LOCUS       NM_001374828           10310 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens AT-rich interaction domain 1B (ARID1B), transcript
            variant 3, mRNA.
ACCESSION   NM_001374828 NM_001346813
VERSION     NM_001374828.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10310)
  AUTHORS   Bosch,E., Guse,E., Kirchner,P., Winterpacht,A., Walther,M.,
            Alders,M., Kerkhof,J., Ekici,A.B., Sticht,H., Sadikovic,B., Reis,A.
            and Vasileiou,G.
  TITLE     The missing link: ARID1B non-truncating variants causing
            Coffin-Siris syndrome due to protein aggregation
  JOURNAL   Hum Genet 143 (8), 965-978 (2024)
   PUBMED   39028335
  REMARK    GeneRIF: The missing link: ARID1B non-truncating variants causing
            Coffin-Siris syndrome due to protein aggregation.
REFERENCE   2  (bases 1 to 10310)
  AUTHORS   Martins-Costa,C., Wiegers,A., Pham,V.A., Sidhaye,J., Doleschall,B.,
            Novatchkova,M., Lendl,T., Piber,M., Peer,A., Moseneder,P.,
            Stuempflen,M., Chow,S.Y.A., Seidl,R., Prayer,D., Hoftberger,R.,
            Kasprian,G., Ikeuchi,Y., Corsini,N.S. and Knoblich,J.A.
  TITLE     ARID1B controls transcriptional programs of axon projection in an
            organoid model of the human corpus callosum
  JOURNAL   Cell Stem Cell 31 (6), 866-885 (2024)
   PUBMED   38718796
  REMARK    GeneRIF: ARID1B controls transcriptional programs of axon
            projection in an organoid model of the human corpus callosum.
REFERENCE   3  (bases 1 to 10310)
  AUTHORS   Huang,X., Li,H., Yang,S., Ma,M., Lian,Y., Wu,X., Qi,X., Wang,X.,
            Rong,W. and Sheng,X.
  TITLE     De novo variation in ARID1B gene causes Coffin-Siris syndrome 1 in
            a Chinese family with excessive early-onset high myopia
  JOURNAL   BMC Med Genomics 17 (1), 142 (2024)
   PUBMED   38790056
  REMARK    GeneRIF: De novo variation in ARID1B gene causes Coffin-Siris
            syndrome 1 in a Chinese family with excessive early-onset high
            myopia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10310)
  AUTHORS   Hurlstone,A.F., Olave,I.A., Barker,N., van Noort,M. and Clevers,H.
  TITLE     Cloning and characterization of hELD/OSA1, a novel BRG1 interacting
            protein
  JOURNAL   Biochem J 364 (Pt 1), 255-264 (2002)
   PUBMED   11988099
  REMARK    GeneRIF: Cloning and characterization of hELD/OSA1, a novel BRG1
            interacting protein.
REFERENCE   5  (bases 1 to 10310)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   6  (bases 1 to 10310)
  AUTHORS   Imbert,G., Saudou,F., Yvert,G., Devys,D., Trottier,Y.,
            Garnier,J.M., Weber,C., Mandel,J.L., Cancel,G., Abbas,N., Durr,A.,
            Didierjean,O., Stevanin,G., Agid,Y. and Brice,A.
  TITLE     Cloning of the gene for spinocerebellar ataxia 2 reveals a locus
            with high sensitivity to expanded CAG/glutamine repeats
  JOURNAL   Nat Genet 14 (3), 285-291 (1996)
   PUBMED   8896557
REFERENCE   7  (bases 1 to 10310)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   8  (bases 1 to 10310)
  AUTHORS   Vergano,S.A., van der Sluijs,P.J. and Santen,G.
  TITLE     ARID1B-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31132234
REFERENCE   9  (bases 1 to 10310)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
REFERENCE   10 (bases 1 to 10310)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355297.20, AL162578.13,
            AL049820.23 and AL591545.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 17, 2019 this sequence version replaced NM_001346813.1.
            
            Summary: This locus encodes an AT-rich DNA interacting
            domain-containing protein. The encoded protein is a component of
            the SWI/SNF chromatin remodeling complex and may play a role in
            cell-cycle activation. The protein encoded by this locus is similar
            to AT-rich interactive domain-containing protein 1A. These two
            proteins function as alternative, mutually exclusive ARID-subunits
            of the SWI/SNF complex. The associated complexes play opposing
            roles. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1927366.1,
                                           SRR14038196.2083939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636930.2/ ENSP00000490491.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2094              AL355297.20        152256-154349
            2095-2289           AL162578.13        34987-35181
            2290-2439           AL162578.13        107136-107285
            2440-2550           AL162578.13        141226-141336
            2551-2794           AL049820.23        91557-91800
            2795-2884           AL049820.23        117367-117456
            2885-3064           AL049820.23        139923-140102
            3065-3392           AL049820.23        155519-155846
            3393-3538           AL049820.23        173935-174080
            3539-3648           AL049820.23        180903-181012
            3649-3807           AL049820.23        181742-181900
            3808-4017           AL591545.6         2357-2566
            4018-4222           AL591545.6         5619-5823
            4223-4361           AL591545.6         11030-11168
            4362-4534           AL591545.6         11426-11598
            4535-4685           AL591545.6         17553-17703
            4686-4782           AL591545.6         20199-20295
            4783-5566           AL591545.6         22093-22876
            5567-5697           AL591545.6         25254-25384
            5698-10310          AL591545.6         27555-32167
FEATURES             Location/Qualifiers
     source          1..10310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..10310
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="AT-rich interaction domain 1B"
                     /db_xref="GeneID:57492"
                     /db_xref="HGNC:HGNC:18040"
                     /db_xref="MIM:614556"
     exon            1..2094
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..7422
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     BRG1-binding protein ELD/OSA1; ELD (eyelid)/OSA protein;
                     BRG1-associated factor 250b; ARID domain-containing
                     protein 1B; AT rich interactive domain 1B (SWI1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 1B
                     isoform 3"
                     /protein_id="NP_001361757.1"
                     /db_xref="CCDS:CCDS87459.2"
                     /db_xref="GeneID:57492"
                     /db_xref="HGNC:HGNC:18040"
                     /db_xref="MIM:614556"
                     /translation="MAARAAAAAAAAAARARARAGSGERRAPPGPRPAPGARDLEAGA
                     RGAAAAAAAPGPMLGGGGDGGGGLNSVHHHPLLPRHELNMAHNAGAAAAAGTHSAKSG
                     GSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPA
                     APPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPIS
                     NNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMG
                     EPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPC
                     FDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGG
                     GGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGV
                     LSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTS
                     PSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
                     AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQ
                     SSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQP
                     YYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLI
                     QQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHL
                     SSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPM
                     PQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQM
                     SQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSA
                     GMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR
                     QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMS
                     PGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASIS
                     SFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFME
                     ERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAAS
                     SLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQS
                     TGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMT
                     PNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQS
                     PSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPN
                     YKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSR
                     ERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQA
                     PPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPS
                     LPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIR
                     REITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINIL
                     LYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKD
                     DSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEK
                     PKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFE
                     SKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDAN
                     PGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNI
                     VRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSK
                     DEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPF
                     PTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNP
                     VCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQ
                     PPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
                     VLFQIGQL"
     exon            2095..2289
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2439
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2550
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2794
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2884
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3064
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3392
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3538
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3648
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3807
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..4017
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..4222
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4223..4361
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4362..4534
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4535..4685
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4686..4782
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..5566
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            5567..5697
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            5698..10310
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      8562
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="major polyA site"
     regulatory      8568..8573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATGAA"
     polyA_site      8578
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     regulatory      8765..8770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATAAA"
     polyA_site      8799
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     regulatory      9859..9864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATAAA"
     polyA_site      9884
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     regulatory      10259..10264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATAAA"
     regulatory      10271..10276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AAGAAA"
     polyA_site      10289
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     polyA_site      10310
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
ORIGIN      
        1 aagccatgct gggcccgata ggctcagcta gtcgtgtatt tacccatatc cgggctagag
       61 aggaaaagag aaaagtttca tttaaacctg aactaaaaac tttcaccatg aaagcacaca
      121 gcaggagcag gcccagagcg taaggcgtgc ccggcccggc gctccggcgg ggcctgcgga
      181 gggggagggg gtcgcggctt cccggcgggc cgcgtggatg cgcacaggag gggccgcggc
      241 ctgaaaagtg ggggttattg tctccccccg ccccccgccc ggcctcgcca cgccgcggcg
      301 atcatggccg cgcgggcagc agcggcggcg gcggcggcgg cggcgcgggc gcgggcgcgg
      361 gcaggcagcg gcgaacggcg ggcgcccccc gggccgcggc cggcgcccgg agcccgggac
      421 ctggaggcgg gggcgcgcgg cgcggcggcg gcggcggcgg caccgggacc catgctgggg
      481 ggcggcggcg acggcggcgg cggcctgaac agtgtgcacc accaccccct gctcccccgt
      541 cacgaactca acatggccca taacgcgggc gccgcggccg ccgccggcac ccacagcgcc
      601 aagagcggcg gctccgaggc ggctctcaag gagggtggaa gcgccgccgc gctgtcctcc
      661 tcctcctcct cctccgcggc ggcagcggcg gcatcctctt cctcctcgtc gggcccgggc
      721 tcggccatgg agacggggct gctccccaac cacaaactga aaaccgttgg cgaagccccc
      781 gccgcgccgc cccaccagca gcaccaccac caccaccatg cccaccacca ccaccaccat
      841 gcccaccacc tccaccacca ccacgcacta cagcagcagc taaaccagtt ccagcagcag
      901 cagcagcagc agcaacagca gcagcagcag cagcagcaac agcaacatcc catttccaac
      961 aacaacagct tgggcggcgc gggcggcggc gcgcctcagc ccggccccga catggagcag
     1021 ccgcaacatg gaggcgccaa ggacagtgct gcgggcggcc aggccgaccc cccgggcccg
     1081 ccgctgctga gcaagccggg cgacgaggac gacgcgccgc ccaagatggg ggagccggcg
     1141 ggcggccgct acgagcaccc gggcttgggc gccctgggca cgcagcagcc gccggtcgcc
     1201 gtgcccgggg gcggcggcgg cccggcggcc gtcccggagt ttaataatta ctatggcagc
     1261 gctgcccctg cgagcggcgg ccccggcggc cgcgctgggc cttgctttga tcaacatggc
     1321 ggacaacaaa gccccgggat ggggatgatg cactccgcct ccgccgccgc cgccggggcc
     1381 cccggcagca tggaccccct gcagaactcc cacgaagggt accccaacag ccagtgcaac
     1441 cattatccgg gctacagccg gcccggcgcg ggcggcggcg gcggcggcgg cggcggagga
     1501 ggaggaggca gcggaggagg aggaggagga ggaggagcag gagcaggagg agcaggagcg
     1561 ggagctgtgg cggcggcggc cgcggcggcg gcggcagcag caggaggcgg cggcggcggc
     1621 ggctatgggg gctcgtccgc ggggtacggg gtgctgagct ccccccggca gcagggcggc
     1681 ggcatgatga tgggccccgg gggcggcggg gccgcgagcc tcagcaaggc ggccgccggc
     1741 tcggcggcgg ggggcttcca gcgcttcgcc ggccagaacc agcacccgtc gggggccacc
     1801 ccgaccctca atcagctgct cacctcgccc agccccatga tgcggagcta cggcggcagc
     1861 taccccgagt acagcagccc cagcgcgccg ccgccgccgc cgtcgcagcc ccagtcccag
     1921 gcggcggcgg cgggggcggc ggcgggcggc cagcaggcgg ccgcgggcat gggcttgggc
     1981 aaggacatgg gcgcccagta cgccgctgcc agcccggcct gggcggccgc gcaacaaagg
     2041 agtcacccgg cgatgagccc cggcaccccc ggaccgacca tgggcagatc ccagggcagc
     2101 ccaatggatc caatggtgat gaagagacct cagttgtatg gcatgggcag taaccctcat
     2161 tctcagcctc agcagagcag tccgtaccca ggaggttcct atggccctcc aggcccacag
     2221 cggtatccaa ttggcatcca gggtcggact cccggggcca tggccggaat gcagtaccct
     2281 cagcagcaga tgccacctca gtatggacag caaggtgtga gtggttactg ccagcagggc
     2341 caacagccat attacagcca gcagccgcag cccccgcacc tcccacccca ggcgcagtat
     2401 ctgccgtccc agtcccagca gaggtaccag ccgcagcagg acatgtctca ggaaggctat
     2461 ggaactagat ctcaacctcc tctggccccc ggaaaaccta accatgaaga cttgaactta
     2521 atacagcaag aaagaccatc aagtttacca gatctgtctg gctccattga tgacctcccc
     2581 acgggaacgg aagcaacttt gagctcagca gtcagtgcat ccgggtccac gagcagccaa
     2641 ggggatcaga gcaacccggc gcagtcgcct ttctccccac atgcgtcccc tcatctctcc
     2701 agcatcccgg ggggcccatc tccctctcct gttggctctc ctgtaggaag caaccagtct
     2761 cgatctggcc caatctctcc tgcaagtatc ccaggtagtc agatgcctcc gcagccaccc
     2821 gggagccagt cagaatccag ttcccatccc gccttgagcc agtcaccaat gccacaggaa
     2881 agaggtttta tggcaggcac acaaagaaac cctcagatgg ctcagtatgg acctcaacag
     2941 acaggaccat ccatgtcgcc tcatccttct cctgggggcc agatgcatgc tggaatcagt
     3001 agctttcagc agagtaactc aagtgggact tacggtccac agatgagcca gtatggacca
     3061 caaggtaact actccagacc cccagcgtat agtggggtgc ccagtgcaag ctacagcggc
     3121 ccagggcccg gtatgggtat cagtgccaac aaccagatgc atggacaagg gccaagccag
     3181 ccatgtggtg ctgtgcccct gggacgaatg ccatcagctg ggatgcagaa cagaccattt
     3241 cctggaaata tgagcagcat gacccccagt tctcctggca tgtctcagca gggagggcca
     3301 ggaatggggc cgccaatgcc aactgtgaac cgtaaggcac aggaggcagc cgcagcagtg
     3361 atgcaggctg ctgcgaactc agcacaaagc aggcaaggca gtttccccgg catgaaccag
     3421 agtggactta tggcttccag ctctccctac agccagccca tgaacaacag ctctagcctg
     3481 atgaacacgc aggcgccgcc ctacagcatg gcgcccgcca tggtgaacag ctcggcagca
     3541 tctgtgggtc ttgcagatat gatgtctcct ggtgaatcca aactgcccct gcctctcaaa
     3601 gcagacggca aagaagaagg cactccacag cccgagagca agtcaaagga tagctacagc
     3661 tctcagggta tttctcagcc cccaacccca ggcaacctgc cagtcccttc cccaatgtcc
     3721 cccagctctg ctagcatctc ctcatttcat ggagatgaaa gtgatagcat tagcagccca
     3781 ggctggccaa agactccatc aagccctaag tccagctcct ccaccactac tggggagaag
     3841 atcacgaagg tgtacgagct ggggaatgag ccagagagaa agctctgggt cgaccgatac
     3901 ctcaccttca tggaagagag aggctctcct gtctcaagtc tgcctgccgt gggcaagaag
     3961 cccctggacc tgttccgact ctacgtctgc gtcaaagaga tcgggggttt ggcccaggtt
     4021 aataaaaaca agaagtggcg tgagctggca accaacctaa acgttggcac ctcaagcagt
     4081 gcagcgagct ccctgaaaaa gcagtatatt cagtacctgt ttgcctttga gtgcaagatc
     4141 gaacgtgggg aggagccccc gccggaagtc ttcagcaccg gggacaccaa aaagcagccc
     4201 aagctccagc cgccatctcc tgctaactcg ggatccttgc aaggcccaca gaccccccag
     4261 tcaactggca gcaattccat ggcagaggtt ccaggtgacc tgaagccacc taccccagcc
     4321 tccacccctc acggccagat gactccaatg caaggtggaa gaagcagtac aatcagtgtg
     4381 cacgacccat tctcagatgt gagtgattca tccttcccga aacggaactc catgactcca
     4441 aacgccccct accagcaggg catgagcatg cccgatgtga tgggcaggat gccctatgag
     4501 cccaacaagg acccctttgg gggaatgaga aaagtgcctg gaagcagcga gccctttatg
     4561 acgcaaggac agatgcccaa cagcagcatg caggacatgt acaaccaaag tccctccgga
     4621 gcaatgtcta acctgggcat ggggcagcgc cagcagtttc cctatggagc cagttacgac
     4681 cgaaggcatg aaccttatgg gcagcagtat ccaggccaag gccctccctc gggacagccg
     4741 ccgtatggag ggcaccagcc cggcctgtac ccacagcagc cgaattacaa acgccatatg
     4801 gacggcatgt acgggccccc agccaagcgc cacgagggcg acatgtacaa catgcagtac
     4861 agcagccagc agcaggagat gtacaaccag tatggaggct cctactcggg cccggaccgc
     4921 aggcccatcc agggccagta cccgtatccc tacagcaggg agaggatgca gggcccgggg
     4981 cagatccaga cacacggaat cccgcctcag atgatgggcg gcccgctgca gtcgtcctcc
     5041 agtgaggggc ctcagcagaa tatgtgggca gcacgcaatg atatgcctta tccctaccag
     5101 aacaggcagg gccctggcgg ccctacacag gcgccccctt acccaggcat gaaccgcaca
     5161 gacgatatga tggtacccga tcagaggata aatcatgaga gccagtggcc ttctcacgtc
     5221 agccagcgtc agccttatat gtcgtcctca gcctccatgc agcccatcac acgcccacca
     5281 cagccgtcct accagacgcc accgtcactg ccaaatcaca tctccagggc gcccagccca
     5341 gcgtccttcc agcgctccct ggagaaccgc atgtctccaa gcaagtctcc ttttctgccg
     5401 tctatgaaga tgcagaaggt catgcccacg gtccccacat cccaggtcac cgggccacca
     5461 ccccaaccac ccccaatcag aagggagatc acctttcctc ctggctcagt agaagcatca
     5521 caaccagtct tgaaacaaag gcgaaagatt acctccaaag atatcgttac tcctgaggcg
     5581 tggcgtgtga tgatgtccct taaatcaggt cttttggctg agagtacgtg ggctttggac
     5641 actattaata ttcttctgta tgatgacagc actgttgcta ctttcaatct ctcccagttg
     5701 tctggatttc tcgaactttt agtcgagtac tttagaaaat gcctgattga catttttgga
     5761 attcttatgg aatatgaagt gggagacccc agccaaaaag cacttgatca caacgcagca
     5821 aggaaggatg acagccagtc cttggcagac gattctggga aagaggagga agatgctgaa
     5881 tgtattgatg acgacgagga agacgaggag gatgaggagg aagacagcga gaagacagaa
     5941 agcgatgaaa agagcagcat cgctctgact gccccggacg ccgctgcaga cccaaaggag
     6001 aagcccaagc aagccagtaa gttcgacaag ctgccaataa agatagtcaa aaagaacaac
     6061 ctgtttgttg ttgaccgatc tgacaagttg gggcgtgtgc aggagttcaa tagtggcctt
     6121 ctgcactggc agctcggcgg gggtgacacc accgagcaca ttcagactca ctttgagagc
     6181 aagatggaaa ttcctcctcg caggcgccca cctcccccct taagctccgc aggtagaaag
     6241 aaagagcaag aaggcaaagg cgactctgaa gagcagcaag agaaaagcat catagcaacc
     6301 atcgatgacg tcctctctgc tcggccaggg gcattgcctg aagacgcaaa ccctgggccc
     6361 cagaccgaaa gcagtaagtt tccctttggt atccagcaag ccaaaagtca ccggaacatc
     6421 aagctgctgg aggacgagcc caggagccga gacgagactc ctctgtgtac catcgcgcac
     6481 tggcaggact cgctggctaa gcgatgcatc tgtgtgtcca atattgtccg tagcttgtca
     6541 ttcgtgcctg gcaatgatgc cgaaatgtcc aaacatccag gcctggtgct gatcctgggg
     6601 aagctgattc ttcttcacca cgagcatcca gagagaaagc gagcaccgca gacctatgag
     6661 aaagaggagg atgaggacaa gggggtggcc tgcagcaaag atgagtggtg gtgggactgc
     6721 ctcgaggtct tgagggataa cacgttggtc acgttggcca acatttccgg gcagctagac
     6781 ttgtctgctt acacggaaag catctgcttg ccaattttgg atggcttgct gcactggatg
     6841 gtgtgcccgt ctgcagaggc acaagatccc tttccaactg tgggacccaa ctcggtcctg
     6901 tcgcctcaga gacttgtgct ggagaccctc tgtaaactca gtatccagga caataatgtg
     6961 gacctgatct tggccactcc tccatttagt cgtcaggaga aattctatgc tacattagtt
     7021 aggtacgttg gggatcgcaa aaacccagtc tgtcgagaaa tgtccatggc gcttttatcg
     7081 aaccttgccc aaggggacgc actagcagca agggccatag ctgtgcagaa aggaagcatt
     7141 ggaaacttga taagcttcct agaggatggg gtcacgatgg cccagtacca gcagagccag
     7201 cacaacctca tgcacatgca gcccccgccc ctggaaccac ctagcgtaga catgatgtgc
     7261 agggcggcca aggctttgct agccatggcc agagtggacg aaaaccgctc ggaattcctt
     7321 ttgcacgagg gccggttgct ggatatctcg atatcagctg tcctgaactc tctggttgca
     7381 tctgtcatct gtgatgtact gtttcagatt gggcagttat gacataagtg agaaggcaag
     7441 catgtgtgag tgaagattag agggtcacat ataactggct gttttctgtt cttgtttatc
     7501 cagcgtagga agaaggaaaa gaaaatcttt gctcctctgc cccattcact atttaccaat
     7561 tgggaattaa agaaataatt aatttgaaca gttatgaaat taatatttgc tgtctgtgtg
     7621 tataagtaca tcctttgggg tttttttttt ctcttttttt taaccaaagt tgctgtctag
     7681 tgcattcaaa ggtcactttt tgttcttcac agatcttttt aatgttcttt cccatgttgt
     7741 attgcatttt tgggggaagc aaattgactt taaagaaaaa agttgtggca aaagatgcta
     7801 agatgcgaaa atttcaccac actgagtcaa aaaggtgaaa aattatccat ttcctatgcg
     7861 ttttactcct cagagaatga aaaaaactgc atcccatcac ccaaagttct gtgcaataga
     7921 aatttctaca gatacaggta taggggctca aggaggtatg tcggtcagta gtcaaaacta
     7981 tgaaatgata ctggtttctc cacaggaata tggttccatt aggctgggag caaaaacaat
     8041 gttttttaag attgagaata catacctgac aacgatccgg aaactgctcc tcaccactcc
     8101 cgtcatgcct gctgtcggcg tttgaccttc cacgtgacag ttcttcacaa ttcctttcat
     8161 cattttttaa atattttttt tactgcctat gggctgtgat gtatatagaa gttgtacatt
     8221 aaacataccc tcattttttt cttttctttt tttttttttt ttttagtaca aagttttagt
     8281 ttctttttca tgatgtggta actacgaagt gatggtagat ttaaataatt ttttattttt
     8341 attttatata ttttttcatt agggccatat ctccaaaaaa agaaagaaaa aatacaaaaa
     8401 acaaaaacaa aaaaaaaaga gggtaatgta caagtttctg tatgtataaa gtcatgctcg
     8461 atttcaggag agcagctgat cacaatttgc ttcatgaatc aaggtgtgga aatggttata
     8521 tatggattga tttagaaaat ggttaccagt acagtcaaaa aagagaaaat gaaaaaaata
     8581 caactaaaag gaagaaacac aacttcaaag atttttcagt gatgagaatc cacatttgta
     8641 tttcaagata atgtagttta aaaaaaaaaa aaagaaaaaa acttgatgta aattcctcct
     8701 tttcctctgg cttaatgaat atcatttatt cagtataaaa tctttatatg ttccacatgt
     8761 taagaataaa tgtacattaa atcttgttaa gcactgtgat gggtgttctt gaatactgtt
     8821 ctagtttcct taaagtggtt tcctagtaat caagttattt acaagaaata ggggaatgca
     8881 gcagtgtatt cacattataa aaccctacat ttggaagaga cctttagggg ttacctactt
     8941 tagagtgggg agcaacagtt tgattttctc aaattactta gctaattagt ctttctttga
     9001 agcaattaac tctaacgaca ttgaggtatg atcattttca gtatttatgg gaggtggctg
     9061 ctgacccact tgaggtgaga tctcagaagc ttaactggcc tgaaaatgta acattctgcc
     9121 ttttactaac tccatcttag tttaatcaaa gttcaatcta ttccttgttt cttctgtgtg
     9181 cctcagagtt attttgcatt tagtttactc caccgtgtat aatatttata ctgtgcaatg
     9241 ttaaaaaaga atctgttata ttgtatgtgg tgtacatagt gcaaagtgat gatttctatt
     9301 tcagggcata ttatggttct catattcctt cctacctggt gcacagtagc tttttaatac
     9361 tagtcacttc taatttaaac tttctcttcc tgggtcattg actgttactg tgtaataatc
     9421 gatttctttg aaactgctgc ataattatgc tgttagtgga cctctacctc ttctcttccc
     9481 tctcccaatc acagtatact cagaatcccc agcccctcgc atacattgtg tcggttcaca
     9541 ttactcacag taatatatgg aagagttaga caagaacatg cagttacagt cattgtgaga
     9601 cgtgactctc cagtgtcacg aggaaaaaaa tcatcttttc tgcaaacagt ctctcatctg
     9661 tcaactccca cattactgag tcaaacagtc ttcttacata acaatgcaac caaatatatg
     9721 ttgaattaaa gacccattta taattctgct ttaaatacat ctgcttgcta agaacagatt
     9781 tcagtgctcc aagcttcaaa tatggagatt tgtaagaggg aattcaatat tattctaatt
     9841 tctctcttac agagtacaaa taaaaggtgt atacaaactc cgaacatatc cagtattcca
     9901 attcctttgt caatcagaag agtaaaataa ttaacaaaag actgttgtta tggtttgcat
     9961 tgtaaccgat acgcagagtc tgaccgttgg gcaacaagtt tttctatcct gatgcgcaac
    10021 acagtctcta gagactaatc caggaagact ttagcctcct ttccatattc tcacccccga
    10081 atcaagattt acagaagccc acgaagaatt tacagcctgc ttgagatcat cttgcctata
    10141 aactgagtta ttgctttgtc ctaaaaatta gtcggttttt ttttttctat gaggcttttc
    10201 agaaatttac aggatgccca gactttacat gtgtaccaaa aaaaaaaaaa agataaaaaa
    10261 taaaggtgca aagaaagttt agtattttgg aatggtgcta taaagttgaa
//
