LOCUS       XM_047430742            4985 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Rho guanine nucleotide exchange factor 7
            (ARHGEF7), transcript variant X23, mRNA.
ACCESSION   XM_047430742
VERSION     XM_047430742.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     gene            1..4985
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /note="Rho guanine nucleotide exchange factor 7; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 mRNAs, 65 ESTs, 1090 long SRA reads, 3 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
     CDS             388..2364
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X15"
                     /protein_id="XP_047286698.1"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
                     /translation="MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWW
                     EGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNIL
                     ETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTK
                     LPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGI
                     LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKR
                     KELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLS
                     ASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWV
                     EHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSH
                     HGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEVRSLDHSNSQMTDLS
                     KSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNS
                     SSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMK
                     KSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL"
ORIGIN      
        1 acttcctggt gcgggaaggg gcagagattg gtgcagcccc ggaggaagaa aaaagggtga
       61 ggagaagcag cggctgagcg ggtctacccc gagccccgga gcgagagcga gtgcctgagc
      121 aacatccgcg agttcctgcg cggctgcggg gcttccctgc ggctggagac gtttgatgca
      181 aatgatttgt atcaggggca gaattttaac aaggtcctca gttccttagt gactctaaat
      241 aaagtaacag cagacatcgg gctggggagt gactccgtgt gtgcccggcc ctcgtctcac
      301 cgcataaagt cttttgactc ccttggatca cagtctttgc acactcggac ttcaaaactg
      361 ttccagggcc agtatcggag tttggacatg accgataata gcaacaatca actggtagta
      421 agagcaaagt ttaacttcca gcagaccaat gaggacgagc tttccttctc aaaaggagac
      481 gtcatccatg tcacccgtgt ggaagaggga ggctggtggg agggcacact caacggccgg
      541 accggctggt tccccagcaa ctacgtgcgc gaggtcaagg ccagcgagaa gcctgtgtct
      601 cccaaatcag gaacactgaa gagccctccc aaaggatttg atacgactgc cataaacaaa
      661 agctattaca atgtggtgct acagaatatt ttagaaacag aaaatgaata ttctaaagaa
      721 cttcagactg tgctttcaac gtacctacgg ccattgcaga ccagtgagaa gttaagttca
      781 gcaaacattt catatttaat gggaaatcta gaagaaatat gttctttcca gcaaatgctc
      841 gtacagtctt tagaagaatg caccaagttg cccgaagctc agcagagagt cggaggctgc
      901 tttttaaacc tgatgccaca gatgaaaacc ctgtacctca cgtattgtgc caatcaccct
      961 tctgcagtga atgtcctcac ggaacacagt gaggagttgg gggagttcat ggagaccaaa
     1021 ggtgccagca gccctgggat tctcgtgctg accacgggcc tgagcaaacc cttcatgcgc
     1081 ctggataaat accctacgct gctcaaagag ctcgagagac acatggagga ttatcataca
     1141 gatagacaag atattcaaaa atccatggct gccttcaaaa acctttcagc ccaatgtcaa
     1201 gaagtccgga agaggaaaga gcttgagctg cagatcctga cggaagccat ccggaactgg
     1261 gagggcgatg acattaaaac tctgggcaac gtcacttaca tgtcccaggt cctgattcag
     1321 tgtgccggaa gtgaggaaaa gaatgaaaga tatcttctac tcttcccaaa tgttttgcta
     1381 atgttgtctg ccagtcctag gatgagtggc tttatctatc agggaaagct tccaacgaca
     1441 ggaatgacaa tcacaaagct tgaggacagt gaaaatcata gaaatgcatt tgaaatatca
     1501 gggagcatga ttgagcggat attagtgtcg tgcaacaacc agcaggatct gcaggaatgg
     1561 gtggagcacc tacagaagca aacgaaggtc acgtctgtgg gaaaccccac cataaagcct
     1621 cattcagtgc catctcatac cctcccctcc cacccggtca ctccgtccag caagcacgca
     1681 gacagcaagc ccgcgccgct gacgcccgcc taccacacgc tgccccaccc ctcccaccac
     1741 ggcaccccgc acaccaccat caactgggga cccctggagc ctccgaaaac acccaagccc
     1801 tggagcctga gctgcctgcg gcccgcgcct cccctccggc cctcagctgc tctctgctac
     1861 aaggaggtga ggtcccttga ccactcaaac agccagatga cggatcttag taagagccct
     1921 aagaccatga aaaagctgct gcccaagcgc aaacctgaac ggaagccttc agatgaggag
     1981 ttcgcgtccc ggaaaagcac agctgctttg gaagaagatg ctcagattct gaaagtcatt
     2041 gaagcttact gcaccagcgc caaaacaagg caaacactca attcaagttc acgcaaagaa
     2101 tctgctccac aagttttgct tccagaagaa gagaaaatta tagtggaaga aactaaaagt
     2161 aatggtcaga cagtgataga agaaaagagt cttgtggata ccgtatatgc attaaaggat
     2221 gaagttcaag aattaagaca ggacaacaaa aagatgaaga aatctctaga ggaagaacag
     2281 agagcccgca aagacctgga gaagctggtg aggaaagtcc tgaagaacat gaatgatcct
     2341 gcctgggatg agaccaatct ataagggatg tcctcagttc tttctgttga agaccagttc
     2401 tgaggtgaag ctgggcaccc ctgacccaag tcggggtgca ctcaggacca cagggcaggg
     2461 ctgggtgggg cgccaccttg ctctctgtat atagaaaagc tggagcttat tctgcgaatg
     2521 gagacgatca aaccatgact gatgaatcca gacaggaggg attgactctg aggacctgag
     2581 ctacatcaat ccactctgtg aacatctcag ttacctcatt ctgcaataag ttcagtgact
     2641 gactaaaagt cttgtttttc cagactttga attgaatata taaatattat atatacatgt
     2701 ttcttgtaaa tatcccattt tgaatgcata cctgtggtgg ttctgtccgg gctaatcccc
     2761 atgctagaat gtcctttcca gctacgtgaa taagaagtcc catgcccgca tccaccggaa
     2821 gcagaagcct ggtggatgcc tggttcgttc cgcagcacca gggcctccac cgtgctgtgg
     2881 cagcaccccc catgtcggta tttctaaata accttattta tacctgcaga gatacacttc
     2941 agtcccattc agaagtcttc tcttaaagca gcattacagt cccagacctg cgggtttctg
     3001 agggcaactt gctggctgac agactcagtc ttgacctcaa ggaaggccca tacggcactg
     3061 ccgcatccac ctagaggtgt ttgctcttgt ccgctgtctg agtactgtga ttctcagatg
     3121 agtttgctgc gttttgggag gacacagacg gttctgtata ggctagttca gtaacaacaa
     3181 aatacactgt tttgtcttcc ctcaaagaga gatcttacta gaacctgtaa atagaatgta
     3241 ttatttatta taagtcactg cagctgatga aaacagatgg aggccatgct gcaggctgat
     3301 actgatgggt ggagttttgt catcaggcca gcctcatccc gaggtctcct ccaccattgg
     3361 ccgtagccag caggcttcag tgctcaccga aagtaaaatc ccctccttca gcaagaataa
     3421 agcaatatac accttaggtt ccactaagta acataggcat aagcagggaa cgtttccccc
     3481 actgtgttcc agtgcagagg agacgaagcc tgtcctcacc gcggctcgct gggcccaggc
     3541 tggctctgga aagcctgtgc ggtcctgggc aggaagcccg gcccgtggag caggttttcg
     3601 ttctgcttca gcaataaata agggtgacca cagggacttt gcttttggtt tcctttcctg
     3661 tgaaaaggtt ggttttaaag tgagatacac ttttccgtag aacaagtgtt ctatctttaa
     3721 aaacccaaat tgcagcaccg tggattactg gtctcagaac aactcattgc gcatcagatt
     3781 tgactctctg attttctgtc tattggccaa attgcccttt aactgcacct gaatcctttg
     3841 tgtactgatg cctttgagct gggcaccttg ggagagtgtt gtgttgctgt ttacggttct
     3901 tccttgccct tgctaattac agtctctggt gcccagcaag cccctttggc ttccttccgt
     3961 gactggtcac gttgtctgcc tgggctcagc gtggacctgc cccatgctgc agaacctggc
     4021 ctcacctgga cttttcacta gaattgccag cttcctcaac ttagcagatc attcactcat
     4081 gcgggcacaa gcaaagatca acactttctt ttttggtaag cttgagtttt acaagttatt
     4141 ttttggtgat gcgtaagaca ttgcagtggg aaaccattca acttgagttt attggagttt
     4201 gctgttgtag caggttttaa ctcaggaaca actcttgtct gatctctccg cccctctgcc
     4261 gggaggcgac attaactgtc ctctcggagc cggtagcgtt gctgtccgag tccccaggac
     4321 ggatctcctg cagacctgcc ttaatgctca gatcgaagta tttcacaaga atacttgtgt
     4381 ttttaacagc ccttcccctg gacggtgcgg ccatgagggc ctcatgttac ggcattgcct
     4441 tttctttctg tggatccagt atcttcctcg gctttttagg gagcaggaaa aatgcgtctg
     4501 agagcaactc tttttaaaaa cctgccctgt tgtatataac tgtgtctgtt tcaccgtgtg
     4561 acctcccaag ggggtgggaa cttgatataa acgtttaaag gggccacgat ttgcccgagg
     4621 gttactcctt tgctctcacc ttgtatggat gaggagatga agccatttct tatcctgtag
     4681 atgtgaagca ctttcagttt tcagcgatgt tggaatgtag catcagaagc tcgttccttc
     4741 acactcagtg gcgtctgtgc ttgtccacat gcgctgggcg tctgggacct tgaatgcctg
     4801 ccctggttgt gtggactcct taatgccaat catttcttca cttctctggg acacccaggg
     4861 cgcctgttga caagtgtgga gaaactccta atttaaatgt cacagacaat gtcctagtgt
     4921 tgactactac aatgttgatg ctacactgtt gtaattatta aactgattat ttttcttatg
     4981 tcaca
//
