LOCUS       NM_001177               3197 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens ARF like GTPase 1 (ARL1), transcript variant 1, mRNA.
ACCESSION   NM_001177
VERSION     NM_001177.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3197)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3197)
  AUTHORS   Feng,H.P., Cheng,H.Y., Hsiao,T.F., Lin,T.W., Hsu,J.W., Huang,L.H.
            and Yu,C.J.
  TITLE     ArfGAP1 acts as a GTPase-activating protein for human
            ADP-ribosylation factor-like 1 protein
  JOURNAL   FASEB J 35 (4), e21337 (2021)
   PUBMED   33715220
  REMARK    GeneRIF: ArfGAP1 acts as a GTPase-activating protein for human
            ADP-ribosylation factor-like 1 protein.
REFERENCE   3  (bases 1 to 3197)
  AUTHORS   Ishida,M. and Bonifacino,J.S.
  TITLE     ARFRP1 functions upstream of ARL1 and ARL5 to coordinate
            recruitment of distinct tethering factors to the trans-Golgi
            network
  JOURNAL   J Cell Biol 218 (11), 3681-3696 (2019)
   PUBMED   31575603
  REMARK    GeneRIF: The ARFRP1 functions upstream of two other ARL GTPases,
            ARL1 and ARL5, which in turn recruit golgins and GARP,
            respectively, to the trans-Golgi network (TGN).
            Erratum:[J Cell Biol. 2019 Nov 4;218(11):3880-3881. doi:
            10.1083/jcb.20190509710072019c. PMID: 31604800]
REFERENCE   4  (bases 1 to 3197)
  AUTHORS   Galindo,A., Soler,N., McLaughlin,S.H., Yu,M., Williams,R.L. and
            Munro,S.
  TITLE     Structural Insights into Arl1-Mediated Targeting of the Arf-GEF
            BIG1 to the trans-Golgi
  JOURNAL   Cell Rep 16 (3), 839-850 (2016)
   PUBMED   27373159
  REMARK    GeneRIF: Plasticity allows Arl1 to interact with different
            effectors of unrelated structure.
REFERENCE   5  (bases 1 to 3197)
  AUTHORS   D'Souza,R.S., Semus,R., Billings,E.A., Meyer,C.B., Conger,K. and
            Casanova,J.E.
  TITLE     Rab4 orchestrates a small GTPase cascade for recruitment of adaptor
            proteins to early endosomes
  JOURNAL   Curr Biol 24 (11), 1187-1198 (2014)
   PUBMED   24835460
  REMARK    GeneRIF: Together the findings indicate that Arl1 links
            Rab4-dependent formation of endosomal sorting domains with
            downstream assembly of adaptor protein complexes that constitute
            the endosomal sorting machinery.
REFERENCE   6  (bases 1 to 3197)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   7  (bases 1 to 3197)
  AUTHORS   Zhao,L., Helms,J.B., Brunner,J. and Wieland,F.T.
  TITLE     GTP-dependent binding of ADP-ribosylation factor to coatomer in
            close proximity to the binding site for dilysine retrieval motifs
            and p23
  JOURNAL   J Biol Chem 274 (20), 14198-14203 (1999)
   PUBMED   10318838
REFERENCE   8  (bases 1 to 3197)
  AUTHORS   Hong,J.X., Lee,F.J., Patton,W.A., Lin,C.Y., Moss,J. and Vaughan,M.
  TITLE     Phospholipid- and GTP-dependent activation of cholera toxin and
            phospholipase D by human ADP-ribosylation factor-like protein 1
            (HARL1)
  JOURNAL   J Biol Chem 273 (25), 15872-15876 (1998)
   PUBMED   9624189
REFERENCE   9  (bases 1 to 3197)
  AUTHORS   Ding,M., Vitale,N., Tsai,S.C., Adamik,R., Moss,J. and Vaughan,M.
  TITLE     Characterization of a GTPase-activating protein that stimulates GTP
            hydrolysis by both ADP-ribosylation factor (ARF) and ARF-like
            proteins. Comparison to the ARD1 gap domain
  JOURNAL   J Biol Chem 271 (39), 24005-24009 (1996)
   PUBMED   8798635
REFERENCE   10 (bases 1 to 3197)
  AUTHORS   Zhang,G.F., Patton,W.A., Lee,F.J., Liyanage,M., Han,J.S.,
            Rhee,S.G., Moss,J. and Vaughan,M.
  TITLE     Different ARF domains are required for the activation of cholera
            toxin and phospholipase D
  JOURNAL   J Biol Chem 270 (1), 21-24 (1995)
   PUBMED   7814376
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX537387.1, AC063948.44 and
            AI802608.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001177.5.
            
            Summary: The protein encoded by this gene belongs to the ARL
            (ADP-ribosylation factor-like) family of proteins, which are
            structurally related to ADP-ribosylation factors (ARFs). ARFs,
            described as activators of cholera toxin (CT)
            ADP-ribosyltransferase activity, regulate intracellular vesicular
            membrane trafficking, and stimulate a phospholipase D (PLD)
            isoform. Although, ARL proteins were initially thought not to
            activate CT or PLD, later work showed that they are weak
            stimulators of PLD and CT in a phospholipid dependent manner.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.53922.1,
                                           SRR1803616.185226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261636.13/ ENSP00000261636.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1950              BX537387.1         21-1970
            1951-3000           AC063948.44        42931-43980
            3001-3188           AI802608.1         18-205              c
            3189-3189           AC063948.44        44169-44169
            3190-3193           AI802608.1         13-16               c
            3194-3197           AC063948.44        44174-44177
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..3197
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /note="ARF like GTPase 1"
                     /db_xref="GeneID:400"
                     /db_xref="HGNC:HGNC:692"
                     /db_xref="MIM:603425"
     exon            1..131
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..673
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-like protein 1; ADP-ribosylation
                     factor-like 1; ADP ribosylation factor like GTPase 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 1 isoform
                     1"
                     /protein_id="NP_001168.1"
                     /db_xref="CCDS:CCDS44958.1"
                     /db_xref="GeneID:400"
                     /db_xref="HGNC:HGNC:692"
                     /db_xref="MIM:603425"
                     /translation="MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVT
                     TIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGI
                     SKSELVAMLEEEELRKAILVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSA
                     TKGTGLDEAMEWLVETLKSRQ"
     exon            132..269
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..351
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..463
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..642
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..3197
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      956..961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /note="hexamer: ATTAAA"
     polyA_site      992
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /note="major polyA site"
     regulatory      3151..3156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /note="hexamer: AATAAA"
     regulatory      3172..3177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /note="hexamer: AACAAA"
     polyA_site      3177
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
                     /note="major polyA site"
     polyA_site      3197
                     /gene="ARL1"
                     /gene_synonym="ARFL1"
ORIGIN      
        1 cccgcccccg cctggagtcc gacgtggaag ttgctggctg actgggcttg cgaggaaacc
       61 gcctcggagc tgcagccgaa ggccaaggaa tcactgaaga tcggcgaggg aggacagggg
      121 gttcatcatg ggtggctttt tctcaagtat attttccagt ctgtttggaa ctcgggaaat
      181 gagaatttta attttgggat tagatggagc aggaaaaacc acaattttgt acagattaca
      241 agtgggagaa gttgttacta ctatacctac cattggattt aatgtagaga cggtgacgta
      301 caaaaacctt aaattccaag tctgggattt aggaggacag acaagtatca ggccatactg
      361 gagatgttac tattcaaaca cagatgcagt catttatgta gtagacagtt gtgaccgaga
      421 ccgaattggc atttccaaat cagagttagt tgccatgttg gaggaagaag agctgagaaa
      481 agccatttta gtggtgtttg caaataaaca ggacatggaa caggccatga cttcctcaga
      541 gatggcaaat tcacttgggt tacctgcctt gaaggaccga aaatggcaga tattcaaaac
      601 gtcagcaacc aaaggcaccg gccttgatga ggcaatggaa tggttagttg aaacattaaa
      661 aagcagacag taattcagtc cattcttctc ccctgaaatg aagactacat cacctctctc
      721 cctttggaaa cagtcaagtg tacttcacac tactagatgt taaaactata tgattattgg
      781 catatactga ctgactgcaa tatttgtagt aaatagggaa aataagtatt tagttggagg
      841 gataatttga tcgaatcacc tgaatgttct atgtaatgta aaatattctt ttcttgcttt
      901 cttgtgttaa ggtatatatt ctatttgtat ggaattctta ttcaaataca gttctattaa
      961 agagtatact cctattggat gaaaaaaacc tatttttgaa tagtagttgc agcttgtttg
     1021 tataaatact aaaaaatatc ttaacagatt tttttcccct taaaatgaat tatctttcca
     1081 aagattagac tcagtatgag agtaggtgag gaacatagtt tgtgtaatat aatctttatt
     1141 tgcttacctg accacttttt attaagctgt tttgtttaaa agcttttggt tataggcatg
     1201 aatattgttt tgatggttaa cttcactgac ttatctgtaa gtgtcatttt atagtacttt
     1261 acagttgtca aaaaaaatct tacatatatt gatctagttg atcggtagag gaagcttgtg
     1321 aagtaggtag gacaggttat gatgtcttca ctgtatggac gtgaacccag ggttctaata
     1381 ggttggcttg cccaaggtca cctgctagct tgtaaggtag gaatagggct caaagtaaaa
     1441 cttttggttc agaagcttga ctcataaact atactatata ttcccaaaaa tgtcagtatt
     1501 gacaacacag tctaactctt aaataaaatt atgctaatta gttacattca aaataatgtt
     1561 tataaattta tttgtctata ctagtagaag tgatcagtga catactataa ataatcctaa
     1621 atggttatat ttgatagaat tcataacaca ttaaagagaa aatttcacat taaaggaagg
     1681 tttaaaaatc tattttcaga ttataaaagg tgtctttact ggttttcatt ccttttatct
     1741 acatgtaatt ggacatgtaa acttgttaaa aatcaaaatc ttactgattg tacagggaga
     1801 aattaagcat tctgttttaa aaattaggct tattgctaga ctgtaagttt aaaaacaatt
     1861 catgttcaaa ggagcttttc aaattaccca gtccaccaca gaatcagcta atgtgacaga
     1921 agtaaatata gtgcgtcata attgctaaaa acagggtgaa tttctttcac ttaagttgga
     1981 aaaccagcct ctaaaaaatt aggtgctggt aatgagagct taataccatg gttccctgca
     2041 ggtctcagaa acattagtag ttcctttctt ggccctcact gtccttccag tgttggcctc
     2101 tggcctcttc ccctcacatt tatgttcatt ctccgggctt atattcattc tctgctgctt
     2161 tctcccttca cccgtgggac tctcaccctt cttgctcatt ctccagcacc cattcctact
     2221 ttagtctctt tgaaatcttt tttggagatt ttccttcagc tacaaatgtt ccagtacaac
     2281 caatattact cctgaggggc aaagactttt tcatatttat gtccctagta tctggtatgg
     2341 cgcctggcat atggcatttc agaatatgtt catagttgaa acagtaggat agatatttgt
     2401 catcttgaca agtagccctt tgcaatttat acttgagttc actcctggtc aatggcacat
     2461 ggctggaaaa tgcagaaagc aagttcactt acagcctgag gcttataaag cttgtacagc
     2521 tgcctcccgg cagtccagga aaactgcaaa aaatgggaag taaggtcctg gcaggcagac
     2581 ccggcatgta gccgctggcc atcttgaatc ctagggcatg aagttgcccc aaagttcagc
     2641 acttggttaa gcctgatccc tctggtttat cacaaagaat aggatgggat aaagaaagtg
     2701 gacacttaaa taagctataa attatatggt ccttgtctag caggagacaa ctgcacaggt
     2761 atactaccag cgtttggata ttgatatata catggcaaat ctgaatattg ttttatgaga
     2821 ggcctggcaa tgggtaaaac accaaacttg aaatcagaac ataggtgcaa atggccactc
     2881 ctgtagtttc ttttctgtaa aatgggatct ggacgaatga taccaaacgt ttctttctaa
     2941 cattgtattt tataactctg gcctatgatt gtgttgtgtc ttgcattaaa aaaaaaaatt
     3001 tgagagtggt agaattactt ctgttatctg aaatacctga gatgcacttt aaactgttga
     3061 aatgtaagct ctgagggcag ggaccgtatc ttatttactg ttagtatccg ttgcatctag
     3121 tgtggtgcac ctggcacaca gtaggcactc aataaatatg tattgattaa aaacaaagac
     3181 gtcttcaata tgccaga
//
