LOCUS       NM_145055               5456 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens arkadia (RNF111) N-terminal like PKA signaling
            regulator 2N (ARK2N), transcript variant 1, mRNA.
ACCESSION   NM_145055
VERSION     NM_145055.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5456)
  AUTHORS   Blazev,R., Carl,C.S., Ng,Y.K., Molendijk,J., Voldstedlund,C.T.,
            Zhao,Y., Xiao,D., Kueh,A.J., Miotto,P.M., Haynes,V.R., Hardee,J.P.,
            Chung,J.D., McNamara,J.W., Qian,H., Gregorevic,P., Oakhill,J.S.,
            Herold,M.J., Jensen,T.E., Lisowski,L., Lynch,G.S., Dodd,G.T.,
            Watt,M.J., Yang,P., Kiens,B., Richter,E.A. and Parker,B.L.
  TITLE     Phosphoproteomics of three exercise modalities identifies canonical
            signaling and C18ORF25 as an AMPK substrate regulating skeletal
            muscle function
  JOURNAL   Cell Metab 34 (10), 1561-1577 (2022)
   PUBMED   35882232
  REMARK    GeneRIF: Phosphoproteomics of three exercise modalities identifies
            canonical signaling and C18ORF25 as an AMPK substrate regulating
            skeletal muscle function.
REFERENCE   2  (bases 1 to 5456)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 5456)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5456)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5456)
  AUTHORS   Siddiqi,U.Z., Vaidya,A.S., Li,X., Marcon,E., Tsao,S.W.,
            Greenblatt,J. and Frappier,L.
  TITLE     Identification of ARKL1 as a Negative Regulator of Epstein-Barr
            Virus Reactivation
  JOURNAL   J Virol 93 (20), e00989-19 (2019)
   PUBMED   31341047
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5456)
  AUTHORS   Cao,J.Y., Shire,K., Landry,C., Gish,G.D., Pawson,T. and Frappier,L.
  TITLE     Identification of a novel protein interaction motif in the
            regulatory subunit of casein kinase 2
  JOURNAL   Mol Cell Biol 34 (2), 246-258 (2014)
   PUBMED   24216761
  REMARK    GeneRIF: ARKL1 binds CK2beta through the KSSR motif and this
            involves a polyserine sequence resembling the CK2beta binding
            sequence in EBNA1.
REFERENCE   7  (bases 1 to 5456)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5456)
  AUTHORS   Pickard,B.S., Malloy,M.P., Clark,L., Lehellard,S., Ewald,H.L.,
            Mors,O., Porteous,D.J., Blackwood,D.H. and Muir,W.J.
  TITLE     Candidate psychiatric illness genes identified in patients with
            pericentric inversions of chromosome 18
  JOURNAL   Psychiatr Genet 15 (1), 37-44 (2005)
   PUBMED   15722956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118647.4, AC021763.10 and KF573673.1.
            
            On Aug 31, 2019 this sequence version replaced NM_145055.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005125.1, SRR11853567.14461.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615052.5/ ENSP00000481626.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AC118647.4         58861-59157
            298-1082            AC021763.10        44755-45539
            1083-1265           AC021763.10        68949-69131
            1266-1392           KF573673.1         108-234             c
            1393-5456           AC021763.10        91870-95933
FEATURES             Location/Qualifiers
     source          1..5456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..5456
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /note="arkadia (RNF111) N-terminal like PKA signaling
                     regulator 2N"
                     /db_xref="GeneID:147339"
                     /db_xref="HGNC:HGNC:28172"
     exon            1..297
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..1082
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..1582
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /note="isoform a is encoded by transcript variant 1;
                     ARKadia-like 1; uncharacterized protein C18orf25;
                     ARKadia-like protein 1; ARKadia (RNF111) N-terminal like
                     PKA signaling regulator protein 2N; protein ARK2N"
                     /codon_start=1
                     /product="protein ARK2N isoform a"
                     /protein_id="NP_659492.1"
                     /db_xref="CCDS:CCDS42430.1"
                     /db_xref="GeneID:147339"
                     /db_xref="HGNC:HGNC:28172"
                     /translation="MKMEEAVGKVEELIESEAPPKASEQETAKEEDGSVELESQVQKD
                     GVADSTVISSMPCLLMELRRDSSESQLASTESDKPTTGRVYESDSSNHCMLSPSSSGH
                     LADSDTLSSAEENEPSQAETAVEGDPSGVSGATVGRKSRRSRSESETSTMAAKKNRQS
                     SDKQNGRVAKVKGHRSQKHKERIRLLRQKREAAARKKYNLLQDSSTSDSDLTCDSSTS
                     SSDDDEEVSGSSKTITAEIPDGPPVVAHYDMSDTNSDPEVVNVDNLLAAAVVQEHSNS
                     VGGQDTGATWRTSGLLEELNAEAGHLDPGFLASDKTSAGNAPLNEEINIASSDSEVEI
                     VGVQEHARCVHPRGGVIQSVSSWKHGSGTQYVSTRQTQSWTAVTPQQTWASPAEVVDL
                     TLDEDSRRKYLL"
     exon            1083..1265
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1392
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..5456
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1742..1747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /note="hexamer: ATTAAA"
     polyA_site      1768
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /note="major polyA site"
     regulatory      4902..4907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /note="hexamer: AATAAT"
     polyA_site      4924
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
     regulatory      5434..5439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /note="hexamer: AATAGA"
     polyA_site      5456
                     /gene="ARK2N"
                     /gene_synonym="ARKL1; C18orf25; RNF111L1"
                     /note="major polyA site"
ORIGIN      
        1 agtgaggcgc ccagcggaac ggcctctggt gacattttct tgggggcggc gcggacgact
       61 gaagggactt ggtggtagag gctgcggagg cggcgaggtt cactttggtc ccggcagggg
      121 ctctgaccgc gacccactgc tcgctgccgg ggcttgttcc gaggaggaga aggcggcggt
      181 ggccgtcgcg tcctgagtca ccgcagcggg gaagagtccc ggccgggggt tcggtgcgtg
      241 ccccgacggg gcgcgcgcga agcgagcgag aaggcacgga gtcgccgcgg agcgcaggtt
      301 gctttcctgt tgcatctttg atatcatttc ctagactcta ctccatgatt taacttgaaa
      361 ttctgaaatg aagatggagg aggcagtggg aaaagttgaa gaactcattg agtccgaagc
      421 cccaccaaaa gcatctgaac aagagacagc caaggaggaa gatggatctg tagaactgga
      481 atctcaagtt cagaaagatg gtgtagcgga ttctacagtt atttcttcaa tgccctgctt
      541 gttgatggaa ctgagaaggg actcttctga gtctcagtta gcatccacag agagtgacaa
      601 gcctacaact ggccgagttt atgagagtga ctcctctaat cactgcatgc tttccccttc
      661 ctctagtggt cacctggctg attcagatac gttgtcttcc gcagaagaga atgaaccctc
      721 tcaggcagaa acggcggtag aaggagaccc ttcaggagtg tctggtgcca cagttgggcg
      781 caagtctagg cggtcccgat ctgaaagtga aacttccact atggctgcca agaaaaaccg
      841 gcaatccagt gataaacaga atggccgagt cgccaaggtt aaaggtcatc ggagccaaaa
      901 gcacaaggag aggatcaggc tactgaggca gaaacgggag gctgctgcaa ggaagaaata
      961 taacctgctg caggacagta gtaccagtga tagtgacctg acttgtgact caagcacgag
     1021 ctcatcagat gatgatgaag aggtttcagg gagcagcaag acaatcactg cagagatacc
     1081 agatggacct ccagttgtag ctcattatga tatgtctgac accaactctg acccagaagt
     1141 ggtaaatgtg gacaatttat tggcggctgc agtagttcaa gagcacagta attctgtagg
     1201 cggccaggac acaggagcta cctggaggac cagcgggctt ctagaggagc tgaatgcaga
     1261 ggcaggtcat ttggatccag gattcctagc aagtgacaaa acatctgctg gcaatgcgcc
     1321 actcaatgaa gaaattaaca ttgcgtcttc agatagtgaa gtagagattg tgggagttca
     1381 ggaacatgca aggtgtgttc atcctcgagg tggtgtgatt cagagtgttt cttcatggaa
     1441 gcatggctcg ggcacgcagt atgttagcac caggcaaaca cagtcatgga ctgctgtgac
     1501 tccccagcag acttgggctt caccagcaga agttgttgac cttaccttgg atgaggatag
     1561 caggcgtaaa tacctactgt aatacaatgt cactgtgttt cctctgcact gttcccttcc
     1621 acttcctcat cctctttgtg acatggaagt tcattgtcat agcttcagct tcagaagctg
     1681 tttgtggcat ttgtaggatt caaactcatg gaaaattccc tcctcttccc cccttttttt
     1741 aattaaaaga agtcacttag gaaaataaca tcacagagaa aagaatttct tctttccctc
     1801 agtaggaata tagaatgatg aattttatta gacaacttta ttttacttgg tgacttttaa
     1861 tcttaggaaa ctctgccttc cttttagaat aatattttaa ttgccaggca aaatgggttt
     1921 cagtttttga atcttgtatt tatttttctg tataatgaaa ttaatatcta gacttgacca
     1981 ctatctgccc accccattgg cactcccatc ttagggcatt cgcacacata tcagtcaggt
     2041 ccttattggc acctagtagg gcatgtgcat ttaaaaactt gtccttaaaa atagaagaca
     2101 gaagtattaa aattatattt tcttttattt taagtcttct gccttctttc ttgagtttgc
     2161 tcctgttgac ttcccacagc acagataatt gacatgtccc tttgtgttta taaatactac
     2221 taaggtgacc tagttgttct ccttgttgca ataattaata actctttgca aaatgtctcc
     2281 tttgagacag aggcatttca gatagatacc caccatgagg tgttctgggc atctgaaggt
     2341 attaagagtt cagtgggaaa aatctctctc cctcgccttt ttttctggtt tagtcaaata
     2401 acgggtgaac atagaaacct gttgggaaga atatgaaaag ttatgtggcc tctgaggcta
     2461 caggcacttg caaatccgag aggaaagtgc cgtctttcat agctggtctc tgtataaaga
     2521 gtatgtagca acaactgttt aacatccgag atgaagtgga cctgatgctg tatttgggta
     2581 tttttctcct ctaccttcta aaaaaaaata ccataagaag aatcagaatg taccataaga
     2641 aatcagatgc aaagcacgtt aatgtcattg gtaagtttta cagagtctaa aaggattagc
     2701 aaagggtagc aggagcttca gggaattcag gaaatgccag cattggaatt ttgtggcatt
     2761 agttactacc ttctttctta taatatgttg tagttactag tgaattcttt taaaagcaat
     2821 acctagagtt agaacactat gtactctgca cagggggagt gaagtaatat tggcttagaa
     2881 gacttcacct tttgtttttc atggtttttg tttgttttgt ttttgttttt gtttccattg
     2941 ttaccgttgc tatggccctt tgcctgtctc tccaaatccc ctggtggctc ttcttatcat
     3001 taagagtatg agaattacca ttttcagttt tcattcagca aacaaattta ccaagtgcct
     3061 gctctgcata aggcactgtg aggggtgggt gctctggggg ctgctgagat gaatgacaca
     3121 caccgcacat acacatgcat cagtgtctgc ctgcctccac ctgcccagcc tgttcttctt
     3181 cttcttcttc atcttcttct tttttttttt tttttgtaaa gacaagttta ttcctttacg
     3241 cttcttgttg cattagttct cctgtatgtt ccttcttcca caggaatgta tttgtgcata
     3301 tgttctttga tcttctctga tagcatctca tttgatctgg cctctgtcct tcatcagctt
     3361 ttattttttt tatttttatt ttctgctttt gttagataag gcttttaaga tcatgaacct
     3421 ccagctttag caactcatat atcagtctct cacatggcca caattctaga caaaaaccaa
     3481 agacccagag gccagagcaa agtaggacct tctgaagatt cactactggt gtatccttgg
     3541 accttcacat tttactttag gattaattta ttgaatttta ctgttacaca tagtttttga
     3601 cttgaattaa aatactagac aaagcagaaa tgtacaattt ctggtctgtg ttttccagga
     3661 aattcataga gaagagaata gagtggatga tgtgacttga agtttttgca gcttattttt
     3721 tcccccactg tcagggcaga ggcccatttt aatgaatgtt tttgcatgac ctgttcttat
     3781 gttaaccaca tatttttttt cccaattcca cacagcaggt gatttcccgt gtgacatatt
     3841 ttcttcatag tccctaatat agtcatcctc tacagagttg gcgtgctgtg tgcactgtgg
     3901 attaggaaca gagtggagct gtaaccagtc tcttctctgg ccctttgcct ttatgtcagc
     3961 ttgcactttt gcctcactta ttcctagtcc agctcccaac tgcctgactt aatggaccag
     4021 aacggagatt tggatattaa gatgcagagg gggaggggaa gggatggtag agatagacag
     4081 ctctccccta ctaggttggg tcatttcccc taataactat agagagactg tgtttcaact
     4141 ctcttttcat tgctgtttcc agaagagtgg agagtgtggt ttcaggcaag gtattaatga
     4201 tacaattccg tggtatacag ctcctgtgac atttgaagtt tcttttaaag gggtttttct
     4261 taatcaaagt tttacatttg gtagcataag tagttcttta tgcttcacag gacattgtct
     4321 tcagagtaat ctctctgcta aaatggtaca tgtgggtcac agattggttt atgccactga
     4381 cttggttaag tttccacccc ctccaatttg tgaaaaacag agcagtgacc tagctgttgc
     4441 atcatcatga ctgccatgta acctgtaatt gctgctctcc agtaattgtc ttttcatttt
     4501 gatggtaggg gccagactga atgaataatg cattcttttt tattcaattt atttcattca
     4561 gtttattctt ggcaatcaaa catcccataa actttgcttt tattatcaat tatgaatatg
     4621 aattgtctgg tttactaatg tagtcatttg ttcatcttta cttttagcag attagcacca
     4681 taactaactt aaaactaagt ttgttacctg ctttttatac tgtcacaaag gtttttgaaa
     4741 aagctgggga cactattttg tcttttagtt ttaaactttt ttaaggcaaa gcaagctccc
     4801 caatccctgt tctccaatat gtgtatgatg tgacttccat gtagatataa aaatgattgt
     4861 gccctaacca aacttcctca gattgtgcac tgtttgttta aaataatcac gtattttagt
     4921 ctgatgctgt tgtatttttt cattttattt aaaacactac ttacttctta ttctcttaac
     4981 aaattttaaa aggtagtgat cttaaaaaaa aatcactgga taactaggaa atatttttgt
     5041 tgttgttttg tttcttaaag agtacagagg ccattgaagc cttttgctcc tcttaccgtg
     5101 aaaatgaaat gttagccatt gtatggctag gaaccaatgc acttggcagt taatggatct
     5161 gctgttgctg gagtgtgagc gtggacttga tgcagtgatg acaaatcatt gcttagaatt
     5221 aatgttttca aatgtgcaac tctagttttt aaaacaaaat ttggttcttt acattcatta
     5281 tttcgttttt gtttcccttt agtatttaat ggtctttgga gaaaaaataa taaaacagag
     5341 tgttatatat atattttttg gtgcaagata agattttctg ttttttgaaa taagtctgta
     5401 gcataaaggt taaactattt taagacaaaa taaaatagag tgtatttaaa caatga
//
