRIF: Identification of Neural Progenitor Cell-associated
            Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for
            Prognosis of Glioma.
REFERENCE   5  (bases 1 to 3866)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 3866)
  AUTHORS   Wei,S.M., Xie,C.G., Abe,Y. and Cai,J.T.
  TITLE     ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin
            and modulates intracellular vesicular transport
  JOURNAL   Biochem Biophys Res Commun 384 (3), 352-356 (2009)
   PUBMED   19409876
  REMARK    GeneRIF: ARL7 might modulate the intracellular vesicular transport
            via interaction with microtubules.
REFERENCE   7  (bases 1 to 3866)
  AUTHORS   Hofmann,I., Thompson,A., Sanderson,C.M. and Munro,S.
  TITLE     The Arl4 family of small G proteins can recruit the cytohesin Arf6
            exchange factors to the plasma membrane
  JOURNAL   Curr Biol 17 (8), 711-716 (2007)
   PUBMED   17398095
  REMARK    GeneRIF: Study shows that three related Arf-like GTPases Arl4a,
            Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to
            the plasma membrane by binding to their PH domains irrespective of
            whether they are in the diglycine or triglycine form.
REFERENCE   8  (bases 1 to 3866)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 3866)
  AUTHORS   Engel,T., Lueken,A., Bode,G., Hobohm,U., Lorkowski,S.,
            Schlueter,B., Rust,S., Cullen,P., Pech,M., Assmann,G. and
            Seedorf,U.
  TITLE     ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by
            cholesterol loading and participates in apolipoprotein AI-dependent
            cholesterol export
  JOURNAL   FEBS Lett 566 (1-3), 241-246 (2004)
   PUBMED   15147902
REFERENCE   10 (bases 1 to 3866)
  AUTHORS   Jacobs,S., Schilf,C., Fliegert,F., Koling,S., Weber,Y.,
            Schurmann,A. and Joost,H.G.
  TITLE     ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup
            of the ARF family characterization by rapid nucleotide exchange and
            a nuclear localization signal
  JOURNAL   FEBS Lett 456 (3), 384-388 (1999)
   PUBMED   10462049
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105145.6, BC089043.1 and
            AJ579850.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001282431.1.
            
            Summary: ADP-ribosylation factor-like 4C is a member of the
            ADP-ribosylation factor family of GTP-binding proteins. ARL4C is
            closely similar to ARL4A and ARL4D and each has a nuclear
            localization signal and an unusually high guanine nucleotide
            exchange rate. This protein may play a role in cholesterol
            transport. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ579850.1, SRR1803616.266572.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339728.6/ ENSP00000339754.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC105145.6         559-586             c
            29-481              BC089043.1         1-453
            482-3866            AJ579850.1         1-3385
FEATURES             Location/Qualifiers
     source          1..3866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3866
                     /gene="ARL4C"
                     /gene_synonym="ARL7; LAK"
                     /note="ARF like GTPase 4C"
                     /db_xref="GeneID:10123"
                     /db_xref="HGNC:HGNC:698"
                     /db_xref="MIM:604787"
     exon            1..1070
                     /gene="ARL4C"
                     /gene_synonym="ARL7; LAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..1101
                     /gene="ARL4C"
                     /gene_synonym="ARL7; LAK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like 7; ADP-ribosylation
                     factor-like protein 4C; ADP ribosylation factor-like
                     protein 7; ADP-ribosylation factor-like protein LAK;
                     ADP-ribosylation factor-like 4C; ADP ribosylation factor
                     like GTPase 4C"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 4C isoform
                     1"
                     /protein_id="NP_001269360.1"
                     /db_xref="CCDS:CCDS63169.1"
                     /db_xref="GeneID:10123"
                     /db_xref="HGNC:HGNC:698"
                     /db_xref="MIM:604787"
                     /translation="MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPT
                     IGFNTEKIKLSNGTAKGISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLE
                     EAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPA
                     CAIIGEGLTEGMDKLYEMILKRRKSLKQKKKRTGDLRSCEV"
     exon            1071..3866
                     /gene="ARL4C"
                     /gene_synonym="ARL7; LAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3844..3849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL4C"
                     /gene_synonym="ARL7; LAK"
                     /note="hexamer: AATAAA"
     polyA_site      3866
                     /gene="ARL4C"
                     /gene_synonym="ARL7; LAK"
                     /note="major polyA site"
ORIGIN      
        1 aggctggcgg ctgctgcggc ggcgcgggga ctgtgaggct gccgagcgga cagcgactcc
       61 cggggaagcc cgcgctccgg gagcgggagc gggagcagga gcaggagcag cgccgtccca
      121 ggccagaggc gagcgccggg cgccgggaga gcggagagcc cgggcagctg ccggagcgcg
      181 ggggcgcggc ccgaggaaac cacagagcga gcccaggcct ggggagggcg ccgaacatct
      241 gaggcggctt cgcgggagac aaagccgcgc gtagagacgc gatgcccgcc gatcgcgagc
      301 ccggccggcg agggcgcggg gactgcggcg tctgagcgcg ccaagccgtg cgcccgcggg
      361 gacgccgagc cccggggccg gtgcgggcgg cggcgggcgg ggcccaggtg cgcccggccg
      421 cgtcgggccc gtgactgctc ggggggcggc gccctcccgc cgcagccgca gtggctggcg
      481 ccgcagccag gagccatggg caacatctcc tctaacatct cggccttcca gtccctgcat
      541 atcgtcatgt tgggcttgga ctcggccggc aagaccacgg tgctctaccg gctcaagttc
      601 aacgagttcg tgaacacggt gcccaccatc ggcttcaaca ccgagaagat caagctgagc
      661 aacggcacgg ccaagggcat cagctgccac ttctgggacg tgggcggcca ggagaagctg
      721 cggccgctgt ggaagtccta cagccgctgc acggacggca tcatctacgt ggtggactcg
      781 gtggacgtgg accggctgga ggaggccaag acggagctgc acaaggtgac caagttcgcc
      841 gagaaccagg gcacgccgct gctggtcatc gccaacaagc aggacctgcc caagtcgctg
      901 ccggtggcag agattgagaa gcagctggcg ctgcacgagc ttatcccggc caccacctat
      961 cacgtccagc cggcgtgcgc catcatcggc gagggcctca ccgagggcat ggacaagctc
     1021 tatgagatga tcctgaaacg caggaagtcc ctcaagcaga agaagaagcg gactggtgac
     1081 ttaaggagct gcgaagtctg atttaccggc ctactctcga cctgcccccc acccccagct
     1141 caggggacct tttgtctgaa cgccagagct actgaccagg tcggggggcc gcggtgggga
     1201 gtggaagagc cggtcctgct gtccgccctc ccagccccag gtggaaggct cagttgtcgg
     1261 aaagacaaaa gcgatttctt cccactcctg cagggccaga agttcaggct gccccgcctc
     1321 cactggggga tcgcacctgt gaattacctg aggtatgcat ttcccagaac cgtgggcgta
     1381 cccaccttgg ggggcatgtt ggttctgggg ggaccacctc tccttgcatt caggggctgt
     1441 gaagctgagt aattttcggt cacagggcag gcccctgttg aaatttcatt tgtcctgctc
     1501 tgggcccaaa ggtggtggtg gtttgggtca tcagaggact gcctgggacg gttcagcggg
     1561 cacggagcgc tgtgctggcc tggctgggga tggccgcgga ggtgcccttt tcctggtgct
     1621 ttgtggtggc tgcagaagac cagttttgtt gagaactgct tttcagcctg gaatcagaca
     1681 tcttccagat ggtttggacc ctgtccatgt gtaggtcatt atcacacaaa gagaccaata
     1741 aaaataaaaa aaataaaaaa aaaaaaagac gaactattgg aggtggtggc caatgatgca
     1801 tttactgttt gcaggatagt taaaggtgtt taaagggtaa ggcttttggt gtaaatgctg
     1861 gatggggtgt gtgtgtgtgt ggatataggg acctccctct gtactgtgta ctgtgtaatc
     1921 ggcattaata cctagactca tatgtatgga attttaaatt ctcttagcct actgattggt
     1981 ttggatgagc acaccagctg caggtgtgtg ctgaattgca agatggtatt ttttttttta
     2041 accaagggat gtctcttgta atactaaccg cgtgataatg ggttttcaga catgatgaaa
     2101 aaaaaaaact tttacaaatg aatacttacc ttagaaatat tcaccttagg aaaaaagact
     2161 ttgctctgcc cttttatatt cctttatgct gcaagtggtg acatgttcag atttctaatt
     2221 tggttcattg tggcctatct ggtttaagtc tttcattaaa aatgtctcgt tagagtattt
     2281 gatgtcatgc accaaaaaaa taaaacccca ccttgttgca aaagctgacc tcgttgcatg
     2341 gaattaaaag agaaggaaaa acacaaggat gaagtctttc cgaattcatt cttgtgggaa
     2401 ctggccttcg gagccagcca gcactttggg caaatgcaaa caacaatgag tgcttgagat
     2461 aaaagaaagt gtgacgtcat ggtcactggt actcaggcac ttcacagttt acttgaaaga
     2521 ggctttggaa aatagataaa gtgaaagaag aataaataca tatttttaat aatgtaattt
     2581 taaaaatcct ttataatcag gactgagtct tggtttgcag aagctgtcac ttaccctgaa
     2641 acacagtatc aaaagggaaa cttaaaacat actgtttgat ttttttattt cctcttacaa
     2701 tccatgtttt caggtagaat tatgactttc cccccattgt tacacatttc tttacaaagg
     2761 aggcctgtag aaattggaca cgatcatgct tgagcatgtg agttagtcaa attatgagtc
     2821 cctgcctatt gtccattaca caccgaatgt taatttaaga accagaggca gaagttctgg
     2881 cttcctgctt gaaacccaat tcttatatga aattttttaa aagcagaaac ctagcagccc
     2941 atctgctttt tctcttttgt cggtgtattt ggtacccctc caatgctggt ctttttgtag
     3001 aaactcagta gagaaagtct agctaagcag tgttgaaaag cctgcaagat ttcagtttac
     3061 atatcgacag catatccact gatttctaaa tgggctggtc ccatcatctg aagattctgt
     3121 atagaattat taaaaaaaaa atccatcttt ctttattttc ttcacatgcg acaatttctt
     3181 aagcactttg acattttggt agttccacac tattgagaga ataatatatt tattttgtga
     3241 cattgcagat gccaaatact gtaaccttct catgataaca atacttaggt tcaagatcac
     3301 tgttcaaacc ctgtcatgct ttaaaactga tgcgagatga ttttgttttt tgcataatca
     3361 atacttaagg gtgcaatcaa ctgttagtaa ttgtgcagta aagtaaagcc ctgtggtgta
     3421 tcaactacta gttaagagtc tcagttgatt tctgtaatgt ttgacctaat aatagcccgt
     3481 ttcgtctctg acccaacaga ggaagcacag atcaaatcac cttggagtgg tcaccagggg
     3541 gacagggagc cccccaccaa tgtatcaatg ggtgatttat gatgccttct gccctttggc
     3601 gagtgaatgg gtttcccata ggggaagttg gcctccctcc gtgagctttg gaaatgtttt
     3661 ctaatagaca cagggaggcc agttctgttt cagagcaatt atcttcccaa attctctgtt
     3721 ctggtgttgg aactgtgtgc cctggtttct gttttccttt ctactgctgt aattctctgt
     3781 ctcatcatcc ttctcttttg tttccatagc cttttataat gcatatatga tgctgtgaac
     3841 agaaataaat tatttataca atcaaa
//
