LOCUS       NM_012106               1969 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens ARF like GTPase 2 binding protein (ARL2BP), mRNA.
ACCESSION   NM_012106
VERSION     NM_012106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Park,M.C., Kim,H., Choi,H., Chang,M.S. and Lee,S.K.
  TITLE     Epstein-Barr Virus miR-BART1-3p Regulates the miR-17-92 Cluster by
            Targeting E2F3
  JOURNAL   Int J Mol Sci 22 (20), 10936 (2021)
   PUBMED   34681596
  REMARK    GeneRIF: Epstein-Barr Virus miR-BART1-3p Regulates the miR-17-92
            Cluster by Targeting E2F3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   ElMaghloob,Y., Sot,B., McIlwraith,M.J., Garcia,E., Yelland,T. and
            Ismail,S.
  TITLE     ARL3 activation requires the co-GEF BART and effector-mediated
            turnover
  JOURNAL   Elife 10, e64624 (2021)
   PUBMED   33438581
  REMARK    GeneRIF: ARL3 activation requires the co-GEF BART and
            effector-mediated turnover.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Bartolini,F., Bhamidipati,A., Thomas,S., Schwahn,U., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Functional overlap between retinitis pigmentosa 2 protein and the
            tubulin-specific chaperone cofactor C
  JOURNAL   J Biol Chem 277 (17), 14629-14634 (2002)
   PUBMED   11847227
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Sharer,J.D., Shern,J.F., Van Valkenburgh,H., Wallace,D.C. and
            Kahn,R.A.
  TITLE     ARL2 and BART enter mitochondria and bind the adenine nucleotide
            transporter
  JOURNAL   Mol Biol Cell 13 (1), 71-83 (2002)
   PUBMED   11809823
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Van Valkenburgh,H., Shern,J.F., Sharer,J.D., Zhu,X. and Kahn,R.A.
  TITLE     ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both
            specific and shared effectors: characterizing ARL1-binding proteins
  JOURNAL   J Biol Chem 276 (25), 22826-22837 (2001)
   PUBMED   11303027
REFERENCE   9  (bases 1 to 1969)
  AUTHORS   Sharer,J.D. and Kahn,R.A.
  TITLE     The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning,
            and initial characterization
  JOURNAL   J Biol Chem 274 (39), 27553-27561 (1999)
   PUBMED   10488091
REFERENCE   10 (bases 1 to 1969)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003087.1, BF590083.1 and
            AC009090.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012106.3.
            
            Summary: ADP-ribosylation factor (ARF)-like proteins (ARLs)
            comprise a functionally distinct group of the ARF family of
            RAS-related GTPases. The protein encoded by this gene binds to
            ARL2.GTP with high affinity but does not interact with ARL2.GDP,
            activated ARF, or RHO proteins. The lack of detectable membrane
            association of this protein or ARL2 upon activation of ARL2 is
            suggestive of actions distinct from those of the ARFs. This protein
            is considered to be the first ARL2-specific effector identified,
            due to its interaction with ARL2.GTP but lack of ARL2
            GTPase-activating protein activity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.49844.1,
                                           SRR3476690.1049778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219204.8/ ENSP00000219204.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1930              BC003087.1         6-1935
            1931-1967           BF590083.1         2-38                c
            1968-1969           AC009090.12        9943-9944           c
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..1969
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /note="ARF like GTPase 2 binding protein"
                     /db_xref="GeneID:23568"
                     /db_xref="HGNC:HGNC:17146"
                     /db_xref="MIM:615407"
     exon            1..147
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..601
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /note="binder of Arl Two; binder of Arl2; Arf-like 2
                     binding protein BART1; binder of ARF2 protein 1; ARF-like
                     2-binding protein; ARL2-binding protein; retinitis
                     pigmentosa 66 (autosomal recessive); ADP-ribosylation
                     factor like 2 binding protein; ADP ribosylation factor
                     like GTPase 2 binding protein"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 2-binding
                     protein"
                     /protein_id="NP_036238.1"
                     /db_xref="CCDS:CCDS10776.1"
                     /db_xref="GeneID:23568"
                     /db_xref="HGNC:HGNC:17146"
                     /db_xref="MIM:615407"
                     /translation="MDALEGESFALSFSSASDAEFDAVVGYLEDIIMDDEFQLLQRNF
                     MDKYYLEFEDTEENKLIYTPIFNEYISLVEKYIEEQLLQRIPEFNMAAFTTTLQHHKD
                     EVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSLPASQNN
                     LRH"
     exon            148..209
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /inference="alignment:Splign:2.1.0"
     exon            210..316
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /inference="alignment:Splign:2.1.0"
     exon            317..402
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /inference="alignment:Splign:2.1.0"
     exon            403..499
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1969
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /note="hexamer: ATTAAA"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /note="hexamer: AGTAAA"
     polyA_site      1936
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /note="major polyA site"
     polyA_site      1969
                     /gene="ARL2BP"
                     /gene_synonym="BART; BART1; RP66; RP82"
                     /note="major polyA site"
ORIGIN      
        1 agtgagctgg ccgcggcctt ggctgagagg ccttaacccc gccgggcggc cgcgccctgc
       61 atgcgagttg ggccgcgggc ggggttggag cctactcggg gcgactgcga tggacgcctt
      121 agaaggagag agctttgcgc tgtctttctc ctccgcctct gatgcagaat ttgatgctgt
      181 ggttggatat ttagaggaca ttatcatgga tgacgagttc cagttattac agagaaattt
      241 catggacaag tactacctgg agtttgaaga cacagaagag aataaactca tctacacacc
      301 tatttttaat gaatacattt ctttggtaga aaaatacatt gaagaacagc tgctgcagcg
      361 gattcctgag ttcaacatgg cagccttcac cacaacatta cagcaccata aggatgaagt
      421 ggctggtgac atattcgaca tgctgctcac cttcacagat tttctggctt ttaaagaaat
      481 gtttttggac tacagagcag aaaaagaagg ccgaggactg gacttaagca gtggcttagt
      541 ggtgacttca ttgtgcaaat catcttctct gccagcttcc cagaacaatc tgcggcacta
      601 ggtcctacct ccagccaatg aatgggatca ttctggatgt caccagccca ataggctcag
      661 ctcatgatga cagaacacat cttggaaaga ctgactctgt tatgtaactc ttcatttatg
      721 ttaagtatta ataggtcaaa accaaaatga cctaaccctc ctggacctat ttatcctgaa
      781 acaccttctt gtattcatta accatagtac tcctccccac ctcaagtaga cacctctctc
      841 aggagcttct gagtcagacg cctctggagc gagccctatg tcaggcactc cacctggggg
      901 gcccttcccc agcatacctg ctggtgtgta agtgtggact aacccgccgc caccaccctc
      961 tgttccagca ggctctgcat gaatctttgt gcacttgcac ctctttttca catgggccac
     1021 agtttcagta cttcagcctc agtggggttc ctgatgttta tctagggtgt tactcaagcc
     1081 cagtttgaga ttttggagtc tcctgtgatc acatcttgtc tcggctgtag gaatcaacag
     1141 aaggagacgt cctctacata aaagctccat gtgaaaagct actcctagtc ttaacatttg
     1201 cagtccttgt gtcactgtct tctggtcctg atgtagtccc actgtttcta gaagtctctt
     1261 ttaagcatta tttttgaaaa aaaaaatatt tttatagatg aatactcagg ctaacctagt
     1321 ggatgtgatc ttggaacttc catgattatc cacttaaaga tcaaagtatt atatgctgtg
     1381 tgctttttag gtgtttgtta gtactgtgaa ggcaaaaatg ctttctacat tgacattcat
     1441 tcctatttta ctgggcacct atgaatgtat gctgtgtgct agaaatagac taaaacatat
     1501 tcctatagca tgttagtgtg tttgcatgtt tgctgaaaat cctttgtgta taaaccagtt
     1561 tgtaaggttc tctgggttag gtagggactc tgcagtttct tcctgtcaaa atctctccta
     1621 ccaagatggt gttccactgt ccagcccagc atgagtagca ggtagagcac agctttactg
     1681 gctgtttgta tgctttggtt tagtgcaatg tgtggtagat tacttatcag aaaacatata
     1741 tgtcatctct agaacgaaga aaaagcatag tagttcaatt cccagtgtgt ccctttgatt
     1801 tttttttttt aatagtaaaa ataagaatct gtactgactt ttcacttggc cattctggtt
     1861 ttaaaggaca agctacaagc tctgtgtttc tgtactgatg tgtcacttat taaatacttt
     1921 tgtaccatga gtaaaacttc aggtgtttcg caagaaccac cattctcaa
//
