LOCUS       NM_005744              21679 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ariadne RBR E3 ubiquitin protein ligase 1 (ARIH1),
            mRNA.
ACCESSION   NM_005744
VERSION     NM_005744.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 21679)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 21679)
  AUTHORS   Wu,Y., Zhang,C., Liu,X., He,Z., Shan,B., Zeng,Q., Zhao,Q., Zhu,H.,
            Liao,H., Cen,X., Xu,X., Zhang,M., Hou,T., Wang,Z., Yan,H., Yang,S.,
            Sun,Y., Chen,Y., Wu,R., Xie,T., Chen,W., Najafov,A., Ying,S. and
            Xia,H.
  TITLE     ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for
            proteasomal degradation
  JOURNAL   Nat Commun 12 (1), 2346 (2021)
   PUBMED   33879767
  REMARK    GeneRIF: ARIH1 signaling promotes anti-tumor immunity by targeting
            PD-L1 for proteasomal degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 21679)
  AUTHORS   Kelsall,I.R., Kristariyanto,Y.A., Knebel,A., Wood,N.T., Kulathu,Y.
            and Alpi,A.F.
  TITLE     Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR
            E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling
  JOURNAL   J Biol Chem 294 (8), 2651-2664 (2019)
   PUBMED   30587576
  REMARK    GeneRIF: ubiquitin-associated (UBA) domain-containing DCNL1 is
            monoubiquitylated when bound to CRLs and that this
            monoubiquitylation depends on the CRL-associated Ariadne RBR
            ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the
            DCNL1's UBA domain.
REFERENCE   4  (bases 1 to 21679)
  AUTHORS   Tan,K.L., Haelterman,N.A., Kwartler,C.S., Regalado,E.S., Lee,P.T.,
            Nagarkar-Jaiswal,S., Guo,D.C., Duraine,L., Wangler,M.F.,
            Bamshad,M.J., Nickerson,D.A., Lin,G., Milewicz,D.M. and Bellen,H.J.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Ari-1 Regulates Myonuclear Organization Together with Parkin and Is
            Associated with Aortic Aneurysms
  JOURNAL   Dev Cell 45 (2), 226-244 (2018)
   PUBMED   29689197
  REMARK    GeneRIF: Variants in ARIH1 are associated with developing aortic
            aneurysms.
REFERENCE   5  (bases 1 to 21679)
  AUTHORS   Tan,N.G., Ardley,H.C., Scott,G.B., Rose,S.A., Markham,A.F. and
            Robinson,P.A.
  TITLE     Human homologue of ariadne promotes the ubiquitylation of
            translation initiation factor 4E homologous protein, 4EHP
  JOURNAL   FEBS Lett 554 (3), 501-504 (2003)
   PUBMED   14623119
REFERENCE   6  (bases 1 to 21679)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
REFERENCE   7  (bases 1 to 21679)
  AUTHORS   Zhang,Y., Redina,O., Altshuller,Y.M., Yamazaki,M., Ramos,J.,
            Chneiweiss,H., Kanaho,Y. and Frohman,M.A.
  TITLE     Regulation of expression of phospholipase D1 and D2 by PEA-15, a
            novel protein that interacts with them
  JOURNAL   J Biol Chem 275 (45), 35224-35232 (2000)
   PUBMED   10926929
REFERENCE   8  (bases 1 to 21679)
  AUTHORS   Aguilera,M., Oliveros,M., Martinez-Padron,M., Barbas,J.A. and
            Ferrus,A.
  TITLE     Ariadne-1: a vital Drosophila gene is required in development and
            defines a new conserved family of ring-finger proteins
  JOURNAL   Genetics 155 (3), 1231-1244 (2000)
   PUBMED   10880484
REFERENCE   9  (bases 1 to 21679)
  AUTHORS   Tan,N.G., Ardley,H.C., Rose,S.A., Leek,J.P., Markham,A.F. and
            Robinson,P.A.
  TITLE     Characterisation of the human and mouse orthologues of the
            Drosophila ariadne gene
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 242-245 (2000)
   PUBMED   11124525
REFERENCE   10 (bases 1 to 21679)
  AUTHORS   Moynihan,T.P., Ardley,H.C., Nuber,U., Rose,S.A., Jones,P.F.,
            Markham,A.F., Scheffner,M. and Robinson,P.A.
  TITLE     The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with
            RING finger/IBR motif-containing domains of HHARI and H7-AP1
  JOURNAL   J Biol Chem 274 (43), 30963-30968 (1999)
   PUBMED   10521492
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079322.5 and AC100827.2.
            
            On May 17, 2019 this sequence version replaced NM_005744.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243190.1, AJ130976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379887.9/ ENSP00000369217.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-685               AC079322.5         93324-94008         c
            686-753             AC079322.5         50204-50271         c
            754-898             AC079322.5         23374-23518         c
            899-991             AC079322.5         12975-13067         c
            992-1047            AC079322.5         12431-12486         c
            1048-1114           AC079322.5         6789-6855           c
            1115-1221           AC079322.5         4838-4944           c
            1222-1264           AC079322.5         1733-1775           c
            1265-1336           AC079322.5         1161-1232           c
            1337-1467           AC100827.2         84638-84768         c
            1468-1525           AC100827.2         82780-82837         c
            1526-1786           AC100827.2         73954-74214         c
            1787-1899           AC100827.2         72758-72870         c
            1900-21679          AC100827.2         51958-71737         c
FEATURES             Location/Qualifiers
     source          1..21679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..21679
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /note="ariadne RBR E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:25820"
                     /db_xref="HGNC:HGNC:689"
                     /db_xref="MIM:605624"
     exon            1..685
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1984
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /EC_number="2.3.2.31"
                     /note="ariadne, Drosophila, homolog of; protein ariadne-1
                     homolog; ARI-1; MOP-6; H7-AP2; monocyte protein 6;
                     ubcH7-binding protein; ubcM4-interacting protein;
                     ubiquitin-conjugating enzyme E2-binding protein 1; ariadne
                     homolog, ubiquitin-conjugating enzyme E2 binding protein,
                     1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ARIH1"
                     /protein_id="NP_005735.2"
                     /db_xref="CCDS:CCDS10244.1"
                     /db_xref="GeneID:25820"
                     /db_xref="HGNC:HGNC:689"
                     /db_xref="MIM:605624"
                     /translation="MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGE
                     VELVEPGLGVGGERDGLLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYE
                     VLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAE
                     CHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTT
                     KIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWC
                     PAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETS
                     NWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRY
                     NEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM
                     SWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGY
                     LERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED"
     exon            686..753
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            754..898
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            899..991
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1047
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1114
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1221
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1264
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1336
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1467
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1525
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1786
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1899
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..21679
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5228..5233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /note="hexamer: AATAAA"
     polyA_site      5247
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /note="major polyA site"
     regulatory      10520..10525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /note="hexamer: AATAAA"
     polyA_site      10538
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
     regulatory      10892..10897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /note="hexamer: AATAAA"
     polyA_site      10917
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
     regulatory      21137..21142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /note="hexamer: CATAAA"
     polyA_site      21158
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
     regulatory      21660..21665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
                     /note="hexamer: AATATA"
     polyA_site      21679
                     /gene="ARIH1"
                     /gene_synonym="ARI; HARI; HHARI; UBCH7BP"
ORIGIN      
        1 agtagcgata gcagcggccg tggaggtggc gttggggact gttttctctc ggaggccgga
       61 gcggagccgc gtctgactga ggcgggcagc aagcggcccc ctcgctccct ccctccctcc
      121 tccgcgccct ccccgccgcc accagccgtc aaacgccaac cgccgctcct ggggaggagc
      181 cgcggctcgc ggggccggag ccaggcctgc gtccggacat cagccggagc cggagcgaga
      241 gccggggcct cggcgtcccc gccctctccc cgcctcggcc agcgtccgcc gggcccccgc
      301 gcgtcgcgcc atggactcgg acgagggcta caactacgag ttcgacgagg acgaggagtg
      361 cagtgaggag gacagcggcg ccgaggagga ggaggacgaa gacgacgacg agccggacga
      421 tgataccctg gatctgggcg aggtggagct ggtggagccc gggctgggcg tcggcgggga
      481 gcgggacgga ctgctgtgcg gggagacggg cggtggcggc ggcagcgctc tggggcccgg
      541 cggtggcggc ggcggcggcg gcggcggtgg tggtggcggg ccggggcatg agcaggagga
      601 ggattaccgc tacgaggtgc tcacggccga gcagattcta caacacatgg tggaatgtat
      661 ccgggaggtc aacgaggtca tccagaatcc agcaactatc acaagaatac tccttagcca
      721 cttcaattgg gataaagaga agctaatgga aaggtacttt gatggaaacc tggagaagct
      781 ctttgctgag tgtcatgtaa ttaatccaag taaaaagtct cgaacacgcc agatgaatac
      841 aaggtcatca gcacaggata tgccttgtca gatctgctac ttgaactacc ctaactcgta
      901 tttcactggc cttgaatgtg gacataagtt ttgtatgcag tgctggagtg aatatttaac
      961 taccaaaata atggaagaag gcatgggtca gactatttcg tgtcctgctc atggttgtga
     1021 tatcttagtg gatgacaaca cagttatgcg cctgatcaca gattcaaaag ttaaattaaa
     1081 gtatcagcat ttaataacaa atagctttgt agagtgcaat cgactgttaa agtggtgtcc
     1141 tgccccagat tgccaccatg ttgttaaagt ccaatatcct gatgctaaac ctgttcgctg
     1201 caaatgtggg cgccaatttt gctttaactg tggagaaaat tggcatgatc ctgttaaatg
     1261 taagtggtta aagaaatgga ttaaaaagtg tgatgatgac agtgaaacct ccaattggat
     1321 tgcagccaac acaaaggaat gtcccaaatg ccatgtcaca attgagaagg atggtggttg
     1381 taatcacatg gtctgtcgta accagaattg taaagcagag ttttgctggg tgtgtcttgg
     1441 cccatgggaa ccacatggat ctgcctggta caactgtaac cgctataatg aggatgatgc
     1501 aaaggcagca agagatgcac aggagcgatc tagggcagcc ctgcagaggt acctgttcta
     1561 ctgtaatcgc tatatgaacc acatgcagag cctgcgcttt gagcacaaac tatatgctca
     1621 ggtgaaacag aaaatggagg agatgcagca gcacaacatg tcctggattg aggtgcagtt
     1681 cctgaagaag gcagttgatg tcctctgcca gtgtcgtgcc acactcatgt acacttatgt
     1741 cttcgctttc tacctcaaaa agaataacca gtccattatc tttgagaata accaagcaga
     1801 tctagagaat gccacagagg tgctctcggg ctaccttgaa cgagatattt cccaagattc
     1861 tctgcaggat ataaagcaga aagtacaaga caagtacaga tactgtgaga gtcgacgaag
     1921 ggttttgtta cagcatgtgc atgaaggcta tgaaaaagat ctgtgggagt acattgagga
     1981 ctgagaatgg ccctgcataa aatgaactct gaaaacttta ccatctagag tgctcatgca
     2041 attaaaacaa aacaaacaca aacaaggagg cactaagcct attctgacac cactggtctg
     2101 tagtaccaga attgttttgt taatggaaag tttaagtaaa ttatattgta ataaaaaggt
     2161 agataaacca ttgtacaaca gtattctagg ccaccaacaa aagtgtgaca gacacactaa
     2221 aagccctcca actttaactt gtaacgtagc ttcattctca aagctgactc cttttttttc
     2281 tttttccttt tcctgagtgt agtacagtta aaatttcaaa cagctccttg acactgcttt
     2341 tcatgttcaa accagccatt ttgttgtact ttggtaaagg acctcttccc cttcctcccc
     2401 tacacataca gatacaccca cacacagact gactctcttt ctctcatacc ccaaggtcat
     2461 gagtgaatga tgcttagttc cttgtaaaga aaatcttggg atggggaaag gggtaggcag
     2521 caagaggatt caacaaacga aaaacataaa aactttgtat atgactttta aaacaagagg
     2581 acaacacagt atttttcaaa attgtatata gcgcatatgc atggacaaag caagcgtggc
     2641 acgtgtttgc ataatgttta attacaaaaa aatatttatt ctttaaaaat cttcaagatt
     2701 atgtctattt gctgtgcatt ttctttcagt ttgcttatct ttcccgggtt ggggttggga
     2761 taaaggtgtg tcggtttagc acctctggaa gacctatcta gagctctttc actttcctga
     2821 ggttattttg ccctttctgg tgttggtatg tctgttgccg gccatgggcc tcatgccttg
     2881 aattcctgct cttgatcagg gacaagggag gtcaagctct gactaatgcc atgacctgat
     2941 taaggggtac agcagggagt tttgttgcta cagctcatga attaacctgt cccaacctaa
     3001 tccccctcca tggcatcatg cctctaccca agcctttgtg tgcccatgtt atgcacacag
     3061 ctgtaggcat tcttaagtcc cctgtcgcat ccagtggaag cattttaaaa tttcttttac
     3121 tttttggttt tcccttaatt gctgcttttc agattttagt tatggctcgt ctgctcaccc
     3181 cttctctaca ttagggtgtc aaagagaatg ttttgcttta aatataaata gccattcatt
     3241 tagtctcaga ttgtgaattt aaaatggtgg ataccgaaat tgcttgtgtg tgttgctgtg
     3301 ggtttggttt gaaggcaaac acccctagaa catgatattc ccatctagtg catttaaata
     3361 gaaatcactg agtttgctgc ttttttattg tcagcagata ggagaattaa taatgcattt
     3421 tagctgtgat gtccattttt atgaaattcc tactaagagc tatgttaaaa gtaaaggatg
     3481 gtggtggttg tattaactat atacctgttt aggccattct ggctgtggta tttttcaata
     3541 ggtcagcatc tgtaaatctg tcagttttat acaggagtgc agagtgaact aggcaactag
     3601 attaagaggt ctaaatatga aataccagtt gaggctgagg acctcttcgt cttcctttaa
     3661 atgtcttttg cctagggagt gtttaccatt tgtgaggcag ctttgtctgc tcttacactg
     3721 tacatcctat tactccattg ggaagtaggt tcactttcct ctggcctttt gcctaagtta
     3781 ggctttgctg aatcaaccct acttttcctt ttagaaaagg ttgttacagg agatttactg
     3841 gcaactgttc ttttcccatc aaaaatcagt gaatgtttgc tgagtataaa tgctgcttcc
     3901 ttaaaccact tgtcgcttta ggatcaactt tacctgtacc ttttctcctt tcctcccttg
     3961 ccacctcagg tgcaaatctg aactcagtgt ctgcttcttc cattttctcg tctctctccc
     4021 ctcttccccc attatccata tgacattatt ttacttcaaa tgacagcatc aatcttaaaa
     4081 agatatacat taaaactaag gagttttttt aaagaaagcc tgaataagtt cctttccctg
     4141 gtaactttga aaagcagtca gagttgctat atagatatat gtggctcctt taaaatgctt
     4201 tgtgtatgtg tggtgtttaa aaaaaaaaaa tcttaccagt taactttgca gtgtctaggt
     4261 ttgagtgtca taaatccacg tgttcctgtt gcaacaaata cccaaaaatt gtgtgtgcac
     4321 ttcctaatac cagtcttcac ccatggagga acagtgcttt ttagagatgc tttctatttc
     4381 aatgttggca tactgcctga gggtattgca gttgtgggtg cattccctaa tttgtatgat
     4441 caagatgaac tggccctttt ctacttccaa gcttttaaca gataccacca tatttgacag
     4501 aattcccaga gtgaattgct tgtgttatta gtagattcag tgcccccagc tgggataggc
     4561 aagccatgac agcttccctg tttcacctac agaagtctta tctgagggat ctattcacag
     4621 taagcaccaa ggtctccatg tcttgaggtc agtttcattg tcttttgaaa agtgcatgct
     4681 tcatttgaac aattcattca gcagcagatg gactttcagt gatttaaaat aaaattttga
     4741 tccaaagctc aggacacaaa ccacagtggt aaaattgagt agcatataat atcagactaa
     4801 attatctgta attttccaca acccagattg tatgtgtttt atgtgtgttt aaataaatat
     4861 gttagataca cgtgtataca tacacccata tacaacagat ccaagactgg ctgacttcat
     4921 ttgaaatggt tgaatctgct gtgtaataaa gtggttcaac catgattagg aactgaaatt
     4981 tagtagaaga gggaaaagga gttaatgtaa caaattattt tagctacaaa ccccggtaat
     5041 agagcacttg ggggatggga tggggtgggt tggtgagaca atcagaatgg taaattgatt
     5101 aaatgctcct aaccctgtaa ttttgtgcat agagcaccct atgctgtgga aataactgtt
     5161 cttagatttc attgtaactg gactgttcag gttgcccaga gggaaagaac attcctaatt
     5221 ctaataaaat aaacttttat tttgttattc cattagttac ttatgtttat ttttatagtt
     5281 aaaaaatgac taaaggtggc taatagccac ccgtattatg tgccttattc actgttccca
     5341 cttaatataa aatgtcaaaa attggttgtt tctttgcagg gaactgtgaa tgagcccatt
     5401 cccccaacat ttaacttggt taatgaagct ttcagagcat tttctgaaag atttccaatt
     5461 tctgcatctc agatattgaa tttaaattgt ttgtgttgta acagtgatac aaaaatgttc
     5521 aatagctctt tgaatgccac tttttttaaa gaaaatactt taaaagtcat tcttagctaa
     5581 cctcaaaact cctttacatt actttcattt tagctcactc ttaaagctga tactgttata
     5641 tagggatgaa gggagagttt tcttaaagaa ggtcccaaag ttgaagatcg tttgtcattg
     5701 atactctggc caagtccagg ttttaggaca atttaattta ctcttatttg gatctgtaat
     5761 tatgggagtt tatcactttt cctcttcaaa gcacttcaac ttactgtcta aaacaagtgg
     5821 agaagaaatt gccatttttt ataaaggagg aagataaggc tcactgaggt taaataactc
     5881 cctcaatttt tcatttcctt ctacctgaaa cttaacatca tgctacctct ttgtatcata
     5941 ttttgttatt ctggtcacag aatgacctag tattctgtac cagggaaggt agttcttaac
     6001 tatattgtac ttttaaacca cattaaagac tattataaat gcctatcact gctactgtta
     6061 gaggttgctc tatactatct ctgatctttc atttgttgca gtttgcaaca cagtagttga
     6121 gaataagtgg tttagtatga tttgcttaat agtacccaag taatttgcag ttgttggttt
     6181 agttattcaa atgaatttcc attgtaaaga attttggata gtctgcagga aattgttaca
     6241 ggatgcacag aacatcccat atccattgga tctcagcctt tgaggcttta aaaagatgat
     6301 aagcagtgag ttttatgaga aaattttggc tccttcagaa acaggaagat aagtgggccc
     6361 ctcagatttt tcatatatct ttggggataa agttggttat atctggttta ttttagggat
     6421 tttgcttctg tagttaccca agatcaaata gccaactcag aaatactcag ttggatatca
     6481 atcaaatagt gcctaccagg ggagtaaaca gacaactttt aggtttttag tttttgcttt
     6541 tgtgtggagt tgagtccaat ttttaaggca actattgttg acctttctct aggcggtagc
     6601 atttaggatg ggaaaaaata atatgagtta tgtgcgaaaa gcagttttca ggctatcatt
     6661 tagggccaca gatatgctta tttaggacta ttttcagggt aggagccagt taaagtttgt
     6721 atatcagtca cacattgata tgtagcagct ctatcaatac cacaacaacc ttattaccat
     6781 agtaattcag gggtctcaag taatccagga gtctcaaact gaaatgtcaa caagagccaa
     6841 gtaaatattt tagaaataga gtaccctgga gtagatgggc tctgagagga gcctgtgaaa
     6901 tccagacttc atgtgaattc tcttaattaa atgtgggcca aagaaaaccc ggccatgggc
     6961 agtttttttt tcccagcttc tactagtctt ggcttgcaac aatgccactg tccatctggc
     7021 attacctaga ccagtgatac ttaaacttga ctgcgaattg gaatcactga gaagctttaa
     7081 aaaatattag tgcctgagtg ttactttatg gagattatga tttaattgct ttgggtaggc
     7141 atcagtaatt tttgtaaagc cctttacgca ttctcacccc taattccagc cggtgattct
     7201 cacatgcaga ctaggttgag atccttgatc tagactgcct tctatagttg caaaaagaga
     7261 atataggcga gcaactccag atcataaggg acaaaatgat tcaaggcaaa ttgactggct
     7321 cagaataggg cctcactgga ggccctagtt gagtgggttt tgtggaatgg tgcctcccaa
     7381 gggtctggtg tgcagtgccc aatttggttt tttgttggtt ttctggtaag tggtccacct
     7441 tggagaaaat cacaaaacta aaagtcttac caagaagtag aactgacaag cagccatgtt
     7501 gattggcagt acattctctt accaaggggg agaaatctat ctagggaaaa taatacagag
     7561 tctgagcaaa ggaagttgag tggttataag caaaactgtc attaaagcta gttgcgtcaa
     7621 gtctgcacaa ttccacgagc acttaagagt ttacaagttt ctcatgtcta tcattctttt
     7681 gataatcttg tatttttatt tcaagtgtgg tatagtagta agaatattgg tatttctcag
     7741 ccatagattt cccttttgta aaatgggaat actaatagga actgtaattt gttgagtgct
     7801 ttttgccaga tgccttactt ttgtctgtat cttccaagca gccctaaagc aaaatgggca
     7861 ttgttaccct atttttatga ggaaagacac tcatatacta ctaacttact caaaagttac
     7921 acattgagtg tataacaggg ccatgcttgt ctgattccat atgttcattc tattatgctg
     7981 ctgttgtctg ttacatagga atattgtgag gatcaaagaa catgtgaaaa caaaacctag
     8041 ttacaataat aagcacacca gtgctaactt gggcaaaaga taaggataca gagctgtctc
     8101 agagactccc aaaggcagga tgagattggg aactagaaaa ccattttgga cccctaaagt
     8161 ggtattgtct actatctgta catcattctc ttacagctct tactgctgct tttcctgtca
     8221 gttaccccat agctccaggt attacatgtt aactgttcct gacacatgta gacagaacca
     8281 atcagatcca tggggcagga tcatcaatac aaacatgggt gttgagagct taacttaatc
     8341 gggaaggaga tcttggagat catagttcgc tgggttcaca tcatggaaat cgtctttgac
     8401 aaaactgaaa tgccctgaag ttttaatttt ttaaatacat gtaatgaatt ggtatatggt
     8461 agatactcgt ggctacttag tatttaccaa atgctttgtt tccatctcgt ttatttttat
     8521 tttttatttt tttaagagac agtcttgcta tgttgcccag gctggacttg aactcctagt
     8581 ctcagccaac cccttctgcc tcagcctcct gagtagctgg gatcataggc atgtgccact
     8641 gctcctagct cttccatctc agtcttatga tgtagttact attttcattt tataaataag
     8701 aaaatagaag ctcaaataaa atgggtagtt tccttgaggt catcctgtta gtaagtggtg
     8761 gaatgaagtt acaaacctag gttttattgg tcagcacaca cagtgccggg cactggcagt
     8821 acagcagtga acaaaaggtc tgttggtttg tctgaagctc tcaaccttga ttctgcatag
     8881 actcggtgga ttgcccaagg ccactcaacc agttaatatc agagccagct ctgctgtttg
     8941 accagtatat tattttcacc atgctgtatc tgcttctcag tcaccaaaag caccagctaa
     9001 aattgtatat agactgatta ggggacttcc aacctaagat tgtcctggaa acttaattct
     9061 tatcttggct catctcttca aaacagatgc ctctttcgtt ggtgacctca gatacactgt
     9121 tcagaagtac tcaaagtatt ccttttttct cacatttgag agtcactcta gcattttaat
     9181 gagttaagca agccagccct gcatttccaa acccttccca gaagtctaac cttactttga
     9241 tctgatgaca tgggcttttt aaaagattac tattttttta gaggtggggt ctcactatgt
     9301 tgcccaggct ggaatataat ggctattcac aggcacagtt agggtgcact actgccgtga
     9361 actccaggac tcaagccatc ttcctgccac agcctcctga gtaacctagg actataggtg
     9421 catgccacca tgcccagctg acaatggctt tatatacata atatttcctc agcaacaatt
     9481 tatgtcttat ttggcacctg taaaaccctc ttcactgatt atgcctgttt aaaggtttgg
     9541 tatttactcc aagtcacctg cctttagcca tggagtattc aagtttcttt cagaatgaga
     9601 atttggaggg tgctcataga aatataaaac aaggctgggc atggcggctt acaccttgta
     9661 atcccagcac tttaggaggc tgaggcaggt ggatcacgag gtcgggagtt cgagaccagc
     9721 ctggccaaca cagtgaaacc tcatctctac taaaaataca aaaattagcc aggcatggtg
     9781 gtgcatgcct gtaattccag ctgctcggaa ggctgaggca ggagaatcgc ttgaacgcgg
     9841 gaggtggagt ttgcagtgag ccaggatcac accactgcac tccagcctgg gcgacagaga
     9901 gactctgtct caaaaaaaaa aaaaaaaaaa aaaaagaaga agaagaagaa atacaaaacc
     9961 aactctttat agtagacagt ttatccccca gaaagctttt taggctgaaa acgtttctat
    10021 agattttgga tttccttctg atagctaaaa tttgtttctg tataacagag tagtgcccta
    10081 taagccagtt cagtgcacat taaatggctg ttcttagaat tatgaatctg aggcttatgc
    10141 agtgaggctc tagctctctg gagtcagttg gtcaagtggg attcctgagg actgagcaaa
    10201 cacacacaga gcaggatttt gtcctaagtt ttcttaggga tcctatccaa aaacaccatt
    10261 acttgaattt cccagcttcc ttttacaggg agacttcctt gctatgtgta ctcccacctc
    10321 ggtatgtcaa atcattttct cagaggaagt acagcataaa ataataacca gcatttgtag
    10381 agcacttctt gtgggccttc ttgggcaaat agacattctc atggaatgct ctaaaattgt
    10441 taagttcttg cacttgctct caagtcattt ataatctaat tgctggtctt cctggtatga
    10501 acaaagatgt ttgcttgtta ataaattcct accacatacc cagacttgtg gtttatttct
    10561 atctaactag ggaaagcact aaagagtttt ccaataagga agaatgatct gagtgtctac
    10621 ctgctttgga aaagatgtct gccatggata ggaaatgatt ttgtatccca aaatcctagt
    10681 actaatttgg agtgttgtaa aggtcagggc agcaaatgct agagagtggg attaatgaaa
    10741 agttatagtg ttctgcatgc ctttgaataa ttaattttta ctccattttt actcgcttgc
    10801 aataaagtag gttaagtgct gtactttaag gaagtccatg tacaagccag tgccttaaca
    10861 atggtcaaat ggttgctcac taaccaatgg aaataaatga ctgttgtttc cacaaaattg
    10921 ctttacagat tctaaatgct atctctggga cactggattg tgtgctcttt aagataaatt
    10981 ccataatcaa gggcctggcc ctgaatagat tggagcccaa aaatctcact gaagcaaaga
    11041 gataataggc cagtaaagag tgggagacaa acactcctgg aataggaagc cactactcac
    11101 ctttatttta aattgatata tagaaattaa tattacaaaa tgcacacatc ttaagtgtga
    11161 agtttgatgt tttgacagtt gtatacgtct gtgtaataac taccaaaaga agacataata
    11221 tgttacaatt aacccagaaa attctcaagt acttttaaat cacccctgag cacctcccca
    11281 ctccagtgat cacttcttga tttttatcac taaagatttg ttgtacctgc ttttggatta
    11341 catataagtg gaatcatata ataatgtact cttttgcatc tggcttcttt cactgataat
    11401 gctttaaaga cacgcatact gtatgtatta ggacattgtt ctttattgct gagtagtatt
    11461 tcattctata aatataccac aatttgttta ttcattctcc tattgaagga cctttaggtt
    11521 gtttccagtt tggggcaatt atgaataagg atgctatcga tattcttaca cagccttttg
    11581 tttttgtttt ttgtggatat acatcttcac ttgtcttgga taaataagag tagaaaatta
    11641 ctgggtcata tggtaagtgc atgtttataa gaaactgccc tcttattctc caaagtggtt
    11701 ttaccatttt gtactcctat cagtgatgta tgagagttac agttgcttca catgtctgtc
    11761 aacatttaca ctgtcactgt tttttatatt agccatttta gcatatatga aataactgat
    11821 tttaatttac attacatttc cctgattaat gagttgagca ctttttcata tgcttatttt
    11881 tcatttgtat atctttcaag aagtgtcttt catgtctttt ctcattttaa agttgggtgt
    11941 ctttttattg taggtgttat tctttgtatt ttgaatataa atcctttgat agatatgcta
    12001 tgatttttta aagactctat gtattcactt attgggatct ttcgatgaac aaattttttt
    12061 tataaaatcc actttatcag ttttttattt tatggtttta tgacctcaaa gtcacaaaga
    12121 atatattttc ttctagaagt tttatggttt gggattttat gtttaggtct gtgatccatc
    12181 tcaaattaat ttttgtgaac agaatgaggt ttggtttttt tccaacatgg atatacagtt
    12241 gttccagcaa catttactta aaaagacttt tctttaccca ttagattgac ttggtagctt
    12301 ggttaaaaat tgatcacgtg tgtgtgtatt tctacatttt ctgttctgtt ccattaatct
    12361 atttgtgtat ccttacatca gtaccacact ttggattatt gaaactttct agtaagtctt
    12421 taaattagta aatccttcct ttttgttatt tttcaagatc gctttggtta ttgtcgattc
    12481 tttggattgt cataaaagtt ttacaattag ctcatcttgt ttttcaaacg tagatgtgct
    12541 gggttagctg tgttcatgcc actgcattcc agcttgggtg acagcaagac cctgtcaaaa
    12601 aaaaaaaaga aaagaaaaaa ctgctagaat cttgatatgg ggttttgttg agtctatagg
    12661 tcaatttaga atgaacattt taatagtatt gagtcagcta attcatgaac atattaagtc
    12721 ttgtcattta tttaggtatt aaattttttt ctcagcaatg ttttgtagct tcccttgcgt
    12781 aacacttgct tatcttacat tagacttttt cttaagcatt tgatttttaa aatatttttg
    12841 attttctttt ctttttcttt ttttcttttt ttttttttga gacggagttt tgctcttgtt
    12901 ggctaggctg gagtgcagtg gcgcgatctt ggctcactgc aacctccgcc tcccgggttc
    12961 aagcaattct cctgcctcag ccttttgagt agctgggatt ataggcacac accatcatgc
    13021 ctggctaatt tttgtatttt tagtacagac ggggtttcac catgttggtc agcctggtct
    13081 cgagctcctg acctcgtgat ccaaccacct tggcctccca aagtgctgcc attacaggcg
    13141 tgagccaccg cgcctggcta attttcattt ttaagttgtt tgctgctagt atctagaaat
    13201 acaattgatt ttttgtttgt ttctttagag atgggtctca ctatgttgcc caggttggtc
    13261 ttaaactcct gagctcaagg gattctcatg cctcagccac ccaagtagct gggactttat
    13321 tcacgtgcca gtgtgcctgg ctgatttttg tatgctgatc ttgaatcgtg ccaccttgct
    13381 aaattcattt attctagaaa tagttcttgt agactccgta gagttttata ttaaatagat
    13441 acacaacagt gtagtctgca aataatgttt ttacttcttt ttctgatttt atgccttttc
    13501 ttcttttttt tttttttttt tttttttttt gtctttctcc actggctaca atatctagtg
    13561 caatgtttaa cgtgtggtga gagcagacac cttgccttgt tttcttaatc ttagggataa
    13621 agattttaat gtttcatcac taagtataat gttaactgta agtttttcac agaccagccc
    13681 aaagaagttc ctttctattc ctaatttgtt gataattttt attaggaagg gttattaaat
    13741 tttgtgagat gcgtttttag cttttaataa gattattatg tatttctctt tttattttgt
    13801 taagatggta tgttacaggg gttggcaaac tgtggcccat gggccagatc cagcccatgg
    13861 acagttttgt tgttgctgtt ttagagacag tctcactctt ttgctcaggc tgccaggctg
    13921 gagtgcaatg acatgatcat agctcactgc agccttgagc tcctggactc aagcgaccct
    13981 cctgcctcag cctcctgagt agctaggaat acaggtgcat gtcaccacac caggcaaatt
    14041 taagaaattt tttgtagatc ttgccgtgtt gcccatgatg gtctcaaact cctggcctca
    14101 agcaatcctc ctgccttggc ctcctacagt gctgggatta gaggtgtgag ccaccacact
    14161 tggctctcat ggactgtttt tgtttttgtt ttgagacagg gtctctgtca cgcaggctgg
    14221 agtgtggtgg catgaacgtg gctcactgca gcctcaactt tcttggctcc agcaatcatc
    14281 ctgcctcagc ctcccgagta gctgggacca caggtgtgcg ctaccacagc tggctaattt
    14341 ttctttttca tttttgtaga catggagtct tgatatgttg cccagattga tctggaactg
    14401 ctaggctcaa gtgatcttcc tgccttgcac tcccgaagtg ttggcattac aggcatgaga
    14461 cacagtgccc agcctattgc agtgtttttt gttttttctg tttttttttt ttttttttca
    14521 tctttgtttt tgtttttttg agactgagtc ttgctctatc tcccaggctg tggtgcagtg
    14581 gtgcaatctg caacctccgc ctcccaggtt taagcgattc tcctgcctca gcctcccaag
    14641 taagtgggat tataggcaca tgtcaccaag ctcagctaac ttttatattt ttagtagaaa
    14701 cggggtttca ccatattggc caggctggtc ttgaactcct ggcctcaggt gatctgccca
    14761 ccttggcctc ccaaagtgct gggattacag gtcactaggc gtagtagggc tactacgcct
    14821 ggccctactg cagtttttaa taagagatga gttctctcag cttttgtcta taagagaatg
    14881 tccttacttt tatttttgag gggtatttta gttggatata ggactctatg ttgacctttt
    14941 atttcttctt tcagtacttt aaagaagtta ttttattgta ctcaggcctc atttgtttct
    15001 ggtgagaagt cattcatcat tttaattttt atttcctttc cgtaatgtgt ggttgttctc
    15061 aatggctgca tctgtgcatt atatttactt ttcagtagat tgactaggga atgtctaggt
    15121 atgtttttct ttgtatagag tttactgaac ttcttggatc tgtgttgatg tctttcatta
    15181 atattggttc tttcttggcc gttatccgtt tacatttttc tcttgtctca tactctcttg
    15241 cttctcctct tctttggaga ttctagttac atgtatatta gatgatttga tataaaccta
    15301 cagatctcag atgatttttc ccctgccctg ttttcttttt gttttcagtt tggatacttt
    15361 ccatttaacc atctttaagt tttttgatgc tttccaatgt taacctgtta aacttgttta
    15421 ttgaattctc catttaaaaa tttttatttt tagttattta tggatacata gttgtactga
    15481 attattcatt tctaatattt ttatttctag catttcatta tatttgtata gttacaattt
    15541 tctgctgaaa tttcctattt cttcatgcat gttttccaca ttttccattc tactttttag
    15601 cattttaatc agttatttta ttgggttttt tctgtttttt ctttcatttt taatcagtta
    15661 ttttaaggat ccaaactgat aattcaacat ctgggtcttt tctagttctg cttctattga
    15721 gcccttcctc tcccttacca tgaatcttat tttcttgctt ttgcacgtct tgtatatttg
    15781 attggatgat ggacgtttta tgttgaaaaa aaaaagaaat tgaagaaaat gtttacttcc
    15841 aaaacagagc atgccctttg tttttttttc aggccacttg aatggtggct caatctgatg
    15901 tatatgaatt ctagactggg gcttcactgc agttttagtt tgattcagtt tgcctctagc
    15961 ttcaaatatt tgaaggaacg tagaatcaga actctcatat caccagggcc tgagttttgg
    16021 gcattggcaa gattccagag atctgacttt gcttcatagc taagccacca gcttttatca
    16081 atgtgggaga tctttcccta ctttacaacc ttgctgccag gatttttttt tttaatcaat
    16141 gggctgggga taggaggatc tttctcagct ctcatgtgtg ccctgccctt ttgtagagga
    16201 atgcccacaa tgcctagggg atgggtttct cagcatttct gaccccattt aggctccaag
    16261 agtgcctctg ttggatttca caacaatcct gcctcccctt tcatttttaa agggtatttt
    16321 gcccttggga gaagtcaagc tctctcagcg ttccttctat tatccacacc tttagtgtac
    16381 tacaccttcc tgtacctggt tatcatctaa ggggtaagat tggtgggaag ccttcctctg
    16441 tggatttggg tcatctaggt tctaatgtca aaccagcctc caaggggttg tgaaaatgtt
    16501 gttaaatttc agcaggtttc tcttttctcc cccctgtagt attcctcttc ctaccatagt
    16561 tcaactagga ataacaacag ctagggggtc tcttctctcc tatgaaggac ttggcacttt
    16621 ctggagtttg gatcatttag gtttctttgg tttttgtttt tattttgaga cagggtctca
    16681 ctcttaccca gcctggagta cagcctgtag tgatctcagc tcactacaac ctctgccttc
    16741 ctggctcagt tgatcctccc acctcagcct cctgagcagc tgggactaca ggcgtgtacc
    16801 accacacccg gctaattttt gtattttttg ttgagatagg gttttaccat gttgcccagg
    16861 ctgatctcaa acttctgagc tcaagcgatc tgcctgcctc agcaccccaa agtcctgggg
    16921 ttacaggcat aaaccactgc acccaaccta gatttctttg tgtccttagc tttctgatga
    16981 attaaacata tgttttattt tctagctcat ctggcctttt gttgttgttt gctagagtgg
    17041 gaggtatatt ccttgtgact ttgttcatat cactagtgaa tttcagaagt aggagtttat
    17101 ttttttaata aaaaattttt ttaggtcagg cacagtgtct catgcctgta atcccagcac
    17161 tttgggaggc cgaggcaggt ggatcacctg agatcaggag tttgagacca gcctggccaa
    17221 catagtgaaa ccccaactct actaaaaata ctaaaattag ccaggtgtgg tggtgggcgc
    17281 ctgtaatccc agctacttga gagactgagt caggagattt gcttgaacct gggaggcgga
    17341 ggttgcagtg agccgagatt gtgccactgc actccagcct gggtgacaga gcaagactcc
    17401 ctctcaaaaa aaaaaaaaaa aatttttttt taaacacgtc tcactgccac ccaggcttga
    17461 gtgccatgac atgatcatag ctcactgctg gcttgacctt ctgggctcaa gtgatcctct
    17521 tgcctcagcc tcttgagtag ctgggaccac agtcatgtgc caccatgcct ggcttttttt
    17581 tttttgtaga gtttgggtct cgctatgttg cctgtgatcc tcccaccttg gttttccaaa
    17641 gtgctgggat taaaggcatg agccaccatg cctggttagg aatgggagtt taaacaatgg
    17701 ttttatttac atatttcatt agctagtatt tttttctttt ttgagacaga gtctggctct
    17761 gttgcccagg ctggagtgca gtggcacgat ctaggctcat tgcaacctct gcctcgtgat
    17821 tctcgtgact cagcctcctg agtagctggg attacaggcg cccgccacca cacccagcta
    17881 atttttgtat ttttagtaga gacagggttt caccatgttg gccaggttgg tctccaactc
    17941 ctgacctcag ttgatccacc cgcctcagcc tcccaaagtg ctgggattac aggtgtgagc
    18001 catcgctcct ggcctcatta actgttttca aaagtaaaag tacatggata atacaaagtt
    18061 aaattttgta gaatcataaa gaaaagcaac accttcccat cttaactccc ctagtgcctc
    18121 tactccctcc acagagacaa atatcttacc agttggttgt gttttctttt ccaaactgta
    18181 tttctaaaat gtgtcaatat ctcttccttt tattttttat tttttgtaga gacaggggtc
    18241 tcactgtgct gcctaggctg gtctcaaact cctggcctcc tacctcgact tctcatagtt
    18301 ctggcgtgag ctactgcacc tggcctcccc cttattattt ttttaaacat gaatggaagc
    18361 atactatatt ttctacactt tatttgtttt atgtaactat tttaacaacc tgaggacttt
    18421 tacaggctgc ataatatgtc ttaatatgga tgtatcttag tttatttaaa cagttactgg
    18481 tgatggacat ttccatgttt ccagtatttt ttctcacaaa caatgcagta ttatgccttt
    18541 gtccacattc accattgatt gctattgagt atatctgtag catcaagaat aggcatactg
    18601 aaaatcctcc atgaagtcca gtgaagcttc atattatttt gaagtgatat ttcccagtgt
    18661 tggctggact ctcaagcgtt tgtggtatag gttttgggag gactggacac ttccaaagag
    18721 aaataagatg ttacagactt gtccagcagg tggcatcaga acaaagctgg ctatggacct
    18781 tgtcagtaca aatgataaaa cattaaaaat gtaaaaactc aactgtagct ccttgtttat
    18841 acatatattg ggggtgttga aaagttaccg atgcctgatt cctcttctat gtcctcagcc
    18901 cccaccataa aaatagataa atgccatttt ttttgtatgc ccagcacagc tatatgattt
    18961 gaataatctt gataagcagg gtcacatttg aggagatttg ctaagggaaa tgaagatcca
    19021 tctgtgacac aagaaacatg ttctatgtga tttctgggat tttcctgtga acatacttct
    19081 tgtttgtttg ttttacagtg gatctcactc tgtcacccag gctggagttc agtggtgcaa
    19141 tcatagctca ctgcaacctt gagctcctgg gctcaggaga gcctctctcc tcagtctccc
    19201 aagtagctag gactacagac acatgccatc atgccaggct cattttaaaa ttttttgtag
    19261 agacgggtct cactatgttg ctcaggctgg tattgaactc ctgggctcaa gcaatcctcc
    19321 tgcctcagca tctcaaagtg ttgggattac aggtgtgaac catagtatcc aacctattat
    19381 gtttttttaa aaagagattg ttctaattat gtatataatt aaagtacatt aggtttagtg
    19441 attgcaattt gagaaaccaa tgtcctttct tattgaaaaa ggccctggta cagaaagtgt
    19501 tctatcttcc tcacaagatc tgaggtcaaa ggagagattt tgaaacatta tagcaatggc
    19561 ttctagttat tgaataaaga atgtcatttg ctcctcacag gacccctttc agggagattt
    19621 cacatattgg gaaacagcct catgagcttt ctacaaacat ctttgtcctt aagtcttccc
    19681 atttcagtaa ttggctgtac cactcatcca gcagctttca aagtaagaaa cctggcaatc
    19741 ttcctttaac atccatttcc ctttccctca ttcccccata tccaatcatg tgtattggag
    19801 gtttttccac ctctaaactt gagaacccat ttactttttc tccatctcct ttgccatcac
    19861 actagtccaa gtgaagtgtt tcatcatctc atttgcagca tcctttagtt taccctagat
    19921 tatcaatttt tgtccccctc ccaattcagt ctctactcat gagctaacat gagtttatta
    19981 agtgttcatt ctgaccatgc cattccttgc tcaaaattct ctagtgcctt cccaatgccc
    20041 ttaaaataaa attcctcata tggcctttgt ggatctgcac tcctacctct tctcctattg
    20101 caaccaaccc tgttaccttt ttctcttttc acactggtct tcattctgtg ctgcaaactg
    20161 gctgagattc ttccatcctc agggcctttg cacaagttct tcctttgcct tagaattctt
    20221 tcctggcctg cacatgtctt catccccttt ccctaagcta atgccttacc ctttaggtct
    20281 cattttaaac atctcttacc caggaaaaat ttccctgtcc aaacaagtct agattggctc
    20341 cccattgttt gttctaactg ttctatattt ctccttctta gcatttatca caattcttgg
    20401 tatgttgtgc ttttcacttt cttagtcgct attattggag taggtaatac atccatatag
    20461 tacaaaattc aaaatgtatt aaaggtatag agtaaaaagt cttctcttcc ctgtcccccc
    20521 gctacccagt tctcctcttt agaaccactt ttagcatttt gaatatcctt ccagaaatat
    20581 tttctaagta tacaagcaat tatgtatata atattcctct ttatttttgc ctttttatta
    20641 atacagatac tatatgcatt ttctgcactt tatctgttaa taatatatct tggcaattat
    20701 tcaatattaa tatgtaaata gttgcctctt tctttttcat gcgccatata atatggactt
    20761 ataatttatt taacctctat ctaggttggt tttaggcatt ggttattaca aataatgctg
    20821 cattgaatac ctttgtatgt aaagtcattt cccacatcta tgcctataga ataaattact
    20881 agaattgaaa taattcagtt aaagattatg tgcattttta attttggtag ttattgccaa
    20941 actgctctca atggaagttt tatgaattcc cactagtgaa tgcatttgtc ctcacaatta
    21001 tgtcagtgaa atttttgttc tttgccaatg caagaaatgg aaagtatctc ttggaaacta
    21061 atttgcatgt tttttttcct tgcacagtta tattttcata tgttaaagag ccatttgtat
    21121 ttcttggtga attgttcata aactttgctt acttattatc taatgtctga ctaatttgct
    21181 acactctaaa ttcccaattc atacttaagt ctcgcccttg caatttagat gtacaatctg
    21241 cctcttcagt ggtttccaca ccaaaaaatc cacaggctcc tgaattttat atgggcctaa
    21301 gagtcttact gaaaattgga agtcttaagg tgtagtctat tttatgcagt gtgaggcctt
    21361 tcatgctctg aaatgtacca ctcttgactg actttttctt cttcaccctg tccggcactg
    21421 tgcccttatt agccagagaa atgttccccc tttctcccag gaaacgttct gaccttaccc
    21481 tggtccctca aggactctcc ttctccccca aattaacttt caaggagttt ctccaaccca
    21541 aaatggcacc cttcctgaaa agatttctag tggatactgt tttctgtacc tcactacgga
    21601 tgtattttgc tgcttggctc cccgtctcca ttttgctatg gcaaacattt ttttccagaa
    21661 atatatcaga taaaatgaa
//
