LOCUS       NM_152641               8598 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens AT-rich interaction domain 2 (ARID2), transcript
            variant 1, mRNA.
ACCESSION   NM_152641 XM_370690
VERSION     NM_152641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8598)
  AUTHORS   Huang,X., Zeng,J., Luo,Y., Luo,S., Li,Y. and Wang,J.
  TITLE     Revealing the clinical impact of MTOR and ARID2 gene mutations on
            MALT lymphoma of the alimentary canal using targeted sequencing
  JOURNAL   Diagn Pathol 19 (1), 102 (2024)
   PUBMED   39054516
  REMARK    GeneRIF: Revealing the clinical impact of MTOR and ARID2 gene
            mutations on MALT lymphoma of the alimentary canal using targeted
            sequencing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8598)
  AUTHORS   Schrier Vergano,S.A.
  TITLE     ARID2, a milder cause of Coffin-Siris Syndrome? Broadening the
            phenotype with 17 additional individuals
  JOURNAL   Am J Med Genet A 194 (6), e63540 (2024)
   PUBMED   38243407
  REMARK    GeneRIF: ARID2, a milder cause of Coffin-Siris Syndrome? Broadening
            the phenotype with 17 additional individuals.
REFERENCE   3  (bases 1 to 8598)
  AUTHORS   Akinjiyan,F.A., Nassief,G., Phillipps,J., Adeyelu,T., Elliott,A.,
            Abdulla,F., Zhou,A.Y., Souroullas,G., Kim,K.B., Vanderwalde,A.,
            Park,S.J. and Ansstas,G.
  TITLE     ARID2 mutations may relay a distinct subset of cutaneous melanoma
            patients with different outcomes
  JOURNAL   Sci Rep 14 (1), 3444 (2024)
   PUBMED   38341515
  REMARK    GeneRIF: ARID2 mutations may relay a distinct subset of cutaneous
            melanoma patients with different outcomes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8598)
  AUTHORS   Shin,D., Lee,Y.J., Jo,Y.H., Kong,J., Lee,Y.J., Nam,S.O., Lee,B.L.,
            Oh,S.H. and Kim,Y.M.
  TITLE     Coffin-Siris Syndrome: Case Series of Three Patients and a Novel
            ARID2 Variant
  JOURNAL   Ann Clin Lab Sci 53 (6), 959-963 (2023)
   PUBMED   38182156
  REMARK    GeneRIF: Coffin-Siris Syndrome: Case Series of Three Patients and a
            Novel ARID2 Variant.
REFERENCE   5  (bases 1 to 8598)
  AUTHORS   Zhang,X., Azhar,G., Zhong,Y. and Wei,J.Y.
  TITLE     Zipzap/p200 is a novel zinc finger protein contributing to cardiac
            gene regulation
  JOURNAL   Biochem Biophys Res Commun 346 (3), 794-801 (2006)
   PUBMED   16782067
  REMARK    GeneRIF: zipzap may serve as a transcription co-activator for the
            regulation of cardiac gene expression
REFERENCE   6  (bases 1 to 8598)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   7  (bases 1 to 8598)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   8  (bases 1 to 8598)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   9  (bases 1 to 8598)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   10 (bases 1 to 8598)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008124.8, DQ096628.1,
            AC009464.8 and BX537879.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152641.3.
            
            Summary: This gene encodes a member of the AT-rich interactive
            domain (ARID)-containing family of DNA-binding proteins. Members of
            the ARID family have roles in embryonic patterning, cell lineage
            gene regulation, cell cycle control, transcriptional regulation and
            chromatin structure modification. This protein functions as a
            subunit of the polybromo- and BRG1-associated factor or PBAF
            (SWI/SNF-B) chromatin remodeling complex which facilitates
            ligand-dependent transcriptional activation by nuclear receptors.
            Mutations in this gene are associated with hepatocellular
            carcinomas. A pseudogene of this gene is found on chromosome1.
            [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.110706.1,
                                           SRR1803613.117100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334344.11/ ENSP00000335044.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC008124.8         31937-32067         c
            132-475             DQ096628.1         1-344
            476-476             AC009464.8         97295-97295         c
            477-2532            DQ096628.1         346-2401
            2533-2533           AC009464.8         58248-58248         c
            2534-5639           DQ096628.1         2403-5508
            5640-6517           AC009464.8         2817-3694           c
            6518-8598           BX537879.1         4011-6091
FEATURES             Location/Qualifiers
     source          1..8598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..8598
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /note="AT-rich interaction domain 2"
                     /db_xref="GeneID:196528"
                     /db_xref="HGNC:HGNC:18037"
                     /db_xref="MIM:609539"
     exon            1..223
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..5639
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRG1-associated factor 200; ARID domain-containing protein
                     2; zinc finger protein with activation potential; AT rich
                     interactive domain 2 (ARID, RFX-like); zipzap/p200;
                     AT-rich interactive domain-containing protein 2"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_689854.2"
                     /db_xref="CCDS:CCDS31783.1"
                     /db_xref="GeneID:196528"
                     /db_xref="HGNC:HGNC:18037"
                     /db_xref="MIM:609539"
                     /translation="MANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKE
                     LDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEK
                     VHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNK
                     LVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFS
                     TVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKL
                     GINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDT
                     LGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLIC
                     EYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLV
                     SMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQH
                     VAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTG
                     FYKCLRTVFPNHTVKRVEDSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRV
                     DSVPDVSPAPSPAGIPHGSQTIGNHFQRTPVANQSSNLTATQMSFPVQGVHTVAQTVS
                     RIPQNPSPHTHQQQNAPVTVIQSKAPIPCEVVKATVIQNSIPQTGVPVSIAVGGGPPQ
                     SSVVQNHSTGPQPVTVVNSQTLLHHPSVIPQQSPLHTVVPGQIPSGTPVTVIQQAVPQ
                     SHMFGRVQNIPACTSTVSQGQQLITTSPQPVQTSSQQTSAGSQSQDTVIIAPPQYVTT
                     SASNIVSATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVSSTVVQQP
                     IQQPQQPTQQSVVIVSQPAQQGQTYAPAIHQIVLANPAALPAGQTVQLTGQPNITPSS
                     SPSPVPATNNQVPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQQHSPAPPPQQVQVQV
                     QQPQQVQMQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPN
                     NARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNVQLVPSAMPPSGGVQTVPIS
                     NLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMS
                     GTQTGVGLPVQTLPATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERK
                     IEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSLPPSNSGKIQSETNQCS
                     LISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPN
                     HKTSNHVGNGEISPMEPQGTLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASN
                     AATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVPDSGSKVS
                     HSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSAT
                     MVAVPAGADPSTVAKVAIESAVQQKQQHPPTYVQNVVPQNTPMPPSPAVQVQGQPNSS
                     QPSPFSGSSQPGDPMRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDVYPGQCL
                     WEGCEPFQRQRFSFITHLQDKHCSKDALLAGLKQDEPGQAGSQKSSTKQPTVGGTSST
                     PRAQKAIVNHPSAALMALRRGSRNLVFRDFTDEKEGPITKHIRLTAALILKNIGKYSE
                     CGRRLLKRHENNLSVLAISNMEASSTLAKCLYELNFTVQSKEQEKDSEMLQ"
     exon            224..317
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            318..415
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            416..549
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            550..768
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            769..836
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            837..903
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1154
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1251
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1461
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1629
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1711
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1846
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2043
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..4904
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4905..5053
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5192
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5193..5278
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5279..5402
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5403..5494
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     exon            5495..8598
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7083..7088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /note="hexamer: AATAAA"
     polyA_site      7101
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /note="major polyA site"
     regulatory      8402..8407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /note="hexamer: AATAAA"
     polyA_site      8422
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
     regulatory      8577..8582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
                     /note="hexamer: AATAAA"
     polyA_site      8598
                     /gene="ARID2"
                     /gene_synonym="BAF200; CSS6; p200; SMARCF3; ZIPZAP"
ORIGIN      
        1 gccggcccat gactgagccc cgccgccgcc ggccgaggaa tgggctccgg gctctggtag
       61 gaagcgctgg gagcgggggg cgcttttaaa acaccgatct gggtttttta aaaacctcct
      121 ttgaaaaaat aatggcaaac tcgacgggga aggcgcctcc ggacgagcgg agaaagggac
      181 tcgctttcct ggacgagctg cggcagttcc accacagcag agggtcgcct tttaaaaaaa
      241 tccctgcggt gggtgggaag gagctggatc ttcacggtct ctacaccaga gtcactactt
      301 taggcggatt cgcgaaggtt tctgagaaga atcagtgggg agaaattgtt gaagagttca
      361 actttcccag aagttgttct aacgctgcct ttgctttaaa acagtattac ttgcgttacc
      421 tagaaaagta cgagaaagtt catcattttg gggaggatga tgatgaggta ccaccaggca
      481 atccaaagcc acagcttcct attggtgcaa ttccatcttc ctacaattac cagcaacaca
      541 gtgtgtcgga ttatctgcgt caaagttatg ggctgtccat ggactttaat tcgccaaatg
      601 attataataa attggtgctt tcactgttat ctggactccc aaatgaagtg gactttgcta
      661 ttaacgtatg cactctccta tcaaatgaaa gcaagcacgt catgcaactt gaaaaagatc
      721 ctaaaatcat cactttacta cttgctaatg ccggggtgtt tgacgacact ttaggatcct
      781 tttccactgt atttggagaa gaatggaaag agaagactga tagagacttc gttaagtttt
      841 ggaaagacat cgttgatgat aatgaagttc gtgacctcat ttctgacaga aacaagtctc
      901 atgaaggtac atcaggagaa tggatttggg agtctttatt tcatccacct cgaaagctgg
      961 gcattaacga tattgaagga cagcgggtac ttcagattgc agtgattttg agaaatcttt
     1021 cctttgagga gggcaatgtt aagctcttgg cagctaatcg tacctgtctt cgtttcctat
     1081 tactttctgc acatagtcat tttatttctt taaggcaatt aggccttgac acattaggaa
     1141 atattgcagc tgagctttta ctggaccctg ttgatttcaa aactactcat ctgatgtttc
     1201 atactgttac aaaatgtcta atgtcaaggg atagattttt aaagatgaga ggcatggaaa
     1261 ttttgggaaa tctttgcaaa gcagaagata atggtgtttt aatttgtgaa tatgtggatc
     1321 aggattccta cagagagatc atttgtcatc tcactttacc tgatgtgctg cttgtaatct
     1381 caacactcga ggtgctatac atgctcacgg aaatgggaga tgttgcttgc acaaaaattg
     1441 caaaagtaga aaagagcata gacatgttag tgtgtctggt ttctatggat attcagatgt
     1501 ttggccctga tgcactagct gcggtaaaac tcattgaaca cccaagttcc agtcatcaaa
     1561 tgttatctga aattaggcca caagctatag agcaagtcca aacccagact catgtagcat
     1621 ctgccccagc ttccagagca gttgtagcgc agcatgttgc tccacctcca ggaatagtgg
     1681 aaatagatag tgagaagttt gcttgtcagt ggctaaatgc tcattttgaa gtaaatccag
     1741 attgttctgt ttctcgagca gaaatgtatt ctgaatacct ctcgacttgc agtaaattag
     1801 ctcgtggtgg aatcctaaca tcaactggat tttataaatg tcttagaacg gtctttccaa
     1861 atcatacagt gaagagagtg gaggattcca gtagcaatgg gcaggcacat attcatgtgg
     1921 taggagtaaa acggagggct ataccacttc ccattcagat gtactatcag cagcaaccag
     1981 tttctacttc tgttgttcgt gttgattctg ttcctgatgt atctcctgct ccttcacctg
     2041 caggaatccc tcatggatca caaaccatag gaaaccattt tcagaggact cctgttgcca
     2101 accaatcttc aaatctgact gcaacacaaa tgtcttttcc tgtacaaggt gttcatactg
     2161 tggcacaaac tgtttcaaga attccacaaa atccttcacc tcatacccac cagcaacaaa
     2221 atgctccagt gactgtcatt caaagtaaag ctccaattcc ttgtgaagtt gttaaggcta
     2281 cagttatcca gaattccata ccccagacag gagttcctgt tagtattgct gttggaggag
     2341 gacctccaca gagttctgtt gttcagaatc atagtacagg gccacaacct gttacagttg
     2401 tgaattctca gacattgctt caccatccat ctgtaattcc acagcagtct ccattacaca
     2461 cagtggtacc aggacagatc ccttcaggca ctcctgttac agtaattcaa caagctgtcc
     2521 cacagagtca tatgtttggc agagtacaga acataccagc atgtacttct acagtttcac
     2581 agggtcaaca gttaatcacc acatcacccc aacctgtgca aacttcatct caacagacat
     2641 cagctggtag ccagtcacaa gatactgtta tcatagcacc cccacagtat gtaacaactt
     2701 ctgcatccaa tattgtctca gcaacttcag tacagaattt tcaggtagct acaggacaaa
     2761 tggttactat tgctggtgtc ccaagtccac aagcctcaag ggtagggttt cagaacattg
     2821 caccaaaacc tctcccttct cagcaagttt catctacagt ggtacagcag cctattcaac
     2881 aaccacagca gccaacccaa caaagcgtag tgattgtaag ccagccagct caacaaggtc
     2941 aaacttatgc accagccatt caccaaattg ttcttgctaa tccagcagct cttccagctg
     3001 gtcagacagt tcagctaact ggacaaccta acataactcc atcttcttca ccatcacctg
     3061 tcccagctac taataaccaa gtccctactg ccatgtcgtc gtcctctacc cctcaatcac
     3121 agggaccacc tcctactgtc agtcaaatgt tatctgtgaa aaggcagcaa cagcagcaac
     3181 attcaccagc acccccacca cagcaggtac aagtacaagt tcagcagccc caacaagtac
     3241 agatgcaagt tcaacctcaa cagtcgaatg caggagttgg tcagcctgcc tctggtgagt
     3301 cgagtctgat taaacagctt ctgcttccga aacgtggtcc ttcaacacca ggtggtaagc
     3361 ttattctccc agctccacag attcctcccc ctaataatgc aagagctcct agccctcagg
     3421 tggtctatca ggtggccagt aaccaagccg caggttttgg agtgcagggg caaactccag
     3481 ctcagcagct attggttggg cagcaaaatg ttcagttggt cccaagtgca atgccaccct
     3541 cagggggagt acaaactgtg cccatttcga acttacaaat attgccaggt ccactgatct
     3601 caaatagccc agcaaccatt ttccaaggga cttctggcaa ccaggtaacc ataacagttg
     3661 tgccaaatac gagttttgca cctgcaactg tgagtcaggg aaatgcaact cagctcattg
     3721 ctccagcagg aattaccatg agcggaacgc agacaggagt tggacttcca gtacaaacgc
     3781 ttccagccac tcaagcatct cctgctggac aatcatcatg tactactgct actcccccat
     3841 tcaaaggtga taaaataatt tgccaaaagg aggaggaagc aaaggaagca acaggtttac
     3901 atgttcatga acgtaaaatt gaagtcatgg agaacccgtc ctgccgacga ggagccacaa
     3961 acaccagcaa tggggataca aaggaaaatg aaatgcatgt gggaagtctt ttaaatggga
     4021 gaaagtacag tgactcaagt ctacctcctt caaactcagg gaaaattcaa agtgagacta
     4081 atcagtgctc actaatcagt aatgggccat cattggaatt aggtgagaat ggagcatctg
     4141 ggaaacagaa ctcagaacaa atagacatgc aagatatcaa aagtgatttg agaaaaccgc
     4201 tagttaatgg aatctgtgat tttgataaag gagatggttc tcatttaagc aaaaacattc
     4261 caaatcataa aacttccaat catgtaggaa atggtgagat atctccaatg gaaccacaag
     4321 ggactttaga tatcactcag caagatactg ccaaaggtga tcaactagaa agaatttcta
     4381 atggacctgt attaactttg ggtggttcat ctgtgagcag tatacaggag gcttcaaatg
     4441 cggcaacaca gcaatttagt ggtactgatt tgcttaatgg acctctagct tcaagtttga
     4501 attcagatgt gcctcagcaa cgcccaagtg tagttgtctc accacattct acaacctctg
     4561 ttatacaggg acatcaaatc atagcagttc ccgactcagg atcaaaagta tcccattctc
     4621 ctgccctatc atctgacgtt cggtctacaa atggcacagc agaatgcaaa actgtaaaga
     4681 ggccagcaga ggatactgat agggaaacag tcgcaggaat tccaaataaa gtaggagtta
     4741 gaattgttac aatcagtgac cccaacaatg ctggctgcag cgcaacaatg gttgctgtgc
     4801 cagcaggagc agatccaagc actgtagcta aagtagcaat agaaagtgct gttcagcaaa
     4861 agcaacagca tccaccaaca tatgtacaga atgtggtccc gcagaacact cctatgccac
     4921 cttcaccagc tgtacaagtg cagggccagc ctaacagttc tcagccttct ccattcagtg
     4981 gatccagtca gcctggagat ccaatgagaa aacctggaca gaacttcatg tgtctgtggc
     5041 agtcttgtaa aaagtggttt cagacaccct cacaggtttt ctaccatgca gcaactgaac
     5101 atggaggaaa agatgtatat ccagggcagt gtctttggga aggttgtgag ccttttcagc
     5161 gacagcggtt ttcttttatt acccacttgc aggataagca ctgttcaaag gatgccctac
     5221 ttgcaggatt aaaacaagat gaaccaggac aagcaggaag tcagaagtct tctaccaagc
     5281 agccaactgt agggggcaca agctcaactc ctagagcaca aaaggccatt gtgaatcatc
     5341 ccagtgctgc acttatggct ctgaggagag gatcaagaaa ccttgtcttt cgagatttta
     5401 cagatgaaaa agagggacca ataactaaac acatccgact aacagctgcc ttaatattaa
     5461 aaaatattgg taaatattca gaatgtggtc gcagattgtt aaagagacat gaaaataact
     5521 tatcagtgct agccattagt aacatggaag cttcctccac ccttgccaaa tgcctttatg
     5581 aacttaattt tacagttcag agtaaggaac aagaaaaaga ctcagaaatg ctgcagtgaa
     5641 aaataattcc acttacacag tgggggactc aaagtcagcc acatttcaca tactgttact
     5701 gaagaaagca ccaagtctta atggaacaaa gaccatagaa tgaattattt tatctcctcc
     5761 catgatgctg agaggaagct tcgtattctg atctctgagt gaatcccttt gttctctgtt
     5821 taaaaaaatc taaaaagaaa aaggaaaaaa aaaaaagaac tgctgtggga ttgtcaacca
     5881 gcttatctgc aggatgtttc agatctgata aatcctgatg gaaactggta tgatcagaat
     5941 tcagtaccat ccacattgga atatacatgg aatattgtaa aacctacatg agcagatgaa
     6001 atagaagcat taaatatttt tatctatatc caaaaaggag cacattttta tatttacaaa
     6061 accgtttaag ctggtttgaa taatttaaaa aagtttcagc acacctatac ccccgatctc
     6121 agagggggcc accaatatct agctatggat cgtgtgtttt gtttagaaat cagtagcttg
     6181 gttttcttac ttgagccaat atattttcac ttatttatta tcataaaaat ttaccagtct
     6241 gaatagatct tgtaaatatt tgtgaataga atgaatacct ttcatgccac tgcagccact
     6301 ggaaatacat tctgtggtgt cctagaagca ttattggtag gttctaaagt tttctagact
     6361 ttcctgtcaa ttgtaagtaa ttgtgatata ttctatgcag tggatgaatg ttctttaaat
     6421 ttgtgtaaat acttctgcaa aggtactgat gctgtaaagt caaaacagtt ttgtggaact
     6481 gtgatttttt tttctttttt cttttttttt ttcttttttt ttttgtatta tacaccttgt
     6541 agaactcatt ttgctggctg aaagagtatg gaataatata tctcatgtca ttttttagaa
     6601 gaaaaactat ttgaaggtat tttttggttt tccttaacat gtatccactg taaacgtttg
     6661 tcgtgtacaa gctcagagct tggacagaat tttttgtatt tgtaaattgg tttaaataca
     6721 tggaatttta tacaggtttt ctcctgtgtt atatatgcat tatgtgcagg tatgatattt
     6781 tcttcactac tttttctatc ttaatatagt gtggaatttt attgtattat tcttccattc
     6841 ttaatactgt accacattcc tgctcagaaa ctgctcactt ccttaaattg tcttttttcc
     6901 cccagcgtga aatgtatcca tttataactg cctattgcct gttctattag catccaaaaa
     6961 tgtggaaggc ctcccaacca ccatttctgc tgtgtcctta ggatgtgcag taaaaaatat
     7021 agacctaaca gtttatgtta tagaatggct ttatttactt tggtgactgt ttatagtttt
     7081 taaataaaag actgaacatt ttcttgagtc cttcatttct gagtatgctt aagacatctt
     7141 aaaaatatag agagaattct aaattcagct gaaggcaagg tataacggtc acctacctat
     7201 ttgattatat gttgattgat aacatattaa atagagaaca aataagagag gtcctttaca
     7261 tgacaaattt gcatgaaata agcagattaa ccaagtattt atttttcatc ttgttataat
     7321 gcagagcaaa tgtagagaac agcaaatgat tgatgcagtt aaagctcaat atgccttttt
     7381 ttactggata ctgtacattt ggctaaaagc ttttattgtt tgatgttgtg tttcttgact
     7441 gtttattcag aatcacagtg tatccaaatc ttcagcttga atttggaggc agattcttag
     7501 agtgaaaaag cctcagtttc catattaaaa atgttttaaa tattttgatt gaattagtac
     7561 caatgtaaaa tctagtttct tcctgaagga ggatccctgg cgctgtcctg ccatgtctca
     7621 aaggaatgtt tgagaaactt catctaatat tagttataag gttgtggaat ttatgcttgg
     7681 cccaccttcc aagactggca ctgcccaaca gacaccgctg aaatcatgtg ggtatcccta
     7741 ggatggcctt cagagccctc aaacttacaa gcacctggta gttgacatca tatggggaat
     7801 tttctattca ccgtacttat ccaaaaatct cttttaaaaa gtaaatttgt gcaacaacgt
     7861 ttatttgaaa gataatgtct tctcaaaatc agaaactgca gtggtaatta aattaataga
     7921 aaagagaaca aactgcaggt ttagaaaaat ggttttcata ttcaccattc ttccacctca
     7981 ttgaattgca tgctgtagtt ctagcttttc tgctataata tgtaaatatg actgtagcct
     8041 tttaagcttc agtctcagca gagaatttcc taaatgcgtt tgacctaatg aaactgatca
     8101 tggcttccca cttaggtttt tcttcttata gctttataga actatataat aatatggact
     8161 tgctgtgtaa tggaattaaa gtgcttttgc acaataagtt ctgcaaaacc ctctcattca
     8221 tgaaaaggtg ctccttgcta gacagaaact tgctgattta cagtattgtt atttttgtct
     8281 aaagttctgt aaatacatgc tttaatgtta tctttgagaa atctatgtaa ataatatagt
     8341 ctacaacata gagactgtat aattctgtgt tatatatgtg cctagtgctc tgttggcact
     8401 caataaattt taagtaacaa aattgataat catatagcga aggcatattt ttcttccaag
     8461 ctcaagtcag gattgtgact atatattaat gagactcagt aatccaaccc acacctgaga
     8521 actcgtctca ttactttata gtcatgtcat gtatgttttt ttaaccatga aatgacaata
     8581 aaatgatttt taaaatga
//
