LOCUS       NM_004311               3834 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ARF like GTPase 3 (ARL3), mRNA.
ACCESSION   NM_004311
VERSION     NM_004311.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3834)
  AUTHORS   Zhang,X., Yao,S., Zhang,L., Yang,L., Yang,M., Guo,Q., Li,Y.,
            Wang,Z., Lei,B. and Jin,X.
  TITLE     Mechanisms underlying morphological and functional changes of cilia
            in fibroblasts derived from patients bearing ARL3T31A and
            ARL3T31A/C118F mutations
  JOURNAL   FASEB J 38 (5), e23519 (2024)
   PUBMED   38457249
  REMARK    GeneRIF: Mechanisms underlying morphological and functional changes
            of cilia in fibroblasts derived from patients bearing ARL3[T31A]
            and ARL3[T31A/C118F] mutations.
REFERENCE   2  (bases 1 to 3834)
  AUTHORS   Travis,A.M. and Pearring,J.N.
  TITLE     Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo
            Delivery to the Cilia, Cause Retinal Dystrophy
  JOURNAL   Adv Exp Med Biol 1415, 283-288 (2023)
   PUBMED   37440046
  REMARK    GeneRIF: Human Mutations in Arl3, a Small GTPase Involved in
            Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy.
REFERENCE   3  (bases 1 to 3834)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3834)
  AUTHORS   Khrenova,M.G., Bulavko,E.S., Mulashkin,F.D. and Nemukhin,A.V.
  TITLE     Mechanism of Guanosine Triphosphate Hydrolysis by the Visual
            Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab
            Initio Type QM/MM Potentials
  JOURNAL   Molecules 26 (13), 3998 (2021)
   PUBMED   34208932
  REMARK    GeneRIF: Mechanism of Guanosine Triphosphate Hydrolysis by the
            Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed
            with Ab Initio Type QM/MM Potentials.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3834)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3834)
  AUTHORS   Linari,M., Hanzal-Bayer,M. and Becker,J.
  TITLE     The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE
            delta, interacts with the Arf-like protein Arl3 in a GTP specific
            manner
  JOURNAL   FEBS Lett 458 (1), 55-59 (1999)
   PUBMED   10518933
REFERENCE   7  (bases 1 to 3834)
  AUTHORS   Kim,H.S.
  TITLE     Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene
            to chromosome 10 band q23.3 by radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 246 (1998)
   PUBMED   10072593
REFERENCE   8  (bases 1 to 3834)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 3834)
  AUTHORS   Cavenagh,M.M., Breiner,M., Schurmann,A., Rosenwald,A.G., Terui,T.,
            Zhang,C., Randazzo,P.A., Adams,M., Joost,H.G. and Kahn,R.A.
  TITLE     ADP-ribosylation factor (ARF)-like 3, a new member of the ARF
            family of GTP-binding proteins cloned from human and rat tissues
  JOURNAL   J Biol Chem 269 (29), 18937-18942 (1994)
   PUBMED   8034651
REFERENCE   10 (bases 1 to 3834)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391121.29.
            
            On Nov 23, 2018 this sequence version replaced NM_004311.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1149522.1,
                                           SRR3476690.185947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260746.6/ ENSP00000260746.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AL391121.29        123623-123747       c
            126-269             AL391121.29        114696-114839       c
            270-386             AL391121.29        108723-108839       c
            387-437             AL391121.29        99243-99293         c
            438-623             AL391121.29        95166-95351         c
            624-3834            AL391121.29        83081-86291         c
FEATURES             Location/Qualifiers
     source          1..3834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..3834
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /note="ARF like GTPase 3"
                     /db_xref="GeneID:403"
                     /db_xref="HGNC:HGNC:694"
                     /db_xref="MIM:604695"
     exon            1..125
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..671
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /note="ARF-like 3; ADP ribosylation factor like GTPase 3;
                     ADP-ribosylation factor-like 3"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 3"
                     /protein_id="NP_004302.1"
                     /db_xref="CCDS:CCDS7538.1"
                     /db_xref="GeneID:403"
                     /db_xref="HGNC:HGNC:694"
                     /db_xref="MIM:604695"
                     /translation="MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISH
                     ITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEE
                     TGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSA
                     LTGEGVQDGMNWVCKNVNAKKK"
     exon            126..269
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /inference="alignment:Splign:2.1.0"
     exon            270..386
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /inference="alignment:Splign:2.1.0"
     exon            387..437
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /inference="alignment:Splign:2.1.0"
     exon            438..623
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /inference="alignment:Splign:2.1.0"
     exon            624..3834
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /note="hexamer: AATAAA"
     regulatory      880..885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /note="hexamer: ATTATA"
     polyA_site      899
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /note="major polyA site"
     polyA_site      902
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /note="major polyA site"
     regulatory      3813..3818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
                     /note="hexamer: AATAAA"
     polyA_site      3834
                     /gene="ARL3"
                     /gene_synonym="ARFL3; JBTS35; RP83"
ORIGIN      
        1 gtattgctgc tcagctcctc agctgtgcgt gcgagggacg tcgggggcgg cgccgcagca
       61 gttgcccctg gtaacggggg aggcagcagg aggaggagga ggaggaggga ctcggcggga
      121 ggatgggctt gctctcaatt ttgcgcaagt tgaaaagtgc accagaccag gaggtgagaa
      181 tacttctcct gggcttggat aatgctggca agaccactct tctgaagcag cttgcatctg
      241 aagacatcag ccacatcaca cctacacagg gtttcaacat caaaagtgta caatcacaag
      301 gttttaaact gaatgtatgg gacattggtg gacagaggaa aatcagacca tactggaaga
      361 attattttga aaataccgat attcttatat atgtaatcga cagtgcagac agaaaaagat
      421 ttgaagagac gggtcaggaa ctagcggaat tactggagga agaaaaacta agttgtgtgc
      481 cagtgctcat ctttgctaat aagcaggatt tgctcacagc agcccctgcc tctgaaattg
      541 cagaaggact gaacctgcat accatccgcg accgagtctg gcagatccag tcttgctcag
      601 ctctcacagg agagggcgtt caggatggca tgaactgggt ctgcaaaaat gtcaatgcaa
      661 agaagaaata aaatctagac gaatggagat gcaggagctg cgggagccga attcggtcct
      721 gaaaaacact aatttgctgc tttctgacca aatgtttttc catctgtgta cagctccagc
      781 tgtttgaaga gagggaacaa cacggtttag aaagaatccc cattccagca gtagatttaa
      841 ctgatctctg aggttcagta tcatttttca aataaaggaa ttatattatt tcctctgcat
      901 aattgaaata gtattaaatg tctcaaagca catgattaga aaatgagatc ttttaaatga
      961 gcaagagatt gcattgcagt ttagacaatt ccagtgggct tttttttcct ctcaaaaaaa
     1021 aaaaaagaaa aagaaaaaga ggaagaagca gctttgctga gttcatttat ttactgaccc
     1081 gtcccttgca ttccctccat ggttttgaaa ccacagacag tgtttgctgg tgctgtcagt
     1141 gatttttacc gtcactagcc cagccaggct tcagtctgtc cgacaggaag ctgctgggtg
     1201 ggggtggggg gagaaaaggc agataattaa accatctcat cgtcttgcag gtcggagact
     1261 acgtatgtaa tcctcactct ttggacagaa aaaaaaaaaa aagtctttct tgcagacaag
     1321 tcactacaga aacatacccc atcccaccca cccctgcctc tgccccagcc agccacacag
     1381 agaagcaaat tcttatgact tttgactgta atgacatctg gaatgtaagg agaggtggga
     1441 ggtttaattc cagaaaaatt acaaggtcct taaaaagctc tcacatcgag ggctcaggct
     1501 agcgtaaaca ggctttctcc agctcagtgg agcagtgagc agccgactct gagattagct
     1561 ggcttctcca cggccgtcct atagacagga tttctaaagc tcaaagaatt ctgtgtttaa
     1621 acgatcacaa taggccgctg ctatcagatt ttagaaataa atgcagcttt accatgaacc
     1681 tgctccactg agaaaagcca ggcagatcga tttttagatc aatttttaca gtgctggcaa
     1741 cttggtggtg tgggatgctc ctggatggag agggtttgct gctggggagg acatgggtgt
     1801 gtgtgtgact gcaggggtcg tgtccaagga atcaagagtc accccagctg ctgggctcct
     1861 ctgcctctct gcagcagaat gtccgtcctc tgttgattga ttggagagga atagcagaac
     1921 atttctcctg cccctcgttg caaaacgagc ttgtttccct gaacctcaga aatcctcagc
     1981 ttcaaacatg gggaaacagg ccagagcatt gcccggctcc tgaattaaac tctgttctgg
     2041 tgcctgagct caggggtttt cagagaatga ataagagact gtccagtgac tggtgggtcc
     2101 ctgggggcca gctgccttct catcctggga ggtggccctt cccaagccca tcagggcgtg
     2161 tgagcagact gaaggggccg ctgcagcccc tggccctcaa tacccagctg cttctggcta
     2221 agagtgcagc agagactgag gcatagccag cttcaaaagc gatctgacat gaaagtcatt
     2281 aacaaagcca gccgtgaaaa ggtgccccag agttgctgtg gacagacctg taaggacttg
     2341 caaaacaaaa gaaagtgagg ggttttttta acctcagagc tagctgctct ctgcagcctc
     2401 ctccactggc ttctctggct cacccaagct ctcccttaca gaggcaacac agaattataa
     2461 ggaatcagaa atcccccttc taccaggctg caaatgtggc tctagcactt gcaaattgtt
     2521 ttttcttccg aatagttcag cagggacaag ttatctgagg ggcaaaatgc ctgcttggag
     2581 gtctgcaatt ttggaacact gcagtatgga actttggcat tggagggtct gtaaaatatt
     2641 tttgttcttt taccaccaac ttaggggact gttttaaaga gccatcccaa ggcctctcct
     2701 agcaggcaga agccactcct ctgataacgg cctctgtaaa tgttctgatt tgctctcagc
     2761 tgcagagaca cagagacact gcagatgtca cacgctttca tcttcccttt gagccctttt
     2821 gaaccctcct ggggctctgg ggtagatgag agaagcctga aaaaggcaga gtttgaaagc
     2881 tcccatttaa aaacaaaata ctttttaaag ccctcttgcc tcttccctgc ccactcctgc
     2941 cccctgacca gaagacagaa tttgaagctg gaaagggaag accccttttc ccctcctcct
     3001 gtccccagtg agtcttagcg agacttttgc cctgcgcaca attgcatctg aatgtgcggg
     3061 ggagagggct gggggccgga gggcaggcaa ggcctggggg gtgctcgtga tatgtgctca
     3121 agccagttgt gggaaaaact cgagtcctcc cctcctcccg acctaccccg tgtggctgct
     3181 tttggctgga ttccctgcac ccagtgcaac acaccctttc cccttcactc tcccttggtt
     3241 actatggaaa caagggtgtc attgatgtgg gctgagctgg ggaacatgtc ggtgcacagc
     3301 tgaaagtcag cgattatgcc ggcggttaga aatgtgccag ggttaaagga gtccgcagct
     3361 cccacggctg ctgggaggac atggtcctgc ccccttcctt cctccctccc tccgtctcca
     3421 cttctctctc cttgcttttg acaaatttct ttattcccct ctggactaaa gtagtggcta
     3481 tttttgtgcc actctgcgcc ccaccctcac tgttggccgc tccttatccg gcctggcctg
     3541 gagggtgaca ccatgtcacc ctcaccagga ctcgtctctc cattcccgtc agagtttgct
     3601 ttgatttccc tttcctttcc ttctcgggga ccagttctta cttcctttta tttttagctc
     3661 tgcactccat gtggtttcag ggttcagtct gatccatcaa aaggttcttt ttttataatc
     3721 ccttttgaaa atgataatca aaggaagaga tgtggtgttt ggtcatgtgg aaaactcaat
     3781 gtataattta gacgtctgtc aaaaatccga caaataaaat ttagctggaa cgaa
//
