LOCUS       NM_006465               4228 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens AT-rich interaction domain 3B (ARID3B), transcript
            variant 2, mRNA.
ACCESSION   NM_006465
VERSION     NM_006465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4228)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4228)
  AUTHORS   Saadat,K.A.S.M., Lestari,W., Pratama,E., Ma,T., Iseki,S.,
            Tatsumi,M. and Ikeda,M.A.
  TITLE     Distinct and overlapping roles of ARID3A and ARID3B in regulating
            E2F-dependent transcription via direct binding to E2F target genes
  JOURNAL   Int J Oncol 58 (4) (2021)
   PUBMED   33649863
  REMARK    GeneRIF: Distinct and overlapping roles of ARID3A and ARID3B in
            regulating E2Fdependent transcription via direct binding to E2F
            target genes.
REFERENCE   3  (bases 1 to 4228)
  AUTHORS   Deutelmoser,H., Lorenzo Bermejo,J., Benner,A., Weigl,K., Park,H.A.,
            Haffa,M., Herpel,E., Schneider,M., Ulrich,C.M., Hoffmeister,M.,
            Chang-Claude,J., Brenner,H. and Scherer,D.
  TITLE     Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy
            and Relationship with the Prognosis of Colorectal Cancer Patients
  JOURNAL   Int J Mol Sci 21 (21), 8150 (2020)
   PUBMED   33142733
  REMARK    GeneRIF: Genotype-Based Gene Expression in Colon Tissue-Prediction
            Accuracy and Relationship with the Prognosis of Colorectal Cancer
            Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4228)
  AUTHORS   Liao,T.T., Lin,C.C., Jiang,J.K., Yang,S.H., Teng,H.W. and Yang,M.H.
  TITLE     Harnessing stemness and PD-L1 expression by AT-rich interaction
            domain-containing protein 3B in colorectal cancer
  JOURNAL   Theranostics 10 (14), 6095-6112 (2020)
   PUBMED   32483441
  REMARK    GeneRIF: Harnessing stemness and PD-L1 expression by AT-rich
            interaction domain-containing protein 3B in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4228)
  AUTHORS   Dausinas,P., Pulakanti,K., Rao,S., Cole,J.M., Dahl,R. and Cowden
            Dahl,K.D.
  TITLE     ARID3A and ARID3B induce stem promoting pathways in ovarian cancer
            cells
  JOURNAL   Gene 738, 144458 (2020)
   PUBMED   32061921
  REMARK    GeneRIF: Study provides a comprehensive list of genes and pathways
            regulated by ARID3A and ARID3B in ovarian cancer cells.
REFERENCE   6  (bases 1 to 4228)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   7  (bases 1 to 4228)
  AUTHORS   Cowden Dahl,K.D., Dahl,R., Kruichak,J.N. and Hudson,L.G.
  TITLE     The epidermal growth factor receptor responsive miR-125a represses
            mesenchymal morphology in ovarian cancer cells
  JOURNAL   Neoplasia 11 (11), 1208-1215 (2009)
   PUBMED   19881956
  REMARK    GeneRIF: We identify AT-rich interactive domain 3B (ARID3B) as a
            target of miR-125a and demonstrate that ARID3B is overexpressed in
            human ovarian cancer
REFERENCE   8  (bases 1 to 4228)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
REFERENCE   9  (bases 1 to 4228)
  AUTHORS   Kortschak,R.D., Tucker,P.W. and Saint,R.
  TITLE     ARID proteins come in from the desert
  JOURNAL   Trends Biochem Sci 25 (6), 294-299 (2000)
   PUBMED   10838570
  REMARK    Review article
REFERENCE   10 (bases 1 to 4228)
  AUTHORS   Numata,S., Claudio,P.P., Dean,C., Giordano,A. and Croce,C.M.
  TITLE     Bdp, a new member of a family of DNA-binding proteins, associates
            with the retinoblastoma gene product
  JOURNAL   Cancer Res 59 (15), 3741-3747 (1999)
   PUBMED   10446990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC396899.1, AF116846.1 and
            AC100835.2.
            
            On Jun 2, 2019 this sequence version replaced NM_006465.3.
            
            Summary: This gene encodes a member of the ARID (AT-rich
            interaction domain) family of DNA-binding proteins. The encoded
            protein is homologous with two proteins that bind to the
            retinoblastoma gene product, and also with the mouse Bright and
            Drosophila dead ringer proteins. A pseudogene on chromosome 1p31
            exists for this gene. Members of the ARID family have roles in
            embryonic patterning, cell lineage gene regulation, cell cycle
            control, transcriptional regulation and possibly in chromatin
            structure modification. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. It
            encodes isoform 2 which is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF116846.1, BC045545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346246.10/ ENSP00000343126.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DC396899.1         44-119
            77-2269             AF116846.1         52-2244
            2270-3112           AC100835.2         71771-72613
            3113-4228           AF116846.1         3087-4202
FEATURES             Location/Qualifiers
     source          1..4228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..4228
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /note="AT-rich interaction domain 3B"
                     /db_xref="GeneID:10620"
                     /db_xref="HGNC:HGNC:14350"
                     /db_xref="MIM:612457"
     exon            1..111
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            112..740
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1871
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /note="isoform 2 is encoded by transcript variant 2; AT
                     rich interactive domain 3B (BRIGHT- like); AT-rich
                     interactive domain-containing protein 3B; bright-like
                     protein; bright and dead ringer protein; ARID
                     domain-containing protein 3B; Bright-derived protein"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 3B
                     isoform 2"
                     /protein_id="NP_006456.1"
                     /db_xref="CCDS:CCDS10264.1"
                     /db_xref="GeneID:10620"
                     /db_xref="HGNC:HGNC:14350"
                     /db_xref="MIM:612457"
                     /translation="MEPLQQQQQQQQQQQKQPHLAPLQMDAREKQGQQMREAQFLYAQ
                     KLVTQPTLLSATAGRPSGSTPLGPLARVPPTAAVAQVFERGNMNSEPEEEDGGLEDED
                     GDDEVAEVAEKETQAASKYFHVQKVARQDPRVAPMSNLLPAPGLPPHGQQAKEDHTKD
                     ASKASPSVSTAGQPNWNLDEQLKQNGGLAWSDDADGGRGREISRDFAKLYELDGDPER
                     KEFLDDLFVFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLVEIINKKIWREITK
                     GLNLPTSITSAAFTLRTQYMKYLYAYECEKKALSSPAELQAAIDGNRREGRRPSYSSS
                     LFGYSPAAATAAAAAGAPALLSPPKIRFPILGLGSSSGTNTSSPRISPATTLRKGDGA
                     PVTTVPVPNRLAVPVTLASQQAGTRTAALEQLRERLESGEPAEKKASRLSEEEQRLVQ
                     QAFQRNFFSMARQLPMKIRINGREDRAEASAAALNLTTSSIGSINMSVDIDGTTYAGV
                     LFAQKPVVHLITGSAPQSLGSSASSSSSSHCSPSPTSSRGTPSAEPSTSWSL"
     exon            741..812
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..885
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1069
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1353
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1608
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1707
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..4228
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4204..4209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /note="hexamer: AATAAA"
     polyA_site      4228
                     /gene="ARID3B"
                     /gene_synonym="BDP; DRIL2"
                     /note="major polyA site"
ORIGIN      
        1 cccgccccgg ctgtggcccc cggctgcgga ggagtccgag acgcagctgc cgcgccgggg
       61 cctgagctgc cgcctcctcc gccgcccgaa aacccggagt gccccgcaca ggtttagacc
      121 cagtgtgcct ggtgggctgt gcccaggttc agagtcatgc cactctgtgg gtgaagcttg
      181 aggcaaaaat ggagccactt cagcagcagc agcagcagca gcagcaacaa cagaagcagc
      241 cacacctggc tcctctgcag atggatgcca gagagaagca gggccagcag atgagagaag
      301 cccagttctt gtatgcccaa aagctggtca cacagccgac tctcctttcc gccacagctg
      361 ggagaccttc tggcagcact cccttaggtc ccttagccag agttccaccc accgcagcag
      421 tggcccaagt gtttgaacgg ggcaacatga actcagagcc tgaggaagag gacggaggtt
      481 tggaagatga ggatggggat gatgaagttg cagaggtggc tgagaaagaa acccaggctg
      541 cttcaaaata ttttcatgtg cagaaagtag ctcgccaaga tcccagagtg gcacccatgt
      601 ccaatctact tccagcacca gggctcccac cacatggaca acaagctaaa gaagaccata
      661 ccaaagatgc ttccaaggcc tcaccttctg tctccacagc aggacagccg aactggaatc
      721 tggatgagca gctcaagcag aatggtggtt tggcctggag tgatgatgca gatggaggcc
      781 ggggaagaga gatctctcga gattttgcca agctgtatga actggacggt gatcctgaaa
      841 ggaaagagtt cctggatgac ctcttcgtct ttatgcagaa gagggggacc cccatcaacc
      901 gaatccccat catggccaaa cagatcctgg acctgtacat gctgtataag ctggtgaccg
      961 agaagggagg cctggtggag atcatcaaca agaagatctg gagggagatc accaaaggcc
     1021 taaacctgcc cacatccatc accagcgccg ccttcaccct caggacgcag tacatgaagt
     1081 atctgtatgc ctatgagtgt gagaagaaag ccttgagttc cccagccgag ctccaggcag
     1141 caattgatgg caaccgcagg gagggccggc ggcccagcta cagctcctcc ctctttggct
     1201 actcacctgc tgcggctact gctgctgccg ctgccggggc ccctgccctt ctctccccac
     1261 ccaagatccg ctttcccatc cttgggcttg gctccagcag tggtaccaat accagtagcc
     1321 ctcggatatc cccagcaacc actctcagga aaggtgatgg agccccagtg acaacagtgc
     1381 ctgtgccaaa tcgtctggct gtgcccgtga ccttggcaag ccagcaggct ggtactcgga
     1441 ccgccgcact ggagcagctg cgggagcggc tggagtcagg ggagcctgct gagaagaagg
     1501 catcgaggct gtctgaggag gagcagcgcc tggtgcagca ggccttccag cgcaactttt
     1561 tcagcatggc acggcagctc cccatgaaga tcaggatcaa cggcagggaa gacagagcag
     1621 aggcctcggc tgcagcactg aacctgacca cgagtagcat tgggagcatt aacatgtctg
     1681 tggacatcga tggcaccacc tatgcaggtg tgctgtttgc ccagaagcct gtggtccacc
     1741 tcatcacggg gtctgctccc cagagcctcg gcagcagcgc cagcagcagc agcagctctc
     1801 actgttcacc aagtcctacc tcatcccggg gcacccccag cgcagagccc tccaccagct
     1861 ggtccctctg atgggcagga cccagcttcc cacttgccac tctcctgtcg agagtgaagg
     1921 aagttgatgc acagaattta cctcatctca cagagcccac gtcgacgagc accatttggc
     1981 cagacattga gagtttggac gtgtccgtct gtccaggctc cattcaggtc ctgctgtact
     2041 ctgggggcag ggagaggcta gaggggcagg acagacagcg ttgtccaatc agggattgtc
     2101 ctggagaact gggtgggggt ctgtgggtgt ccagcttcct ccagggttcc ccagccacct
     2161 cccagctcag ggcacagtgt atcgacaatc tgtcagccga cgcagggctg gaggccctcc
     2221 atttccctcc ccttttaatt tatttccctg accctgcctt ctgccatgac cccagggcca
     2281 ctagtctctt cccctgtttt taagtcccat gtggggctgc caggagccaa gagcatgcct
     2341 tcatgccctt ctctgcagag catgggatgg ggcccttcca gcccactttg cctactgtta
     2401 ggttcctggg gtacgggtcc ctcaaacaca agtcttgaat cagtcctcag ggccccagat
     2461 cccccttcta atagtctgaa ggaagaggct gtgagggcag ttcagggcca gggcccacag
     2521 ggcatctgct gatgggaagg cagagcctcg gggctgccca gccctggcac ctgcttcaca
     2581 cggaccattc tctgaccgcc cccgccaaac ctcatgctcc ccacttgccc ttattggcct
     2641 gctttcccaa aaacagccca ctcatccttt ccccagccct cttcagccct ccccagtcct
     2701 ccccagcctt cttcagcctt cttcagctca gccctcttct atttcttatg gggccatctt
     2761 ggcctcacca tccccacacg tgccgatgtc aggttcattg aaatacctca gatttgtaat
     2821 tgttgatgtt tgagtcttca ggaagtattt gcatctctga aatctttttt atatgtgttt
     2881 tgctgacttt tgtttttttt ttattttaaa atttttatcg tagcaccaaa gaaatgaaaa
     2941 cagatcaccc ccaaagccaa gcaagtgatt gggtaacccg gcccctctgg cccttccctc
     3001 aagcccagtg aggaggtggg tggaggcatg caggggagac gactcaggga tcgcgggggc
     3061 ggggaggtgg agtggagagg cccgctctca caccgggtcg ggccctgaaa ctgtaccagt
     3121 tctgaagacc gttttctgcc acacccccac ccccagctga ccagggaggc agaggacacc
     3181 tccccatcac tcagcattcc cagctcaggg cacaggcagg ctggggtcct cgctggcctt
     3241 gccagaggtt gagccgcccc agggtatgag gagatgaata actccacagc tcctcctgga
     3301 ccctgcgcgg gagcaggcag ctcctgtgct gtaaagaaaa ttgattcgct tgcggctcac
     3361 ctcagtcgag gaagccctgg aatgttcagc agaacaccac cactgtgaca tggggctgtg
     3421 gcagtgggag acaccgcgcg tggcgtgggt gtgtgtggca gcgtggctcg cattcagtcc
     3481 tgtgtaggag aggaaaggga atcaaaagct tgagcacaaa cagatacctc agcccggtaa
     3541 gctgcagctc tgctcaactg cgtcttctct cagccctcca cacacactca cccccactcc
     3601 cacacacata cacacacaca cacacatacc ccatctcccg agggctgacc tcctctggcc
     3661 tcagcctgca gggtgtgggc agagaagggc atctgggacg tggtgccagt gaggagccca
     3721 gttggctggc actgggccca tttgaaggtg tctcagacat ttggccagta tgtctttctc
     3781 aggggtttgg tcacaaagga tggactcttc ccacccagag gatgcaggga aagcacactg
     3841 tgtctttccg gtcattggat cctctccctt tccccaggca gctcgcctgg ccacaccgtt
     3901 ggagtgaacc ctcactgccc tcaaggacaa cagcagggtg tcacccagag cccgatgagg
     3961 ggtgccagca ggtgccccca cgagtggggc cttggcccaa gcagagcttc ccctgaaggt
     4021 gccatcagcc agggcagctc tgtcccctcc tgctctccat cttatatgta ttctaaccag
     4081 gaaaaatgtg atagcacatg ggtagcctag gcagtgagta aatacctcag atgtcctcct
     4141 gcagcaagtg tctatatgtt gtggttattt tctatcttac atgttctcga atgtttatat
     4201 ttcaataaac ctctacctct tcacacaa
//
