LOCUS       NM_001371656           10807 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens AT-rich interaction domain 1B (ARID1B), transcript
            variant 5, mRNA.
ACCESSION   NM_001371656
VERSION     NM_001371656.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10807)
  AUTHORS   Bosch,E., Guse,E., Kirchner,P., Winterpacht,A., Walther,M.,
            Alders,M., Kerkhof,J., Ekici,A.B., Sticht,H., Sadikovic,B., Reis,A.
            and Vasileiou,G.
  TITLE     The missing link: ARID1B non-truncating variants causing
            Coffin-Siris syndrome due to protein aggregation
  JOURNAL   Hum Genet 143 (8), 965-978 (2024)
   PUBMED   39028335
  REMARK    GeneRIF: The missing link: ARID1B non-truncating variants causing
            Coffin-Siris syndrome due to protein aggregation.
REFERENCE   2  (bases 1 to 10807)
  AUTHORS   Martins-Costa,C., Wiegers,A., Pham,V.A., Sidhaye,J., Doleschall,B.,
            Novatchkova,M., Lendl,T., Piber,M., Peer,A., Moseneder,P.,
            Stuempflen,M., Chow,S.Y.A., Seidl,R., Prayer,D., Hoftberger,R.,
            Kasprian,G., Ikeuchi,Y., Corsini,N.S. and Knoblich,J.A.
  TITLE     ARID1B controls transcriptional programs of axon projection in an
            organoid model of the human corpus callosum
  JOURNAL   Cell Stem Cell 31 (6), 866-885 (2024)
   PUBMED   38718796
  REMARK    GeneRIF: ARID1B controls transcriptional programs of axon
            projection in an organoid model of the human corpus callosum.
REFERENCE   3  (bases 1 to 10807)
  AUTHORS   Huang,X., Li,H., Yang,S., Ma,M., Lian,Y., Wu,X., Qi,X., Wang,X.,
            Rong,W. and Sheng,X.
  TITLE     De novo variation in ARID1B gene causes Coffin-Siris syndrome 1 in
            a Chinese family with excessive early-onset high myopia
  JOURNAL   BMC Med Genomics 17 (1), 142 (2024)
   PUBMED   38790056
  REMARK    GeneRIF: De novo variation in ARID1B gene causes Coffin-Siris
            syndrome 1 in a Chinese family with excessive early-onset high
            myopia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10807)
  AUTHORS   Hurlstone,A.F., Olave,I.A., Barker,N., van Noort,M. and Clevers,H.
  TITLE     Cloning and characterization of hELD/OSA1, a novel BRG1 interacting
            protein
  JOURNAL   Biochem J 364 (Pt 1), 255-264 (2002)
   PUBMED   11988099
  REMARK    GeneRIF: Cloning and characterization of hELD/OSA1, a novel BRG1
            interacting protein.
REFERENCE   5  (bases 1 to 10807)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   6  (bases 1 to 10807)
  AUTHORS   Imbert,G., Saudou,F., Yvert,G., Devys,D., Trottier,Y.,
            Garnier,J.M., Weber,C., Mandel,J.L., Cancel,G., Abbas,N., Durr,A.,
            Didierjean,O., Stevanin,G., Agid,Y. and Brice,A.
  TITLE     Cloning of the gene for spinocerebellar ataxia 2 reveals a locus
            with high sensitivity to expanded CAG/glutamine repeats
  JOURNAL   Nat Genet 14 (3), 285-291 (1996)
   PUBMED   8896557
REFERENCE   7  (bases 1 to 10807)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   8  (bases 1 to 10807)
  AUTHORS   Vergano,S.A., van der Sluijs,P.J. and Santen,G.
  TITLE     ARID1B-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31132234
REFERENCE   9  (bases 1 to 10807)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
REFERENCE   10 (bases 1 to 10807)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355297.20, AL162578.13,
            AL049820.23 and AL591545.6.
            
            Summary: This locus encodes an AT-rich DNA interacting
            domain-containing protein. The encoded protein is a component of
            the SWI/SNF chromatin remodeling complex and may play a role in
            cell-cycle activation. The protein encoded by this locus is similar
            to AT-rich interactive domain-containing protein 1A. These two
            proteins function as alternative, mutually exclusive ARID-subunits
            of the SWI/SNF complex. The associated complexes play opposing
            roles. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF468300.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2144335 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL355297.20        150904-151004
            102-2711            AL355297.20        151740-154349
            2712-2906           AL162578.13        34987-35181
            2907-2945           AL162578.13        77374-77412
            2946-3095           AL162578.13        107136-107285
            3096-3206           AL162578.13        141226-141336
            3207-3450           AL049820.23        91557-91800
            3451-3540           AL049820.23        117367-117456
            3541-3720           AL049820.23        139923-140102
            3721-4048           AL049820.23        155519-155846
            4049-4194           AL049820.23        173935-174080
            4195-4304           AL049820.23        180903-181012
            4305-4514           AL591545.6         2357-2566
            4515-4719           AL591545.6         5619-5823
            4720-4858           AL591545.6         11030-11168
            4859-5031           AL591545.6         11426-11598
            5032-5182           AL591545.6         17553-17703
            5183-5279           AL591545.6         20199-20295
            5280-6063           AL591545.6         22093-22876
            6064-6194           AL591545.6         25254-25384
            6195-10807          AL591545.6         27555-32167
FEATURES             Location/Qualifiers
     source          1..10807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..10807
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="AT-rich interaction domain 1B"
                     /db_xref="GeneID:57492"
                     /db_xref="HGNC:HGNC:18040"
                     /db_xref="MIM:614556"
     exon            1..101
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            102..2711
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             921..7919
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="isoform 2 is encoded by transcript variant 5;
                     BRG1-binding protein ELD/OSA1; ELD (eyelid)/OSA protein;
                     BRG1-associated factor 250b; ARID domain-containing
                     protein 1B; AT rich interactive domain 1B (SWI1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 1B
                     isoform 2"
                     /protein_id="NP_001358585.1"
                     /db_xref="CCDS:CCDS55072.2"
                     /db_xref="GeneID:57492"
                     /db_xref="HGNC:HGNC:18040"
                     /db_xref="MIM:614556"
                     /translation="MAARAAAAAAAAAARARARAGSGERRAPPGPRPAPGARDLEAGA
                     RGAAAAAAAPGPMLGGGGDGGGGLNSVHHHPLLPRHELNMAHNAGAAAAAGTHSAKSG
                     GSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPA
                     APPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPIS
                     NNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMG
                     EPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPC
                     FDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGG
                     GGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGV
                     LSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTS
                     PSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
                     AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQ
                     SSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQ
                     QGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPL
                     APGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNP
                     AQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQS
                     ESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSF
                     QQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQ
                     PCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAA
                     AVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVN
                     SSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYEL
                     GNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKK
                     WRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQ
                     PPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVH
                     DPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPF
                     MTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPS
                     GQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSY
                     SGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARN
                     DMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSA
                     SMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMP
                     TVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSL
                     KSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
                     EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDE
                     KSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLL
                     HWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIA
                     TIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCT
                     IAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRA
                     PQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPIL
                     DGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSR
                     QEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLED
                     GVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLL
                     DISISAVLNSLVASVICDVLFQIGQL"
     exon            2712..2906
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..2945
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3095
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3206
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3450
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3540
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3720
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..4048
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4049..4194
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4304
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..4514
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4515..4719
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4858
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4859..5031
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5182
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5279
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            5280..6063
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            6064..6194
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            6195..10807
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      9059
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="major polyA site"
     regulatory      9065..9070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATGAA"
     polyA_site      9075
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     regulatory      9262..9267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATAAA"
     polyA_site      9296
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     regulatory      10356..10361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATAAA"
     polyA_site      10381
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     regulatory      10756..10761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AATAAA"
     regulatory      10768..10773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
                     /note="hexamer: AAGAAA"
     polyA_site      10786
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
     polyA_site      10807
                     /gene="ARID1B"
                     /gene_synonym="6A3-5; BAF250B; BRIGHT; CSS1; DAN15;
                     ELD/OSA1; MRD12; OSA2; P250R; SMARCF2"
ORIGIN      
        1 gtcaaacaaa taaccactgc tgcagtggaa atgaactaaa atagttttta tggaaagctg
       61 aagaatgaaa taattttgga aaactatact ctaccaaaac cttggaagaa gttgtgggaa
      121 ttacgccgat ggcccgaaat caaggcagag gcgaacgttc tgaaaattac ataactcctg
      181 ggagagaccg tgcttttgca gattgcctaa atattttctt tctccgtcgg ctccttgtaa
      241 cctctgaggc caatagacaa ctttgtttcc cagcccttct ccctcttttg tctgctcgtc
      301 agactcgttt tccacctttg tatcgttcct tttagacgtg aaaacaaaca tgcgaacgcc
      361 cggttggcaa ggagacagcg gcccgggggg aaagtgcagg ttccggccgc cccacgccgc
      421 cgcgctccga gcggccgccg agccgccccg gccccggccc cggccccagc cttagcccaa
      481 gcccggctgg gtcccgcgag gctgcgccgg ggcgggcggc ggcggcccgg ggacgagtcc
      541 agtccgcgtt ttgcgagtgc gcgggagtaa tgcgagcgaa gtggataata gttgctcgag
      601 ctcgcccgct gcctctcaag ccatgctggg cccgataggc tcagctagtc gtgtatttac
      661 ccatatccgg gctagagagg aaaagagaaa agtttcattt aaacctgaac taaaaacttt
      721 caccatgaaa gcacacagca ggagcaggcc cagagcgtaa ggcgtgcccg gcccggcgct
      781 ccggcggggc ctgcggaggg ggagggggtc gcggcttccc ggcgggccgc gtggatgcgc
      841 acaggagggg ccgcggcctg aaaagtgggg gttattgtct ccccccgccc cccgcccggc
      901 ctcgccacgc cgcggcgatc atggccgcgc gggcagcagc ggcggcggcg gcggcggcgg
      961 cgcgggcgcg ggcgcgggca ggcagcggcg aacggcgggc gccccccggg ccgcggccgg
     1021 cgcccggagc ccgggacctg gaggcggggg cgcgcggcgc ggcggcggcg gcggcggcac
     1081 cgggacccat gctggggggc ggcggcgacg gcggcggcgg cctgaacagt gtgcaccacc
     1141 accccctgct cccccgtcac gaactcaaca tggcccataa cgcgggcgcc gcggccgccg
     1201 ccggcaccca cagcgccaag agcggcggct ccgaggcggc tctcaaggag ggtggaagcg
     1261 ccgccgcgct gtcctcctcc tcctcctcct ccgcggcggc agcggcggca tcctcttcct
     1321 cctcgtcggg cccgggctcg gccatggaga cggggctgct ccccaaccac aaactgaaaa
     1381 ccgttggcga agcccccgcc gcgccgcccc accagcagca ccaccaccac caccatgccc
     1441 accaccacca ccaccatgcc caccacctcc accaccacca cgcactacag cagcagctaa
     1501 accagttcca gcagcagcag cagcagcagc aacagcagca gcagcagcag cagcaacagc
     1561 aacatcccat ttccaacaac aacagcttgg gcggcgcggg cggcggcgcg cctcagcccg
     1621 gccccgacat ggagcagccg caacatggag gcgccaagga cagtgctgcg ggcggccagg
     1681 ccgacccccc gggcccgccg ctgctgagca agccgggcga cgaggacgac gcgccgccca
     1741 agatggggga gccggcgggc ggccgctacg agcacccggg cttgggcgcc ctgggcacgc
     1801 agcagccgcc ggtcgccgtg cccgggggcg gcggcggccc ggcggccgtc ccggagttta
     1861 ataattacta tggcagcgct gcccctgcga gcggcggccc cggcggccgc gctgggcctt
     1921 gctttgatca acatggcgga caacaaagcc ccgggatggg gatgatgcac tccgcctccg
     1981 ccgccgccgc cggggccccc ggcagcatgg accccctgca gaactcccac gaagggtacc
     2041 ccaacagcca gtgcaaccat tatccgggct acagccggcc cggcgcgggc ggcggcggcg
     2101 gcggcggcgg cggaggagga ggaggcagcg gaggaggagg aggaggagga ggagcaggag
     2161 caggaggagc aggagcggga gctgtggcgg cggcggccgc ggcggcggcg gcagcagcag
     2221 gaggcggcgg cggcggcggc tatgggggct cgtccgcggg gtacggggtg ctgagctccc
     2281 cccggcagca gggcggcggc atgatgatgg gccccggggg cggcggggcc gcgagcctca
     2341 gcaaggcggc cgccggctcg gcggcggggg gcttccagcg cttcgccggc cagaaccagc
     2401 acccgtcggg ggccaccccg accctcaatc agctgctcac ctcgcccagc cccatgatgc
     2461 ggagctacgg cggcagctac cccgagtaca gcagccccag cgcgccgccg ccgccgccgt
     2521 cgcagcccca gtcccaggcg gcggcggcgg gggcggcggc gggcggccag caggcggccg
     2581 cgggcatggg cttgggcaag gacatgggcg cccagtacgc cgctgccagc ccggcctggg
     2641 cggccgcgca acaaaggagt cacccggcga tgagccccgg cacccccgga ccgaccatgg
     2701 gcagatccca gggcagccca atggatccaa tggtgatgaa gagacctcag ttgtatggca
     2761 tgggcagtaa ccctcattct cagcctcagc agagcagtcc gtacccagga ggttcctatg
     2821 gccctccagg cccacagcgg tatccaattg gcatccaggg tcggactccc ggggccatgg
     2881 ccggaatgca gtaccctcag cagcaggact ctggagatgc cacatggaaa gaaacattct
     2941 ggttgatgcc acctcagtat ggacagcaag gtgtgagtgg ttactgccag cagggccaac
     3001 agccatatta cagccagcag ccgcagcccc cgcacctccc accccaggcg cagtatctgc
     3061 cgtcccagtc ccagcagagg taccagccgc agcaggacat gtctcaggaa ggctatggaa
     3121 ctagatctca acctcctctg gcccccggaa aacctaacca tgaagacttg aacttaatac
     3181 agcaagaaag accatcaagt ttaccagatc tgtctggctc cattgatgac ctccccacgg
     3241 gaacggaagc aactttgagc tcagcagtca gtgcatccgg gtccacgagc agccaagggg
     3301 atcagagcaa cccggcgcag tcgcctttct ccccacatgc gtcccctcat ctctccagca
     3361 tcccgggggg cccatctccc tctcctgttg gctctcctgt aggaagcaac cagtctcgat
     3421 ctggcccaat ctctcctgca agtatcccag gtagtcagat gcctccgcag ccacccggga
     3481 gccagtcaga atccagttcc catcccgcct tgagccagtc accaatgcca caggaaagag
     3541 gttttatggc aggcacacaa agaaaccctc agatggctca gtatggacct caacagacag
     3601 gaccatccat gtcgcctcat ccttctcctg ggggccagat gcatgctgga atcagtagct
     3661 ttcagcagag taactcaagt gggacttacg gtccacagat gagccagtat ggaccacaag
     3721 gtaactactc cagaccccca gcgtatagtg gggtgcccag tgcaagctac agcggcccag
     3781 ggcccggtat gggtatcagt gccaacaacc agatgcatgg acaagggcca agccagccat
     3841 gtggtgctgt gcccctggga cgaatgccat cagctgggat gcagaacaga ccatttcctg
     3901 gaaatatgag cagcatgacc cccagttctc ctggcatgtc tcagcaggga gggccaggaa
     3961 tggggccgcc aatgccaact gtgaaccgta aggcacagga ggcagccgca gcagtgatgc
     4021 aggctgctgc gaactcagca caaagcaggc aaggcagttt ccccggcatg aaccagagtg
     4081 gacttatggc ttccagctct ccctacagcc agcccatgaa caacagctct agcctgatga
     4141 acacgcaggc gccgccctac agcatggcgc ccgccatggt gaacagctcg gcagcatctg
     4201 tgggtcttgc agatatgatg tctcctggtg aatccaaact gcccctgcct ctcaaagcag
     4261 acggcaaaga agaaggcact ccacagcccg agagcaagtc aaagaagtcc agctcctcca
     4321 ccactactgg ggagaagatc acgaaggtgt acgagctggg gaatgagcca gagagaaagc
     4381 tctgggtcga ccgatacctc accttcatgg aagagagagg ctctcctgtc tcaagtctgc
     4441 ctgccgtggg caagaagccc ctggacctgt tccgactcta cgtctgcgtc aaagagatcg
     4501 ggggtttggc ccaggttaat aaaaacaaga agtggcgtga gctggcaacc aacctaaacg
     4561 ttggcacctc aagcagtgca gcgagctccc tgaaaaagca gtatattcag tacctgtttg
     4621 cctttgagtg caagatcgaa cgtggggagg agcccccgcc ggaagtcttc agcaccgggg
     4681 acaccaaaaa gcagcccaag ctccagccgc catctcctgc taactcggga tccttgcaag
     4741 gcccacagac cccccagtca actggcagca attccatggc agaggttcca ggtgacctga
     4801 agccacctac cccagcctcc acccctcacg gccagatgac tccaatgcaa ggtggaagaa
     4861 gcagtacaat cagtgtgcac gacccattct cagatgtgag tgattcatcc ttcccgaaac
     4921 ggaactccat gactccaaac gccccctacc agcagggcat gagcatgccc gatgtgatgg
     4981 gcaggatgcc ctatgagccc aacaaggacc cctttggggg aatgagaaaa gtgcctggaa
     5041 gcagcgagcc ctttatgacg caaggacaga tgcccaacag cagcatgcag gacatgtaca
     5101 accaaagtcc ctccggagca atgtctaacc tgggcatggg gcagcgccag cagtttccct
     5161 atggagccag ttacgaccga aggcatgaac cttatgggca gcagtatcca ggccaaggcc
     5221 ctccctcggg acagccgccg tatggagggc accagcccgg cctgtaccca cagcagccga
     5281 attacaaacg ccatatggac ggcatgtacg ggcccccagc caagcgccac gagggcgaca
     5341 tgtacaacat gcagtacagc agccagcagc aggagatgta caaccagtat ggaggctcct
     5401 actcgggccc ggaccgcagg cccatccagg gccagtaccc gtatccctac agcagggaga
     5461 ggatgcaggg cccggggcag atccagacac acggaatccc gcctcagatg atgggcggcc
     5521 cgctgcagtc gtcctccagt gaggggcctc agcagaatat gtgggcagca cgcaatgata
     5581 tgccttatcc ctaccagaac aggcagggcc ctggcggccc tacacaggcg cccccttacc
     5641 caggcatgaa ccgcacagac gatatgatgg tacccgatca gaggataaat catgagagcc
     5701 agtggccttc tcacgtcagc cagcgtcagc cttatatgtc gtcctcagcc tccatgcagc
     5761 ccatcacacg cccaccacag ccgtcctacc agacgccacc gtcactgcca aatcacatct
     5821 ccagggcgcc cagcccagcg tccttccagc gctccctgga gaaccgcatg tctccaagca
     5881 agtctccttt tctgccgtct atgaagatgc agaaggtcat gcccacggtc cccacatccc
     5941 aggtcaccgg gccaccaccc caaccacccc caatcagaag ggagatcacc tttcctcctg
     6001 gctcagtaga agcatcacaa ccagtcttga aacaaaggcg aaagattacc tccaaagata
     6061 tcgttactcc tgaggcgtgg cgtgtgatga tgtcccttaa atcaggtctt ttggctgaga
     6121 gtacgtgggc tttggacact attaatattc ttctgtatga tgacagcact gttgctactt
     6181 tcaatctctc ccagttgtct ggatttctcg aacttttagt cgagtacttt agaaaatgcc
     6241 tgattgacat ttttggaatt cttatggaat atgaagtggg agaccccagc caaaaagcac
     6301 ttgatcacaa cgcagcaagg aaggatgaca gccagtcctt ggcagacgat tctgggaaag
     6361 aggaggaaga tgctgaatgt attgatgacg acgaggaaga cgaggaggat gaggaggaag
     6421 acagcgagaa gacagaaagc gatgaaaaga gcagcatcgc tctgactgcc ccggacgccg
     6481 ctgcagaccc aaaggagaag cccaagcaag ccagtaagtt cgacaagctg ccaataaaga
     6541 tagtcaaaaa gaacaacctg tttgttgttg accgatctga caagttgggg cgtgtgcagg
     6601 agttcaatag tggccttctg cactggcagc tcggcggggg tgacaccacc gagcacattc
     6661 agactcactt tgagagcaag atggaaattc ctcctcgcag gcgcccacct ccccccttaa
     6721 gctccgcagg tagaaagaaa gagcaagaag gcaaaggcga ctctgaagag cagcaagaga
     6781 aaagcatcat agcaaccatc gatgacgtcc tctctgctcg gccaggggca ttgcctgaag
     6841 acgcaaaccc tgggccccag accgaaagca gtaagtttcc ctttggtatc cagcaagcca
     6901 aaagtcaccg gaacatcaag ctgctggagg acgagcccag gagccgagac gagactcctc
     6961 tgtgtaccat cgcgcactgg caggactcgc tggctaagcg atgcatctgt gtgtccaata
     7021 ttgtccgtag cttgtcattc gtgcctggca atgatgccga aatgtccaaa catccaggcc
     7081 tggtgctgat cctggggaag ctgattcttc ttcaccacga gcatccagag agaaagcgag
     7141 caccgcagac ctatgagaaa gaggaggatg aggacaaggg ggtggcctgc agcaaagatg
     7201 agtggtggtg ggactgcctc gaggtcttga gggataacac gttggtcacg ttggccaaca
     7261 tttccgggca gctagacttg tctgcttaca cggaaagcat ctgcttgcca attttggatg
     7321 gcttgctgca ctggatggtg tgcccgtctg cagaggcaca agatcccttt ccaactgtgg
     7381 gacccaactc ggtcctgtcg cctcagagac ttgtgctgga gaccctctgt aaactcagta
     7441 tccaggacaa taatgtggac ctgatcttgg ccactcctcc atttagtcgt caggagaaat
     7501 tctatgctac attagttagg tacgttgggg atcgcaaaaa cccagtctgt cgagaaatgt
     7561 ccatggcgct tttatcgaac cttgcccaag gggacgcact agcagcaagg gccatagctg
     7621 tgcagaaagg aagcattgga aacttgataa gcttcctaga ggatggggtc acgatggccc
     7681 agtaccagca gagccagcac aacctcatgc acatgcagcc cccgcccctg gaaccaccta
     7741 gcgtagacat gatgtgcagg gcggccaagg ctttgctagc catggccaga gtggacgaaa
     7801 accgctcgga attccttttg cacgagggcc ggttgctgga tatctcgata tcagctgtcc
     7861 tgaactctct ggttgcatct gtcatctgtg atgtactgtt tcagattggg cagttatgac
     7921 ataagtgaga aggcaagcat gtgtgagtga agattagagg gtcacatata actggctgtt
     7981 ttctgttctt gtttatccag cgtaggaaga aggaaaagaa aatctttgct cctctgcccc
     8041 attcactatt taccaattgg gaattaaaga aataattaat ttgaacagtt atgaaattaa
     8101 tatttgctgt ctgtgtgtat aagtacatcc tttggggttt tttttttctc ttttttttaa
     8161 ccaaagttgc tgtctagtgc attcaaaggt cactttttgt tcttcacaga tctttttaat
     8221 gttctttccc atgttgtatt gcatttttgg gggaagcaaa ttgactttaa agaaaaaagt
     8281 tgtggcaaaa gatgctaaga tgcgaaaatt tcaccacact gagtcaaaaa ggtgaaaaat
     8341 tatccatttc ctatgcgttt tactcctcag agaatgaaaa aaactgcatc ccatcaccca
     8401 aagttctgtg caatagaaat ttctacagat acaggtatag gggctcaagg aggtatgtcg
     8461 gtcagtagtc aaaactatga aatgatactg gtttctccac aggaatatgg ttccattagg
     8521 ctgggagcaa aaacaatgtt ttttaagatt gagaatacat acctgacaac gatccggaaa
     8581 ctgctcctca ccactcccgt catgcctgct gtcggcgttt gaccttccac gtgacagttc
     8641 ttcacaattc ctttcatcat tttttaaata ttttttttac tgcctatggg ctgtgatgta
     8701 tatagaagtt gtacattaaa cataccctca tttttttctt ttcttttttt tttttttttt
     8761 tagtacaaag ttttagtttc tttttcatga tgtggtaact acgaagtgat ggtagattta
     8821 aataattttt tatttttatt ttatatattt tttcattagg gccatatctc caaaaaaaga
     8881 aagaaaaaat acaaaaaaca aaaacaaaaa aaaaagaggg taatgtacaa gtttctgtat
     8941 gtataaagtc atgctcgatt tcaggagagc agctgatcac aatttgcttc atgaatcaag
     9001 gtgtggaaat ggttatatat ggattgattt agaaaatggt taccagtaca gtcaaaaaag
     9061 agaaaatgaa aaaaatacaa ctaaaaggaa gaaacacaac ttcaaagatt tttcagtgat
     9121 gagaatccac atttgtattt caagataatg tagtttaaaa aaaaaaaaaa gaaaaaaact
     9181 tgatgtaaat tcctcctttt cctctggctt aatgaatatc atttattcag tataaaatct
     9241 ttatatgttc cacatgttaa gaataaatgt acattaaatc ttgttaagca ctgtgatggg
     9301 tgttcttgaa tactgttcta gtttccttaa agtggtttcc tagtaatcaa gttatttaca
     9361 agaaataggg gaatgcagca gtgtattcac attataaaac cctacatttg gaagagacct
     9421 ttaggggtta cctactttag agtggggagc aacagtttga ttttctcaaa ttacttagct
     9481 aattagtctt tctttgaagc aattaactct aacgacattg aggtatgatc attttcagta
     9541 tttatgggag gtggctgctg acccacttga ggtgagatct cagaagctta actggcctga
     9601 aaatgtaaca ttctgccttt tactaactcc atcttagttt aatcaaagtt caatctattc
     9661 cttgtttctt ctgtgtgcct cagagttatt ttgcatttag tttactccac cgtgtataat
     9721 atttatactg tgcaatgtta aaaaagaatc tgttatattg tatgtggtgt acatagtgca
     9781 aagtgatgat ttctatttca gggcatatta tggttctcat attccttcct acctggtgca
     9841 cagtagcttt ttaatactag tcacttctaa tttaaacttt ctcttcctgg gtcattgact
     9901 gttactgtgt aataatcgat ttctttgaaa ctgctgcata attatgctgt tagtggacct
     9961 ctacctcttc tcttccctct cccaatcaca gtatactcag aatccccagc ccctcgcata
    10021 cattgtgtcg gttcacatta ctcacagtaa tatatggaag agttagacaa gaacatgcag
    10081 ttacagtcat tgtgagacgt gactctccag tgtcacgagg aaaaaaatca tcttttctgc
    10141 aaacagtctc tcatctgtca actcccacat tactgagtca aacagtcttc ttacataaca
    10201 atgcaaccaa atatatgttg aattaaagac ccatttataa ttctgcttta aatacatctg
    10261 cttgctaaga acagatttca gtgctccaag cttcaaatat ggagatttgt aagagggaat
    10321 tcaatattat tctaatttct ctcttacaga gtacaaataa aaggtgtata caaactccga
    10381 acatatccag tattccaatt cctttgtcaa tcagaagagt aaaataatta acaaaagact
    10441 gttgttatgg tttgcattgt aaccgatacg cagagtctga ccgttgggca acaagttttt
    10501 ctatcctgat gcgcaacaca gtctctagag actaatccag gaagacttta gcctcctttc
    10561 catattctca cccccgaatc aagatttaca gaagcccacg aagaatttac agcctgcttg
    10621 agatcatctt gcctataaac tgagttattg ctttgtccta aaaattagtc ggtttttttt
    10681 tttctatgag gcttttcaga aatttacagg atgcccagac tttacatgtg taccaaaaaa
    10741 aaaaaaaaga taaaaaataa aggtgcaaag aaagtttagt attttggaat ggtgctataa
    10801 agttgaa
//
