LOCUS       NM_212481               2181 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens AT-rich interaction domain 5A (ARID5A), transcript
            variant 3, mRNA.
ACCESSION   NM_212481
VERSION     NM_212481.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2181)
  AUTHORS   Metwally,H., Tanaka,T., Li,S., Parajuli,G., Kang,S., Hanieh,H.,
            Hashimoto,S., Chalise,J.P., Gemechu,Y., Standley,D.M. and
            Kishimoto,T.
  TITLE     Noncanonical STAT1 phosphorylation expands its transcriptional
            activity into promoting LPS-induced IL-6 and IL-12p40 production
  JOURNAL   Sci Signal 13 (624) (2020)
   PUBMED   32209697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2181)
  AUTHORS   Anwar,T., Sen,B., Aggarwal,S., Nath,R., Pathak,N., Katoch,A.,
            Aiyaz,M., Trehanpati,N., Khosla,S. and Ramakrishna,G.
  TITLE     Differentially regulated gene expression in quiescence versus
            senescence and identification of ARID5A as a quiescence associated
            marker
  JOURNAL   J Cell Physiol 233 (5), 3695-3712 (2018)
   PUBMED   29044508
  REMARK    GeneRIF: Overexpression of ARID5A resulted in more number of cells
            in G0/G1 phase of cell cycle
REFERENCE   5  (bases 1 to 2181)
  AUTHORS   Saito,Y., Kagami,S., Sanayama,Y., Ikeda,K., Suto,A.,
            Kashiwakuma,D., Furuta,S., Iwamoto,I., Nonaka,K., Ohara,O. and
            Nakajima,H.
  TITLE     AT-rich-interactive domain-containing protein 5A functions as a
            negative regulator of retinoic acid receptor-related orphan nuclear
            receptor gammat-induced Th17 cell differentiation
  JOURNAL   Arthritis Rheumatol 66 (5), 1185-1194 (2014)
   PUBMED   24782182
  REMARK    GeneRIF: AT-rich-interactive domain-containing protein 5A functions
            as a negative regulator of retinoic acid receptor-related orphan
            nuclear receptor gammat-induced Th17 cell differentiation.
REFERENCE   6  (bases 1 to 2181)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 2181)
  AUTHORS   Georgescu,S.P., Li,J.H., Lu,Q., Karas,R.H., Brown,M. and
            Mendelsohn,M.E.
  TITLE     Modulator recognition factor 1, an AT-rich interaction domain
            family member, is a novel corepressor for estrogen receptor alpha
  JOURNAL   Mol Endocrinol 19 (10), 2491-2501 (2005)
   PUBMED   15941852
REFERENCE   8  (bases 1 to 2181)
  AUTHORS   Patsialou,A., Wilsker,D. and Moran,E.
  TITLE     DNA-binding properties of ARID family proteins
  JOURNAL   Nucleic Acids Res 33 (1), 66-80 (2005)
   PUBMED   15640446
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2181)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 2181)
  AUTHORS   Huang,T.H., Oka,T., Asai,T., Okada,T., Merrills,B.W., Gertson,P.N.,
            Whitson,R.H. and Itakura,K.
  TITLE     Repression by a differentiation-specific factor of the human
            cytomegalovirus enhancer
  JOURNAL   Nucleic Acids Res 24 (9), 1695-1701 (1996)
   PUBMED   8649988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY002073.1, M62324.1 and AI085152.1.
            
            On Nov 23, 2018 this sequence version replaced NM_212481.2.
            
            Summary: Members of the ARID protein family, including ARID5A, have
            diverse functions but all appear to play important roles in
            development, tissue-specific gene expression, and regulation of
            cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by
            OMIM, Mar 2008].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (c)
            has the same N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.690925.1,
                                           SRR3476690.221946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357485.8/ ENSP00000350078.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               HY002073.1         34-162
            130-2122            M62324.1           115-2107
            2123-2181           AI085152.1         16-74               c
FEATURES             Location/Qualifiers
     source          1..2181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2181
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /note="AT-rich interaction domain 5A"
                     /db_xref="GeneID:10865"
                     /db_xref="HGNC:HGNC:17361"
                     /db_xref="MIM:611583"
     exon            1..79
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1860
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /note="isoform c is encoded by transcript variant 3;
                     modulator recognition factor I; AT-rich interactive
                     domain-containing protein 5A; RFVG5814; modulator
                     recognition factor 1; ARID domain-containing protein 5A;
                     AT rich interactive domain 5A (MRF1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 5A
                     isoform c"
                     /protein_id="NP_997646.1"
                     /db_xref="CCDS:CCDS33251.1"
                     /db_xref="GeneID:10865"
                     /db_xref="HGNC:HGNC:17361"
                     /db_xref="MIM:611583"
                     /translation="MAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPE
                     AGGEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAY
                     ELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPR
                     KQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQ
                     QGLASGSSVSFVGASGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQ
                     EEGCRHGAEPQASPAVHLPESPQSPKGLTENSRHRLTPQEGLQAPGGSLREEAQAGPC
                     PAAPIFKGCFYTHPTEVLKPVSQHPRDFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGD
                     ANRPSAFHKGGSRKGILYPKPKACWVSPMAKVPAESPTLPPTFPSSPGLGSKRSLEEE
                     GAAHSGKRLRAVSPFLKEADAKKCGAKPAGSGLVSCLLGPALGPVPPEAYRGTMLHCP
                     LNFTGTPGPLKGQAALPFSPLVIPAFPAHFLATAGPSPMAAGLMHFPPTSFDSALRHR
                     LCPASSAWHAPPVTTYAAPHFFHLNTKL"
     exon            80..195
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /inference="alignment:Splign:2.1.0"
     exon            196..334
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /inference="alignment:Splign:2.1.0"
     exon            335..387
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /inference="alignment:Splign:2.1.0"
     exon            388..485
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /inference="alignment:Splign:2.1.0"
     exon            486..645
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /inference="alignment:Splign:2.1.0"
     exon            646..2181
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /note="hexamer: AATAAA"
     polyA_site      2181
                     /gene="ARID5A"
                     /gene_synonym="MRF-1; MRF1; RP11-363D14"
                     /note="major polyA site"
ORIGIN      
        1 atctcagaga gcgcggggtc cggacagccg cgcgctgagg gtctcggggc gggcgccgcg
       61 ggacctctcc gggccatggc agcccctgtc aaagggaaca ggaagcagtc cacggagggt
      121 gacgccctag acccacctgc atcccccaaa cctgctggca agcagaacgg aatccagaac
      181 cccatctcgc tggaggactc ccccgaggca ggcggggagc gggaggagga gcaggagcgg
      241 gaggaggagc aggccttcct ggtcagcctc tacaagttca tgaaggagcg acacacgccc
      301 atcgagaggg tgccccatct cggcttcaag cagattaacc tgtggaagat ctacaaagca
      361 gtggagaagc tgggggccta tgagctggtg accgggcgcc gcctctggaa gaacgtgtac
      421 gacgagctgg ggggcagccc aggcagcacc agcgcggcca cgtgcacgcg ccgccactac
      481 gagaggctgg tcctgccata cgtgcggcac ctgaaggggg aggatgacaa gccgctgccc
      541 acctccaagc ccaggaaaca gtacaagatg gctaaggaga acagggggga tgatggggcc
      601 accgagaggc cgaagaaggc caaggaggag cggcgcatgg accagatgat gccaggaaag
      661 accaaagcag atgctgctga cccagcacca cttcccagcc aggagccccc caggaacagc
      721 acagaacagc agggcctggc ctctgggtct tctgtgtcct ttgtgggtgc cagcggctgt
      781 cctgaggcct acaagcggct cctatccagc ttctactgca aggggacaca cggcatcatg
      841 tcaccactgg ccaaaaagaa gctcctggcc caggtgagca aggtggaggc cttgcagtgc
      901 caggaggagg gctgccgcca tggggcagag ccccaggcgt ccccagctgt tcacctccca
      961 gagagtcccc agagccccaa agggctgact gagaactcca ggcaccggct gacccctcag
     1021 gagggattgc aggccccagg tggcagcctc agagaggagg cgcaggcagg cccctgcccg
     1081 gcagccccca tcttcaaggg ctgcttctac acccacccca ccgaggtgct gaagcctgtc
     1141 agccagcacc ccagggactt cttctctaga cttaaagatg gggtgctatt ggggcctcct
     1201 ggcaaagagg ggctgtcagt gaaagagccc cagctggtgt ggggcggaga cgctaaccgc
     1261 ccttctgcgt tccataaagg tggctccaga aagggcatcc tctaccccaa gcccaaagcc
     1321 tgctgggtgt cccccatggc caaggtccca gccgagagcc ccacgctccc gcccaccttc
     1381 cccagtagcc caggcctggg cagcaagcgc agcctggagg aagagggtgc tgcccacagt
     1441 gggaagagac tgcgggccgt gtctcccttt cttaaggagg cggatgccaa gaagtgtggg
     1501 gccaaacctg cagggtccgg cctggtctcc tgccttctgg gcccagccct ggggcctgtg
     1561 cccccagagg cctacagggg caccatgctg cactgcccgc tgaacttcac tggcaccccg
     1621 ggccccttga agggccaggc tgcactcccc ttcagccccc tggtcatccc ggccttcccg
     1681 gcccacttcc tggccaccgc aggcccctcg cccatggccg ctggcctgat gcacttcccc
     1741 ccaacgtcct tcgacagtgc cctccgccac agactttgcc cggcctcatc tgcctggcac
     1801 gcaccaccag tcacaaccta tgcagcgccc cacttcttcc acctcaacac caagctgtag
     1861 gccagcccat ggtgttgtgt acactgtgga gtcgacaggg gcctacaaca ggcaggtact
     1921 gctgccaggg ggctctgaac tagtgcctgc tacccaggac acccgggcca tgcccctggc
     1981 tgggcagcct ggcacaagtg aagaagaagg cagtgggaaa actgggttta tctcaaggca
     2041 gcagcctgag cccaggagca gaggacccag ttgttataag gcgctgggag aggatgggca
     2101 gctcccactg ccccagagcg gagctcgaag cacccaggtt gcccacggaa aatccaataa
     2161 aaagacacca gtgtgaatcc a
//
