LOCUS       NM_005224               5948 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens AT-rich interaction domain 3A (ARID3A), mRNA.
ACCESSION   NM_005224
VERSION     NM_005224.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5948)
  AUTHORS   Kruk,B., Liebe,R., Weber,S.N., Milkiewicz,P. and Krawczyk,M.
  TITLE     ARID3A variant and the risk of primary biliary cholangitis in a
            Central European cohort
  JOURNAL   J Hepatol 80 (6), e256-e257 (2024)
   PUBMED   38036008
  REMARK    GeneRIF: ARID3A variant and the risk of primary biliary cholangitis
            in a Central European cohort.
REFERENCE   2  (bases 1 to 5948)
  AUTHORS   Li,Y., Li,Z., Chen,R., Lian,M., Wang,H., Wei,Y., You,Z., Zhang,J.,
            Li,B., Li,Y., Huang,B., Chen,Y., Liu,Q., Lyu,Z., Liang,X., Miao,Q.,
            Xiao,X., Wang,Q., Fang,J., Shi,Y., Liu,X., Seldin,M.F.,
            Gershwin,M.E., Tang,R. and Ma,X.
  TITLE     A regulatory variant at 19p13.3 is associated with primary biliary
            cholangitis risk and ARID3A expression
  JOURNAL   Nat Commun 14 (1), 1732 (2023)
   PUBMED   36977669
  REMARK    GeneRIF: A regulatory variant at 19p13.3 is associated with primary
            biliary cholangitis risk and ARID3A expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5948)
  AUTHORS   Liu,C., Yan,S., Chen,H., Wu,Z., Li,L. and Li,Y.
  TITLE     Several genetic variants associated with systemic sclerosis in a
            Chinese Han population
  JOURNAL   Clin Rheumatol 42 (3), 773-781 (2023)
   PUBMED   36301368
  REMARK    GeneRIF: Several genetic variants associated with systemic
            sclerosis in a Chinese Han population.
REFERENCE   4  (bases 1 to 5948)
  AUTHORS   Shen,M., Li,S., Zhao,Y., Liu,Y., Liu,Z., Huan,L., Qiao,Y., Wang,L.,
            Han,L., Chen,Z. and He,X.
  TITLE     Hepatic ARID3A facilitates liver cancer malignancy by cooperating
            with CEP131 to regulate an embryonic stem cell-like gene signature
  JOURNAL   Cell Death Dis 13 (8), 732 (2022)
   PUBMED   36008383
  REMARK    GeneRIF: Hepatic ARID3A facilitates liver cancer malignancy by
            cooperating with CEP131 to regulate an embryonic stem cell-like
            gene signature.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5948)
  AUTHORS   Li,Y., Tang,J., Li,J., Du,Y., Bai,F., Yang,L., Li,X., Jin,X. and
            Wang,T.
  TITLE     ARID3A promotes the chemosensitivity of colon cancer by inhibiting
            AKR1C3
  JOURNAL   Cell Biol Int 46 (6), 965-975 (2022)
   PUBMED   35257428
  REMARK    GeneRIF: ARID3A promotes the chemosensitivity of colon cancer by
            inhibiting AKR1C3.
REFERENCE   6  (bases 1 to 5948)
  AUTHORS   Goebel,P., Montalbano,A., Ayers,N., Kompfner,E., Dickinson,L.,
            Webb,C.F. and Feeney,A.J.
  TITLE     High frequency of matrix attachment regions and cut-like protein
            x/CCAAT-displacement protein and B cell regulator of IgH
            transcription binding sites flanking Ig V region genes
  JOURNAL   J Immunol 169 (5), 2477-2487 (2002)
   PUBMED   12193717
  REMARK    GeneRIF: Variations in Bright binding and matrix attachment region
            activity contribute to localized control of accessibility and
            therefore nonrandom gene use during V(D)J recombination.
REFERENCE   7  (bases 1 to 5948)
  AUTHORS   Peeper,D.S., Shvarts,A., Brummelkamp,T., Douma,S., Koh,E.Y.,
            Daley,G.Q. and Bernards,R.
  TITLE     A functional screen identifies hDRIL1 as an oncogene that rescues
            RAS-induced senescence
  JOURNAL   Nat Cell Biol 4 (2), 148-153 (2002)
   PUBMED   11812999
  REMARK    GeneRIF: Results show that DRIL1 disrupts cellular protection
            against RAS(V12)-induced proliferation downstream of the
            p19(ARF)/p53 pathway.
REFERENCE   8  (bases 1 to 5948)
  AUTHORS   Kortschak,R.D., Tucker,P.W. and Saint,R.
  TITLE     ARID proteins come in from the desert
  JOURNAL   Trends Biochem Sci 25 (6), 294-299 (2000)
   PUBMED   10838570
  REMARK    Review article
REFERENCE   9  (bases 1 to 5948)
  AUTHORS   Suzuki,M., Okuyama,S., Okamoto,S., Shirasuna,K., Nakajima,T.,
            Hachiya,T., Nojima,H., Sekiya,S. and Oda,K.
  TITLE     A novel E2F binding protein with Myc-type HLH motif stimulates
            E2F-dependent transcription by forming a heterodimer
  JOURNAL   Oncogene 17 (7), 853-865 (1998)
   PUBMED   9780002
REFERENCE   10 (bases 1 to 5948)
  AUTHORS   Kortschak,R.D., Reimann,H., Zimmer,M., Eyre,H.J., Saint,R. and
            Jenne,D.E.
  TITLE     The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene
            structure, and mapping to D19S886, a marker on 19p13.3 that is
            strictly linked to the Peutz-Jeghers syndrome
  JOURNAL   Genomics 51 (2), 288-292 (1998)
   PUBMED   9722953
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005379.1, BC060828.1,
            U88047.1 and AC005391.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005224.2.
            
            Summary: This gene encodes a member of the ARID (AT-rich
            interaction domain) family of DNA binding proteins. It was found by
            homology to the Drosophila dead ringer gene, which is important for
            normal embryogenesis. Other ARID family members have roles in
            embryonic patterning, cell lineage gene regulation, cell cycle
            control, transcriptional regulation, and possibly in chromatin
            structure modification. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060828.1, SRR11853561.14077.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263620.8/ ENSP00000263620.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC005379.1         20589-20590
            3-398               BC060828.1         1-396
            399-2256            U88047.1           307-2164
            2257-2768           AC005391.1         30647-31158
            2769-2825           BC060828.1         2769-2825
            2826-5948           AC005391.1         31216-34338
FEATURES             Location/Qualifiers
     source          1..5948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..5948
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /note="AT-rich interaction domain 3A"
                     /db_xref="GeneID:1820"
                     /db_xref="HGNC:HGNC:3031"
                     /db_xref="MIM:603265"
     exon            1..25
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            26..660
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2074
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /note="AT rich interactive domain 3A (BRIGHT- like)
                     protein; dead ringer-like 1; B-cell regulator of IgH
                     transcription; E2F-binding protein 1; ARID
                     domain-containing 3A; dead ringer-like protein 1; ARID
                     domain-containing protein 3A; AT rich interactive domain
                     3A (BRIGHT-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein
                     3A"
                     /protein_id="NP_005215.1"
                     /db_xref="CCDS:CCDS12050.1"
                     /db_xref="GeneID:1820"
                     /db_xref="HGNC:HGNC:3031"
                     /db_xref="MIM:603265"
                     /translation="MKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAPD
                     EDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSP
                     GRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLG
                     PPGPASLGTTALFPRKAQPPQAFRGDGVPRVLGGQERPGPGPAHPGGAAHVAPQLQPP
                     DHGDWTYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLY
                     VLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSN
                     PNELQAAIDSNRREGRRQSFGGSLFAYSPGGAHGMLSSPKLPVSSLGLAASTNGSSIT
                     PAPKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLR
                     EKLESAEPPEKKMALVADEQQRLMQRALQQNFLAMAAQLPMSIRINSQASESRQDSAV
                     NLTGTNGSNSISMSVEINGIMYTGVLFAQPPAPTPTSAPNKGGGGGGGSSSNAGGRGG
                     NTGTSGGQAGPAGLSTPSTSTSNNSLP"
     exon            661..985
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1058
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1242
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1490
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1787
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1886
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..5948
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /note="hexamer: AATAAA"
     polyA_site      2301
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /note="major polyA site"
     regulatory      5909..5914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
                     /note="hexamer: ATTAAA"
     polyA_site      5948
                     /gene="ARID3A"
                     /gene_synonym="BRIGHT; DRIL1; DRIL3; E2FBP1"
ORIGIN      
        1 agacgcggac gcggctggcg gctcggtttc tgcaaatgcg tgaatgagcc ggatgccagc
       61 ctctgtcccc tggagcccag cgtgaggaag aggcatgccc catcagcctt cagcttgagc
      121 ccggcggccc ccgcccccgc cccctgccac cctgcactgc cccggctccc ccgcggcccc
      181 cacgctgcag tgcggccggg ccccctcccc gcaggggccg cccccgccgc ccacccctag
      241 cgcccgtggt ggtggtggtg gtggtggtgg tggtggcccg ggccgcaggg ccatgaaact
      301 acaggccgtg atggagacgc tgttgcagcg gcagcagcgg gcgcgccagg agctggaggc
      361 ccggcagcag ctgccccccg atccccctgc tgcacccccc ggccgggccc gggctgcccc
      421 cgacgaggac agagagcccg agagtgcccg gatgcagcgg gctcagatgg ccgcactggc
      481 agccatgcgg gctgcagctg cgggcctggg acacccagcc agccccggcg gctctgagga
      541 tgggccccca ggctcggagg aggaggacgc ggcccgggag gggacaccgg gctcacccgg
      601 gcgaggcaga gaagggccag gagaggagca ctttgaggac atggcctccg acgaggacat
      661 gaagcccaaa tgggaggagg aggagatgga ggaagacctc ggggaggatg aggaggagga
      721 ggaggaggat tacgaggatg aggaggagga ggaggacgag gaggggctgg gccccccagg
      781 ccctgccagc ttgggcacca cggcactgtt cccccgaaag gcccagccac cccaggcctt
      841 ccgcggcgat ggcgttccca gggtgctggg gggccaggag cggccggggc ctggccctgc
      901 ccaccccgga ggggccgccc acgtagcccc gcagctgcag ccgcctgacc acggcgactg
      961 gacttacgag gagcagttta agcagctcta cgaactcgac ggggacccca agaggaagga
     1021 attcctggat gacttgttca gcttcatgca gaagcgaggg acacctgtga accgcatccc
     1081 catcatggcc aaacaggtcc ttgacctgtt catgctgtac gtgctggtga cggagaaggg
     1141 cggcctcgtg gaggtcatca acaagaagct gtggcgtgag atcaccaagg gcctcaacct
     1201 gcccacgtcc atcaccagtg cagccttcac cctgcggacc caatacatga agtacctgta
     1261 cccctacgag tgtgagaagc ggggcctcag taaccccaat gagctccagg cagccataga
     1321 cagcaaccga cgggagggcc ggcgccagag ctttggtggc tccctctttg cctactcgcc
     1381 aggcggggca cacggcatgc tctcctcacc caagctaccc gtgtcctccc tgggcctggc
     1441 cgcaagcacc aatggcagct ccatcacccc cgcccctaag atcaagaaag aggaggactc
     1501 agccatcccc atcacagtcc ctggccgcct gcctgtgtcc ctggcgggcc accctgtggt
     1561 ggcagcccag gcagcagctg tgcaagcagc agccgcccaa gcagctgtgg ccgcacaggc
     1621 agctgccctg gaacagctgc gggagaagct ggagtctgca gagcctccgg agaagaagat
     1681 ggccctggtg gccgatgagc agcaacggct gatgcaacgt gcactccagc agaacttcct
     1741 ggccatggcg gcccagctgc ccatgagcat tcggatcaac agccaagcct ccgaaagccg
     1801 ccaggactct gctgtgaacc tgacgggcac caacggcagc aacagcatca gcatgtcggt
     1861 ggagatcaac ggcatcatgt acacaggagt tctgtttgct cagccgccgg cccccacgcc
     1921 aacctctgct cccaacaaag gaggcggcgg cggcggcggc agcagcagca acgcaggcgg
     1981 ccggggagga aacaccggaa ccagcggcgg ccaggctggg ccagcggggc tgtccacacc
     2041 ctccacatct acctcaaata actcgttgcc ttaaccgcat cactccccac ccgccaccca
     2101 ccctggagcc cgccggcctg ggcagggggt ccaggtgggc cacacagggg ccaggatggc
     2161 ggaagatacg ggtggggagg gaagatatcc agaaaggagc cacagctgac gccaaaaaga
     2221 aaagaaaaaa gatatatata tatatatata tatatacacg tatatatata aagagaattt
     2281 aataaaacag gggaaaacca aggaacactt gaatttctca ggttttggac attcagagag
     2341 atgaattgtg agaacagcaa agaaatccat cagaaaaaca gaaagaggca gacgtttccc
     2401 agggcgttca ggcagccctg atggaccgaa ggctctggtg tctggtttgg ccccacagca
     2461 gtgtgggccg atcctgttta cctcatacat ccctgcactg tgtgttttca tttttgtctg
     2521 ctttagttct cttttatttt ctattcacca cacactcacc actcccagct tctcgtgtcc
     2581 agtgaaaccc ctgaaccaag atcactgaat ttttgttttt ttcttgttgc tttgggaaat
     2641 ttttttttct ctgtagggtt tttaagaggt ttcgggggtt ttgttgtgta aatattctat
     2701 tttattcttg gggggatcaa accttaggaa aaggatatct atatatctat atagctatat
     2761 atttgtgttc cttcagggaa actggtcttg aaaaagcaag aaaaaaaagc aaaaaaaaaa
     2821 aaaaaaaaaa aaaaaaaaaa ctcacctttt tatttttccc atgaccaatt tgggtccctt
     2881 tgtccatttc tgggggtgcg ttgggcagct gtgagcccag cacatcggat ccctggggct
     2941 agagccgcgg agccaatgaa ctcaggtgct atgggccggg ctggggcaga gggtgcatgc
     3001 tggggtccca ccggccaggg gcccctgaca gtgaattgct gactgtgata ttccacgatg
     3061 cttttgcttg tgccgtgctt gtctgctggg ctctcgagtc aggggcctgg aaattttttt
     3121 tttttttttt ttttgagacg gagttttgct cttgtcgccc aggctggagt gagtgcaatg
     3181 gtgcgatctt ggctcactgc aacctgcacc tcccaggtgc aagcgattct cctgcctcag
     3241 cctccggagt agctgggatt acaggcgccc gccaccacgc ccagttaatt tttgtatttt
     3301 tagtagagat gggggttttg ccatgttggt caggctgatc tcgaactcct gacctcaggt
     3361 gatctgcccg ccttggcctc ccaaagtgct gggattacag gcatgagccg ccacgctggc
     3421 ccggtctgga aatcttatct aaaaagtagc aagtgctgga aaaagggcct ggggggcggg
     3481 ggtggttctt gtcgaagccc ccaggctcct gtctcaggga tgaatgtggc gtctcattgg
     3541 gattcttctc ttgcccgaaa gggctgcttt tgaggactat caatactggg gagtgggggt
     3601 gaagccggac ctcactcagg gtgaggattt cagggccccg gcatcctgaa caccccccac
     3661 accccaacat tctcctcgct ctgtcccttc ctcttctccc aacccctttt gtgctggggc
     3721 tgcgagctcc ccgagttctg cggtgactaa atcgaggccg agaagggagg ctgcccccca
     3781 ccaccctgtg ggtcagtacc cctccccctg gcttggagaa agtggggtca ccgcagctga
     3841 gctggggggt tattttggct ggagctgctg gagcagaaag gctgggtctg aaatgcccag
     3901 cagggtctgg ggacttcgtt ggacccgcgt ggtgttgggc ggggctgtcg tgtcctacac
     3961 gggagctctg ggctttcatt tctcttgggg tgcagtgggg attaactcag ctattcccag
     4021 ggtaagcctg ggtctctaat tgggccctgg gagccctgtt aggccaccgg catgggggct
     4081 tggtgaggaa ggggactccc cagctccccc cactcccaac cacctcccca ttgccttgga
     4141 gacccctggg gagggggctg gggggcttct gagcccctga gtctaggttc actttcccgt
     4201 cgggctgtgg gaggggactg tcactttcct gtgtctttgg ggaggggacc cccacttcct
     4261 tctcggatct cagggccgtg gacacacacc ccctttccag gagggggtgg tgggcgtcta
     4321 ggttttcctt gtcccttcct ggggccagca ccgtagcagc acaatcaccc cgggaagggg
     4381 gtgtctgttt gcctccagac acaatcgggc cccactcgca gaaccacctg gactctgtcc
     4441 gtgtctgtcc cccggcctcc agggctcctc tcccgggacc cccgtcccac gcctgggccc
     4501 cgcgccgggg gaagcgcctg ctgcctatct ctgtctacct caggtctgac ttttgatgcc
     4561 aaaatctgag cccctggggt gcctctcccc cgcctcccgt gcaccagggt ctgcagcagc
     4621 cactggggcc tggctgcctg ctgcatctgg cggccctgga cccctggggc ccccgtgcac
     4681 ctgcccacct cggagcctgg ggaggggccg tgcagggtcg agggctgggt cgtctccctc
     4741 gggctgcgtg tgtgtgtcgg gaatcctgcg tgtcgtgtct gtgggcgatc cggcctcccg
     4801 gcggtgggtg gacctggatt ctaactcaga ggacttgagc ctgctgttaa ctccgatgat
     4861 tgtagggaca ggcggggtgg gtggggggtg ggcgcgaggc tgggtcccgg cccaggagaa
     4921 ggaagtcgct gaaggcagtg gccatgctgg ccgtggaaat gggaggcggt tgcagagggt
     4981 ctatggggcc cggtcctgga tactcggcag gaagccgtgt ctgcagaggc tcctccctgc
     5041 ctcaggtggc cccgttcaac cccagccgtg cccatctcct gccaccgcct gtcggtgggg
     5101 gtttaaattc ggtgtggctt tctggggtgc agctcagcac ccccccttat gcagactggg
     5161 agggggtcgg gcagtcccct cagccacgag gaccctggat gggttctagt tcacttggga
     5221 ccgtggggcc tggctgcgta ctgagtgggt gccccacagt caaggccaac gggggctccc
     5281 cctgctctga gatgttggga gaaaggcggc ttctggaacc ttccgtggga cccgtaagtg
     5341 gctgtccaga aaggcgggag ggtgggcacg gggcacgggg ggcagctggg gtcgttgtta
     5401 agggtcacgc atctgtacag ttgaatttcc tttctcttat catgttttac ccaccttgtc
     5461 ccttttttcc ccaattgtgc ttttgcattt ttttccttgg caaatgtaaa ctcagccttt
     5521 cattcatgac gtgtgaaatt tcagtttctc tggagtttgt cagacggcgt gggaaccacg
     5581 cctgaaactc aggtaatagg aggaaaaaaa aaaaaactta aaaaaatttt taaaaaacat
     5641 aaaactactc tctacctctg gctgggccca gcctgtctcg ccctggccgc ggcagggtgg
     5701 cctgtaacaa tttcagtttt cgcagaacat tcaggtatta aaaggaaaaa aaaaaaaaaa
     5761 gacaaaaaga ccaaaaaaaa aaaaaagtgt gattttgaaa tttaaaagaa cactgaaagt
     5821 ttacatttta tagtaacatt attatgcaga ttgtatttaa acttcagaaa tatttaagac
     5881 gattgtaacc ctgtaaagct gatgagatat taaaacgaga caaaacactt ctgactttta
     5941 acagaaaa
//
