LOCUS       NM_016374               6022 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens AT-rich interaction domain 4B (ARID4B), transcript
            variant 1, mRNA.
ACCESSION   NM_016374
VERSION     NM_016374.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6022)
  AUTHORS   Ren,J., Yao,H., Hu,W., Perrett,S., Gong,W. and Feng,Y.
  TITLE     Structural basis for the DNA-binding activity of human ARID4B Tudor
            domain
  JOURNAL   J Biol Chem 296, 100506 (2021)
   PUBMED   33675746
  REMARK    Erratum:[J Biol Chem. 2022 Oct;298(10):102492. doi:
            10.1016/j.jbc.2022.102492.. PMID: 36191578]
REFERENCE   2  (bases 1 to 6022)
  AUTHORS   Miao,X., Xi,Z., Zhang,Y., Li,Z., Huang,L., Xin,T., Shen,R. and
            Wang,T.
  TITLE     Circ-SMARCA5 suppresses colorectal cancer progression via
            downregulating miR-39-3p and upregulating ARID4B
  JOURNAL   Dig Liver Dis 52 (12), 1494-1502 (2020)
   PUBMED   32807692
  REMARK    GeneRIF: Circ-SMARCA5 suppresses colorectal cancer progression via
            downregulating miR-39-3p and upregulating ARID4B.
REFERENCE   3  (bases 1 to 6022)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6022)
  AUTHORS   Liang,Y.K., Han,Z.D., Lu,J.M., Liu,Z.Z., Zhuo,Y.J., Zhu,X.J.,
            Chen,J.X., Ye,J.H., Liang,Y.X., He,H.C. and Zhong,W.D.
  TITLE     Downregulation of ARID4A and ARID4B promote tumor progression and
            directly regulated by microRNA-30d in patient with prostate cancer
  JOURNAL   J Cell Biochem 119 (9), 7245-7255 (2018)
   PUBMED   29797600
  REMARK    GeneRIF: ARID4A and ARID4B may play the role as tumor suppressor
            gene in prostate cancer by inhibiting cell proliferation,
            migration, and invasion. Moreover, co-downregulation of ARID4A and
            ARID4B can predict poorer prognosis in prostate cancer, suggesting
            they might be the novel marker of prognosis and potential
            therapeutic targets for prostate cancer in human.
REFERENCE   5  (bases 1 to 6022)
  AUTHORS   Luo,J., Liu,L., Zhou,N., Shen,J., Sun,Q., Zhu,Y. and Chen,M.
  TITLE     miR-519b-3p promotes responsiveness to preoperative
            chemoradiotherapy in rectal cancer patients by targeting ARID4B
  JOURNAL   Gene 655, 84-90 (2018)
   PUBMED   29477868
  REMARK    GeneRIF: miR-519b-3p directly binds to the 3' UTR of ARID4B mRNA
            whose expression was inversely correlated with miR-519b-3p
            expression.
REFERENCE   6  (bases 1 to 6022)
  AUTHORS   Fleischer,T.C., Yun,U.J. and Ayer,D.E.
  TITLE     Identification and characterization of three new components of the
            mSin3A corepressor complex
  JOURNAL   Mol Cell Biol 23 (10), 3456-3467 (2003)
   PUBMED   12724404
REFERENCE   7  (bases 1 to 6022)
  AUTHORS   Bommel,H., Xie,G., Rossoll,W., Wiese,S., Jablonka,S., Boehm,T. and
            Sendtner,M.
  TITLE     Missense mutation in the tubulin-specific chaperone E (Tbce) gene
            in the mouse mutant progressive motor neuronopathy, a model of
            human motoneuron disease
  JOURNAL   J Cell Biol 159 (4), 563-569 (2002)
   PUBMED   12446740
REFERENCE   8  (bases 1 to 6022)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   9  (bases 1 to 6022)
  AUTHORS   Cao,J., Gao,T., Stanbridge,E.J. and Irie,R.
  TITLE     RBP1L1, a retinoblastoma-binding protein-related gene encoding an
            antigenic epitope abundantly expressed in human carcinomas and
            normal testis
  JOURNAL   J Natl Cancer Inst 93 (15), 1159-1165 (2001)
   PUBMED   11481388
REFERENCE   10 (bases 1 to 6022)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391994.28, AB210032.1 and
            AL133418.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016374.5.
            
            Summary: This gene encodes a protein with sequence similarity to
            retinoblastoma-binding protein-1. The encoded protein is a subunit
            of the histone deacetylase-dependant SIN3A transcriptional
            corepressor complex, which functions in diverse cellular processes
            including proliferation, differentiation, apoptosis, oncogenesis,
            and cell fate determination. The gene product is recognized by IgG
            antibody isolated from a breast cancer patient and appears to be a
            molecular marker associated with a broad range of human
            malignancies. Alternate transcriptional splice variants encoding
            different isoforms have been characterized. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 3
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143719.1, SRR14038192.3755488.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000264183.9/
                                                  ENSP00000264183.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               AL391994.28        109843-110253       c
            412-5627            AB210032.1         329-5544
            5628-6022           AL133418.4         24561-24955         c
FEATURES             Location/Qualifiers
     source          1..6022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..6022
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /note="AT-rich interaction domain 4B"
                     /db_xref="GeneID:51742"
                     /db_xref="HGNC:HGNC:15550"
                     /db_xref="MIM:609696"
     exon            1..411
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            412..466
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..4399
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Rb-binding protein homolog; retinoblastoma-binding protein
                     1-like 1; breast carcinoma-associated antigen; breast
                     cancer-associated antigen 1; SIN3A-associated protein 180;
                     sin3-associated polypeptide p180; ARID domain-containing
                     protein 4B; 180 kDa Sin3-associated polypeptide; breast
                     cancer-associated antigen BRCAA1; histone deacetylase
                     complex subunit SAP180; AT rich interactive domain 4B
                     (RBP1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 4B
                     isoform 1"
                     /protein_id="NP_057458.4"
                     /db_xref="CCDS:CCDS31061.1"
                     /db_xref="GeneID:51742"
                     /db_xref="HGNC:HGNC:15550"
                     /db_xref="MIM:609696"
                     /translation="MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRH
                     DSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLR
                     RSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSD
                     EDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFK
                     DGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSS
                     EAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLG
                     YRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYG
                     FEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPR
                     EEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTT
                     RVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEF
                     ECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKI
                     VRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKL
                     DLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDH
                     LTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEED
                     EVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMEN
                     SSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDE
                     RLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTV
                     AEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESP
                     SSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSS
                     PAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKK
                     GKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDL
                     KEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRK
                     RLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR"
     exon            467..577
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            578..643
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            644..734
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            735..814
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            815..906
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1045
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1125
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1202
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1357
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1430
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1525
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1623
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1867
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2043
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2301
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2386
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2585
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..3794
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3908
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4124
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4271
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..6022
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6000..6005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /note="hexamer: AATAAA"
     polyA_site      6022
                     /gene="ARID4B"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180"
                     /note="major polyA site"
ORIGIN      
        1 gtttgcccgt cagtcgagtc cggagtgagg agctcggtcg ccgaagcgga gggagactct
       61 tgagcttcat cttgccgccg ccacggccac cgcctggacc tttgcccgga gggagctgca
      121 gagggtccat cgccgccgtc ctctggaggg cagcgcgatt gggggcccgg acctccagtc
      181 cgggggggat ttttcgtcgt ccccctcccc ccaaccaggg agcccgagcg gccgccaaac
      241 aaaggtacca gtcgccgccg cgggaggagg aggagccgga gcctctgcct cagcagccgc
      301 tggacccgcc gcccttcttc cccatctctc ccccgggcct gctggttttg ggggggagaa
      361 ggagagaggg gactctggac gtgccagggt cagatctcgc ctccgaggaa ggtgcagctg
      421 aacctggtgt tttagaggat accttggtcc cagagtcatc atgaaggccc ttgatgagcc
      481 tccctatttg acagtgggca ctgatgtgag tgctaaatac agaggagcct tttgtgaagc
      541 caagatcaag acagcaaaaa gacttgtcaa agtcaaggtg acatttagac atgattcttc
      601 aacagtggaa gttcaggatg accacataaa gggcccacta aaggtaggag ctattgtgga
      661 agtgaagaat cttgatggtg catatcagga agctgttatc aataaactaa cagatgcgag
      721 ttggtacact gtagtttttg atgacggaga tgagaagaca ctgagacgat cttcactgtg
      781 cctgaaagga gagaggcatt ttgctgaaag tgaaacatta gaccagctcc cactcaccaa
      841 ccctgagcat tttggcactc cagtcatagg aaagaaaaca aatagaggaa gaagatctaa
      901 tcatatacca gaggaagagt cttcatcatc ctccagtgat gaagatgagg atgataggaa
      961 acagattgat gagctactag gcaaagttgt atgtgtagat tacattagtt tggataaaaa
     1021 gaaagcactg tggtttcctg cattggtggt ttgtcctgat tgtagtgatg agattgctgt
     1081 aaaaaaggac aatattcttg ttcgatcttt caaagatgga aaatttactt cagttccaag
     1141 aaaagatgtc catgaaatta ctagtgacac tgcaccaaag cctgatgctg ttttaaagca
     1201 agcctttgaa caggcacttg aatttcacaa aagtagaact attcctgcta actggaagac
     1261 tgaattgaaa gaagatagct ctagcagtga agcagaggaa gaagaggagg aggaagatga
     1321 tgaaaaagaa aaggaggata atagcagtga agaagaagaa gaaatagaac catttccaga
     1381 agaaagggag aactttcttc agcaattgta caaatttatg gaagatagag gtacacctat
     1441 taacaaacga cctgtacttg gatatcgaaa tttgaatctc tttaagttat tcagacttgt
     1501 acacaaactt ggaggatttg ataatattga aagtggagct gtttggaaac aagtctacca
     1561 agatcttgga atccctgtct taaattcagc tgcaggatac aatgttaaat gtgcttataa
     1621 aaaatactta tatggttttg aggagtactg tagatcagcc aacattgaat ttcagatggc
     1681 attgccagag aaagttgtta acaagcaatg taaggagtgt gaaaatgtaa aagaaataaa
     1741 agttaaggag gaaaatgaaa cagagatcaa agaaataaag atggaggagg agaggaatat
     1801 aataccaaga gaagaaaagc ctattgagga tgaaattgaa agaaaagaaa atattaagcc
     1861 ctctctggga agtaaaaaga atttattaga atctatacct acacattctg atcaggaaaa
     1921 agaagttaac attaaaaaac cagaagacaa tgaaaatctg gatgacaaag atgatgacac
     1981 aactagggta gatgaatccc tcaacataaa ggtagaagct gaggaagaaa aagcaaaatc
     2041 tggagatgaa acgaataaag aagaagatga agatgatgaa gaagcagaag aggaggagga
     2101 ggaggaagaa gaagaagagg atgaagatga tgatgacaac aatgaggaag aggagtttga
     2161 gtgctatcca ccaggcatga aagtccaagt gcggtatgga cgagggaaaa atcaaaaaat
     2221 gtatgaagct agtattaaag attctgatgt cgaaggtgga gaggtccttt acttggtgca
     2281 ttactgcgga tggaatgtga gatacgatga atggattaaa gcagataaaa tagtaagacc
     2341 tgctgataaa aatgtgccaa agataaaaca tcggaagaaa ataaagaata aattagacaa
     2401 agaaaaagac aaagatgaaa aatactctcc aaaaaactgt aaacttcggc gcttgtccaa
     2461 accaccattt cagacaaatc catctcctga aatggtatcc aaactggatc tcactgatgc
     2521 caaaaactct gatactgctc atattaagtc catagaaatt acttcgatcc ttaatggact
     2581 tcaagcttct gaaagttctg ctgaagacag tgagcaggaa gatgagagag gtgctcaaga
     2641 catggataat aatggcaaag aggaatctaa gattgatcat ttgaccaaca acagaaatga
     2701 tcttatttca aaggaggaac agaacagttc atctttgcta gaagaaaaca aagttcatgc
     2761 agatttggta atatccaaac cagtgtcaaa atctccagaa agattaagga aagatataga
     2821 agtattatcc gaagatactg attatgaaga agatgaagtc acaaaaaaga gaaaggatgt
     2881 caagaaggac acaacagata aatcttcaaa accacaaata aaacgtggta aaagaaggta
     2941 ttgcaataca gaagagtgtc taaaaactgg atcacctggc aaaaaggaag agaaggccaa
     3001 gaacaaagaa tcactttgca tggaaaacag tagcaacagc tcttcagatg aagatgaaga
     3061 agaaacaaaa gcaaagatga caccaactaa gaaatacaat ggtttggagg aaaaaagaaa
     3121 atctctacgg acaactggtt tctattcagg attttcagaa gtggcagaaa aaaggattaa
     3181 acttttaaat aactctgatg aaagacttca aaacagcagg gccaaagatc gaaaagatgt
     3241 ctggtcaagt attcagggac agtggcctaa aaaaacgctg aaagagcttt tttcagactc
     3301 tgatactgag gctgcagctt ccccaccgca tcctgcccca gaggaggggg tggcagagga
     3361 gtcactgcag actgtggctg aagaggagag ttgttcaccc agtgtagaac tagaaaaacc
     3421 acctccagtc aatgtcgata gtaaacccat tgaagaaaaa acagtagagg tcaatgacag
     3481 aaaagcagaa tttccaagta gtggcagtaa ttcagtgcta aatacccctc ctactacacc
     3541 tgaatcgcct tcatcagtca ctgtaacaga aggcagccgg cagcagtctt ctgtaacagt
     3601 atcagaacca ctggctccaa accaagaaga ggttcgaagt atcaagagtg aaactgatag
     3661 cacaattgag gtggatagtg ttgctgggga gctccaagac ctccagtctg aagggaatag
     3721 ctcgccagca ggttttgatg ccagtgtgag ctcaagcagt agtaatcagc cagaaccaga
     3781 acatcctgaa aaagcctgta caggtcagaa aagagtgaaa gatgctcagg gaggaggaag
     3841 ttcatcaaaa aagcagaaaa gaagccataa agcaacagtg gtaaacaaca aaaagaaggg
     3901 aaaaggcaca aatagtagtg atagtgaaga actttcagct ggtgaaagta taactaagag
     3961 tcagccagtc aaatcagttt ccactggaat gaagtctcat agtaccaaat ctcccgcaag
     4021 gacgcagtct ccaggaaaat gtggaaagaa tggtgataag gatcctgatc tcaaggaacc
     4081 cagtaatcga ttacccaaag tttacaaatg gagttttcag atgtcggacc tggaaaatat
     4141 gacaagtgcc gaacgcatca caattcttca agaaaaactt caagaaatca gaaaacatta
     4201 tctgtcatta aaatctgaag tagcttccat tgatcggagg agaaagcgtt taaagaagaa
     4261 agagagagaa agtgctgcta catcctcatc ctcctcttca ccttcatcca gttccataac
     4321 agctgctgtt atgttaactt tagctgaacc gtcaatgtcc agcgcatcac aaaatggaat
     4381 gtcagttgag tgcaggtgac agcaggactt gctaaagcac tttgcactta atggctgttg
     4441 agggccactt tttttttata ctgcacagtg gcacaaaaaa atatcagaca agcactattt
     4501 tatatttaaa aattgtttct tgacaagctg acttggcact taagtgcact tttttatgaa
     4561 gaaaaagtac aatgaactgc ttttcctcaa gcaataattg tttccaactt gtctgggaat
     4621 tgtgtgtctg gtaactggaa ggccttccac tgtggcaaat ggaggctttt cactgcctgt
     4681 agagacaata cagtaagcat agttaagggg tgggtcagaa catgttaaga taacttactg
     4741 tatatgtatt cccttgtatt ttgttaaagc tggaacattt gatatttttc catttattta
     4801 tgaaaaaata tgaacctatt ttcatttgta caaggtaatt gttttttaaa gcaagtcacc
     4861 ttagggtggc tttaattgta taagtcaagc acatgtaata aattcaaaac ctgcagttaa
     4921 caggatatta gacatcaatc ctggtaacca aatattaaag attctcttta aaaaagactg
     4981 aacatgttta caggtttgaa ttaggctaaa aggtcttgca gtggcttttc atggcccttc
     5041 aaattggaat ggaactactg tactttgcca tttttctata aatcagtatt tttttttaat
     5101 tttgatatac attgtgtgaa aaaagaaaat ggctaataaa ctgtattaaa tcttaaacaa
     5161 tgtataaaga ttgtacttag ccagttcaaa gtgtatattt attcataatg aattataaca
     5221 gttatatttt tgtgttttct tgtaaatgtt tcttttccct taaatacaga taattcattt
     5281 gtattgctta ttttattatg agctacaaca aaaggacttc aggaacaagt aatgtattag
     5341 tatggttcaa gattgttgat aggaactgtc tcaaaaggat ggtggttatt ttaaatataa
     5401 atagctaatg ggggtggtag gcctataaaa ttaaatgcct tgtataaaat ccaaaatgaa
     5461 tgcaaaattg ttttcacttg tattgacttt atgttgtatg attccaatct ctgttctgtt
     5521 tggcacttgt atttaattct tcacctttgt aagacatttg tatattgtgg atgtgttcat
     5581 tcaagctatt taatatctgg cactgttaat acacagtact ttattgtaca gactgtttta
     5641 ctgttttaat tgtagttctg tgtacttttt ttggatgggg ctggcatgtt ttctttgttt
     5701 cctggcaata cgacgtggga atttcaatgc gttttgttgt agatgctaac gtgtcagaat
     5761 cctttacatt caacttttct aagaaaagca ttttcagtct tgtagtgtgt gcttacagta
     5821 actaattttg ttgaaaatgg tttcaagtta ttcaaatttg tacaggactg taaagatttg
     5881 ttgacagcaa aatgttgaag aaaaaagctt atagaataaa agctataaag tatatattag
     5941 gatctgcaaa caatgaagaa ttatgtaata tattgtacaa atgtaagcaa aggctctgaa
     6001 ataaaatgcc atagtttgtg aa
//
