LOCUS       XM_017029975            4953 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Rac/Cdc42 guanine nucleotide exchange
            factor 6 (ARHGEF6), transcript variant X1, mRNA.
ACCESSION   XM_017029975
VERSION     XM_017029975.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000023.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017029975.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
     gene            1..4953
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /note="Rac/Cdc42 guanine nucleotide exchange factor 6;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 28 ESTs, 437 long SRA reads, and
                     99% coverage of the annotated genomic feature by RNAseq
                     alignments, including 26 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:9459"
                     /db_xref="HGNC:HGNC:685"
                     /db_xref="MIM:300267"
     CDS             51..2474
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 6 isoform
                     X1"
                     /protein_id="XP_016885464.1"
                     /db_xref="GeneID:9459"
                     /db_xref="HGNC:HGNC:685"
                     /db_xref="MIM:300267"
                     /translation="MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKL
                     INRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLST
                     LLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGS
                     HQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIK
                     SSDGVSLLLPGLECNGAISAHHNLCLPGSKRPLSPKAVKGFETAPLTKNYYTVVLQNI
                     LDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECS
                     KFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPG
                     ILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRK
                     RKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIML
                     SASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEW
                     LEQLNRLIRGPASCSSLSKTSSSSCSAHSTFSQSFSSTGQPRGPLEPPQIIKPWSLSC
                     LRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTA
                     ALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIM
                     EEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGE
                     SSSKTSILP"
ORIGIN      
        1 agtccttgca gctgccccag agtgctgttt ggagtgtacc gtcctcagta atgaatccag
       61 aagaacaaat cgtgacatgg cttatatctt tgggagtttt agagtcccct aaaaagacca
      121 tctgtgatcc ggaggagttt ttaaagtcct cgctgaaaaa tggggtagtt ctgtgcaaac
      181 tgatcaacag actcatgcct ggctctgtgg aaaagttttg tctggatccc caaactgaag
      241 ctgactgcat caacaacatc aatgacttcc tgaaaggatg tgcaaccctc caagtggaaa
      301 tatttgatcc tgatgacctt tattcagggg tcaatttctc caaggtactg agtactcttt
      361 tagctgtcaa caaagcaaca gaagatcagc tatcagaaag accatgtgga cgttcctctt
      421 ctcttagtgc tgctaatact tctcagacaa acccacaggg agcagtttct agcacagttt
      481 cagggctgca aaggcagtca aagacagtgg agatgacgga aaatggaagt catcagttga
      541 tagtaaaagc aagattcaac tttaagcaga ctaatgagga tgaactgtca gtttgtaagg
      601 gggacatcat ttacgtcaca cgagttgaag aaggaggctg gtgggaaggc acattaaatg
      661 ggagaacagg ctggttcccc agtaattatg tccgtgaaat taaatccagt gatggagttt
      721 cgctcttgtt gcccgggctg gagtgcaatg gcgcgatctc agctcaccac aacctctgcc
      781 tcccaggttc aaagagacct ctctccccaa aagccgtcaa aggatttgaa actgctccac
      841 ttaccaagaa ttattatact gtggtgttac agaacatcct ggacactgaa aaagaatatg
      901 ctaaagaact tcagtctctt cttgttactt acttaagacc cctgcagtcc aataacaatc
      961 tgagtactgt ggaggttaca tctttactgg gaaacttcga ggaagtatgc acatttcaac
     1021 agacactctg ccaagccttg gaagaatgtt caaagtttcc agaaaaccag cacaaagtag
     1081 gaggttgtct actgagtctc atgcctcatt ttaaatctat gtatctggct tactgtgcaa
     1141 accatccttc agctgtaaat gtgctcactc agcacagtga tgagttggaa caattcatgg
     1201 aaaatcaagg tgcatcgagc ccaggtatcc tcattttaac aacaaacctc agcaaaccat
     1261 tcatgcgact ggagaaatat gttactctct tgcaagagtt agaacggcat atggaggata
     1321 ctcatccaga tcatcaggat attctgaaag caatcgtagc attcaaaact ctcatggggc
     1381 aatgtcaaga tctgaggaag agaaaacagc tggagttaca gatactgtcc gaacctattc
     1441 aggcatggga aggagaagat attaaaaact tgggaaatgt gatttttatg tcacaagtaa
     1501 tggtgcagta tggagcatgt gaggaaaaag aggagcggta ccttatgtta ttttcaaatg
     1561 tcctgataat gttatctgca agtcctcgga tgagtggctt tatctatcag ggaaaaatac
     1621 caatagcagg aacggtggtg actagattag atgaaattga agggaatgac tgcacatttg
     1681 aaatcactgg taacacagtg gagagaattg tggtccattg taacaacaac caggacttcc
     1741 aggaatggtt ggagcagctg aacagactga tcagaggacc tgcctcttgc agttcattat
     1801 ccaaaacctc atcgtcatca tgtagtgctc attctacatt ttcccagtct tttagctcta
     1861 ccggacagcc ccgaggaccc ttggagcctc ctcaaattat aaaaccgtgg agtttaagtt
     1921 gtctacgacc tgcacctcca cttagaccat cagcagcact aggttataaa gagaggatgt
     1981 cttatatctt aaaggagtct agtaaaagcc ctaaaacgat gaagaaattt cttcataaaa
     2041 ggaagactga gagaaaacca tcggaggagg aatatgtgat taggaaaagt acagctgctc
     2101 tggaagagga tgctcaaatc cttaaagtga tcgaagccta ctgcaccagc gcaaattttc
     2161 aacaaggcca tggctcaagt actcgaaaag attccattcc acaagtccta ctccctgagg
     2221 aagagaaact catcattgaa gaaaccagaa gcaacggcca gaccatcatg gaagaaaaga
     2281 gccttgttga tactgtttac gccttgaagg acgaggtcag agaactgaag caggaaaata
     2341 aaagaatgaa gcaatgcctg gaagaagaac tgaaatcaag aagggaccta gaaaagctgg
     2401 tgcggaggct tttgaagcaa acagatgagt gtattcgagg cgagtccagt agcaagacct
     2461 caattcttcc ataaccatca ctgtgccact gggtggagtg tgccttcagg gcatcttgaa
     2521 atgtcccgct gaatgatttg actcagtttg ctcacttctt tggcttttgt tttgtgtttg
     2581 agtctctctc tctctctccc tctctcttct ctttctctcc ccgctgtgtg catatgtgtg
     2641 tgcgtgcacg tgcgcgcttg ggcatttgct gttgtttggt tattggttgg ttgttcattt
     2701 tttttttcaa caggtgaaaa agcaggaagt ggtggtagag atggcctcag agtcttttcc
     2761 attcagtaag aaagagaaag ggaatgcagg ccagttactt aaaaggtctt cagattgcct
     2821 tcagttcaca gtgcctctgc aacagccatt gccctcaggt cacattcttt gggctggctg
     2881 cccttgcaaa gcagctggcc aaggcttatt aaatgtgaac ccaacttttc cccagggctt
     2941 tcctgtacct gcaagcctct tagtacttaa tttaccgaag gcaaatcttc cagactatgg
     3001 cttgagtagg atgaaagaca aacacatctg cccaatgatc cagctgccct tccttagacc
     3061 atcacatgcc tcccctcaat cacaggtttt aaaattactg ccctatgttg tctataagac
     3121 caagaaaact gtagtaccct tattcctttt gtgtcatgta aattgtaact caggggggca
     3181 gaagctctgg tcacccacac caacaccaaa tccatcagca aattctactg gacaatcctc
     3241 ccttttagta gcagagttga ccgccttttc ccattgcatg ataggtttct ttccctcatt
     3301 ctgcctagtg tgtaagtttt ctatttcccc agtactttta gccaacctta ccaagtggtg
     3361 tgtaaactag tatgtatgtg ctttgcttac tttttaaaaa aatgtagtta gactgtgagg
     3421 agttacttta tgtacgttgc atattcaaac tgtgatgttt tatccttcaa aacaatctgc
     3481 attaagaaga tattgtgccc tactagacag ctttcattca ctttattact ctctcatata
     3541 tgctgtgaga agttgtaata ttaattggcc tctttgggtg ggactctaag cagtatttgc
     3601 agaaatatgc ttctggtcca acttgtacat ccagaacaaa agggcccctc tagtagctgt
     3661 gtgctggatt attcaggact gattaactca agttgctcat tgaatcacat catccacttt
     3721 atcccagaaa ctagaactgt gagaaaccag gtttagaaga cagtcacaga acagcacaca
     3781 tccaaattca gcgccattga aagttggcct aaggctcagt gccactcacc cctccctccc
     3841 caaaagacaa gagaaatttg gccagatggg gaaggtcact ggaaattgag gccaaagggc
     3901 tgatcagaat tgcctttata atatatttga tggatgccta taaatgtggg ttttgcaaat
     3961 attgtttaaa aaccaaactt gaagccaggc atggtggccc acacctgtgg tcccagctac
     4021 tcaggaggct gaggtgggag gatcatttga gcccaggagg tcaaggctgc agtgagctgt
     4081 gatgacacca ctgcactcca acctaggtaa cagagagaca cctctgtctc tgaaaaaaca
     4141 aaacttgaag tttgaaaccc ccagcttgct gaggagccct ttttattttt ggtactgaga
     4201 gtctcaaggt cccatagcta catggtacag ggctgttgtc tgcttgctgc acagcagaaa
     4261 ttacaccatc cacaggaaat ggactatttt tgcagtccaa catcagccaa ccacacacag
     4321 ccgtgtttgg aagctgaaga gtaaagaaat ttctaggaat ggctgttgtt ctgtttttta
     4381 gcacagccat ttagatataa catccttcac ttaaaaatta aaaacatcag tactaccacc
     4441 accaccaaca acatcaacac agatcttcac atctgcccat tctgtggtta gtcaatggct
     4501 tgcaataaat gtgcaaactg catctatagg aaacattttt gtgattacgg aatactttag
     4561 ttgattgctg aaaatattga aaggtcttca ttttacagtg atgagtacat atgcatgttt
     4621 cggggacttg gcccttctga tgaggggccc tcggtactct ggataacgaa gcttgtgcag
     4681 agtggtaacc atgcttacac actaaactat aatataaagg aaatgaagcc atgttaatct
     4741 gagagcagtg tcgccatagt tgtgttgttt acaatactct ataaatgggt tcctgttgcc
     4801 ctgtaattaa actgctgccc gtagaggcct ttcagttcct tttctgtcct tccccttctt
     4861 aacacaagct caaattttct aacttgtttt tattttgaag acttttaaaa tggacatttt
     4921 caatacataa aaataaacag tgctttataa aaa
//
