LOCUS       NM_004840               4860 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Rac/Cdc42 guanine nucleotide exchange factor 6
            (ARHGEF6), transcript variant 1, mRNA.
ACCESSION   NM_004840
VERSION     NM_004840.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4860)
  AUTHORS   Zheng,T., Zhou,H., Zheng,Z., Guo,Y., Liu,J., Zhang,J. and Li,S.
  TITLE     The pathological significance and potential mechanism of ARHGEF6 in
            lung adenocarcinoma
  JOURNAL   Comput Biol Med 158, 106894 (2023)
   PUBMED   37058762
  REMARK    GeneRIF: The pathological significance and potential mechanism of
            ARHGEF6 in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 4860)
  AUTHORS   Li,K., Wang,H., Yang,C., Li,C., Xue,B. and Zhou,J.
  TITLE     Clinical implication and potential function of ARHGEF6 in acute
            myeloid leukemia: An in vitro study
  JOURNAL   PLoS One 18 (4), e0283934 (2023)
   PUBMED   37027440
  REMARK    GeneRIF: Clinical implication and potential function of ARHGEF6 in
            acute myeloid leukemia: An in vitro study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4860)
  AUTHORS   Klambt,V., Buerger,F., Wang,C., Naert,T., Richter,K., Nauth,T.,
            Weiss,A.C., Sieckmann,T., Lai,E., Connaughton,D.M., Seltzsam,S.,
            Mann,N., Majmundar,A.J., Wu,C.W., Onuchic-Whitford,A.C., Shril,S.,
            Schneider,S., Schierbaum,L., Dai,R., Bekheirnia,M.R., Joosten,M.,
            Shlomovitz,O., Vivante,A., Banne,E., Mane,S., Lifton,R.P.,
            Kirschner,K.M., Kispert,A., Rosenberger,G., Fischer,K.D.,
            Lienkamp,S.S., Zegers,M.M.P. and Hildebrandt,F.
  TITLE     Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the
            Kidneys and Urinary Tract in Humans, Mice, and Frogs
  JOURNAL   J Am Soc Nephrol 34 (2), 273-290 (2023)
   PUBMED   36414417
  REMARK    GeneRIF: Genetic Variants in ARHGEF6 Cause Congenital Anomalies of
            the Kidneys and Urinary Tract in Humans, Mice, and Frogs.
REFERENCE   4  (bases 1 to 4860)
  AUTHORS   Wang,N., Li,Y., Zhou,X., Wang,X. and Yang,G.
  TITLE     Comprehensive analysis identifies ARHGEF6 as a potential prognostic
            and immunological biomarker in lung adenocarcinoma
  JOURNAL   Comput Biol Med 153, 106448 (2023)
   PUBMED   36586227
  REMARK    GeneRIF: Comprehensive analysis identifies ARHGEF6 as a potential
            prognostic and immunological biomarker in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 4860)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4860)
  AUTHORS   Yoshii,S., Tanaka,M., Otsuki,Y., Wang,D.Y., Guo,R.J., Zhu,Y.,
            Takeda,R., Hanai,H., Kaneko,E. and Sugimura,H.
  TITLE     alphaPIX nucleotide exchange factor is activated by interaction
            with phosphatidylinositol 3-kinase
  JOURNAL   Oncogene 18 (41), 5680-5690 (1999)
   PUBMED   10523848
REFERENCE   7  (bases 1 to 4860)
  AUTHORS   Yntema,H.G., Hamel,B.C., Smits,A.P., van Roosmalen,T., van den
            Helm,B., Kremer,H., Ropers,H.H., Smeets,D.F. and van Bokhoven,H.
  TITLE     Localisation of a gene for non-specific X linked mental retardation
            (MRX46) to Xq25-q26
  JOURNAL   J Med Genet 35 (10), 801-805 (1998)
   PUBMED   9783701
REFERENCE   8  (bases 1 to 4860)
  AUTHORS   Ebinu,J.O., Bottorff,D.A., Chan,E.Y., Stang,S.L., Dunn,R.J. and
            Stone,J.C.
  TITLE     RasGRP, a Ras guanyl nucleotide- releasing protein with calcium-
            and diacylglycerol-binding motifs
  JOURNAL   Science 280 (5366), 1082-1086 (1998)
   PUBMED   9582122
REFERENCE   9  (bases 1 to 4860)
  AUTHORS   Manser,E., Loo,T.H., Koh,C.G., Zhao,Z.S., Chen,X.Q., Tan,L.,
            Tan,I., Leung,T. and Lim,L.
  TITLE     PAK kinases are directly coupled to the PIX family of nucleotide
            exchange factors
  JOURNAL   Mol Cell 1 (2), 183-192 (1998)
   PUBMED   9659915
REFERENCE   10 (bases 1 to 4860)
  AUTHORS   Nomura,N., Nagase,T., Miyajima,N., Sazuka,T., Tanaka,A., Sato,S.,
            Seki,N., Kawarabayasi,Y., Ishikawa,K. and Tabata,S.
  TITLE     Prediction of the coding sequences of unidentified human genes. II.
            The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by
            analysis of cDNA clones from human cell line KG-1 (supplement)
  JOURNAL   DNA Res 1 (5), 251-262 (1994)
   PUBMED   7584048
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC039856.1 and BC033768.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004840.2.
            
            Summary: Rho GTPases play a fundamental role in numerous cellular
            processes that are initiated by extracellular stimuli that work
            through G protein coupled receptors. The encoded protein belongs to
            a family of cytoplasmic proteins that activate the Ras-like family
            of Rho proteins by exchanging bound GDP for GTP. It may form a
            complex with G proteins and stimulate Rho-dependent signals. This
            protein is activated by PI3-kinase. Mutations in this gene can
            cause X-chromosomal non-specific cognitive disability. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039856.1, BX537390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250617.7/ ENSP00000250617.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2539              BC039856.1         413-2951
            2540-4860           BC033768.1         1123-3443
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..4860
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /note="Rac/Cdc42 guanine nucleotide exchange factor 6"
                     /db_xref="GeneID:9459"
                     /db_xref="HGNC:HGNC:685"
                     /db_xref="MIM:300267"
     exon            1..215
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2381
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Rac/Cdc42 guanine exchange factor (GEF) 6; rho guanine
                     nucleotide exchange factor 6; PAK-interacting exchange
                     factor, alpha; Rac/Cdc42 guanine nucleotide exchange
                     factor (GEF) 6"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 6 isoform
                     1"
                     /protein_id="NP_004831.1"
                     /db_xref="CCDS:CCDS14660.1"
                     /db_xref="GeneID:9459"
                     /db_xref="HGNC:HGNC:685"
                     /db_xref="MIM:300267"
                     /translation="MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKL
                     INRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLST
                     LLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGS
                     HQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIK
                     SSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNN
                     LSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAY
                     CANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELER
                     HMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNV
                     IFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDE
                     IEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSA
                     HSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPK
                     TMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRK
                     DSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLE
                     EELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP"
     exon            216..299
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            300..384
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            385..509
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            510..711
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            712..782
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            783..877
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            878..973
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1096
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1235
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1295
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1442
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1529
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1608
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1754
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1880
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1901
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1995
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2085
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2185
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2240
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..4860
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4839..4844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /note="hexamer: AATAAA"
     polyA_site      4860
                     /gene="ARHGEF6"
                     /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46;
                     PIXA"
                     /note="major polyA site"
ORIGIN      
        1 agtccttgca gctgccccag agtgctgttt ggagtgtacc gtcctcagta atgaatccag
       61 aagaacaaat cgtgacatgg cttatatctt tgggagtttt agagtcccct aaaaagacca
      121 tctgtgatcc ggaggagttt ttaaagtcct cgctgaaaaa tggggtagtt ctgtgcaaac
      181 tgatcaacag actcatgcct ggctctgtgg aaaagttttg tctggatccc caaactgaag
      241 ctgactgcat caacaacatc aatgacttcc tgaaaggatg tgcaaccctc caagtggaaa
      301 tatttgatcc tgatgacctt tattcagggg tcaatttctc caaggtactg agtactcttt
      361 tagctgtcaa caaagcaaca gaagatcagc tatcagaaag accatgtgga cgttcctctt
      421 ctcttagtgc tgctaatact tctcagacaa acccacaggg agcagtttct agcacagttt
      481 cagggctgca aaggcagtca aagacagtgg agatgacgga aaatggaagt catcagttga
      541 tagtaaaagc aagattcaac tttaagcaga ctaatgagga tgaactgtca gtttgtaagg
      601 gggacatcat ttacgtcaca cgagttgaag aaggaggctg gtgggaaggc acattaaatg
      661 ggagaacagg ctggttcccc agtaattatg tccgtgaaat taaatccagt gagagacctc
      721 tctccccaaa agccgtcaaa ggatttgaaa ctgctccact taccaagaat tattatactg
      781 tggtgttaca gaacatcctg gacactgaaa aagaatatgc taaagaactt cagtctcttc
      841 ttgttactta cttaagaccc ctgcagtcca ataacaatct gagtactgtg gaggttacat
      901 ctttactggg aaacttcgag gaagtatgca catttcaaca gacactctgc caagccttgg
      961 aagaatgttc aaagtttcca gaaaaccagc acaaagtagg aggttgtcta ctgagtctca
     1021 tgcctcattt taaatctatg tatctggctt actgtgcaaa ccatccttca gctgtaaatg
     1081 tgctcactca gcacagtgat gagttggaac aattcatgga aaatcaaggt gcatcgagcc
     1141 caggtatcct cattttaaca acaaacctca gcaaaccatt catgcgactg gagaaatatg
     1201 ttactctctt gcaagagtta gaacggcata tggaggatac tcatccagat catcaggata
     1261 ttctgaaagc aatcgtagca ttcaaaactc tcatggggca atgtcaagat ctgaggaaga
     1321 gaaaacagct ggagttacag atactgtccg aacctattca ggcatgggaa ggagaagata
     1381 ttaaaaactt gggaaatgtg atttttatgt cacaagtaat ggtgcagtat ggagcatgtg
     1441 aggaaaaaga ggagcggtac cttatgttat tttcaaatgt cctgataatg ttatctgcaa
     1501 gtcctcggat gagtggcttt atctatcagg gaaaaatacc aatagcagga acggtggtga
     1561 ctagattaga tgaaattgaa gggaatgact gcacatttga aatcactggt aacacagtgg
     1621 agagaattgt ggtccattgt aacaacaacc aggacttcca ggaatggttg gagcagctga
     1681 acagactgat cagaggacct gcctcttgca gttcattatc caaaacctca tcgtcatcat
     1741 gtagtgctca ttcttctttt agctctaccg gacagccccg aggacccttg gagcctcctc
     1801 aaattataaa accgtggagt ttaagttgtc tacgacctgc acctccactt agaccatcag
     1861 cagcactagg ttataaagag aggatgtctt atatcttaaa ggagtctagt aaaagcccta
     1921 aaacgatgaa gaaatttctt cataaaagga agactgagag aaaaccatcg gaggaggaat
     1981 atgtgattag gaaaagtaca gctgctctgg aagaggatgc tcaaatcctt aaagtgatcg
     2041 aagcctactg caccagcgca aattttcaac aaggccatgg ctcaagtact cgaaaagatt
     2101 ccattccaca agtcctactc cctgaggaag agaaactcat cattgaagaa accagaagca
     2161 acggccagac catcatggaa gaaaagagcc ttgttgatac tgtttacgcc ttgaaggacg
     2221 aggtcagaga actgaagcag gaaaataaaa gaatgaagca atgcctggaa gaagaactga
     2281 aatcaagaag ggacctagaa aagctggtgc ggaggctttt gaagcaaaca gatgagtgta
     2341 ttcgaggcga gtccagtagc aagacctcaa ttcttccata accatcactg tgccactggg
     2401 tggagtgtgc cttcagggca tcttgaaatg tcccgctgaa tgatttgact cagtttgctc
     2461 acttctttgg cttttgtttt gtgtttgagt ctctctctct ctctccctct ctcttctctt
     2521 tctctccccg ctgtgtgcat atgtgtgtgc gtgcacgtgc gcgcttgggc atttgctgtt
     2581 gtttggttat tggttggttg ttcatttttt ttttcaacag gtgaaaaagc aggaagtggt
     2641 ggtagagatg gcctcagagt cttttccatt cagtaagaaa gagaaaggga atgcaggcca
     2701 gttacttaaa aggtcttcag attgccttca gttcacagtg cctctgcaac agccattgcc
     2761 ctcaggtcac attctttggg ctggctgccc ttgcaaagca gctggccaag gcttattaaa
     2821 tgtgaaccca acttttcccc agggctttcc tgtacctgca agcctcttag tacttaattt
     2881 accgaaggca aatcttccag actatggctt gagtaggatg aaagacaaac acatctgccc
     2941 aatgatccag ctgcccttcc ttagaccatc acatgcctcc cctcaatcac aggttttaaa
     3001 attactgccc tatgttgtct ataagaccaa gaaaactgta gtacccttat tccttttgtg
     3061 tcatgtaaat tgtaactcag gggggcagaa gctctggtca cccacaccaa caccaaatcc
     3121 atcagcaaat tctactggac aatcctccct tttagtagca gagttgaccg ccttttccca
     3181 ttgcatgata ggtttctttc cctcattctg cctagtgtgt aagttttcta tttccccagt
     3241 acttttagcc aaccttacca agtggtgtgt aaactagtat gtatgtgctt tgcttacttt
     3301 ttaaaaaaat gtagttagac tgtgaggagt tactttatgt acgttgcata ttcaaactgt
     3361 gatgttttat ccttcaaaac aatctgcatt aagaagatat tgtgccctac tagacagctt
     3421 tcattcactt tattactctc tcatatatgc tgtgagaagt tgtaatatta attggcctct
     3481 ttgggtggga ctctaagcag tatttgcaga aatatgcttc tggtccaact tgtacatcca
     3541 gaacaaaagg gcccctctag tagctgtgtg ctggattatt caggactgat taactcaagt
     3601 tgctcattga atcacatcat ccactttatc ccagaaacta gaactgtgag aaaccaggtt
     3661 tagaagacag tcacagaaca gcacacatcc aaattcagcg ccattgaaag ttggcctaag
     3721 gctcagtgcc actcacccct ccctccccaa aagacaagag aaatttggcc agatggggaa
     3781 ggtcactgga aattgaggcc aaagggctga tcagaattgc ctttataata tatttgatgg
     3841 atgcctataa atgtgggttt tgcaaatatt gtttaaaaac caaacttgaa gccaggcatg
     3901 gtggcccaca cctgtggtcc cagctactca ggaggctgag gtgggaggat catttgagcc
     3961 caggaggtca aggctgcagt gagctgtgat gacaccactg cactccaacc taggtaacag
     4021 agagacacct ctgtctctga aaaaacaaaa cttgaagttt gaaaccccca gcttgctgag
     4081 gagccctttt tatttttggt actgagagtc tcaaggtccc atagctacat ggtacagggc
     4141 tgttgtctgc ttgctgcaca gcagaaatta caccatccac aggaaatgga ctatttttgc
     4201 agtccaacat cagccaacca cacacagccg tgtttggaag ctgaagagta aagaaatttc
     4261 taggaatggc tgttgttctg ttttttagca cagccattta gatataacat ccttcactta
     4321 aaaattaaaa acatcagtac taccaccacc accaacaaca tcaacacaga tcttcacatc
     4381 tgcccattct gtggttagtc aatggcttgc aataaatgtg caaactgcat ctataggaaa
     4441 catttttgtg attacggaat actttagttg attgctgaaa atattgaaag gtcttcattt
     4501 tacagtgatg agtacatatg catgtttcgg ggacttggcc cttctgatga ggggccctcg
     4561 gtactctgga taacgaagct tgtgcagagt ggtaaccatg cttacacact aaactataat
     4621 ataaaggaaa tgaagccatg ttaatctgag agcagtgtcg ccatagttgt gttgtttaca
     4681 atactctata aatgggttcc tgttgccctg taattaaact gctgcccgta gaggcctttc
     4741 agttcctttt ctgtccttcc ccttcttaac acaagctcaa attttctaac ttgtttttat
     4801 tttgaagact tttaaaatgg acattttcaa tacataaaaa taaacagtgc tttataaaaa
//
