LOCUS       NM_152470               7802 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens arkadia (RNF111) C-terminal like ring finger ubiquitin
            ligase 2C (ARK2C), transcript variant 1, mRNA.
ACCESSION   NM_152470
VERSION     NM_152470.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7802)
  AUTHORS   Wright,J.D., Mace,P.D. and Day,C.L.
  TITLE     Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3
            ligase activity
  JOURNAL   Nat Struct Mol Biol 23 (1), 45-52 (2016)
   PUBMED   26656854
REFERENCE   2  (bases 1 to 7802)
  AUTHORS   Kelly,C.E., Thymiakou,E., Dixon,J.E., Tanaka,S., Godwin,J. and
            Episkopou,V.
  TITLE     Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon
            extension
  JOURNAL   PLoS Biol 11 (4), e1001538 (2013)
   PUBMED   23610558
REFERENCE   3  (bases 1 to 7802)
  AUTHORS   Pickard,B.S., Malloy,M.P., Clark,L., Lehellard,S., Ewald,H.L.,
            Mors,O., Porteous,D.J., Blackwood,D.H. and Muir,W.J.
  TITLE     Candidate psychiatric illness genes identified in patients with
            pericentric inversions of chromosome 18
  JOURNAL   Psychiatr Genet 15 (1), 37-44 (2005)
   PUBMED   15722956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015959.9, AK127467.1, AK122819.1, BM680948.1, AW160725.1 and
            AC018931.9.
            
            On Nov 23, 2018 this sequence version replaced NM_152470.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127467.1, BK005135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269439.12/ ENSP00000269439.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC015959.9         58496-58701         c
            207-1973            AK127467.1         1-1767
            1974-5029           AK122819.1         1344-4399
            5030-5328           BM680948.1         7-305               c
            5329-5482           AW160725.1         409-562
            5483-7802           AC018931.9         81208-83527
FEATURES             Location/Qualifiers
     source          1..7802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..7802
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /note="arkadia (RNF111) C-terminal like ring finger
                     ubiquitin ligase 2C"
                     /db_xref="GeneID:494470"
                     /db_xref="HGNC:HGNC:31696"
     exon            1..318
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1298
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF165; lncRNA activated in
                     metastatic PCa; ring finger protein 165; E3
                     ubiquitin-protein ligase ARK2C"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ARK2C isoform 1"
                     /protein_id="NP_689683.2"
                     /db_xref="CCDS:CCDS32823.1"
                     /db_xref="GeneID:494470"
                     /db_xref="HGNC:HGNC:31696"
                     /translation="MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQ
                     PQQLAPDFPLAHPVQSQPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQA
                     LHQQYLLQQQLLEAQHRRLVSHPRRSQERVSVHPHRLHPSFDFGQLQTPQPRYLAEGT
                     DWDLSVDAGLSPAQFQVRPIPQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQL
                     HFLALQGLNPSRHTSAVRESYEELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRPQ
                     DGKGKKDEGEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPIC
                     RVDIETQLGADS"
     exon            319..634
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     exon            635..742
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     exon            743..872
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     exon            873..977
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1073
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1180
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..7802
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5333..5338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /note="hexamer: AATAAA"
     polyA_site      5353
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
     regulatory      7780..7785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /note="hexamer: AATGAA"
     polyA_site      7802
                     /gene="ARK2C"
                     /gene_synonym="ARKL2; lncAMPC; RNF111L2; RNF165"
                     /note="major polyA site"
ORIGIN      
        1 attggctgcg cgcgcctttg tgtggcggca gctgcggccc cagcgccttt gaatgtcgag
       61 aggggccggg aagggagcct ttccatgggc catctgtctc cccgccagcc gccgccccac
      121 cgccgcccgc gccccgcgct ccgcctcccg ccccggcggc tcccgcagcc ccgccgccgc
      181 ccgcgcccgc gccccggagc cgcgccacaa agggcccgcg cgcagccgcc gccgccgccg
      241 ccgcgcgagg agccaggatg gtcctggtcc acgtcggcta tctcgtgctt ccagtgtttg
      301 gctctgtgcg aaacagaggt gccccctttc aaaggtctca gcatcctcac gctacctcct
      361 gccgccactt ccacctgggc cccccgcagc cgcagcagct cgctcccgac ttcccgctgg
      421 cccaccccgt gcagtcgcag ccaggcctca gcgcccacat ggccccggcc caccagcaca
      481 gcggcgccct gcaccagtcg ctgaccccgc tgcccaccct gcagttccag gacgtcacag
      541 gtccctcctt cctacctcag gccctgcacc agcaatacct cctgcagcag cagctcctgg
      601 aagcccagca ccgcaggctg gtctcgcacc ccaggcggag tcaggagcgt gtatctgtcc
      661 acccccaccg cctccatccc agcttcgact tcggccaact gcagacacct cagcccaggt
      721 atttggctga gggcactgac tgggatctca gtgtggatgc tggcttgagt cctgctcagt
      781 tccaggtgcg gcccatccct cagcactatc agcattacct agccactcct cgaatgcacc
      841 actttcccag aaactcctcc tccacacaga tggtcgtcca tgaaatccga aactaccctt
      901 accctcagct tcacttcctt gctctccagg gactaaatcc cagcagacac acctccgccg
      961 tacgggagag ctatgaggag ctgctgcagc tcgaggacag gttgggtaat gtgactcggg
     1021 gagctgtaca gaacaccatt gagaggttca ccttccccca caagtataag aagcgaagac
     1081 cccaggatgg caagggcaag aaggatgagg gggaggagtc agacacagat gagaaatgca
     1141 caatttgtct gtctatgctg gaagatggag aagatgtgag acgcctaccc tgtatgcatc
     1201 tctttcacca actgtgcgtg gaccagtggc tcgccatgag caagaaatgc cccatctgcc
     1261 gagtggacat tgagacacaa ctgggagccg acagctgagg gaggaattag ccagtggaca
     1321 ccccatttcc ttcaccaggt ccccccacgg ccatagccct tgcagccaaa ctttgccttc
     1381 tgagccattt gacgtagagg aaaagcctgc aagcacattt tgtggaaaga ggagttggtg
     1441 gtatcggtgt cgagggagag gagggggttg gggaggaccc acctctccag aatggcgact
     1501 gtccccatcc gcctggctga gcaggagaga gggagctggc ggtgcccagc gcaagggcgg
     1561 gaaggagggg cccaggctgc ggagaaccca ggtgggatcc tgaaggcact agctgacaga
     1621 cgggcccctc aatcctgtcc tctgaaggat tgtatatata cctctcgacc acgtaggaac
     1681 catgtagggg tctctagcta tttctgtgga tggcagccgg agcatgttag cttaagaaaa
     1741 atgttgtgtg tggtgctcta gtcatcttgt ggtggacatg tcgctattac cgaattcgca
     1801 ccaaatattt ctcattgagt ttcttgtttt ggtgcctgac cgaaccaacg acagccccaa
     1861 tcttcccgtc tttatgagag aaaaggaaaa aggaatcaaa ggtggaagaa aaaaaaagcc
     1921 aaattctgtt tacggtgaaa aaggattttg tttttcaccc aatttgggag gcgggagggg
     1981 ggggttctcg ttttattttt gtttttgttt ttaccttggc ttttgttttt ctcatgttta
     2041 cagtgcacgg agtgtggaag ggggtctagg agagggagag ctggaaaagg agctgatggg
     2101 gtcttatcct ggcctctgag ggttcagcgg aggtgaggaa ggcagcagag ctccagcagg
     2161 tgaagggaga gttcatctag gcggggctcc ccaggcccag ggctcaactt catggcccca
     2221 gctatatccc cccagttcca cactaaacca gggagggctc ggccctcagc tactggtacc
     2281 caatgtgttc ctgggagccg agagacccat ggtcactcca actccttcct ttaggctgtg
     2341 ctcttgcctg tcacaaagag gcaacgtagc cactgcctcc ctatgcaaaa aattaaccag
     2401 atgatgcaga taagacagca taggtgatgg ctgcttggtc ttggccacag tgctctcagc
     2461 cagcactaag ggctgaggtc aataccgcag accttgggga ggaagctgag catcccccgg
     2521 gatgtctcca gtcctgacac agtccctcag agatggccct ggctctgagg tcacatcagc
     2581 taggtttggg aggcccctca gcttggtttg ggagtgcccg tgttcctggt ctctggctgc
     2641 ttctctgact ctttgataac cttgggcaag tccctttctt tctctgtgcc tcagtttcct
     2701 tctcctttga ggggggagag agaacagtgc agccccattt ccggtcctgc tacctcacct
     2761 agatgttgtg aggattcata ttctctgtcc agcgtgttct atgctctctt ctgagaacct
     2821 tgtggggtgt cgggatgggg gtgctgggag acacagacct gatacagtat gtctttctgc
     2881 accacctcac aattttcctg aaccccaaag ggagcagaga gataagagga cagaagaatg
     2941 gagatgggaa aatccaccaa attccaaccc aaacccaact ttctttctcc ctatgtggaa
     3001 gacaccagat tagctggaat tctgccacct tcctttgtgc cccacccccc actgttccct
     3061 catttgcact gctctgtaag cctccccctc acctccattc ataacccagt ctcaatgccc
     3121 tcgtatcaat aagaccgggg taagggggac aggatacttg tcacatattt gaagaaattc
     3181 catacagtga aggaaatttg agtctgtatt gctgctacaa gggtaaaacc aggaccaatg
     3241 ggtaaaagta acaggcgggc agattttggc ttgaggaaga gcttctagca cgactggttc
     3301 atgcgggaat agctgctctg gccacctgca ggcagaaagt gggggaagtg gctcctggca
     3361 ggagatttct cccagcacta atatcctggt gttctataaa atctttattg agtgcctacc
     3421 ggtgcaggcg ctgggagaga caatagcttt gaggagctca caatctagct gaggagacaa
     3481 gacacatcca atgctgcaaa aatggtgaat aacctgattc agggttagca gcaatgagta
     3541 tcacagcgtc caactcagta gctccagtgt atgaaaatgt ctccagggct aaaggctgga
     3601 gatctcacca gtggggaaag tacatctgag tcaggatttt gggggaaagc tagttactga
     3661 tagccacagg aagttgagac ttctgcccca ttctctccaa tggctgggtg aaaaccaaga
     3721 attcatcgga agatggcttt ggcctggagg tagctagggt ggtctaggaa gctcactcct
     3781 ctcttagtct cagtctttca ttctttctgc tgagactggc ctgaaaggct ggcaagtggg
     3841 agggagtcag tggggaggcc aggatagaac tagagctggt gtcccaggtt ccagtctggg
     3901 ctcttcactg acaaagtggg caacactaga aacttccctt tgtctctctg ggccttagtt
     3961 tcctcagtta caacctaagg aggttggatt ggatgcttgc taatttcctt ctgacactca
     4021 cactccctaa catcaacaca tcttcaaggc ggcagagctg tgcgcccacc cagctattga
     4081 aaaggacttt ctgtgggcac acactctgtt tcagactggg ctgggggcac acgtgctggg
     4141 tgagacagtg ggccctcgtc ccctcccccc tcccaattct ctgccccagg ctaatattag
     4201 ggactgggga ggggaccacc agaggggaga gggaagctgc ttactttggg ggtagaccct
     4261 gaagcccctc ctccttcccc cacagatggg gacaggaggt gatggggtgc tcagaaccct
     4321 gcagctccca cttctttagc cgggcagctg tttgggggac aagagagggc cagggtctgt
     4381 gcttctgctc ccggcactgg tcagggagtc tgggaagagt ggagaagagg cagggtcagg
     4441 cctcagcatc tcacatccac cacctccagg aggggagacc actggtaagt cctcctcctg
     4501 ctcaactcaa gggactcaga ccctttcttg actgagacgc atgagtgcct tctggggtga
     4561 gagcagcccc agggtttaag ttgggcgtcc tagcagctgc agcagctgtg ccgccgcggg
     4621 tccaccgagg acgccaatca atcaacccaa caccacaagc ttggttgggt gcaagcagag
     4681 ggtgagcagg ggctgcccct ccacctggcc aggaccccct tcggcaccca gttgcccttg
     4741 gccaccacct gtggcaggac tcaagctcct cttctgcaaa tgttcccagc ctccgtgcaa
     4801 gtattcttaa ctctttacgc ctaatgaaca agcacagttt ttcaatggtg aagaaaaaag
     4861 caccagactt tttttctttt tttcctaaag aaatccccta agccccccgc ctgtaggcgg
     4921 gacaaacact ccctgcgtgg ggctgtagca acgtctgtca ggcccccttg tgtttcatct
     4981 cctgcgcgcg tagagcaaat gctagagcga tttcagctga tagaaaaaca aaaatgaaaa
     5041 aaaaaacaca aaaaacaaaa aacatggcac gttgctagtt tacagggttt tgtgagttta
     5101 aatgccttat atttaacaat cataatttat gactaacttg tagatatcgt gggttcttat
     5161 ttaattattt ttatagttgt tttgcatttt taattataat ttatttattt agaaaggata
     5221 ctaatttttt ttattactcc tattacctca ttttggcgtt gtttctggga gtggaatgct
     5281 ttgcatgcat tggtacgatg acaaacaact acgaatacaa aaaaaaaatt taaataaaat
     5341 tctgcaaact ttatttcgtc cgaactatca gggtgtgtga ttgcaagctg tcctaccgtg
     5401 gtgctggcct ctttggatac attccatacg aaatgcaaac ctttgattct gtatgctgtg
     5461 atctagtgaa aaactccaat atagtgactg tatttagcac atatataaat ataatttgca
     5521 cttgtcagca gactggggta atcctttcac ttgctacact tggcaccccc ccgcccccac
     5581 cacaaccctg cctctccatc atgaacctgc ctttcctcct ccctcgctcc tcccacaacc
     5641 tcagcccacc cagccggtat cctctgagga aagtcttggg gcactagagg ccactgtctc
     5701 cacctggcct ccaactccag aattggagcc ctccagacat tacaagagga acatcagaga
     5761 gccaaaaagc ctgacttctt agaaggagcc ctggactggg gagccgggag gctcaggttt
     5821 tcaaatctgc tccatgacag acgtcccaat gaccttgagc aagtcccttg gcccctgagt
     5881 ctcagttttc tgggtggggt gagtgaggag aactgggaga tctttagggt cccttagatt
     5941 caagtagaat gtgacacaga tcccgtggga aaccactgtg ctgtgctgtc tcaccttctg
     6001 aggagagaag aaagagggag aaaaggcagg gcatggtggc tcacgcctgt aatcccagca
     6061 ctttgtgagg ccaaggtggg cagatcactt gagatcagga gtttgagacc agcctggcca
     6121 acatggtgaa accctgtctc tactaaaaat acaaaaatta gctgggcgtg gtggtaggcg
     6181 tctgtaatcc cagctactcg ggaggctgag gcaggagaat ggcttgaacc caggagacgg
     6241 aggttgcagt gagctgggag cgtgcaccac tgcactctag cctgggtgat aagaacaaaa
     6301 ctcagtccaa aaaaaaaaaa aaaaaaaaag agggaaagag ggagaaagga ttgggaggag
     6361 aaaaggagag caaagaagaa gagaagaata gagagagtga gctgagaatt tgagcttgct
     6421 cagagttgac tttcgggagg gtttttgtcc tataatatgt ggcatcctgt gggtgacagg
     6481 gaggtgagtt aggtggacac gtataggacg tgccctttca taaggcttgg gcagtcattt
     6541 ggcgagtgag ctgaaatcca tgtcttgtta gagataggga tggggtaggc agaaaggagc
     6601 tccaaactat gggtttggga ttggcacccc tatcctatca tcacccagag tcttcattgt
     6661 tgagatgctg cccatggaaa acagattggg acatagattt tggaatcaag gtctctgctc
     6721 ctggcatctc ctctgtgcgt ctccctctgc ctttgctccc tggggactgt gggcaggagg
     6781 agcttcttcg gaggaccggg agtgggcctc cagtccccct gcccctgtag aggaataatg
     6841 agggaggaca tggggaagtc actgtcaaag gctggcacag ctgtgagccc aatgcctctg
     6901 agcgaaaagg agagagaggg agttcacgcc cctgagagta gccccctgag ccggctggga
     6961 cctggactgc ctgctttcct cctgcctctt cccctttccc tccttcacag cttatcctcc
     7021 ttcttccctc tttacatcac tgcctttacc tggtggggat gaggccccat ggggaaggtg
     7081 ctgatgtgga gggaggaagt ggagaccgag attcgccata ctgcccaggg aggctgtgtg
     7141 agaactgggc tgtgtatggt ccctaaagcc tcaactctgc cccagctggg cgatgggtgc
     7201 ccctctctgg gcttcctgcc tagcttcccc ttctgcctcc agcctggagc cttgctttcc
     7261 ctggagacaa gcccgtggag tcccccacca cactggaggg agcacgacca ccacactgct
     7321 gggcctggca gacaccacat ctttggcagg gctcctggac gggcatgcct tatgctgctc
     7381 tgcagggtca gagtggaaag gggccctttg ccctggctgg cctgtgccct cacccttgag
     7441 cccctccccc cactccaccc ctggcctcgg atgcggctaa tttctcagcc atggagccag
     7501 ctgcaccagc cctcgagggg gtaattttgt tgcccctggc aagtgaaagg attatcctca
     7561 gtgttgattg tccttttttg taatcctcct gctgttctgt tctgttgtgc tgtgcaacat
     7621 tttgctacat agactatttt atagcagaaa gctagaagaa tatttattat gaatattaaa
     7681 gcaatagtgc atcaatgaaa aggcggagac attaggaatt gtgtaaatgc ttagattcac
     7741 ttttggtgga ttttttgtac tttatttata actaataaaa atgaactgca ttgctaacta
     7801 ca
//
