LOCUS       NM_138450               3552 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF like GTPase 11 (ARL11), mRNA.
ACCESSION   NM_138450
VERSION     NM_138450.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3552)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3552)
  AUTHORS   Hamadou,W.S., Besbes,S., Mani,R., Bourdon,V., Ben Youssef,Y.,
            Achour,B., Regaieg,H., Eisinger,F., Mari,V., Gesta,P., Dreyfus,H.,
            Bonadona,V., Dugast,C., Zattara,H., Faivre,L., Noguchi,T.,
            Khelif,A., Sobol,H. and Soua,Z.
  TITLE     ARLTS1, potential candidate gene in familial aggregation of
            hematological malignancies
  JOURNAL   Bull Cancer 104 (2), 123-127 (2017)
   PUBMED   27866680
  REMARK    GeneRIF: ARLTS1 gene mutations can be considered as a potential
            predisposing factor in familial hematological malignancies
REFERENCE   3  (bases 1 to 3552)
  AUTHORS   Siltanen,S., Fischer,D., Rantapero,T., Laitinen,V., Mpindi,J.P.,
            Kallioniemi,O., Wahlfors,T. and Schleutker,J.
  TITLE     ARLTS1 and prostate cancer risk--analysis of expression and
            regulation
  JOURNAL   PLoS One 8 (8), e72040 (2013)
   PUBMED   23940804
  REMARK    GeneRIF: A statistically significant (p = 0.0037) decrease of
            ARLTS1 expression in prostate cancer cases was detected.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3552)
  AUTHORS   Gourraud,P.A., Sdika,M., Khankhanian,P., Henry,R.G., Beheshtian,A.,
            Matthews,P.M., Hauser,S.L., Oksenberg,J.R., Pelletier,D. and
            Baranzini,S.E.
  TITLE     A genome-wide association study of brain lesion distribution in
            multiple sclerosis
  JOURNAL   Brain 136 (Pt 4), 1012-1024 (2013)
   PUBMED   23412934
REFERENCE   5  (bases 1 to 3552)
  AUTHORS   Yendamuri,S., Trapasso,F. and Calin,G.A.
  TITLE     ARLTS1 - a novel tumor suppressor gene
  JOURNAL   Cancer Lett 264 (1), 11-20 (2008)
   PUBMED   18375053
  REMARK    GeneRIF: A novel tumor suppressor gene [ARLTS1 (ADP-ribosylation
            factor-like tumor suppressor gene 1)]is found to be altered in
            human carcinogenesis. It is located in Chromosome 13q14.3.
            Review article
REFERENCE   6  (bases 1 to 3552)
  AUTHORS   Frank,B., Hemminki,K., Brenner,H., Hoffmeister,M., Chang-Claude,J.
            and Burwinkel,B.
  TITLE     ARLTS1 variants and risk of colorectal cancer
  JOURNAL   Cancer Lett 244 (2), 172-175 (2006)
   PUBMED   16488076
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3552)
  AUTHORS   Sellick,G.S., Catovsky,D. and Houlston,R.S.
  TITLE     Relationship between ARLTS1 polymorphisms and risk of chronic
            lymphocytic leukemia
  JOURNAL   Leuk Res 30 (12), 1573-1576 (2006)
   PUBMED   16581122
  REMARK    GeneRIF: The study does not support the postulate that variants of
            ARLTS1 influence the risk of chronic lymphocytic leukemia(CLL).
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3552)
  AUTHORS   Masojc,B., Mierzejewski,M., Cybulski,C., van de Wetering,T.,
            Debniak,T., Gorski,B., Jaworowska,E., Tarnowska,C., Lenner,M.,
            Scott,R.J. and Lubinski,J.
  TITLE     Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1
            gene
  JOURNAL   Breast Cancer Res Treat 99 (1), 59-62 (2006)
   PUBMED   16570116
  REMARK    GeneRIF: the G446A in ARLTS1 gene is probably not associated with
            an increased risk of sporadic breast cancer, prostate cancer,
            melanoma, thyroid papillary cancer or laryngeal cancer
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3552)
  AUTHORS   Frank,B., Hemminki,K., Meindl,A., Wappenschmidt,B., Klaes,R.,
            Schmutzler,R.K., Untch,M., Bugert,P., Bartram,C.R. and Burwinkel,B.
  TITLE     Association of the ARLTS1 Cys148Arg variant with familial breast
            cancer risk
  JOURNAL   Int J Cancer 118 (10), 2505-2508 (2006)
   PUBMED   16353159
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3552)
  AUTHORS   Calin,G.A., Trapasso,F., Shimizu,M., Dumitru,C.D., Yendamuri,S.,
            Godwin,A.K., Ferracin,M., Bernardi,G., Chatterjee,D.,
            Baldassarre,G., Rattan,S., Alder,H., Mabuchi,H., Shiraishi,T.,
            Hansen,L.L., Overgaard,J., Herlea,V., Mauro,F.R., Dighiero,G.,
            Movsas,B., Rassenti,L., Kipps,T., Baffa,R., Fusco,A., Mori,M.,
            Russo,G., Liu,C.G., Neuberg,D., Bullrich,F., Negrini,M. and
            Croce,C.M.
  TITLE     Familial cancer associated with a polymorphism in ARLTS1
  JOURNAL   N Engl J Med 352 (16), 1667-1676 (2005)
   PUBMED   15843669
  REMARK    GeneRIF: A genetic variant of ARLTS1 predisposes patients to
            familial cancer.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF441378.1 and AK091249.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_138450.5.
            
            Summary: This gene encodes a tumor suppressor related to the
            ADP-ribosylation factor (ARF) family of proteins. The encoded
            protein may play a role in apoptosis in a caspase-dependent manner.
            Polymorphisms in this gene have been associated with some familial
            cancers. [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF441378.1, SRR1660805.72979.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282026.2/ ENSP00000282026.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1655              AF441378.1         209-1863
            1656-2839           AK091249.1         1675-2858
            2840-3552           AF441378.1         3048-3760
FEATURES             Location/Qualifiers
     source          1..3552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..3552
                     /gene="ARL11"
                     /gene_synonym="ARLTS1"
                     /note="ARF like GTPase 11"
                     /db_xref="GeneID:115761"
                     /db_xref="HGNC:HGNC:24046"
                     /db_xref="MIM:609351"
     exon            1..109
                     /gene="ARL11"
                     /gene_synonym="ARLTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..3552
                     /gene="ARL11"
                     /gene_synonym="ARLTS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..718
                     /gene="ARL11"
                     /gene_synonym="ARLTS1"
                     /note="ADP-ribosylation factor-like tumor suppressor
                     protein 1; ADP-ribosylation factor-like 11;
                     ADP-ribosylation factor-like tumor suppressor gene 1; ADP
                     ribosylation factor like GTPase 11"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 11"
                     /protein_id="NP_612459.1"
                     /db_xref="CCDS:CCDS9419.1"
                     /db_xref="GeneID:115761"
                     /db_xref="HGNC:HGNC:24046"
                     /db_xref="MIM:609351"
                     /translation="MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTV
                     GFNVEPLKAPGHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAE
                     LTEVLNDPNMAGVPFLVLANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGE
                     GLPEALQSLWSLLKSRSCMCLQARAHGAERGDSKRS"
ORIGIN      
        1 gcttccttcc catctcgctc ttgggtcatg cctggccagc agaaagcagc tccatagggg
       61 aggagagcca cgcaggatct cacagctgca gtctaatagt aacacagagg attcagcagt
      121 ggccaccatg ggttctgtga attccagagg tcacaaggcg gaagcccagg tggtgatgat
      181 gggcctggac tcggcgggca agaccacgct cctttacaag ctgaagggcc accagctggt
      241 ggagaccctg cccactgttg gtttcaacgt ggagcctctg aaagctcctg ggcacgtgtc
      301 actgactctc tgggacgttg gggggcaggc cccgctcaga gccagctgga aggactatct
      361 ggaaggcaca gatatcctcg tgtacgtgct ggacagcaca gatgaagccc gcttacccga
      421 gtcggcggct gagctcacag aagtcctgaa cgaccccaac atggctggcg tccccttctt
      481 ggtgctggcc aacaagcagg aggcacctga tgcacttccg ctgcttaaga tcagaaacag
      541 gctgagtcta gagagattcc aggaccactg ctgggagctc cggggctgca gtgccctcac
      601 tggggagggg ctgcccgagg ccctgcagag cctgtggagc ctcctgaaat ctcgcagctg
      661 catgtgtctg caggcgagag cccatggggc tgagcgcgga gacagcaaga gatcttgatc
      721 cagacagagc agcatatctt tgctcataca aactagaaga accagctgat ccttgagaaa
      781 tttacgctta gtctatcaaa caagaaatgc tggcttggcc cggtggctca tgcctgtaat
      841 cccagcactg tgggagacca cggtggggga atcccttgag cccaggagtt ggagagcaac
      901 atcacaacac cccatttcta ctaataatca aaaaattggc cgggcatggt ggcatgtgcc
      961 tgtagtccca gctacttggg aggctgaggc aggagaatcg cttgagccca agaggtagag
     1021 gttgcagtga gccaagatcg cgccactgca ctccagtctg ggcaacagag tgagaccctg
     1081 tctcaataat aataataata ataatgatga tactctaaga aaaaaatctc aacatacttc
     1141 atttaatagc tcgttaccaa gtgtgaatga agcaatatgt cataatagag tagccactgg
     1201 ttgcataata atagagacct aaattctcaa atagggaaag aggttttaaa atcaaatttg
     1261 aggccaggtg cagtggctca tgggcggagg agggcagatt acttgaggct aggagttcaa
     1321 gaccagcctg gccaacatgg tgaaacccca tctctactga aaatacaaaa attaggcata
     1381 gtggtgcacg cctgcagtcc cagctactca ggaggttgag gcagaagaat cgcttgaacc
     1441 caggaagtgg aggttgcagt gagccgagat tgtgctgctg cactccagcc tgggtgaaaa
     1501 agacaggctg tgtctccaaa aagaaaaaaa aaagtcaaat tcaaatatca tctggacatg
     1561 tcacaatgga tcgcggatcc ttatgagtga ttttccccag tggcccctgg ggatgtgcca
     1621 ctgtcactca gaagggcaag ctaggcaggg cccatacaac agcaggggtc tgcaggttag
     1681 acgttccctg ccctgggacg ctcacccctg ggcaagaggc tggaagttca caccatccaa
     1741 aatttatcct tgtttttttt ctgatgctaa ttagcctctc ccgattttat gacatcttgt
     1801 gttgatcttt ttcaaaaact cattttcttt tttttccttc tcttttctcc ttcttgtagc
     1861 acatatcttt cgttaaagat cagatcaata aaatatttta tttattcatt aatttaacaa
     1921 aaaaaacaga gcatttagtt tgtggcaaaa acactgagct ttcgaatatg aatcatgtgc
     1981 tttaggtggg aattgtgaat tctgaagata cagatgacag tgacgaatgc cttctgtctc
     2041 atgattgaca gggaaaagga aggttgacca tagcatccta gaaggctcat caggtgatca
     2101 ttacctagca tccatgaagc acctgaaatt atttgcaaaa tgttacgctt tggaccattt
     2161 ttccggggaa ggagatccag aactttttac cagattttca aagacatctg tgactcccaa
     2221 aagttaacaa tcactgatgt ggttgttgta tccctcatcc aaccccagaa cactttctgt
     2281 aatctgagtt ttttaatggc aagtggccta tatttagcac ctgttctcat gttaaacagc
     2341 tctgaatgtt agatattctt tcttatcctg gactggttct ctctatctct ggagtaatgc
     2401 agtataaatt ggccatcagt accctcctaa aatctgagat ctgccaggcc cctcttctaa
     2461 caccaggtta ggcatgcttg gttatttcca gtacttgtca gtcaacatgt ttcaagacgc
     2521 tgtgttagac actagggatg caaagatgaa tgagataagg cctcaggcct catggaaggt
     2581 gagacagtaa agacattact cccataaaaa tgtgaggaga gagactcagt tcagcaactg
     2641 tttattctgt ttattgagca cttacttgga ccaagcactg tggtcttggt gttttacata
     2701 gactgtctct aattctcaca actctgcaaa atatatatat tcccatttta taaaactaca
     2761 aactgaggct cagagaaggt gtgacctctt gttgcttgag gcacagagtt ataaagtaac
     2821 atatctggaa tttgaaatca gatctgttta gggctaatgc tgcatttttc tacaacatca
     2881 tgcctctaga aggtttaagc taggtaggct ttcagccagc agacatgatg gggagagcct
     2941 tctaataaga gggaagagac tgcttggaag catgaaggga ggtgtaagaa agataagtaa
     3001 gtcagtgtac ttgcaacaga ggcttgggat gaagggtggg tgaagttgac atcacgatag
     3061 aaaacaaaac tggaatggga gtttaggtcc aatttgggca aggttgtttg aatttcaata
     3121 atcaggggtt tgggtcaagg aagaaaaatc atgggacttg ccatttagga ggataatttt
     3181 gtggtagtgt ggaggtgaaa taaagagaaa agggaacctt ggagctggga aggcaggaaa
     3241 ccggctagat gaccatcaca cagcaaagga gggagtggaa gagagatgag aaaattgaga
     3301 gctattatta agaaaaacag ttgagagagg aagaatttga agagggctca agattttgag
     3361 tccacatgac agaaggactg gaatgccatg aactggagaa ggtgagcgct gaagaaccag
     3421 gatgggacgg ggctggaaca gctgggttca gcttttgcag ggtgggtacg tgtttggtta
     3481 tagctgcttt cagattgttc cattatctgt actcccaaca accctgccgg atatatttgt
     3541 tggctttcac tc
//
