LOCUS       NM_005738               2889 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 4A (ARL4A), transcript variant 1,
            mRNA.
ACCESSION   NM_005738
VERSION     NM_005738.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2889)
  AUTHORS   Lin,M.C., Yu,C.J. and Lee,F.S.
  TITLE     Phosphorylation of Arl4A/D promotes their binding by the HYPK
            chaperone for their stable recruitment to the plasma membrane
  JOURNAL   Proc Natl Acad Sci U S A 119 (30), e2207414119 (2022)
   PUBMED   35857868
  REMARK    GeneRIF: Phosphorylation of Arl4A/D promotes their binding by the
            HYPK chaperone for their stable recruitment to the plasma membrane.
REFERENCE   2  (bases 1 to 2889)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2889)
  AUTHORS   Chiang,T.S., Lin,M.C., Tsai,M.C., Chen,C.H., Jang,L.T. and Lee,F.S.
  TITLE     ADP-ribosylation factor-like 4A interacts with Robo1 to promote
            cell migration by regulating Cdc42 activation
  JOURNAL   Mol Biol Cell 30 (1), 69-81 (2019)
   PUBMED   30427759
  REMARK    GeneRIF: Arl4A participates in Slit2/Robo1 signaling to modulate
            cell motility by regulating Cdc42 activity.
REFERENCE   4  (bases 1 to 2889)
  AUTHORS   Lin,Y.C., Chiang,T.C., Liu,Y.T., Tsai,Y.T., Jang,L.T. and Lee,F.J.
  TITLE     ARL4A acts with GCC185 to modulate Golgi complex organization
  JOURNAL   J Cell Sci 124 (Pt 23), 4014-4026 (2011)
   PUBMED   22159419
  REMARK    GeneRIF: Deletion of the ARL4A-interacting region of GCC185 results
            in inability to maintain Golgi structure and modulate
            endosome-to-Golgi transport.
REFERENCE   5  (bases 1 to 2889)
  AUTHORS   Patel,M., Chiang,T.C., Tran,V., Lee,F.J. and Cote,J.F.
  TITLE     The Arf family GTPase Arl4A complexes with ELMO proteins to promote
            actin cytoskeleton remodeling and reveals a versatile Ras-binding
            domain in the ELMO proteins family
  JOURNAL   J Biol Chem 286 (45), 38969-38979 (2011)
   PUBMED   21930703
  REMARK    GeneRIF: membrane targeting of ELMO via Arl4A promotes cytoskeletal
            reorganization including membrane ruffling and stress fiber
            disassembly via an ELMO-DOCK1800-Rac signaling pathway.
REFERENCE   6  (bases 1 to 2889)
  AUTHORS   Hofmann,I., Thompson,A., Sanderson,C.M. and Munro,S.
  TITLE     The Arl4 family of small G proteins can recruit the cytohesin Arf6
            exchange factors to the plasma membrane
  JOURNAL   Curr Biol 17 (8), 711-716 (2007)
   PUBMED   17398095
  REMARK    GeneRIF: Study shows that three related Arf-like GTPases Arl4a,
            Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to
            the plasma membrane by binding to their PH domains irrespective of
            whether they are in the diglycine or triglycine form.
REFERENCE   7  (bases 1 to 2889)
  AUTHORS   Lin,C.Y., Huang,P.H., Liao,W.L., Cheng,H.J., Huang,C.F., Kuo,J.C.,
            Patton,W.A., Massenburg,D., Moss,J. and Lee,F.J.
  TITLE     ARL4, an ARF-like protein that is developmentally regulated and
            localized to nuclei and nucleoli
  JOURNAL   J Biol Chem 275 (48), 37815-37823 (2000)
   PUBMED   10980193
REFERENCE   8  (bases 1 to 2889)
  AUTHORS   Suzuki,Y., Ishihara,D., Sasaki,M., Nakagawa,H., Hata,H.,
            Tsunoda,T., Watanabe,M., Komatsu,T., Ota,T., Isogai,T., Suyama,A.
            and Sugano,S.
  TITLE     Statistical analysis of the 5' untranslated region of human mRNA
            using 'Oligo-Capped' cDNA libraries
  JOURNAL   Genomics 64 (3), 286-297 (2000)
   PUBMED   10756096
REFERENCE   9  (bases 1 to 2889)
  AUTHORS   Jacobs,S., Schilf,C., Fliegert,F., Koling,S., Weber,Y.,
            Schurmann,A. and Joost,H.G.
  TITLE     ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup
            of the ARF family characterization by rapid nucleotide exchange and
            a nuclear localization signal
  JOURNAL   FEBS Lett 456 (3), 384-388 (1999)
   PUBMED   10462049
REFERENCE   10 (bases 1 to 2889)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ948724.1 and AC011891.3.
            
            On Nov 22, 2018 this sequence version replaced NM_005738.4.
            
            Summary: ADP-ribosylation factor-like 4A is a member of the
            ADP-ribosylation factor family of GTP-binding proteins. ARL4A is
            similar to ARL4C and ARL4D and each has a nuclear localization
            signal and an unusually high guaninine nucleotide exchange rate.
            ARL4A is located in both the nuclear and extranuclear cell
            compartments. Multiple transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longest
            transcript. All four variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.5474.1,
                                           SRR1803613.198679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651779.1/ ENSP00000498350.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               BQ948724.1         515-652
            139-2889            AC011891.3         42066-44816
FEATURES             Location/Qualifiers
     source          1..2889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.3"
     gene            1..2889
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /note="ARF like GTPase 4A"
                     /db_xref="GeneID:10124"
                     /db_xref="HGNC:HGNC:695"
                     /db_xref="MIM:604786"
     exon            1..96
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /inference="alignment:Splign:2.1.0"
     exon            97..2889
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..788
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /note="ADP-ribosylation factor-like 4; ADP-ribosylation
                     factor-like 4A; ADP ribosylation factor like GTPase 4A"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 4A"
                     /protein_id="NP_005729.1"
                     /db_xref="CCDS:CCDS5359.1"
                     /db_xref="GeneID:10124"
                     /db_xref="HGNC:HGNC:695"
                     /db_xref="MIM:604786"
                     /translation="MGNGLSDQTSILSNLPSFQSFHIVILGLDCAGKTTVLYRLQFNE
                     FVNTVPTKGFNTEKIKVTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDS
                     VDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELSSST
                     PWHLQPTCAIIGDGLKEGLEKLHDMIIKRRKMLRQQKKKR"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /note="hexamer: AATAAA"
     polyA_site      1107
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /note="major polyA site"
     regulatory      2045..2050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /note="hexamer: AATAAA"
     polyA_site      2069
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
     regulatory      2391..2396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /note="hexamer: AATAAA"
     polyA_site      2414
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
                     /note="hexamer: TATAAA"
     polyA_site      2889
                     /gene="ARL4A"
                     /gene_synonym="ARL4"
ORIGIN      
        1 agagctgctt ggagagctaa gctggaaggg tgcttatccc tgcgtagaaa cgcctgccaa
       61 tgctttctca tttggaccca gactccagat cgggagcagt cttatagctg gatcagctac
      121 caagagaagt tgtaaaccaa gaagagaaaa gcatttcaat ttgggacatt tatttgcacc
      181 tggaaatggg gaatgggctg tcagaccaga cttctatcct gtccaacctg ccttcatttc
      241 agtctttcca cattgttatt ctgggtttgg actgtgctgg aaagacaact gtcttataca
      301 ggctgcagtt caatgaattt gtaaataccg tacctaccaa aggatttaac actgagaaaa
      361 ttaaggtaac cttgggaaat tctaaaacag tcacttttca cttctgggat gtaggtggtc
      421 aggagaaatt aaggccactg tggaagtcat ataccagatg cacagatggc attgtatttg
      481 ttgtggactc tgttgatgtc gaaaggatgg aagaagccaa aactgaactt cacaaaataa
      541 ctaggatatc agaaaatcag ggagtccctg tacttatagt tgctaacaaa caagatttga
      601 ggaactcatt gtcactttca gaaattgaga aattgttagc aatgggtgaa ctgagctcat
      661 caactccttg gcatttgcag cctacctgtg caatcatagg agatggccta aaggaaggac
      721 ttgagaaact acatgatatg atcattaaaa gaagaaaaat gttgcggcaa cagaaaaaga
      781 aaagatgaat atcaatacct attatatctg tgtggagtag gttttctctg gtctgatttt
      841 gacaaataga agagtgtcta cagcgtggtt tgcctgtctg ccctcctgga tgctattaaa
      901 gctttgtttt gttgaacaat cagatgccca actctgttgc cttgtggaag atgagtaaat
      961 gcagtgcttc ttaaagtggt ctcttctccc taccccacaa atcttttggt actaccattt
     1021 ggggaagcca agcaaggata gtaaattgac cagaacacag ttgtgggaat ttggtctgaa
     1081 gttagtgaaa taaaacttta aagagtgtct gcctagtgtt ttgtgcttac atctttcggg
     1141 gggaagcctt tgcaagaaaa ttgcatacaa ggctttgtaa cgatcaagtg ctaatcgatg
     1201 gaaatgttaa ggtagattaa catatatgca gttatattga tcacattggt ccaaccagtc
     1261 cttttttgaa gtaagggaca aggagtaagt attttctttt ttaagtttct gccaaatgat
     1321 ttttgacgct ttctggaatc aagtaattta atagtatagc ttaattctag acaatgttta
     1381 agttggtcta cctttattaa aaataagata tttggggtat attcaagtgc atggattagt
     1441 tttcctgaca aagcatgttt tggtgtgtag tcttactttt tagaaatagc tatgcatcgt
     1501 tctacacagg tttaaaacaa cttttttggg gatttagggc tattatagga atagtttgtt
     1561 gtcagaagca ctttcacttg aagaacctaa aatgattgac tcattcatag taaatatggg
     1621 catgtaaact aataaatatg cactggatac atatatggat ttatgaagaa ggcgatttag
     1681 tcaagaggat gtaattaaaa tatgtggtct ctaaaatatt ccagttacaa gatatttgtt
     1741 ttattaatat ttgctggcta aaaacaaatg tggtttttat atatttttgt agtgtgttga
     1801 gaagagcaaa agctttataa atatacctga tgcgctgtag aatgaaaatg taaaagataa
     1861 cctgtatgtg ttccgagctt taattttttg tttacaaatt gaacagtgtt acatgggctg
     1921 tccagtcctg attatagaga ggaagaaatg gtaacagtat ggcagataag aattacaatt
     1981 atagaaaatg aggggaaaat aacaaacctg ttttatgaaa attcactggt gctgtttaca
     2041 ttggaataaa aagctctata aggaggaaag gcctttatct aattcttatc tacagacact
     2101 tacttccagt gaccatattt tactaaatca gcttattttt tatgtctaaa gcaacagctg
     2161 ttctgaaaaa tcaccaaaag aaatgcactt tgctagcagg atttgttttg gctttgggtt
     2221 ttgttttttt gttttttttt tttttcagtg gcataacagt ttttggaacc ttgattcttg
     2281 tgtcacacaa aatgaatgaa gtagcttgat gtggagcctt catatgttaa atattcctgc
     2341 actagtgatg gtcacttaga atgtttatag aaatgtggat aataactacc aataaactac
     2401 ttgaggcact aggagaacag tatttgactt tgaattttaa tgtatttcca cttttgctga
     2461 agcttttaat cagatgtgta aaaacaattg accagctagg ctatttagtc ccatagtagt
     2521 tcagatctgc ttagatgtga caggcattga aggctgtttt tttttttttc tcccttcact
     2581 gatactgaaa tcatggtatc tgctgcaaac atgagtagat ccatgatgga ttaataaagc
     2641 ttgctgaaaa aaaaaatctg tgtatcaatt agatttacca gtttgcctgt actttctgtc
     2701 tacctactat gtaaaatagt gctgttttta agtatttcaa aagcttgtgt gttgaccctt
     2761 tgtagcctaa gtacgtaaac aaattaatgt tatctaagtt tttcatattt catggacaac
     2821 aaaagagaaa atggtatgaa cactgtacaa actttgattt ataaaagaca atttcagcta
     2881 taaaaccca
//
