LOCUS       NM_001667                932 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 2 (ARL2), transcript variant 1, mRNA.
ACCESSION   NM_001667
VERSION     NM_001667.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 932)
  AUTHORS   Lee,H., Choi,S., Ha,S., Yoon,S. and Kim,W.Y.
  TITLE     ARL2 is required for homologous recombination repair and colon
            cancer stem cell survival
  JOURNAL   FEBS Open Bio 12 (8), 1523-1533 (2022)
   PUBMED   35567502
  REMARK    GeneRIF: ARL2 is required for homologous recombination repair and
            colon cancer stem cell survival.
REFERENCE   2  (bases 1 to 932)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 932)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 932)
  AUTHORS   Rittig,A.H., Johansen,C., Celis,P., Odum,N., Litman,T.,
            Woetmann,A., Lindahl,L.M. and Iversen,L.
  TITLE     Suppressed microRNA-195-5p expression in mycosis fungoides promotes
            tumor cell proliferation
  JOURNAL   Exp Dermatol 30 (8), 1141-1149 (2021)
   PUBMED   32492224
  REMARK    GeneRIF: Suppressed microRNA-195-5p expression in mycosis fungoides
            promotes tumor cell proliferation.
REFERENCE   5  (bases 1 to 932)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 932)
  AUTHORS   Bartolini,F., Bhamidipati,A., Thomas,S., Schwahn,U., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Functional overlap between retinitis pigmentosa 2 protein and the
            tubulin-specific chaperone cofactor C
  JOURNAL   J Biol Chem 277 (17), 14629-14634 (2002)
   PUBMED   11847227
REFERENCE   7  (bases 1 to 932)
  AUTHORS   Sharer,J.D., Shern,J.F., Van Valkenburgh,H., Wallace,D.C. and
            Kahn,R.A.
  TITLE     ARL2 and BART enter mitochondria and bind the adenine nucleotide
            transporter
  JOURNAL   Mol Biol Cell 13 (1), 71-83 (2002)
   PUBMED   11809823
REFERENCE   8  (bases 1 to 932)
  AUTHORS   Bhamidipati,A., Lewis,S.A. and Cowan,N.J.
  TITLE     ADP ribosylation factor-like protein 2 (Arl2) regulates the
            interaction of tubulin-folding cofactor D with native tubulin
  JOURNAL   J Cell Biol 149 (5), 1087-1096 (2000)
   PUBMED   10831612
REFERENCE   9  (bases 1 to 932)
  AUTHORS   Guru,S.C., Agarwal,S.K., Manickam,P., Olufemi,S.E., Crabtree,J.S.,
            Weisemann,J.M., Kester,M.B., Kim,Y.S., Wang,Y., Emmert-Buck,M.R.,
            Liotta,L.A., Spiegel,A.M., Boguski,M.S., Roe,B.A., Collins,F.S.,
            Marx,S.J., Burns,L. and Chandrasekharappa,S.C.
  TITLE     A transcript map for the 2.8-Mb region containing the multiple
            endocrine neoplasia type 1 locus
  JOURNAL   Genome Res 7 (7), 725-735 (1997)
   PUBMED   9253601
REFERENCE   10 (bases 1 to 932)
  AUTHORS   Clark,J., Moore,L., Krasinskas,A., Way,J., Battey,J., Tamkun,J. and
            Kahn,R.A.
  TITLE     Selective amplification of additional members of the
            ADP-ribosylation factor (ARF) family: cloning of additional human
            and Drosophila ARF-like genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (19), 8952-8956 (1993)
   PUBMED   8415637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG706294.1, BC002530.2 and AI631767.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001667.3.
            
            Summary: This gene encodes a small GTP-binding protein of the RAS
            superfamily which functions as an ADP-ribosylation factor (ARF).
            The encoded protein is one of a functionally distinct group of
            ARF-like genes. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.712375.1,
                                           SRR1163657.315045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246747.9/ ENSP00000246747.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BG706294.1         53-73
            22-613              BC002530.2         1-592
            614-932             AI631767.1         15-333              c
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..932
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /note="ARF like GTPase 2"
                     /db_xref="GeneID:402"
                     /db_xref="HGNC:HGNC:693"
                     /db_xref="MIM:601175"
     exon            1..113
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..603
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like protein 2; ADP-ribosylation
                     factor-like 2; ADP ribosylation factor like GTPase 2"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 2 isoform
                     1"
                     /protein_id="NP_001658.2"
                     /db_xref="CCDS:CCDS8088.1"
                     /db_xref="GeneID:402"
                     /db_xref="HGNC:HGNC:693"
                     /db_xref="MIM:601175"
                     /translation="MGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDIDTI
                     SPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDC
                     QRELQSLLVEERLAGATLLIFANKQDLPGALSSNAIREVLELDSIRSHHWCIQGCSAV
                     TGENLLPGIDWLLDDISSRIFTAD"
     exon            114..224
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..387
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..468
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..932
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      911..916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /note="hexamer: AATAAA"
     polyA_site      932
                     /gene="ARL2"
                     /gene_synonym="ARFL2; MRCS1"
                     /note="major polyA site"
ORIGIN      
        1 gtcccgggac tgggaagaaa cggcggccgg gagggggctc cggggaccat ggggctcctg
       61 accattctga agaagatgaa gcagaaagag cgggagctgc gactgctcat gcttggcctg
      121 gacaatgctg gaaagacaac catcctgaag aagttcaatg gggaggacat cgacaccatc
      181 tccccaacgc tgggcttcaa catcaagacc ctggagcacc gaggattcaa gctgaacatc
      241 tgggatgtgg gtggccagaa gtccctgcgg tcctactggc ggaactactt tgagagcacc
      301 gatggcctca tctgggtagt ggacagcgca gaccgccagc gcatgcagga ctgccagcgg
      361 gagctccaga gcctgctggt ggaggagcgc ctggccggag caaccctcct catctttgct
      421 aataagcagg acctgcctgg agcactgtcc tctaacgcca tccgcgaggt cctggagctg
      481 gactccatcc gcagccacca ctggtgcatc cagggctgca gcgccgtcac cggggagaac
      541 ctgctgccgg gcatcgactg gctcctggat gacatttcca gccgcatttt cacagctgac
      601 tgaaccactc cagatgcccc ccacctagca gtccaggtcc ctcaaccttc accaaacact
      661 acccatgggg ggttgggagt cagccggcca aactaacact ccccctcctc caccccagcc
      721 tgctgctgct actgctgccc gctgctgctc tgtggccacc cggctcccat ggcgggaggg
      781 ctgtgccctg gctgtctctc tggctcctga cctggccttt ggctaccata ccaagaagag
      841 agggctgggc ggggaggagc tgctactgct gctaccgagg ctgtgggcct catccttcac
      901 tcagttgtga aataaaccgc tccttgcccc ga
//
