LOCUS       NM_006015               8595 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens AT-rich interaction domain 1A (ARID1A), transcript
            variant 1, mRNA.
ACCESSION   NM_006015
VERSION     NM_006015.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8595)
  AUTHORS   Okada,M., Yamasaki,S., Nakazato,H., Hirahara,Y., Ishibashi,T.,
            Kawamura,M., Shimizu,K. and Fujii,S.I.
  TITLE     ARID1A-Deficient Tumors Acquire Immunogenic Neoantigens during the
            Development of Resistance to Targeted Therapy
  JOURNAL   Cancer Res 84 (17), 2792-2805 (2024)
   PUBMED   39228255
  REMARK    GeneRIF: ARID1A-Deficient Tumors Acquire Immunogenic Neoantigens
            during the Development of Resistance to Targeted Therapy.
REFERENCE   2  (bases 1 to 8595)
  AUTHORS   Xu,S., Zhu,C., Xu,Q., An,Z., Xu,S., Xuan,G., Lin,C. and Tang,C.
  TITLE     ARID1A restrains EMT and stemness of ovarian cancer cells through
            the Hippo pathway
  JOURNAL   Int J Oncol 65 (2) (2024)
   PUBMED   38873993
  REMARK    GeneRIF: ARID1A restrains EMT and stemness of ovarian cancer cells
            through the Hippo pathway.
REFERENCE   3  (bases 1 to 8595)
  AUTHORS   Maxwell,M.B., Hom-Tedla,M.S., Yi,J., Li,S., Rivera,S.A., Yu,J.,
            Burns,M.J., McRae,H.M., Stevenson,B.T., Coakley,K.E., Ho,J.,
            Gastelum,K.B., Bell,J.C., Jones,A.C., Eskander,R.N.,
            Dykhuizen,E.C., Shadel,G.S., Kaech,S.M. and Hargreaves,D.C.
  TITLE     ARID1A suppresses R-loop-mediated STING-type I interferon pathway
            activation of anti-tumor immunity
  JOURNAL   Cell 187 (13), 3390-3408 (2024)
   PUBMED   38754421
  REMARK    GeneRIF: ARID1A suppresses R-loop-mediated STING-type I interferon
            pathway activation of anti-tumor immunity.
REFERENCE   4  (bases 1 to 8595)
  AUTHORS   Li,S., Meersma,G.J., Kupryjanczyk,J., de Jong,S. and Wisman,G.B.A.
  TITLE     Genome-wide DNA methylation in relation to ARID1A deficiency in
            ovarian clear cell carcinoma
  JOURNAL   J Transl Med 22 (1), 556 (2024)
   PUBMED   38858765
  REMARK    GeneRIF: Genome-wide DNA methylation in relation to ARID1A
            deficiency in ovarian clear cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8595)
  AUTHORS   Dallas,P.B., Cheney,I.W., Liao,D.W., Bowrin,V., Byam,W.,
            Pacchione,S., Kobayashi,R., Yaciuk,P. and Moran,E.
  TITLE     p300/CREB binding protein-related protein p270 is a component of
            mammalian SWI/SNF complexes
  JOURNAL   Mol Cell Biol 18 (6), 3596-3603 (1998)
   PUBMED   9584200
REFERENCE   6  (bases 1 to 8595)
  AUTHORS   Takeuchi,T., Chen,B.K., Qiu,Y., Sonobe,H. and Ohtsuki,Y.
  TITLE     Molecular cloning and expression of a novel human cDNA containing
            CAG repeats
  JOURNAL   Gene 204 (1-2), 71-77 (1997)
   PUBMED   9434167
REFERENCE   7  (bases 1 to 8595)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   8  (bases 1 to 8595)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   9  (bases 1 to 8595)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
REFERENCE   10 (bases 1 to 8595)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512408.12, AF231056.1,
            AF521670.1 and AL034380.26.
            
            On Nov 22, 2018 this sequence version replaced NM_006015.5.
            
            Summary: This gene encodes a member of the SWI/SNF family, whose
            members have helicase and ATPase activities and are thought to
            regulate transcription of certain genes by altering the chromatin
            structure around those genes. The encoded protein is part of the
            large ATP-dependent chromatin remodeling complex SNF/SWI, which is
            required for transcriptional activation of genes normally repressed
            by chromatin. It possesses at least two conserved domains that
            could be important for its function. First, it has a DNA-binding
            domain that can specifically bind an AT-rich DNA sequence known to
            be recognized by a SNF/SWI complex at the beta-globin locus.
            Second, the C-terminus of the protein can stimulate glucocorticoid
            receptor-dependent transcriptional activation. It is thought that
            the protein encoded by this gene confers specificity to the SNF/SWI
            complex and may recruit the complex to its targets through either
            protein-DNA or protein-protein interactions. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF231056.1, AF521670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324856.13/ ENSP00000320485.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL512408.12        44765-44782         c
            19-179              AF231056.1         8-168
            180-180             AL512408.12        44603-44603         c
            181-1391            AF231056.1         170-1380
            1392-7665           AF521670.1         145-6418
            7666-8595           AL034380.26        114128-115057       c
FEATURES             Location/Qualifiers
     source          1..8595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..8595
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /note="AT-rich interaction domain 1A"
                     /db_xref="GeneID:8289"
                     /db_xref="HGNC:HGNC:11110"
                     /db_xref="MIM:603024"
     exon            1..1526
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..7247
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /note="isoform a is encoded by transcript variant 1;
                     SWI/SNF complex protein p270; BRG1-associated factor 250a;
                     chromatin remodeling factor p250; OSA1 nuclear protein;
                     brain protein 120; osa homolog 1; SWI-like protein; ARID
                     domain-containing protein 1A; SWI/SNF-related,
                     matrix-associated, actin-dependent regulator of chromatin
                     subfamily F member 1; AT rich interactive domain 1A
                     (SWI-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 1A
                     isoform a"
                     /protein_id="NP_006006.3"
                     /db_xref="CCDS:CCDS285.1"
                     /db_xref="GeneID:8289"
                     /db_xref="HGNC:HGNC:11110"
                     /db_xref="MIM:603024"
                     /translation="MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAA
                     AERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKN
                     SNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSA
                     VAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPN
                     RSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGG
                     GGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMAS
                     QCWGAAAAAAAAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTPQPSSPMDQMGKMRP
                     QPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQ
                     IPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQP
                     PQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQ
                     QPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGG
                     QEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFS
                     PHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPS
                     MNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQIHTGMGSYQQNSMGSYGP
                     QGGQYGPQGGYPRQPNYNALPNANYPSAGMAGGINPMGAGGQMHGQPGIPPYGTLPPG
                     RMSHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQETAVAMHVAANSIQNRPPG
                     YPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYSMGGTMANNSAGMAASPEMMGLGD
                     VKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAF
                     TEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSA
                     ASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQT
                     PQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFNDGSDSTFQKRNS
                     MTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSR
                     AAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYS
                     PSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGSPFPSQQTTMYQQQQQNYKRPMDGTYG
                     PPAKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYP
                     ATATAATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGGPIQASAEVAQQ
                     GTMWQGRNDMTYNYANRQSTGSAPQGPAYHGVNRTDEMLHTDQRANHEGSWPSHGTRQ
                     PPYGPSAPVPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSG
                     MKMQKAGPPVPASHIAPAPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPE
                     AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIE
                     IFGILKEYEVGDPGQRTLLDPGRFSKVSSPAPMEGGEEEEELLGPKLEEEEEEEVVEN
                     DEEIAFSGKDKPASENSEEKLISKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLL
                     HWRIGGGDTTEHIQTHFESKTELLPSRPHAPCPPAPRKHVTTAEGTPGTTDQEGPPPD
                     GPPEKRITATMDDMLSTRSSTLTEDGAKSSEAIKESSKFPFGISPAQSHRNIKILEDE
                     PHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLIL
                     LHHKHPERKQAPLTYEKEEEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISGQLDLS
                     PYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNV
                     DLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKG
                     SIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENH
                     SEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS"
     exon            1527..1739
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..2192
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2309
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2550
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2640
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2808
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..3121
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3267
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3377
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3587
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3795
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3928
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3929..4104
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4255
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..4393
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4490
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4491..5382
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5513
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5514..8595
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8570..8575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /note="hexamer: AATAAA"
     polyA_site      8595
                     /gene="ARID1A"
                     /gene_synonym="B120; BAF250; BAF250a; BM029; C1orf4; CSS2;
                     ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1"
                     /note="major polyA site"
ORIGIN      
        1 ctcctttctc cggcagcaga aagcggagag tcacagcggg gccaggccct ggggagcgga
       61 gcctccaccg cccccctcat tcccaggcaa gggcttgggg ggaatgagcc gggagagccg
      121 ggtcccgagc ctacagagcc gggagcagct gagccgccgg cgcctcggcc gccgccgccg
      181 cctcctcctc ctccgccgcc gccagcccgg agcctgagcc ggcggggcgg gggggagagg
      241 agcgagcgca gcgcagcagc ggagccccgc gaggcccgcc cgggcgggtg gggagggcag
      301 cccgggggac tgggccccgg ggcggggtgg gaggggggga gaagacgaag acagggccgg
      361 gtctctccgc ggacgagaca gcggggatca tggccgcgca ggtcgccccc gccgccgcca
      421 gcagcctggg caacccgccg ccgccgccgc cctcggagct gaagaaagcc gagcagcagc
      481 agcgggagga ggcggggggc gaggcggcgg cggcggcagc ggccgagcgc ggggaaatga
      541 aggcagccgc cgggcaggaa agcgagggcc ccgccgtggg gccgccgcag ccgctgggaa
      601 aggagctgca ggacggggcc gagagcaatg ggggtggcgg cggcggcgga gccggcagcg
      661 gcggcgggcc cggcgcggag ccggacctga agaactcgaa cgggaacgcg ggccctaggc
      721 ccgccctgaa caataacctc acggagccgc ccggcggcgg cggtggcggc agcagcgatg
      781 gggtgggggc gcctcctcac tcagccgcgg ccgccttgcc gcccccagcc tacggcttcg
      841 ggcaacccta cggccggagc ccgtctgccg tcgccgccgc cgcggccgcc gtcttccacc
      901 aacaacatgg cggacaacaa agccctggcc tggcagcgct gcagagcggc ggcggcgggg
      961 gcctggagcc ctacgcgggg ccccagcaga actctcacga ccacggcttc cccaaccacc
     1021 agtacaactc ctactacccc aaccgcagcg cctacccccc gcccgccccg gcctacgcgc
     1081 tgagctcccc gagaggtggc actccgggct ccggcgcggc ggcggctgcc ggctccaagc
     1141 cgcctccctc ctccagcgcc tccgcctcct cgtcgtcttc gtccttcgct cagcagcgct
     1201 tcggggccat ggggggaggc ggcccctccg cggccggcgg gggaactccc cagcccaccg
     1261 ccacccccac cctcaaccaa ctgctcacgt cgcccagctc ggcccggggc taccagggct
     1321 accccggggg cgactacagt ggcgggcccc aggacggggg cgccggcaag ggcccggcgg
     1381 acatggcctc gcagtgttgg ggggctgcgg cggcggcagc tgcggcggcg gccgcctcgg
     1441 gaggggccca acaaaggagc caccacgcgc ccatgagccc cgggagcagc ggcggcgggg
     1501 ggcagccgct cgcccggacc cctcagccat ccagtccaat ggatcagatg ggcaagatga
     1561 gacctcagcc atatggcggg actaacccat actcgcagca acagggacct ccgtcaggac
     1621 cgcagcaagg acatgggtac ccagggcagc catacgggtc ccagaccccg cagcggtacc
     1681 cgatgaccat gcagggccgg gcgcagagtg ccatgggcgg cctctcttat acacagcaga
     1741 ttcctcctta tggacaacaa ggccccagcg ggtatggtca acagggccag actccatatt
     1801 acaaccagca aagtcctcac cctcagcagc agcagccacc ctactcccag caaccaccgt
     1861 cccagacccc tcatgcccaa ccttcgtatc agcagcagcc acagtctcaa ccaccacagc
     1921 tccagtcctc tcagcctcca tactcccagc agccatccca gcctccacat cagcagtccc
     1981 cggctccata cccctcccag cagtcgacga cacagcagca cccccagagc cagcccccct
     2041 actcacagcc acaggctcag tctccttacc agcagcagca acctcagcag ccagcaccct
     2101 cgacgctctc ccagcaggct gcgtatcctc agccccagtc tcagcagtcc cagcaaactg
     2161 cctattccca gcagcgcttc cctccaccgc aggagctatc tcaagattca tttgggtctc
     2221 aggcatcctc agccccctca atgacctcca gtaagggagg gcaagaagat atgaacctga
     2281 gccttcagtc aagaccctcc agcttgcctg atctatctgg ttcaatagat gacctcccca
     2341 tggggacaga aggagctctg agtcctggag tgagcacatc agggatttcc agcagccaag
     2401 gagagcagag taatccagct cagtctcctt tctctcctca tacctcccct cacctgcctg
     2461 gcatccgagg cccttccccg tcccctgttg gctctcccgc cagtgttgct cagtctcgct
     2521 caggaccact ctcgcctgct gcagtgccag gcaaccagat gccacctcgg ccacccagtg
     2581 gccagtcgga cagcatcatg catccttcca tgaaccaatc aagcattgcc caagatcgag
     2641 gttatatgca gaggaacccc cagatgcccc agtacagttc cccccagccc ggctcagcct
     2701 tatctccgcg tcagccttcc ggaggacaga tacacacagg catgggctcc taccagcaga
     2761 actccatggg gagctatggt ccccaggggg gtcagtatgg cccacaaggt ggctacccca
     2821 ggcagccaaa ctataatgcc ttgcccaatg ccaactaccc cagtgcaggc atggctggag
     2881 gcataaaccc catgggtgcc ggaggtcaaa tgcatggaca gcctggcatc ccaccttatg
     2941 gcacactccc tccagggagg atgagtcacg cctccatggg caaccggcct tatggcccta
     3001 acatggccaa tatgccacct caggttgggt cagggatgtg tcccccacca gggggcatga
     3061 accggaaaac ccaagaaact gctgtcgcca tgcatgttgc tgccaactct atccaaaaca
     3121 ggccgccagg ctaccccaat atgaatcaag ggggcatgat gggaactgga cctccttatg
     3181 gacaagggat taatagtatg gctggcatga tcaaccctca gggaccccca tattccatgg
     3241 gtggaaccat ggccaacaat tctgcaggga tggcagccag cccagagatg atgggccttg
     3301 gggatgtaaa gttaactcca gccaccaaaa tgaacaacaa ggcagatggg acacccaaga
     3361 cagaatccaa atccaagaaa tccagttctt ctactacaac caatgagaag atcaccaagt
     3421 tgtatgagct gggtggtgag cctgagagga agatgtgggt ggaccgttat ctggccttca
     3481 ctgaggagaa ggccatgggc atgacaaatc tgcctgctgt gggtaggaaa cctctggacc
     3541 tctatcgcct ctatgtgtct gtgaaggaga ttggtggatt gactcaggtc aacaagaaca
     3601 aaaaatggcg ggaacttgca accaacctca atgtgggcac atcaagcagt gctgccagct
     3661 ccttgaaaaa gcagtatatc cagtgtctct atgcctttga atgcaagatt gaacggggag
     3721 aagaccctcc cccagacatc tttgcagctg ctgattccaa gaagtcccag cccaagatcc
     3781 agcctccctc tcctgcggga tcaggatcta tgcaggggcc ccagactccc cagtcaacca
     3841 gcagttccat ggcagaagga ggagacttaa agccaccaac tccagcatcc acaccacaca
     3901 gtcagatccc cccattgcca ggcatgagca ggagcaattc agttgggatc caggatgcct
     3961 ttaatgatgg aagtgactcc acattccaga agcggaattc catgactcca aaccctgggt
     4021 atcagcccag tatgaatacc tctgacatga tggggcgcat gtcctatgag ccaaataagg
     4081 atccttatgg cagcatgagg aaagctccag ggagtgatcc cttcatgtcc tcagggcagg
     4141 gccccaacgg cgggatgggt gacccctaca gtcgtgctgc cggccctggg ctaggaaatg
     4201 tggcgatggg accacgacag cactatccct atggaggtcc ttatgacaga gtgaggacgg
     4261 agcctggaat agggcctgag ggaaacatga gcactggggc cccacagccg aatctcatgc
     4321 cttccaaccc agactcgggg atgtattctc ctagccgcta ccccccgcag cagcagcagc
     4381 agcagcagca acgacatgat tcctatggca atcagttctc cacccaaggc accccttctg
     4441 gcagcccctt ccccagccag cagactacaa tgtatcaaca gcaacagcag aattacaagc
     4501 ggccaatgga tggcacatat ggccctcctg ccaagcggca cgaaggggag atgtacagcg
     4561 tgccatacag cactgggcag gggcagcctc agcagcagca gttgccccca gcccagcccc
     4621 agcctgccag ccagcaacaa gctgcccagc cttcccctca gcaagatgta tacaaccagt
     4681 atggcaatgc ctatcctgcc actgccacag ctgctactga gcgccgacca gcaggcggcc
     4741 cccagaacca atttccattc cagtttggcc gagaccgtgt ctctgcaccc cctggcacca
     4801 atgcccagca aaacatgcca ccacaaatga tgggcggccc catacaggca tcagctgagg
     4861 ttgctcagca aggcaccatg tggcaggggc gtaatgacat gacctataat tatgccaaca
     4921 ggcagagcac gggctctgcc ccccagggcc ccgcctatca tggcgtgaac cgaacagatg
     4981 aaatgctgca cacagatcag agggccaacc acgaaggctc gtggccttcc catggcacac
     5041 gccagccccc atatggtccc tctgcccctg tgccccccat gacaaggccc cctccatcta
     5101 actaccagcc cccaccaagc atgcagaatc acattcctca ggtatccagc cctgctcccc
     5161 tgccccggcc aatggagaac cgcacctctc ctagcaagtc tccattcctg cactctggga
     5221 tgaaaatgca gaaggcaggt cccccagtac ctgcctcgca catagcacct gcccctgtgc
     5281 agccccccat gattcggcgg gatatcacct tcccacctgg ctctgttgaa gccacacagc
     5341 ctgtgttgaa gcagaggagg cggctcacaa tgaaagacat tggaaccccg gaggcatggc
     5401 gggtaatgat gtccctcaag tctggtctcc tggcagagag cacatgggca ttagatacca
     5461 tcaacatcct gctgtatgat gacaacagca tcatgacctt caacctcagt cagctcccag
     5521 ggttgctaga gctccttgta gaatatttcc gacgatgcct gattgagatc tttggcattt
     5581 taaaggagta tgaggtgggt gacccaggac agagaacgct actggatcct gggaggttca
     5641 gcaaggtgtc tagtccagct cccatggagg gtggggaaga agaagaagaa cttctaggtc
     5701 ctaaactaga agaggaagaa gaagaggaag tagttgaaaa tgatgaggag atagcctttt
     5761 caggcaagga caagccagct tcagagaata gtgaggagaa gctgatcagt aagtttgaca
     5821 agcttccagt aaagatcgta cagaagaatg atccatttgt ggtggactgc tcagataagc
     5881 ttgggcgtgt gcaggagttt gacagtggcc tgctgcactg gcggattggt gggggggaca
     5941 ccactgagca tatccagacc cacttcgaga gcaagacaga gctgctgcct tcccggcctc
     6001 acgcaccctg cccaccagcc cctcggaagc atgtgacaac agcagagggt acaccaggga
     6061 caacagacca ggaggggccc ccacctgatg gacctccaga aaaacggatc acagccacta
     6121 tggatgacat gttgtctact cggtctagca ccttgaccga ggatggagct aagagttcag
     6181 aggccatcaa ggagagcagc aagtttccat ttggcattag cccagcacag agccaccgga
     6241 acatcaagat cctagaggac gaaccccaca gtaaggatga gaccccactg tgtacccttc
     6301 tggactggca ggattctctt gccaagcgct gcgtctgtgt gtccaatacc attcgaagcc
     6361 tgtcatttgt gccaggcaat gactttgaga tgtccaaaca cccagggctg ctgctcatcc
     6421 tgggcaagct gatcctgctg caccacaagc acccagaacg gaagcaggca ccactaactt
     6481 atgaaaagga ggaggaacag gaccaagggg tgagctgcaa caaagtggag tggtggtggg
     6541 actgcttgga gatgctccgg gaaaacacct tggttacact cgccaacatc tcggggcagt
     6601 tggacctatc tccatacccc gagagcattt gcctgcctgt cctggacgga ctcctacact
     6661 gggcagtttg cccttcagct gaagcccagg accccttttc caccctgggc cccaatgccg
     6721 tcctttcccc gcagagactg gtcttggaaa ccctcagcaa actcagcatc caggacaaca
     6781 atgtggacct gattctggcc acacccccct tcagccgcct ggagaagttg tatagcacta
     6841 tggtgcgctt cctcagtgac cgaaagaacc cggtgtgccg ggagatggct gtggtactgc
     6901 tggccaacct ggctcagggg gacagcctgg cagctcgtgc cattgcagtg cagaagggca
     6961 gtatcggcaa cctcctgggc ttcctagagg acagccttgc cgccacacag ttccagcaga
     7021 gccaggccag cctcctccac atgcagaacc caccctttga gccaactagt gtggacatga
     7081 tgcggcgggc tgcccgcgcg ctgcttgcct tggccaaggt ggacgagaac cactcagagt
     7141 ttactctgta cgaatcacgg ctgttggaca tctcggtatc accgttgatg aactcattgg
     7201 tttcacaagt catttgtgat gtactgtttt tgattggcca gtcatgacag ccgtgggaca
     7261 cctccccccc ccgtgtgtgt gtgcgtgtgt ggagaactta gaaactgact gttgcccttt
     7321 atttatgcaa aaccacctca gaatccagtt taccctgtgc tgtccagctt ctcccttggg
     7381 aaaaagtctc tcctgtttct ctctcctcct tccacctccc ctccctccat cacctcacgc
     7441 ctttctgttc cttgtcctca ccttactccc ctcaggaccc taccccaccc tctttgaaaa
     7501 gacaaagctc tgcctacata gaagactttt tttattttaa ccaaagttac tgttgtttac
     7561 agtgagtttg gggaaaaaaa ataaaataaa aatggctttc ccagtccttg catcaacggg
     7621 atgccacatt tcataactgt ttttaatggt aaaaaaaaaa aaaaaaaata caaaaaaaaa
     7681 ttctgaagga caaaaaaggt gactgctgaa ctgtgtgtgg tttattgttg tacattcaca
     7741 atcttgcagg agccaagaag ttcgcagttg tgaacagacc ctgttcactg gagaggcctg
     7801 tgcagtagag tgtagaccct ttcatgtact gtactgtaca cctgatactg taaacatact
     7861 gtaataataa tgtctcacat ggaaacagaa aacgctgggt cagcagcaag ctgtagtttt
     7921 taaaaatgtt tttagttaaa cgttgaggag aaaaaaaaaa aaggcttttc ccccaaagta
     7981 tcatgtgtga acctacaaca ccctgacctc tttctctcct ccttgattgt atgaataacc
     8041 ctgagatcac ctcttagaac tggttttaac ctttagctgc agcggctacg ctgccacgtg
     8101 tgtatatata tgacgttgta cattgcacat acccttggat ccccacagtt tggtcctcct
     8161 cccagctacc cctttatagt atgacgagtt aacaagttgg tgacctgcac aaagcgagac
     8221 acagctattt aatctcttgc cagatatcgc ccctcttggt gcgatgctgt acaggtctct
     8281 gtaaaaagtc cttgctgtct cagcagccaa tcaacttata gtttattttt ttctgggttt
     8341 ttgttttgtt ttgttttctt tctaatcgag gtgtgaaaaa gttctaggtt cagttgaagt
     8401 tctgatgaag aaacacaatt gagatttttt cagtgataaa atctgcatat ttgtatttca
     8461 acaatgtagc taaaacttga tgtaaattcc tccttttttt ccttttttgg cttaatgaat
     8521 atcatttatt cagtatgaaa tctttatact atatgttcca cgtgttaaga ataaatgtac
     8581 attaaatctt ggtaa
//
