LOCUS       NM_001040025            1087 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 16 (ARL16), transcript variant 1,
            mRNA.
ACCESSION   NM_001040025 XM_290777 XM_941329
VERSION     NM_001040025.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1087)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1087)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1087)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1087)
  AUTHORS   Yang,Y.K., Qu,H., Gao,D., Di,W., Chen,H.W., Guo,X., Zhai,Z.H. and
            Chen,D.Y.
  TITLE     ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its
            C-terminal domain in a GTP-dependent manner
  JOURNAL   J Biol Chem 286 (12), 10568-10580 (2011)
   PUBMED   21233210
  REMARK    GeneRIF: ARF-like protein 16 (ARL16) inhibits RIG-I by binding with
            its C-terminal domain in a GTP-dependent manner
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139530.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 18, 2020 this sequence version replaced NM_001040025.2.
            
            Summary: The protein encoded by this gene belongs to the ARL
            (ADP-ribosylation factor-like) family of proteins, which are
            structurally related to ADP-ribosylation factors (ARFs). This
            protein has been shown to have an inhibitory role in the cellular
            antiviral response. This gene product interacts with the C-terminal
            domain of the DEXD/H-box helicase 58 (DDX58) gene product. This
            interaction was found to suppress the association between the DDX58
            gene product and RNA, thereby negatively regulating the activity of
            the DDX58 gene product. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304718.1, BC042380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622299.5/ ENSP00000483183.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC139530.3         45891-45995
            106-164             AC139530.3         46094-46152
            165-278             AC139530.3         46562-46675
            279-394             AC139530.3         47539-47654
            395-1087            AC139530.3         47809-48501
FEATURES             Location/Qualifiers
     source          1..1087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1087
                     /gene="ARL16"
                     /note="ARF like GTPase 16"
                     /db_xref="GeneID:339231"
                     /db_xref="HGNC:HGNC:27902"
                     /db_xref="MIM:619117"
     exon            1..105
                     /gene="ARL16"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..566
                     /gene="ARL16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like protein 16; ADP ribosylation
                     factor like GTPase 16"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 16 isoform
                     1"
                     /protein_id="NP_001035114.2"
                     /db_xref="CCDS:CCDS45813.2"
                     /db_xref="GeneID:339231"
                     /db_xref="HGNC:HGNC:27902"
                     /db_xref="MIM:619117"
                     /translation="MCLLLGATGVGKTLLVKRLQEVSSRDGKGDLGEPPPTRPTVGTN
                     LTDIVAQRKITIRELGGCMGPIWSSYYGNCRSLLFVMDASDPTQLSASCVQLLGLLSA
                     EQLAEASVLILFNKIDLPCYMSTEEMKSLIRLPDIIACAKQNITTAEISAREGTGLAG
                     VLAWLQATHRAND"
     exon            106..164
                     /gene="ARL16"
                     /inference="alignment:Splign:2.1.0"
     exon            165..278
                     /gene="ARL16"
                     /inference="alignment:Splign:2.1.0"
     exon            279..394
                     /gene="ARL16"
                     /inference="alignment:Splign:2.1.0"
     exon            395..1087
                     /gene="ARL16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1068..1073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL16"
                     /note="hexamer: AATAAA"
     polyA_site      1087
                     /gene="ARL16"
                     /note="major polyA site"
ORIGIN      
        1 gccgcggcgc cgagctacgg gtgccgggtg gagcgaagca cggaatgtgt ctcctgctgg
       61 gggccacggg cgtcgggaag acgctgctgg tgaaacggct gcaggaggtg agctcccggg
      121 atgggaaagg cgacctgggg gagccgcccc cgacacggcc cacggtgggc accaatctta
      181 ctgacatcgt ggcacagaga aagatcacca tccgggagct tggggggtgc atgggcccca
      241 tctggtccag ttactatgga aactgccgtt ctctcctgtt tgtgatggac gcctctgacc
      301 ccacccagct ctctgcatcc tgtgtgcagc tcttaggtct cctttctgca gaacaacttg
      361 cagaagcatc ggtgctgata ctcttcaata aaatcgacct accctgttac atgtccacgg
      421 aggagatgaa gtcattaatc aggcttccag acatcattgc ttgtgccaag cagaacatca
      481 ccacggcaga aatcagcgcc cgtgaaggca ctggcttagc aggggtgctg gcctggctcc
      541 aggccaccca cagagccaac gattgactgc acggcagagg cgcagctggc ctgagctggg
      601 gagaggtggc agagggcagt atggctttgc tgccaatagt ttcttctcac aggggcagaa
      661 taacccaaag taaccctaca tgatggggct ctgtgctgag atgcaatgat gtgtaaactg
      721 aggcatgtgg agatggaagt tgacatctgg cctctgaaaa aagtgtcccc aggggctagg
      781 catggtggct cacacctgta atcccagcac tttgagaggc cgaggcgggt gtatcacctg
      841 aggtcgggag ttcgagacta gcctgaccaa catggagaaa ccctgtctct actaaaaata
      901 caaaattagc tgggtgtgct ggtgcatgcc tgtaatctca gctacttggg aggctgagac
      961 aggagaatcc cttgaacctg ggaggtggag gttgcagtga gtcgagatca tgccattgca
     1021 ctgcacctgg gcaacaagag tgaaactccg tcttaaaaaa tataagaaat aaaaaaataa
     1081 aaacctg
//
