LOCUS       NM_032199               7492 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens AT-rich interaction domain 5B (ARID5B), transcript
            variant 1, mRNA.
ACCESSION   NM_032199 XM_084482
VERSION     NM_032199.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7492)
  AUTHORS   Ragnarsson,C., Yang,M., Moura-Castro,L.H., Aydin,E., Gunnarsson,R.,
            Olsson-Arvidsson,L., Lilljebjorn,H., Fioretos,T., Duployez,N.,
            Zaliova,M., Zuna,J., Castor,A., Johansson,B. and Paulsson,K.
  TITLE     Constitutional and acquired genetic variants in ARID5B in pediatric
            B-cell precursor acute lymphoblastic leukemia
  JOURNAL   Genes Chromosomes Cancer 63 (5), e23242 (2024)
   PUBMED   38738968
  REMARK    GeneRIF: Constitutional and acquired genetic variants in ARID5B in
            pediatric B-cell precursor acute lymphoblastic leukemia.
REFERENCE   2  (bases 1 to 7492)
  AUTHORS   Tan,Y., Qiao,J., Yang,S., Wang,Q., Liu,H., Liu,Q., Feng,W.,
            Yang,B., Li,Z. and Cui,L.
  TITLE     ARID5B-mediated LINC01128 epigenetically activated pyroptosis and
            apoptosis by promoting the formation of the BTF3/STAT3 complex in
            beta2GPI/anti-beta2GPI-treated monocytes
  JOURNAL   Clin Transl Med 14 (1), e1539 (2024)
   PUBMED   38224186
  REMARK    GeneRIF: ARID5B-mediated LINC01128 epigenetically activated
            pyroptosis and apoptosis by promoting the formation of the
            BTF3/STAT3 complex in beta2GPI/anti-beta2GPI-treated monocytes.
REFERENCE   3  (bases 1 to 7492)
  AUTHORS   Al-Zayan,N.R., Ashour,M.J., Abuwarda,H.N. and Sharif,F.A.
  TITLE     ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline polymorphisms and
            predisposition to childhood acute lymphoblastic leukemia
  JOURNAL   Pediatr Hematol Oncol 41 (2), 103-113 (2024)
   PUBMED   37578068
  REMARK    GeneRIF: ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline
            polymorphisms and predisposition to childhood acute lymphoblastic
            leukemia.
REFERENCE   4  (bases 1 to 7492)
  AUTHORS   Deng,Y., Dong,Y., Wu,L., Zhang,Q. and Yang,L.
  TITLE     ARID5B promoted the histone demethylation of SORBS2 and hampered
            the metastasis of ovarian cancer
  JOURNAL   Pathol Res Pract 252, 154911 (2023)
   PUBMED   37948999
  REMARK    GeneRIF: ARID5B promoted the histone demethylation of SORBS2 and
            hampered the metastasis of ovarian cancer.
REFERENCE   5  (bases 1 to 7492)
  AUTHORS   Healy,J., Richer,C., Bourgey,M., Kritikou,E.A. and Sinnett,D.
  TITLE     Replication analysis confirms the association of ARID5B with
            childhood B-cell acute lymphoblastic leukemia
  JOURNAL   Haematologica 95 (9), 1608-1611 (2010)
   PUBMED   20460642
  REMARK    GeneRIF: confirmed the association of 5 SNPs [rs7073837 (P=4.2 x
            10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)),
            rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the
            ARID5B gene with childhood acute lymphoblastic leukemia
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 7492)
  AUTHORS   Wilsker,D., Patsialou,A., Dallas,P.B. and Moran,E.
  TITLE     ARID proteins: a diverse family of DNA binding proteins implicated
            in the control of cell growth, differentiation, and development
  JOURNAL   Cell Growth Differ 13 (3), 95-106 (2002)
   PUBMED   11959810
  REMARK    Review article
REFERENCE   7  (bases 1 to 7492)
  AUTHORS   Zhu,L., Hu,J., Lin,D., Whitson,R., Itakura,K. and Chen,Y.
  TITLE     Dynamics of the Mrf-2 DNA-binding domain free and in complex with
            DNA
  JOURNAL   Biochemistry 40 (31), 9142-9150 (2001)
   PUBMED   11478881
  REMARK    GeneRIF: NMR spectroscopy studies of Mrf-2 in complex with DNA
            suggest that two flexible interhelical loops, the flexible
            C-terminal tail, and one alpha-helix are involved in DNA
            recognition, indicating the importance of protein dynamics in DNA
            binding.
REFERENCE   8  (bases 1 to 7492)
  AUTHORS   Whitson,R.H., Huang,T. and Itakura,K.
  TITLE     The novel Mrf-2 DNA-binding domain recognizes a five-base core
            sequence through major and minor-groove contacts
  JOURNAL   Biochem Biophys Res Commun 258 (2), 326-331 (1999)
   PUBMED   10329386
REFERENCE   9  (bases 1 to 7492)
  AUTHORS   Yuan,Y.C., Whitson,R.H., Liu,Q., Itakura,K. and Chen,Y.
  TITLE     A novel DNA-binding motif shares structural homology to DNA
            replication and repair nucleases and polymerases
  JOURNAL   Nat Struct Biol 5 (11), 959-964 (1998)
   PUBMED   9808040
REFERENCE   10 (bases 1 to 7492)
  AUTHORS   Huang,T.H., Oka,T., Asai,T., Okada,T., Merrills,B.W., Gertson,P.N.,
            Whitson,R.H. and Itakura,K.
  TITLE     Repression by a differentiation-specific factor of the human
            cytomegalovirus enhancer
  JOURNAL   Nucleic Acids Res 24 (9), 1695-1701 (1996)
   PUBMED   8649988
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB014195.1, BC056680.1,
            M73837.1 and AL671972.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032199.2.
            
            Summary: This gene encodes a member of the AT-rich interaction
            domain (ARID) family of DNA binding proteins. The encoded protein
            forms a histone H3K9Me2 demethylase complex with PHD finger protein
            2 and regulates the transcription of target genes involved in
            adipogenesis and liver development. This gene also plays a role in
            cell growth and differentiation of B-lymphocyte progenitors, and
            single nucleotide polymorphisms in this gene are associated with
            acute lymphoblastic leukemia. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279873.12/ ENSP00000279873.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB014195.1         446-447
            3-914               BC056680.1         5-916
            915-1651            M73837.1           1-737
            1652-7492           AL671972.8         112005-117845
FEATURES             Location/Qualifiers
     source          1..7492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..7492
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /note="AT-rich interaction domain 5B"
                     /db_xref="GeneID:84159"
                     /db_xref="HGNC:HGNC:17362"
                     /db_xref="MIM:608538"
     exon            1..32
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..3578
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     modulator recognition factor 2 (MRF2); MRF1-like protein;
                     ARID domain-containing protein 5B; AT-rich interactive
                     domain 5B (MRF1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 5B
                     isoform 1"
                     /protein_id="NP_115575.1"
                     /db_xref="CCDS:CCDS31208.1"
                     /db_xref="GeneID:84159"
                     /db_xref="HGNC:HGNC:17362"
                     /db_xref="MIM:608538"
                     /translation="MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFV
                     RCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKV
                     IVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQKEALLKYRQSTLNSGLNFKDV
                     LKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSR
                     NPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSD
                     GKAVAKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKE
                     RKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAAT
                     CTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPK
                     SKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPL
                     ASRVDPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSAPLAPEKDSALVPGASKQPLTS
                     PSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQPPLANQNETEDDKLPAMADYIA
                     NCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRG
                     NPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIARDDLCSSLSQTHHGQS
                     TDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFKHEKLSRSDPHRCSFSKHHLNPLAD
                     SYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSLYRHTEHHLHNEQTSKY
                     PSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQDKKSAAAEAPTDDQPTDLSLPKNP
                     HKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACRVSPMTMSGPKKYPESL
                     SRSGKPHHVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARA
                     VSPLDPSKEVSGKEKASEQESEGSKAAHGGHSGGGSEGHKLPLSSPIFPGLYSGSLCN
                     SGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAA
                     ATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL"
     exon            33..287
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..513
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..744
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..857
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1059
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1112
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1210
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1409
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..7492
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7468..7473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /note="hexamer: AATAAA"
     polyA_site      7492
                     /gene="ARID5B"
                     /gene_synonym="DESRT; MRF-2; MRF2"
                     /note="major polyA site"
ORIGIN      
        1 agaacgtcga gatggagccc aactcactcc agtgggtcgg ctcaccgtgt ggcttgcacg
       61 gaccttacat tttctacaag gcttttcaat tccaccttga aggcaaacca agaattttgt
      121 cccttggcga ctttttcttt gtaagatgta cgccaaagga tccgatttgc atagcggagc
      181 tccagctgtt gtgggaagag aggaccagcc ggcaactttt atccagctct aaactttatt
      241 tcctcccaga agacactccc cagggcagaa atagcgacca tggcgaggat gaagtcattg
      301 ctgtttccga aaaggtgatt gtgaagcttg aagacctggt caagtgggta cattctgatt
      361 tctccaagtg gagatgtggc ttccacgctg gaccagtgaa aactgaggcc ttgggaagga
      421 atggacagaa ggaagctctg ctgaagtaca ggcagtcaac cctaaacagt ggactcaact
      481 tcaaagacgt tctcaaggag aaggcagacc tgggggagga cgaggaagaa acgaacgtga
      541 tagttctcag ctacccccag tactgccggt accgctcgat gctgaaacgc atccaggata
      601 agccatcttc cattctaacg gaccagtttg cattggccct ggggggcatt gcagtggtca
      661 gcaggaaccc tcagatcctg tactgtcggg acacctttga ccacccgact ctcatagaaa
      721 acgagagtat atgcgatgag tttgcgccaa atcttaaagg cagaccacgc aaaaagaaac
      781 catgcccaca aagaagagat tcattcagtg gtgttaagga ttccaacaac aattccgatg
      841 gcaaagccgt tgccaaggtg aaatgtgagg ccaggtcagc cttgaccaag ccgaagaata
      901 accataactg taaaaaagtc tcaaatgaag aaaaaccaaa ggttgccatt ggtgaagagt
      961 gcagggcaga tgaacaagcc ttcttggtgg cactttataa atacatgaaa gaaaggaaaa
     1021 cgccgataga acgaataccc tatttaggtt ttaaacagat taacctttgg actatgtttc
     1081 aagctgctca aaaactggga ggatatgaaa caataacagc ccgccgtcag tggaaacata
     1141 tttatgatga attaggcggt aatcctggga gcaccagcgc tgccacttgt acccgcagac
     1201 attatgaaag attaatccta ccatatgaaa gatttattaa aggagaagaa gataagcccc
     1261 tgcctccaat caaacctcgg aaacaggaga acagttcaca ggaaaatgag aacaaaacaa
     1321 aagtatctgg aaccaaacgc atcaaacatg aaatacctaa aagcaagaaa gaaaaagaaa
     1381 atgccccaaa gccccaggat gcagcagagg tttcatcaga gcaagaaaaa gaacaagaga
     1441 ctttaataag ccagaaaagc atccctgagc ctctcccagc agcagacatg aagaaaaaaa
     1501 tagaagggta tcaggaattt tcagcgaagc ccctggcatc cagagtagac ccagagaagg
     1561 acaacgaaac agaccaaggt tccaacagtg agaaggtggc agaggaggcg ggagagaagg
     1621 ggcccacacc tccactccca agtgctcctc tggccccaga aaaagattca gccttggtcc
     1681 ctggggccag caaacagcca ctcacctctc ctagtgccct ggtggactca aaacaagaat
     1741 ccaaactgtg ctgttttaca gagagccctg aaagtgaacc ccaagaagca tccttcccca
     1801 gcttccccac cacacagcca ccgctggcaa accagaatga gacggaggat gacaaactgc
     1861 ccgccatggc agattacatt gccaactgca ccgtgaaggt ggaccagctg ggcagtgacg
     1921 acatccacaa tgcgctcaag cagaccccaa aggtccttgt ggtccagtcg tttgacatgt
     1981 tcaaagacaa agacctgact gggcccatga acgagaacca tggacttaat tacacgcccc
     2041 tgctctactc taggggcaac ccaggcatca tgtccccact ggccaagaaa aagcttttgt
     2101 cccaagtgag tggggccagc ctctccagca gctaccctta tggctcccca ccccctttga
     2161 tcagcaaaaa gaaactgatt gctagggatg acttgtgttc cagtttgtcc cagacccacc
     2221 atggccaaag cactgaccat atggcggtca gccggccatc agtgattcag cacgtccaga
     2281 gtttcagaag caagccctcg gaagagagaa agaccatcaa tgacatcttt aagcatgaga
     2341 aactgagtcg atcagatccc caccgctgca gcttctccaa gcatcacctt aacccccttg
     2401 ctgactccta cgtcctgaag caagaaattc aggagggcaa ggataaactc ttagagaaaa
     2461 gggccctccc ccattcccac atgcctagct tcctggctga cttctactcg tcccctcatc
     2521 tccatagcct ctacagacac accgagcacc atcttcataa tgaacagaca tccaaatacc
     2581 cttccaggga catgtacagg gaatcggaaa acagttcttt tccttcccac agacaccaag
     2641 aaaagctcca tgtaaattat ctcacgtccc tgcacctgca agacaaaaag tcggcggcag
     2701 cagaagcccc tacggatgat cagcctacag atctgagcct tcccaagaac ccgcacaaac
     2761 ctaccggcaa ggtcctgggc ctggctcatt ccaccacagg gccccaggag agcaaaggca
     2821 tctcccagtt ccaggtctta ggcagccaga gtcgagactg tcaccccaaa gcctgtcggg
     2881 tatcacccat gaccatgtca ggccctaaaa aataccctga atcgctttca agatcaggaa
     2941 aacctcacca tgtgagactg gagaatttca ggaagatgga aggcatggtc cacccaatcc
     3001 tgcaccggaa aatgagcccg cagaacattg gggcggcgcg gccgatcaag cgcagcctgg
     3061 aggatttgga ccttgtgatt gcagggaaaa aggcccgggc agtgtctccc ttagacccat
     3121 ccaaggaggt ctctgggaag gagaaggcct ctgagcagga gagtgaaggc agcaaagcag
     3181 cgcacggtgg gcattccggg ggcggatcag aaggccacaa gcttcccctc tcctccccta
     3241 tcttcccagg tctgtattcc gggagcctgt gtaactcggg cctcaactcc aggctcccgg
     3301 ctgggtattc tcattctctg cagtacttga aaaaccagac tgtgctttct ccactcatgc
     3361 agcccctggc tttccactcg cttgtgatgc aaagaggaat ttttacatca ccgacaaatt
     3421 ctcagcagct gtacagacac ttggctgcgg ctacacctgt aggaagttca tatggggacc
     3481 ttttgcataa cagcatttac cctttagctg ctataaatcc tcaagctgcc tttccatctt
     3541 cccagctgtc atccgtgcac cccagtacaa aactgtaggc tcagctctgc ccagcagtcc
     3601 aaagcggcat ggccaacaga gcttcactcc ttacccagga gtgctggctt atagagttag
     3661 aagtcagtat ttcttctaat ctgaggctat gatcagtccc agctgtaggg gcccagaggg
     3721 gaggtgaaca tgcctgattt ttgtgggaca actctagccc acaaactgac tggctggtga
     3781 gtcttgactc ccttccaaca cagatgccca ggcacctcca gatcattcac ttcgcacgtg
     3841 ggccttgtga agggatttgt gaatatccag gaagaactta gaggacccca tctgagttcg
     3901 gatggtcagg aaacaatctg ggcaaaaaag aggcaggcat ttcaaaggaa ggggcaagga
     3961 agactggcaa acagatggca agggatgccc ctctttttca taaaactctc caaggttcaa
     4021 tcaatgcaat gtatagtgaa acttcaatag atctttcatt ttgacactat taaacaatcc
     4081 agagaagtaa acactgttaa attgactgta tatatttgct tcttaaaact acctgtatca
     4141 ctgtttgctc acctaattta tatacaggta gttccatttt ctcccagttc cttctcgtct
     4201 tttttttttt tttttttttt ttttttatta aatggtattg cttttgtttg caggtctttt
     4261 tgtttttgtt ttgtttttga ggctgactga ctgtcctagt tgttgtgtgt ttgtaatttt
     4321 tccacatctt attttgagca gctttgggtg gtaaagttat tgtttacaaa ttgaagcaac
     4381 tgattctagt ggaacaaatg aaaaagaaac agtcaagcac acaatagtgc aaagaacgtt
     4441 cctttgtaga tccgcaactt aaggattttg ttcctcataa atggcatagt tgaaagagct
     4501 tatacactgc ttacccagcc aaatgctttg ctttgaagta ttgggttctg tgaaaatatt
     4561 gagcattgta cttaccttat ctaggctgtg aaactgtcct acataccaga gaatcataaa
     4621 aacaaaaacc tcactggcag caagctgccg aataacaaca gagtctagag gacatatttg
     4681 tgggctgcac agatatttta ggaatttcag aaattagaac aggagccaaa atgatttaca
     4741 ttggcgttgg cactgattcc tttaaatggt ctgggaaagg gggttgggaa gaggatggag
     4801 ctcaactggc cagaagagga gcagctgcag tcctgatagc ttctctagcc tcggtctttt
     4861 gagtgataag tagtcatgtt gttttcatcc agttggtttc ttgtcattcc caagaagaat
     4921 ctcccaggcc acatctttgg ggataactga catactggat tagccttttc aaaagaaaag
     4981 tcatcctatt tggttttatg gggtgtgagt tttgtgtgta cacacacaga aacatgtaag
     5041 gtggtttggg tcatgttttt aaccacctgg caatacagtc cactttctgg tttcttttat
     5101 tgtgggaagt aaatggtcaa gctgctcagg cagtgaaaag atgtggagaa tgtccgttgt
     5161 cattcttgcc actgtattcc atttgctacc gagatataac attaaggtgg acacattttc
     5221 taactgtatt aattaaaagt caatggatac agagagtgga ttttctcccc aagtcccatc
     5281 cctgctgaag accgcttgga tgaactcccc aacccactgt gcccctcccg caacactacc
     5341 agtagacttt agaaccatag ttaactaagt cttttacctc tgagatactt aattctggga
     5401 aaattggtga caattttcaa cttctaaata ggtaactcga ctgcaaaata atcaaaactg
     5461 ataacaatga aactgcggct cttaaacaaa gccatgcatg ccgtgcattt gtattgaaat
     5521 gtctccatga tatgaagcca aatattcaat gtaacatact taatatccaa aggtggaaac
     5581 aaaagaatgt agagatccag tgttaagagt tccatttgct tcaattaatt atttaccttc
     5641 ctgtggaata atatatatat atatatttaa tagaaccata gatagactag tagaatttag
     5701 attataaatg tgtgagtgca gattatcctg ctattgcaca agctagaggg gggaaaaatc
     5761 tcaattccag ctggcaagat gctagccagg acacatataa gaaagttgca ctagattgaa
     5821 tggtcacaga atcggaggac atggaagaaa aaggaaactt cggtggttct gcagcagaca
     5881 tgggctaggt catatgtggt ttctatgagt tcgtgtctca aaaaaaaaag gagggggggc
     5941 atctgtcccc ggtggagctc acctatttgg aatatggggc atttgttttt tccactgcaa
     6001 tgatttcagt ctggtttcat catgttggaa ttcgatcaca ccattttcaa acaatgttaa
     6061 catagtccag cttttgtttt tctcatctct tctgagagga gactcactgt ttctgtctga
     6121 ggaagctcat accctcggca aaacatcagg acaaataaag agaaatgggg gtacgcattc
     6181 ccaacagaag cagtgtgtta tttgttttaa aactctgaac agagatcttg gaaatctttc
     6241 aaaaagacca ttgaattctt cattggctga gaacgacgtt ttaaaatgtc ttaaataagg
     6301 ctttgtttgc attgtttgag ttcaaggggc cttattattg aatggaattg cacaagcctt
     6361 tctttgtgca atcaaaccat tgttattggt agttctgtaa aggaaactgt ggaatcgaat
     6421 tggcagtgga gtcataaatc tatttactga gtgtggcttc caagaaatgt tgcaattcaa
     6481 aatgcactaa gtctgtgatt tattggagat ttggagattc taaataatat ttttaaaaaa
     6541 cttccatgca acttctggtt taatgtttgg caactccaca tgataaaaaa ataaaaacag
     6601 cccaaccgag tttcggaatt aagtattctt ctagtaagtg attcaaactt gtaatatttg
     6661 ccacaggact gacttattta tttactagct agaagctctt aagttcactt gtttatcagg
     6721 gcatatacag aagggtttgt taaaactcga tgttaacttt acaactttct gacctggtgc
     6781 atgaattctc aagtactgta tttcactgtg ttggtgtgtc tgatggaaat ttcgaggtgg
     6841 tcccacaaaa atattttatg tagtgtgcct tcaaagagaa ccatttattt ctcttcactt
     6901 atcgtcccac aaagtcacat ttggtggtgg tcagccaagt cgcatctggt ctagttttac
     6961 tcttgtccca attttaaaga gaaatgggaa tgagtttgcc ctggtgagac ccataccatt
     7021 gcaatgatta tcttgagcac ttaaagtcca gtgttggctg ttagtgtatt tgatattctg
     7081 cctgtctcct catggttgaa atatgtctga agaatagcag cataatctct tggctgttta
     7141 tactttttta aactttcctg tgttgtaaat attgtatact tttggtgatt ccagctatgt
     7201 aacctctatg ctctgtaagg tgattatttg tatatagcaa catggcccag tgatattata
     7261 tagtttccca atggagaggt tattgagtaa cctttgcatt agtttaaaca ctaccagaag
     7321 aatgctgagc caactataaa cactcaattt tgtatgtttt ccaaattgta cttattactg
     7381 cttttgatac tgtattacgt gccaatagtt tcccaatcac atagcaggca agagatattt
     7441 tgtacttttt gatccactgt aatatttaat aaaaaatgtt actatctgtt tc
//
